LOCUS       NM_006062               2554 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SMYD family member 5 (SMYD5), mRNA.
ACCESSION   NM_006062 XM_039548
VERSION     NM_006062.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2554)
  AUTHORS   Miao,B., Ge,L., He,C., Wang,X., Wu,J., Li,X., Chen,K., Wan,J.,
            Xing,S., Ren,L., Shi,Z., Liu,S., Hu,Y., Chen,J., Yu,Y., Feng,L.,
            Flores,N.M., Liang,Z., Xu,X., Wang,R., Zhou,J., Fan,J., Xiang,B.,
            Li,E., Mao,Y., Cheng,J., Zhao,K., Mazur,P.K., Cai,J. and Lan,F.
  TITLE     SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine
            methylation to enhance translation output and promote
            hepatocellular carcinoma
  JOURNAL   Cell Res 34 (9), 648-660 (2024)
   PUBMED   39103523
  REMARK    GeneRIF: SMYD5 is a ribosomal methyltransferase that catalyzes
            RPL40 lysine methylation to enhance translation output and promote
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2554)
  AUTHORS   Park,J., Wu,J., Szkop,K.J., Jeong,J., Jovanovic,P., Husmann,D.,
            Flores,N.M., Francis,J.W., Chen,Y.C., Benitez,A.M., Zahn,E.,
            Song,S., Ajani,J.A., Wang,L., Singh,K., Larsson,O., Garcia,B.A.,
            Topisirovic,I., Gozani,O. and Mazur,P.K.
  TITLE     SMYD5 methylation of rpL40 links ribosomal output to gastric cancer
  JOURNAL   Nature 632 (8025), 656-663 (2024)
   PUBMED   39048817
  REMARK    GeneRIF: SMYD5 methylation of rpL40 links ribosomal output to
            gastric cancer.
REFERENCE   3  (bases 1 to 2554)
  AUTHORS   Tae,I.H., Ryu,T.Y., Kang,Y., Lee,J., Kim,K., Lee,J.M., Kim,H.W.,
            Ko,J.H., Kim,D.S., Son,M.Y. and Cho,H.S.
  TITLE     Negative regulation of SH2B3 by SMYD5 controls
            epithelial-mesenchymal transition in lung cancer
  JOURNAL   Mol Cells 47 (5), 100067 (2024)
   PUBMED   38723947
  REMARK    GeneRIF: Negative regulation of SH2B3 by SMYD5 controls
            epithelial-mesenchymal transition in lung cancer.
REFERENCE   4  (bases 1 to 2554)
  AUTHORS   Boehm,D., Lam,V., Schnolzer,M. and Ott,M.
  TITLE     The lysine methyltransferase SMYD5 amplifies HIV-1 transcription
            and is post-transcriptionally upregulated by Tat and USP11
  JOURNAL   Cell Rep 42 (3), 112234 (2023)
   PUBMED   36897778
  REMARK    GeneRIF: The lysine methyltransferase SMYD5 amplifies HIV-1
            transcription and is post-transcriptionally upregulated by Tat and
            USP11.
REFERENCE   5  (bases 1 to 2554)
  AUTHORS   Hou,Y., Sun,X., Gheinani,P.T., Guan,X., Sharma,S., Zhou,Y., Jin,C.,
            Yang,Z., Naren,A.P., Yin,J., Denning,T.L., Gewirtz,A.T., Liu,Y.,
            Xie,Z. and Li,C.
  TITLE     Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial
            Functions via Post-Translational Control of PGC-1alpha Stability
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (2), 375-403 (2022)
   PUBMED   35643234
REFERENCE   6  (bases 1 to 2554)
  AUTHORS   Zhang,Y., Hayden,S., Spellmon,N., Xue,W., Martin,K., Muzzarelli,K.,
            Kovari,L. and Yang,Z.
  TITLE     Sperm chromatin-condensing protamine enhances SMYD5 thermal
            stability
  JOURNAL   Biochem Biophys Res Commun 550, 1-7 (2021)
   PUBMED   33676231
  REMARK    GeneRIF: Sperm chromatin-condensing protamine enhances SMYD5
            thermal stability.
