LOCUS       NM_005985               1705 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens snail family transcriptional repressor 1 (SNAI1),
            mRNA.
ACCESSION   NM_005985
VERSION     NM_005985.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Ryu,K.J., Lee,K.W., Park,S.H., Kim,T., Hong,K.S., Kim,H., Kim,M.,
            Ok,D.W., Kwon,G.N.B., Park,Y.J., Kwon,H.K., Hwangbo,C., Kim,K.D.,
            Lee,J.E. and Yoo,J.
  TITLE     Chaperone-mediated autophagy modulates Snail protein stability:
            implications for breast cancer metastasis
  JOURNAL   Mol Cancer 23 (1), 227 (2024)
   PUBMED   39390584
  REMARK    GeneRIF: Chaperone-mediated autophagy modulates Snail protein
            stability: implications for breast cancer metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Li,M., Zhang,L., Guan,T., Huang,L., Zhu,Y., Wen,Y., Ma,X., Yang,X.,
            Wan,R., Chen,J., Zhang,C., Wang,F., Tang,H. and Liu,T.
  TITLE     Energy stress-activated AMPK phosphorylates Snail1 and suppresses
            its stability and oncogenic function
  JOURNAL   Cancer Lett 595, 216987 (2024)
   PUBMED   38815798
  REMARK    GeneRIF: Energy stress-activated AMPK phosphorylates Snail1 and
            suppresses its stability and oncogenic function.
REFERENCE   3  (bases 1 to 1705)
  AUTHORS   Fang,Y., Wang,Y., Ma,H., Guo,Y., Xu,R., Chen,X., Chen,X., Lv,Y.,
            Li,P. and Gao,Y.
  TITLE     TFAP2A downregulation mediates tumor-suppressive effect of miR-8072
            in triple-negative breast cancer via inhibiting SNAI1 transcription
  JOURNAL   Breast Cancer Res 26 (1), 103 (2024)
   PUBMED   38890750
  REMARK    GeneRIF: TFAP2A downregulation mediates tumor-suppressive effect of
            miR-8072 in triple-negative breast cancer via inhibiting SNAI1
            transcription.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1705)
  AUTHORS   Wu,Z., Zhang,Q., Wang,H., Zhou,S., Fu,B., Fang,L., Cheng,J.C. and
            Sun,Y.P.
  TITLE     Growth differentiation factor-11 upregulates matrix
            metalloproteinase 2 expression by inducing Snail in human
            extravillous trophoblast cells
  JOURNAL   Mol Cell Endocrinol 585, 112190 (2024)
   PUBMED   38369181
  REMARK    GeneRIF: Growth differentiation factor-11 upregulates matrix
            metalloproteinase 2 expression by inducing Snail in human
            extravillous trophoblast cells.
REFERENCE   5  (bases 1 to 1705)
  AUTHORS   Wang,L., Gao,J., Zheng,S., Luo,Z., Xu,Z., Che,H. and Wang,Z.
  TITLE     CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the
            Formation and Progression of RCC with Inferior Vena Cava Tumour
            Thrombus
  JOURNAL   Arch Esp Urol 77 (3), 292-302 (2024)
   PUBMED   38715171
  REMARK    GeneRIF: CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in
            the Formation and Progression of RCC with Inferior Vena Cava Tumour
            Thrombus.
REFERENCE   6  (bases 1 to 1705)
  AUTHORS   Okubo,T., Truong,T.K., Yu,B., Itoh,T., Zhao,J., Grube,B., Zhou,D.
            and Chen,S.
  TITLE     Down-regulation of promoter 1.3 activity of the human aromatase
            gene in breast tissue by zinc-finger protein, snail (SnaH)
  JOURNAL   Cancer Res 61 (4), 1338-1346 (2001)
   PUBMED   11245431
REFERENCE   7  (bases 1 to 1705)
  AUTHORS   Smith,S., Metcalfe,J.A. and Elgar,G.
  TITLE     Identification and analysis of two snail genes in the pufferfish
            (Fugu rubripes) and mapping of human SNA to 20q
  JOURNAL   Gene 247 (1-2), 119-128 (2000)
   PUBMED   10773451
REFERENCE   8  (bases 1 to 1705)
  AUTHORS   Batlle,E., Sancho,E., Franci,C., Dominguez,D., Monfar,M.,
            Baulida,J. and Garcia De Herreros,A.
  TITLE     The transcription factor snail is a repressor of E-cadherin gene
            expression in epithelial tumour cells
  JOURNAL   Nat Cell Biol 2 (2), 84-89 (2000)
   PUBMED   10655587
REFERENCE   9  (bases 1 to 1705)
  AUTHORS   Paznekas,W.A., Okajima,K., Schertzer,M., Wood,S. and Jabs,E.W.
  TITLE     Genomic organization, expression, and chromosome location of the
            human SNAIL gene (SNAI1) and a related processed pseudogene
            (SNAI1P)
  JOURNAL   Genomics 62 (1), 42-49 (1999)
   PUBMED   10585766
REFERENCE   10 (bases 1 to 1705)
  AUTHORS   Twigg,S.R. and Wilkie,A.O.
  TITLE     Characterisation of the human snail (SNAI1) gene and exclusion as a
            major disease gene in craniosynostosis
  JOURNAL   Hum Genet 105 (4), 320-326 (1999)
   PUBMED   10543399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA972913.1 and BC012910.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005985.3.
