LOCUS       NM_130811               2053 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens synaptosome associated protein 25 (SNAP25), transcript
            variant 2, mRNA.
ACCESSION   NM_130811
VERSION     NM_130811.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Wang,W., Gao,W., Gong,P., Song,W., Bu,X., Hou,J., Zhang,L. and
            Zhao,B.
  TITLE     Neuronal-specific TNFAIP1 ablation attenuates postoperative
            cognitive dysfunction via targeting SNAP25 for K48-linked
            ubiquitination
  JOURNAL   Cell Commun Signal 21 (1), 356 (2023)
   PUBMED   38102610
  REMARK    GeneRIF: Neuronal-specific TNFAIP1 ablation attenuates
            postoperative cognitive dysfunction via targeting SNAP25 for
            K48-linked ubiquitination.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Bolognesi,E., Guerini,F.R., Carta,A., Chiappedi,M., Sotgiu,S.,
            Mensi,M.M., Agliardi,C., Zanzottera,M. and Clerici,M.
  TITLE     The Role of SNAP-25 in Autism Spectrum Disorders Onset Patterns
  JOURNAL   Int J Mol Sci 24 (18), 14042 (2023)
   PUBMED   37762342
  REMARK    GeneRIF: The Role of SNAP-25 in Autism Spectrum Disorders Onset
            Patterns.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Yazar,V., Kuhlwein,J.K., Knehr,A., Grozdanov,V., Ekici,A.B.,
            Ludolph,A.C. and Danzer,K.M.
  TITLE     Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients
  JOURNAL   Sci Rep 13 (1), 12019 (2023)
   PUBMED   37491426
  REMARK    GeneRIF: Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS
            patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Zhang,J., Hou,S., Chi,X.Q., Shan,H.F., Li,X.W., Zhang,Q.J.,
            Wang,J.L. and Kang,C.B.
  TITLE     Role of SNAP25 on the occurrence and development of eosinophilic
            gastritis
  JOURNAL   Medicine (Baltimore) 102 (29), e34377 (2023)
   PUBMED   37478220
  REMARK    GeneRIF: Role of SNAP25 on the occurrence and development of
            eosinophilic gastritis.
REFERENCE   5  (bases 1 to 2053)
  AUTHORS   Felicio,D., Dias,A., Martins,S., Carvalho,E., Lopes,A.M., Pinto,N.,
            Lemos,C., Santos,M. and Alves-Ferreira,M.
  TITLE     Non-coding variants in VAMP2 and SNAP25 affect gene expression:
            potential implications in migraine susceptibility
  JOURNAL   J Headache Pain 24 (1), 78 (2023)
   PUBMED   37380951
  REMARK    GeneRIF: Non-coding variants in VAMP2 and SNAP25 affect gene
            expression: potential implications in migraine susceptibility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2053)
  AUTHORS   Hanson,P.I., Otto,H., Barton,N. and Jahn,R.
  TITLE     The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce
            a conformational change in syntaxin
  JOURNAL   J Biol Chem 270 (28), 16955-16961 (1995)
   PUBMED   7622514
REFERENCE   7  (bases 1 to 2053)
  AUTHORS   Hata,Y. and Sudhof,T.C.
  TITLE     A novel ubiquitous form of Munc-18 interacts with multiple
            syntaxins. Use of the yeast two-hybrid system to study interactions
            between proteins involved in membrane traffic
  JOURNAL   J Biol Chem 270 (22), 13022-13028 (1995)
   PUBMED   7768895
REFERENCE   8  (bases 1 to 2053)
  AUTHORS   Chapman,E.R., An,S., Barton,N. and Jahn,R.
  TITLE     SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin
            via domains that may form coiled coils
  JOURNAL   J Biol Chem 269 (44), 27427-27432 (1994)
   PUBMED   7961655
REFERENCE   9  (bases 1 to 2053)
  AUTHORS   Zhao,N., Hashida,H., Takahashi,N. and Sakaki,Y.
  TITLE     Cloning and sequence analysis of the human SNAP25 cDNA
  JOURNAL   Gene 145 (2), 313-314 (1994)
   PUBMED   8056350
REFERENCE   10 (bases 1 to 2053)
  AUTHORS   Abicht,A., Muller,J.S. and Lochmuller,H.
  TITLE     Congenital Myasthenic Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354824.8 and AL023913.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 28, 2019 this sequence version replaced NM_130811.3.
            
            Summary: Synaptic vesicle membrane docking and fusion is mediated
            by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment
            protein receptors) located on the vesicle membrane (v-SNAREs) and
            the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE
            complex consists of a bundle of four helices, one of which is
            supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on
            the plasma membrane, the protein syntaxin supplies one helix and
            the protein encoded by this gene contributes the other two.