REFERENCE   7  (bases 1 to 2554)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   8  (bases 1 to 2554)
  AUTHORS   Kidder,B.L., He,R., Wangsa,D., Padilla-Nash,H.M., Bernardo,M.M.,
            Sheng,S., Ried,T. and Zhao,K.
  TITLE     SMYD5 Controls Heterochromatin and Chromosome Integrity during
            Embryonic Stem Cell Differentiation
  JOURNAL   Cancer Res 77 (23), 6729-6745 (2017)
   PUBMED   28951459
  REMARK    GeneRIF: depletion of SMYD5 in human colon and lung cancer cells
            results in increased tumor growth and upregulation of genes
            overexpressed in colon and lung cancers, respectively. The findings
            implicate an important role for SMYD5 in maintaining chromosome
            integrity by regulating heterochromatin and repressing endogenous
            repetitive DNA elements during differentiation.
REFERENCE   9  (bases 1 to 2554)
  AUTHORS   Shago,M. and Giguere,V.
  TITLE     Isolation of a novel retinoic acid-responsive gene by selection of
            genomic fragments derived from CpG-island-enriched DNA
  JOURNAL   Mol Cell Biol 16 (8), 4337-4348 (1996)
   PUBMED   8754834
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC303248.1 and BC073806.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006062.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.268038.1,
                                           SRR1803615.232867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389501.9/ ENSP00000374152.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DC303248.1         8-24
            18-2554             BC073806.1         1-2537
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.2"
     gene            1..2554
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /note="SMYD family member 5"
                     /db_xref="GeneID:10322"
                     /db_xref="HGNC:HGNC:16258"
                     /db_xref="MIM:619114"
     exon            1..118
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1279
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /EC_number="2.1.1.359"
                     /EC_number="2.1.1.372"
                     /note="retinoic acid induced 15; retinoic acid responsive;
                     SET and MYND domain-containing protein 5; [histone
                     H4]-lysine20 N-trimethyltransferase SMYD5; histone-lysine
                     N-trimethyltransferase SMYD5; retinoic acid-induced
                     protein 15; [histone H3]-lysine20 N-trimethyltransferase
                     SMYD5; [histone H4]-lysine36 N-trimethyltransferase SMYD5"
                     /codon_start=1
                     /product="protein-lysine N-trimethyltransferase SMYD5"
                     /protein_id="NP_006053.2"
                     /db_xref="CCDS:CCDS33221.2"
                     /db_xref="GeneID:10322"
                     /db_xref="HGNC:HGNC:16258"
                     /db_xref="MIM:619114"
                     /translation="MAASMCDVFSFCVGVAGRARVSVEVRFVSSAKGKGLFATQLIRK
                     GETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLPHPELCT
                     VRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSIHY
                     PPETASIMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLE
                     LLRRLFTEALYEEAVSQWFTPDGFRSLFALVGTNGQGIGTSSLSQWVHACDTLELKPQ
                     DREQLDAFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLH
                     VTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFVCSCPKCLAEADEPNVTS
                     EEEEEEEEEEEGEPEDAELGDEMTDV"
     exon            119..227
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            228..367
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            368..489
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            490..559
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            560..664