            
            Summary: The Drosophila embryonic protein snail is a zinc finger
            transcriptional repressor which downregulates the expression of
            ectodermal genes within the mesoderm. The nuclear protein encoded
            by this gene is structurally similar to the Drosophila snail
            protein, and is also thought to be critical for mesoderm formation
            in the developing embryo. At least two variants of a similar
            processed pseudogene have been found on chromosome 2. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012910.1, SRR5189661.136537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244050.3/ ENSP00000244050.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA972913.1         5-19
            16-1705             BC012910.1         1-1690
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..1705
                     /gene="SNAI1"
                     /gene_synonym="dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL;
                     SNAIL1"
                     /note="snail family transcriptional repressor 1"
                     /db_xref="GeneID:6615"
                     /db_xref="HGNC:HGNC:11128"
                     /db_xref="MIM:604238"
     exon            1..162
                     /gene="SNAI1"
                     /gene_synonym="dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL;
                     SNAIL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..875
                     /gene="SNAI1"
                     /gene_synonym="dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL;
                     SNAIL1"
                     /note="snail 1 zinc finger protein; snail 1 homolog; snail
                     family zinc finger 1; protein sna; protein snail homolog
                     1"
                     /codon_start=1
                     /product="zinc finger protein SNAI1"
                     /protein_id="NP_005976.2"
                     /db_xref="CCDS:CCDS13423.1"
                     /db_xref="GeneID:6615"
                     /db_xref="HGNC:HGNC:11128"
                     /db_xref="MIM:604238"
                     /translation="MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAI
                     PPPEILNPTASLPMLIWDSVLAPQAQPIAWASLRLQESPRVAELTSLSDEDSGKGSQP
                     PSPPSPAPSSFSSTSVSSLEAEAYAAFPGLGQVPKQLAQLSEAKDLQARKAFNCKYCN
                     KEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFA
                     DRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSGCPR"
     exon            163..690
                     /gene="SNAI1"
                     /gene_synonym="dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL;
                     SNAIL1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1705
                     /gene="SNAI1"
                     /gene_synonym="dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL;
                     SNAIL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAI1"
                     /gene_synonym="dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL;
                     SNAIL1"
                     /note="hexamer: AATAAA"
     polyA_site      1705
                     /gene="SNAI1"
                     /gene_synonym="dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL;
                     SNAIL1"
                     /note="major polyA site"
ORIGIN      
        1 attgcgccgc ggcacggcct agcgagtggt tcttctgcgc tactgctgcg cgaatcggcg
       61 accccagtgc ctcgaccact atgccgcgct ctttcctcgt caggaagccc tccgacccca
      121 atcggaagcc taactacagc gagctgcagg actctaatcc agagtttacc ttccagcagc
      181 cctacgacca ggcccacctg ctggcagcca tcccacctcc ggagatcctc aaccccaccg
      241 cctcgctgcc aatgctcatc tgggactctg tcctggcgcc ccaagcccag ccaattgcct
      301 gggcctccct tcggctccag gagagtccca gggtggcaga gctgacctcc ctgtcagatg
      361 aggacagtgg gaaaggctcc cagcccccca gcccaccctc accggctcct tcgtccttct
      421 cctctacttc agtctcttcc ttggaggccg aggcctatgc tgccttccca ggcttgggcc
      481 aagtgcccaa gcagctggcc cagctctctg aggccaagga tctccaggct cgaaaggcct
      541 tcaactgcaa atactgcaac aaggaatacc tcagcctggg tgccctcaag atgcacatcc
      601 gaagccacac gctgccctgc gtctgcggaa cctgcgggaa ggccttctct aggccctggc
      661 tgctacaagg ccatgtccgg acccacactg gcgagaagcc cttctcctgt ccccactgca
      721 gccgtgcctt cgctgaccgc tccaacctgc gggcccacct ccagacccac tcagatgtca
      781 agaagtacca gtgccaggcg tgtgctcgga ccttctcccg aatgtccctg ctccacaagc
      841 accaagagtc cggctgctca ggatgtcccc gctgaccctc gaggctccct cttcctctcc
      901 atacctgccc ctgcctgaca gccttcccca gctccagcag gaaggacccc acatccttct
      961 cactgccatg gaattccctc ctgagtgccc cacttctggc cacatcagcc ccacaggact
     1021 ttgatgaaga ccattttctg gttctgtgtc ctctgcctgg gctctggaag aggccttccc
     1081 atggccattt ctgtggaggg agggcagctg gcccccagcc ctgggggatt cctgagctgg
     1141 cctgtctgcg tgggtttttg tatccagagc tgtttggata cagctgcttt gagctacagg
     1201 acaaaggctg acagactcac tgggaagctc ccaccccact caggggaccc cactcccctc
     1261 acacacaccc ccccacaagg aaccctcagg ccaccctcca cgaggtgtga ctaactatgc
     1321 aataatccac ccccaggtgc agccccaggg cctgcggagg cggtggcaga ctagagtctg
     1381 agatgccccg agcccaggca gctatttcag cctcctgttt ggtggggtgg cacctgtttc
     1441 ccgggcaatt taacaatgtc tgaaaaggga ctgtgagtaa tggctgtcac ttgtcggggg
     1501 cccaagtggg gtgctctggt ctgaccgatg tgtctcccag aactattctg ggggcccgac
     1561 aggtgggcct gggaggaaga tgtttacatt tttaaaggta cactggtatt tatatttcaa
     1621 acattttgta tcaaggaaac gttttgtata gttatatgta cagtttattg atattcaata
     1681 aagcagttaa tttatatatt aaaaa
//
