LOCUS       NM_178310               1740 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens snail family transcriptional repressor 3 (SNAI3),
            mRNA.
ACCESSION   NM_178310 XM_370995
VERSION     NM_178310.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Huo,F.C., Zhu,Z.M., Du,Q.Y. and Pei,D.S.
  TITLE     PAK5-stabilized Smuc confers renal cell carcinoma metastasis
  JOURNAL   Clin Transl Med 11 (9), e559 (2021)
   PUBMED   34586742
  REMARK    GeneRIF: PAK5-stabilized Smuc confers renal cell carcinoma
            metastasis.
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Gras,B., Jacqueroud,L., Wierinckx,A., Lamblot,C., Fauvet,F.,
            Lachuer,J., Puisieux,A. and Ansieau,S.
  TITLE     Snail family members unequally trigger EMT and thereby differ in
            their ability to promote the neoplastic transformation of mammary
            epithelial cells
  JOURNAL   PLoS One 9 (3), e92254 (2014)
   PUBMED   24638100
  REMARK    GeneRIF: SNAI1, SNAI2, SNAI3 show unequal oncogenic potential,
            strictly correlating with their ability to promote
            epithelial-to-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human SNAIL3 (SNAI3) gene in
            silico
  JOURNAL   Int J Mol Med 11 (3), 383-388 (2003)
   PUBMED   12579345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138028.1 and BC107058.2.
            
            On Nov 23, 2018 this sequence version replaced NM_178310.3.
            
            Summary: SNAI3 is a member of the SNAIL gene family, named for the
            Drosophila snail gene, which plays roles in mesodermal formation
            during embryogenesis (Katoh and Katoh, 2003 [PubMed
            12579345]).[supplied by OMIM, Apr 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.417785.1,
                                           SRR1163655.513820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332281.6/ ENSP00000327968.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC138028.1         92172-92204
            34-1079             BC107058.2         1-1046
            1080-1740           AC138028.1         100331-100991
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..1740
                     /gene="SNAI3"
                     /gene_synonym="SMUC; SNAIL3; Zfp293; ZNF293"
                     /note="snail family transcriptional repressor 3"
                     /db_xref="GeneID:333929"
                     /db_xref="HGNC:HGNC:18411"
                     /db_xref="MIM:612741"
     exon            1..177
                     /gene="SNAI3"
                     /gene_synonym="SMUC; SNAIL3; Zfp293; ZNF293"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..980
                     /gene="SNAI3"
                     /gene_synonym="SMUC; SNAIL3; Zfp293; ZNF293"
                     /note="zinc finger protein 293; protein snail homolog 3;
                     snail family zinc finger 3"
                     /codon_start=1
                     /product="zinc finger protein SNAI3"
                     /protein_id="NP_840101.1"
                     /db_xref="CCDS:CCDS32505.1"
                     /db_xref="GeneID:333929"
                     /db_xref="HGNC:HGNC:18411"
                     /db_xref="MIM:612741"
                     /translation="MPRSFLVKTHSSHRVPNYRRLETQREINGACSACGGLVVPLLPR
                     DKEAPSVPGDLPQPWDRSSAVACISLPLLPRIEEALGASGLDALEVSEVDPRASRAAI
                     VPLKDSLNHLNLPPLLVLPTRWSPTLGPDRHGAPEKLLGAERMPRAPGGFECFHCHKP
                     YHTLAGLARHRQLHCHLQVGRVFTCKYCDKEYTSLGALKMHIRTHTLPCTCKICGKAF
                     SRPWLLQGHVRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDAKKYRCRRCTKTFSR
                     MSLLARHEESGCCPGP"
     exon            178..798
                     /gene="SNAI3"
                     /gene_synonym="SMUC; SNAIL3; Zfp293; ZNF293"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1740
                     /gene="SNAI3"
                     /gene_synonym="SMUC; SNAIL3; Zfp293; ZNF293"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAI3"
                     /gene_synonym="SMUC; SNAIL3; Zfp293; ZNF293"
                     /note="hexamer: AATAAA"
     polyA_site      1740
                     /gene="SNAI3"
                     /gene_synonym="SMUC; SNAIL3; Zfp293; ZNF293"
                     /note="major polyA site"
ORIGIN      
        1 aatgagcctg accccttcaa gcgccggcgg acgcagcagt ccggacccag gcgcgcccct
       61 cccgccccag cccaccccgg cctgccgccc gggaggggaa catgccgcgc tccttcctgg
      121 tgaaaacgca ctccagccac agggtcccca actaccggcg gctggagacg cagagagaaa
      181 tcaatggtgc ctgctctgcc tgtggggggc tggtggtgcc cctcctcccc cgagacaagg
      241 aggccccttc tgtgcccggt gaccttcccc agccctggga ccgctcctcg gccgtcgcct
      301 gcatctccct gcccctcctg ccacggatcg aggaagctct gggggcctct gggctggacg
      361 ccttggaagt cagcgaggtc gaccctcggg ccagccgggc cgccattgta cccctcaaag
      421 acagcctgaa ccacctcaac ctgcccccac tgctggtgct gcccacacgg tggtccccga
      481 ccttgggccc agaccggcac ggggctccgg aaaaactgct tggggctgag cggatgcccc
      541 gagccccggg cggctttgag tgcttccact gccacaaacc ctaccacacg ctggccgggc
      601 tggccaggca ccggcagctg cactgccacc tgcaggtggg gcgtgtcttc acctgcaagt
      661 actgcgacaa ggagtacacc agcctgggtg ccctcaagat gcacatccgc actcacacgc
      721 tgccctgcac ctgcaagatc tgtggcaagg ccttctccag gccctggtta ctgcagggcc
      781 atgtccgcac ccacacaggg gagaagccct atgcctgctc gcactgcagc agggcctttg
      841 ccgaccgctc caaccttcgg gcccatctgc aaacgcactc agacgccaag aagtaccggt
      901 gccggcgctg caccaagacc ttctcccgca tgtccctcct ggcgcggcat gaggagtctg
      961 gctgctgccc gggcccctga gaggcacgtg gtcggcgcag gtaggaggga tggtcctcac
     1021 cgggagagct ggcgtccctc ctgcccccag aggagccagg agtctgggag ggcggggcct
     1081 ggcctcacac ttggtgcgtc ctccacatct gcgtccaatc agaaccaaag aagtccagcg
     1141 ggggccactg ggccggagga cactccccca ggcatcccac cgcgcggagc ccactcagag
     1201 gagactcctc tcccggggaa ggctttcatc agaacaagag ccatggttcc atttcgacac
     1261 ggccaggtct ccggggctac ccttccaaga gtcagagcct cggggaggtg gccgccagca
     1321 tgggccggca ctgccgccgg atggctggca aggctgccta gttccattgc agcagaaatg
     1381 aacagttctg acttatagtg agcaccgccc tgtggccctt cctcagtagg cacaactacc
     1441 tctcagccag cccccgccag cctttggttt ggggtctggg acgagctgcc ccatgtcaca
     1501 cgtctatgtg catgtgcaca cacactcaaa catgtacaca cacgtgccct ccccacctca
     1561 ctagactctc cgggagatgg ggcaggactg ggagagccca cgattggtga tttgggtgtg
     1621 ttgggatgag gcggagtgcc tgtgggattt gtcccggtca gagcctcagg gggctggggt
     1681 ctcagggcac tcagcttccc aggcaataac agccgtgggg taataaatgg tctctgcaca
//