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            665..727
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            728..798
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            799..905
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            906..962
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1057
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1128
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..2554
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /note="hexamer: AATAAA"
     polyA_site      2554
                     /gene="SMYD5"
                     /gene_synonym="NN8-4AG; RAI15; RRG1; ZMYND23"
                     /note="major polyA site"
ORIGIN      
        1 ataaggcgga ggcgcgccca agatggcggc ctccatgtgc gacgtgttct ccttctgcgt
       61 gggcgtggcg ggccgcgcgc gggtctccgt ggaagtccgt ttcgtgagca gcgccaaggg
      121 aaaggggctg tttgccacac agctcatccg gaagggggag accatcttcg tagaacggcc
      181 cctggtggct gcacagtttc tctggaatgc actttatcgc taccgagcct gtgaccactg
      241 ccttagggca ctagagaagg cagaggagaa tgcccagagg ctgaccggga aaccaggcca
      301 ggttctgcct cacccagagc tgtgcactgt gcgcaaagac ctccaccaga actgtcccca
      361 ttgccaagtg atgtactgca gtgcagaatg tcggttggca gccactgagc aataccacca
      421 ggtcctgtgc ccaggcccct cccaggatga ccccttgcat cctctcaata agcttcagga
      481 ggcatggagg agtattcact acccacctga gactgcaagc atcatgttga tggctaggat
      541 ggtggccaca gtgaagcagg cgaaggacaa ggaccgttgg atcagactct tttcccagtt
      601 ttgtaacaaa acagccaatg aagaggagga aattgtccat aaacttctgg gagacaaatt
      661 caagggccaa ctggaacttc tgcggagact cttcacagag gccctctatg aggaagcagt
      721 cagccagtgg ttcactccag atggattccg gtctctcttt gctcttgttg ggaccaatgg
      781 ccaaggaatc gggaccagct ccctaagcca gtgggtccat gcctgtgaca ctctggagtt
      841 gaagcctcag gaccgtgagc agcttgacgc cttcattgac cagctataca aggacatcga
      901 ggcagcaact ggagagtttc ttaactgtga aggatctggc ctctttgtgc ttcagagctg
      961 ctgcaaccac agttgtgtgc ccaatgcaga gacctccttt ccagaaaaca acttcctttt
     1021 gcatgtcact gctctggagg atattaagcc aggagaggaa atttgtatca gctacttgga
     1081 ctgctgtcag cgggagcgca gccgccacag ccgccacaag atcctcaggg agaactatct
     1141 atttgtctgt tcctgtccca aatgcctggc agaggctgat gaacccaatg tgacctcaga
     1201 agaggaagag gaagaggagg aggaggagga aggagagcca gaagatgcag agctggggga
     1261 tgagatgact gatgtgtgat gttgccctgc ccagaaaggg ccctgcccta gaccctgcca
     1321 gaaaaggggg ctcttccccc agagaagtgg cttggaggga acttcccact cccattgcct
     1381 gctttcccca ttccagccct ctctgctaga gggtaggaga gagcctggat ctctggcccc
     1441 aacccccacc agacctcatg ccctggacac tgctgctgag ttggctcaga ctctgcactg
     1501 gcactgagcc tttcacaact ggcctcccct tgaggttcct ccactctagg gtttgagggg
     1561 ctggaatcag ggccagggcc taacagtgtt tcttcccctc ggccccacgg cccatactca
     1621 ccccttcacc tgaggcttct cccctctcaa cttgctgttg atttcttttg aggggtaaaa
     1681 gaaagaccga gttcattgaa gcagagatgg gaggtggtga ggcgtcctca cctcccccca
     1741 ccacagctgt ggctggtaag gcaactgctt gaccactggc ccagcaagca gaggcgggca
     1801 ggaggatctg ggcatcctga gccccttccc tgaggctgtc tcctgggaat gctggaccag
     1861 ggggattact tcccccaccc acacccccat ttggacatct ggggaagtgg agattaaccc
     1921 ctcccccaga ctcgtgcctt gcctctcagg acctggcaca gtggctggcc ttatggagta
     1981 tggaaaaggc ctctgccttc ctcaggaggg acacatagtg ggtcatcacc ctttctcaca
     2041 cctgcttccc aatgagcact cagcagcatg gctgagacct ggggcttgac aggcctgcgc
     2101 tccttagatt aggatgctct ggtattcctg gggccagtta aaatgggtca gtgaggggct
     2161 ctcctggcct caatctccat ctttagggtc tccacagact aacattgaag tcttccagaa
     2221 acctcgagga gctgggctag atacttcgag agtagccctg tcttgtcccc tcctaccccc
     2281 agattagcac cacccctctc actcttgggt tggatgctat gggaattaca acccatcact
     2341 cccaatgcct ccctttcctg gaggagcctg ctgcattctc ctgctgaggg atcccagaga
     2401 gggcaggtgc ccaccccaca ggccctttcc tggaccatgg agccaggtga aacctgtctg
     2461 gccccttacc cattgggttc ttactccttc acaacggtca gcactcctct cccagccccc
     2521 ctgcccactg ttctcaataa aatgtgagtg gtga
//
