LOCUS       NM_003068               2180 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens snail family transcriptional repressor 2 (SNAI2),
            mRNA.
ACCESSION   NM_003068 XR_017857
VERSION     NM_003068.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2180)
  AUTHORS   Cardoso,I.I.V., Rosa,M.N., Moreno,D.A., Tufi,L.M.B., Ramos,L.P.,
            Pereira,L.A.B., Silva,L., Galvao,J.M.S., Tosi,I.C., Lengert,A.V.H.,
            Da Cruz,M.C., Teixeira,S.A., Reis,R.M., Lopes,L.F. and Pinto,M.T.
  TITLE     Cisplatin-resistant germ cell tumor models: An exploration of the
            epithelial-mesenchymal transition regulator SLUG
  JOURNAL   Mol Med Rep 30 (6) (2024)
   PUBMED   39392037
  REMARK    GeneRIF: Cisplatin-resistant germ cell tumor models: An exploration
            of the epithelial-mesenchymal transition regulator SLUG.
REFERENCE   2  (bases 1 to 2180)
  AUTHORS   Zhang,D., Qiu,Y., Zhang,W., Du,D., Liu,Y., Liu,L., Li,J., Chen,Z.,
            Yu,X., Ye,M., Wang,W., Li,Z. and Shao,J.
  TITLE     Homeobox B9 promotes the invasion and metastasis of hepatocellular
            carcinoma cells via the EZH2-MIR203A-SNAI2 axis
  JOURNAL   J Transl Med 22 (1), 918 (2024)
   PUBMED   39390614
  REMARK    GeneRIF: Homeobox B9 promotes the invasion and metastasis of
            hepatocellular carcinoma cells via the EZH2-MIR203A-SNAI2 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2180)
  AUTHORS   He,Y., Yang,X. and Wu,N.
  TITLE     TGFbeta1, SNAIL2, and PAPP-A Expression in Placenta of Gestational
            Diabetes Mellitus Patients
  JOURNAL   J Diabetes Res 2024, 1386469 (2024)
   PUBMED   39109165
  REMARK    GeneRIF: TGFbeta1, SNAIL2, and PAPP-A Expression in Placenta of
            Gestational Diabetes Mellitus Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2180)
  AUTHORS   Park,S.Y., Choi,H., Choi,S.M., Wang,S., Shim,S., Jun,W., Lee,J. and
            Chung,J.W.
  TITLE     T-plastin contributes to epithelial-mesenchymal transition in human
            lung cancer cells through FAK/AKT/Slug axis signaling pathway
  JOURNAL   BMB Rep 57 (6), 305-310 (2024)
   PUBMED   38835117
  REMARK    GeneRIF: T-plastin contributes to epithelial-mesenchymal transition
            in human lung cancer cells through FAK/AKT/Slug axis signaling
            pathway.
REFERENCE   5  (bases 1 to 2180)
  AUTHORS   Zhang,R., Zhang,D., Han,F., Song,X., Zhang,Y., Zhang,J., Zhu,Q. and
            Qin,Y.
  TITLE     The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic
            mimicry and malignant progression of RMS by balancing SNAI2
            homeostasis
  JOURNAL   J Exp Clin Cancer Res 43 (1), 135 (2024)
   PUBMED   38702792
  REMARK    GeneRIF: The deubiquitinase USP7 and E3 ligase TRIM21 regulate
            vasculogenic mimicry and malignant progression of RMS by balancing
            SNAI2 homeostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2180)
  AUTHORS   Hemavathy,K., Guru,S.C., Harris,J., Chen,J.D. and Ip,Y.T.
  TITLE     Human Slug is a repressor that localizes to sites of active
            transcription
  JOURNAL   Mol Cell Biol 20 (14), 5087-5095 (2000)
   PUBMED   10866665
REFERENCE   7  (bases 1 to 2180)
  AUTHORS   Inukai,T., Inoue,A., Kurosawa,H., Goi,K., Shinjyo,T., Ozawa,K.,
            Mao,M., Inaba,T. and Look,A.T.