            Therefore, this gene product is a presynaptic plasma membrane
            protein involved in the regulation of neurotransmitter release. Two
            alternative transcript variants encoding different protein isoforms
            have been described for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647443.1, D21267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254976.7/ ENSP00000254976.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AL354824.8         76313-76460
            149-283             AL023913.6         49061-49195
            284-325             AL023913.6         51317-51358
            326-374             AL023913.6         58356-58404
            375-492             AL023913.6         66793-66910
            493-618             AL023913.6         70557-70682
            619-763             AL023913.6         72900-73044
            764-2053            AL023913.6         79761-81050
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.2"
     gene            1..2053
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /note="synaptosome associated protein 25"
                     /db_xref="GeneID:6616"
                     /db_xref="HGNC:HGNC:11132"
                     /db_xref="MIM:600322"
     exon            1..148
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            149..283
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..832
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /note="isoform SNAP25B is encoded by transcript variant 2;
                     resistance to inhibitors of cholinesterase 4 homolog;
                     synaptosome associated protein 25kDa;
                     synaptosomal-associated protein, 25kDa"
                     /codon_start=1
                     /product="synaptosomal-associated protein 25 isoform
                     SNAP25B"
                     /protein_id="NP_570824.1"
                     /db_xref="CCDS:CCDS13110.1"
                     /db_xref="GeneID:6616"
                     /db_xref="HGNC:HGNC:11132"
                     /db_xref="MIM:600322"
                     /translation="MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGI
                     RTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYK
                     KAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNL
                     RHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG"
     exon            284..325
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            326..374
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            375..492
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            493..618
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            619..763
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2053
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /note="hexamer: ATTAAA"
     polyA_site      2053
                     /gene="SNAP25"
                     /gene_synonym="bA416N4.2; CMS18; dJ1068F16.2; RIC-4; RIC4;
                     SEC9; SNAP; SNAP-25; SUP"
                     /note="major polyA site"
ORIGIN      
        1 atctttgatg agggcagagc tcacgttgca ttgaagacga aacctcgggg aggtcaggcg
       61 ctgtctttcc ttccctccct gctcggcggc tccaccacag ttgcaacctg cagaggcccg
      121 gagaacacaa ccctcccgag aagcccaggt ccagagccaa acccgtcact gaccccccag
      181 cccaggcgcc cagccactcc ccaccgctac catggccgaa gacgcagaca tgcgcaatga
      241 gctggaggag atgcagcgaa gggctgacca gttggctgat gagtcgctgg aaagcacccg
      301 tcgtatgctg caactggttg aagagagtaa agatgctggt atcaggactt tggttatgtt
      361 ggatgaacaa ggagaacaac tggaacgcat tgaggaaggg atggaccaaa tcaataagga
      421 catgaaagaa gcagaaaaga atttgacgga cctaggaaaa ttctgcgggc tttgtgtgtg
      481 tccctgtaac aagcttaaat caagtgatgc ttacaaaaaa gcctggggca ataatcagga
      541 cggagtggtg gccagccagc ctgctcgtgt agtggacgaa cgggagcaga tggccatcag
      601 tggcggcttc atccgcaggg taacaaatga tgcccgagaa aatgaaatgg atgaaaacct
      661 agagcaggtg agcggcatca tcgggaacct ccgtcacatg gccctggata tgggcaatga
      721 gatcgataca cagaatcgcc agatcgacag gatcatggag aaggctgatt ccaacaaaac
      781 cagaattgat gaggccaacc aacgtgcaac aaagatgctg ggaagtggtt aagtgtgccc
      841 acccgtgttc tcctccaaat gctgtcgggc aagatagctc cttcatgctt ttctcatggt
      901 attatctagt aggtctgcac acataacaca catcagtcca cccccattgt gaatgttgtc
      961 ctgtgtcatc tgtcagcttc ccaacaatac tttgtgtctt ttgttctctc ttggtctctt
     1021 tctttccaaa ggttgtacat agtggtcatt tggtggctct aactccttga ggtcttgagt
     1081 ttcatttttc attttctctc ctcggtggca tttgctgaat aacaacaatt taggaatgct
     1141 caatgtgctg ttgattcttt caatccacag tattgttctt gtaaaactgt gacattccac
     1201 agagttactg ccacggtcct ttgagtgtca ggctctgaat ctctcaaaat gtgccgtctt
     1261 tggttcctca tggctgttat ctgtctttat gatttcatga ttagacaatg tggaattaca
     1321 taacaggcat tgcactaaaa gtgatgtgat ttatgcattt atgcatgaga actaaataga
     1381 tttttagatt cctacttaaa caaaaacttt ccatgacagt agcatactga tgagacaaca
     1441 cacacacaca caaaacaaca gcaacaacaa cagaacaaca acaaagcatg ctcagtattg
     1501 agacactgtc aagattaagt tataccagca aaagtgcagt agtgtcactt ttttcctgtc
     1561 aatatataga gacttctaaa tcataatcat ccttttttaa aaaaaagaat tttaaaaaag
     1621 atggatttga cacactcacc atttaatcat ttccagcaaa atatatgttt ggctgaaatt
     1681 atgtcaaatg gatgtaatat agggtttgtt tgctgctttt gatggctatg ttttggagag
     1741 agcaatcttg ctgtgaaaca gtgtggatgt aaattttata aggctgactc ttactaacca
     1801 ccatttcccc tgtggtttgt tatcagtaca attctttgtt gcttaatcta gagctatgca
     1861 caccaaattg ctgagatgtt tagtagctga taaagaaacc ttttaaaaaa ataatataaa
     1921 tgaatgaaat ataaactgtg agataaatat cattatagca tgtaatatta aattcctcct
     1981 gtctcctctg tcagtttgtg aagtgattga cattttgtag ctagtttaaa attattaaaa
     2041 attatagact cca
//