  TITLE     SLUG, a ces-1-related zinc finger transcription factor gene with
            antiapoptotic activity, is a downstream target of the E2A-HLF
            oncoprotein
  JOURNAL   Mol Cell 4 (3), 343-352 (1999)
   PUBMED   10518215
REFERENCE   8  (bases 1 to 2180)
  AUTHORS   Stegmann,K., Boecker,J., Kosan,C., Ermert,A., Kunz,J. and Koch,M.C.
  TITLE     Human transcription factor SLUG: mutation analysis in patients with
            neural tube defects and identification of a missense mutation
            (D119E) in the Slug subfamily-defining region
  JOURNAL   Mutat Res 406 (2-4), 63-69 (1999)
   PUBMED   10479723
REFERENCE   9  (bases 1 to 2180)
  AUTHORS   Cohen,M.E., Yin,M., Paznekas,W.A., Schertzer,M., Wood,S. and
            Jabs,E.W.
  TITLE     Human SLUG gene organization, expression, and chromosome map
            location on 8q
  JOURNAL   Genomics 51 (3), 468-471 (1998)
   PUBMED   9721220
REFERENCE   10 (bases 1 to 2180)
  AUTHORS   Savagner,P., Yamada,K.M. and Thiery,J.P.
  TITLE     The zinc-finger protein slug causes desmosome dissociation, an
            initial and necessary step for growth factor-induced
            epithelial-mesenchymal transition
  JOURNAL   J Cell Biol 137 (6), 1403-1419 (1997)
   PUBMED   9182671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA522147.1, BC015895.1 and
            AC013701.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003068.4.
            
            Summary: This gene encodes a member of the Snail family of
            C2H2-type zinc finger transcription factors. The encoded protein
            acts as a transcriptional repressor that binds to E-box motifs and
            is also likely to repress E-cadherin transcription in breast
            carcinoma. This protein is involved in epithelial-mesenchymal
            transitions and has antiapoptotic activity. Mutations in this gene
            may be associated with sporatic cases of neural tube defects.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223368.1, SRR3476690.115526.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000020945.4/ ENSP00000020945.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA522147.1         13-44
            33-2010             BC015895.1         1-1978
            2011-2180           AC013701.6         54924-55093         c
FEATURES             Location/Qualifiers
     source          1..2180
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.21"
     gene            1..2180
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /note="snail family transcriptional repressor 2"
                     /db_xref="GeneID:6591"
                     /db_xref="HGNC:HGNC:11094"
                     /db_xref="MIM:602150"
     exon            1..243
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..971
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /note="slug (chicken homolog), zinc finger protein; neural
                     crest transcription factor SLUG; protein snail homolog 2;
                     snail family zinc finger 2"
                     /codon_start=1
                     /product="zinc finger protein SNAI2"
                     /protein_id="NP_003059.1"
                     /db_xref="CCDS:CCDS6146.1"
                     /db_xref="GeneID:6591"
                     /db_xref="HGNC:HGNC:11094"
                     /db_xref="MIM:602150"
                     /translation="MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYSMPVIPQ
                     PEILSSGAYSPITVWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGS
                     ESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFS
                     CKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHC
                     NRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH"
     exon            244..789
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /inference="alignment:Splign:2.1.0"
     exon            790..2180
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1989..1994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /note="hexamer: AATAAA"
     polyA_site      2010
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /note="major polyA site"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
                     /note="hexamer: AATAAA"
     polyA_site      2180
                     /gene="SNAI2"
                     /gene_synonym="SLUG; SLUGH; SLUGH1; SNAIL2; WS2D"
ORIGIN      
        1 agttcgtaaa ggagccgggt gacttcagag gcgccggccc gtccgtctgc cgcacctgag
       61 cacggcccct gcccgagcct ggcccgccgc gatgctgtag ggaccgccgt gtcctcccgc
      121 cggaccgtta tccgcgccgg gcgcccgcca gacccgctgg caagatgccg cgctccttcc
      181 tggtcaagaa gcatttcaac gcctccaaaa agccaaacta cagcgaactg gacacacata
      241 cagtgattat ttccccgtat ctctatgaga gttactccat gcctgtcata ccacaaccag
      301 agatcctcag ctcaggagca tacagcccca tcactgtgtg gactaccgct gctccattcc
      361 acgcccagct acccaatggc ctctctcctc tttccggata ctcctcatct ttggggcgag
      421 tgagtccccc tcctccatct gacacctcct ccaaggacca cagtggctca gaaagcccca
      481 ttagtgatga agaggaaaga ctacagtcca agctttcaga cccccatgcc attgaagctg
      541 aaaagtttca gtgcaattta tgcaataaga cctattcaac tttttctggg ctggccaaac
      601 ataagcagct gcactgcgat gcccagtcta gaaaatcttt cagctgtaaa tactgtgaca
      661 aggaatatgt gagcctgggc gccctgaaga tgcatattcg gacccacaca ttaccttgtg
      721 tttgcaagat ctgcggcaag gcgttttcca gaccctggtt gcttcaagga cacattagaa
      781 ctcacacggg ggagaagcct ttttcttgcc ctcactgcaa cagagcattt gcagacaggt
      841 caaatctgag ggctcatctg cagacccatt ctgatgtaaa gaaataccag tgcaaaaact
      901 gctccaaaac cttctccaga atgtctctcc tgcacaaaca tgaggaatct ggctgctgtg
      961 tagcacactg agtgacgcaa tcaatgttta ctcgaacaga atgcatttct tcactccgaa
     1021 gccaaatgac aaataaagtc caaaggcatt ttctcctgtg ctgaccaacc aaataatatg
     1081 tatagacaca cacacatatg cacacacaca cacacacacc cacagagaga gagctgcaag
     1141 agcatggaat tcatgtgttt aaagataatc ctttccatgt gaagtttaaa attactatat
     1201 atttgctgat ggctagattg agagaataaa agacagtaac ctttctcttc aaagataaaa
     1261 tgaaaagcac attgcatctt ttcttcctaa aaaaatgcaa agatttacat tgctgccaaa
     1321 tcatttcaac tgaaaagaac agtattgctt tgtaatagag tctgtaatag gatttcccat
     1381 aggaagagat ctgccagacg cgaactcagg tgccttaaaa agtattccaa gtttactcca
     1441 ttacatgtcg gttgtctggt tgccattgtt gaactaaagc ctttttttga ttacctgtag
     1501 tgctttaaag tatattttta aaagggagga aaaaaataac aagaacaaaa cacaggagaa
     1561 tgtattaaaa gtatttttgt tttgttttgt ttttgccaat taacagtatg tgccttgggg
     1621 gaggagggaa agattagctt tgaacattcc tggcgcatgc tccattgtct tactatttta
     1681 aaacatttta ataatttttg aaaattaatt aaagatggga ataagtgcaa aagaggattc
     1741 ttacaaattc attaatgtac ttaaactatt tcaaatgcat accacaaatg caataataca
     1801 ataccccttc caagtgcctt tttaaattgt atagttgatg agtcaatgta aatttgtgtt
     1861 tatttttata tgattgaatg agttctgtat gaaactgaga tgttgtctat agctatgtct
     1921 ataaacaacc tgaagacttg tgaaatcaat gtttcttttt taaaaaacaa ttttcaagtt
     1981 ttttttacaa taaacagttt tgatttaaaa tctcgtttgt atactatttt cagagacttt
     2041 acttgcttca tgattagtac caaaccactg tacaaagaat tgtttgttaa caagaaaaaa
     2101 atgaataatg cttattatgc atctgaagtg ttattttatg tgttagatta taataaagta
     2161 agctgctagt attattttta
//
