LOCUS       NM_052928               4405 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens SET and MYND domain containing 4 (SMYD4), mRNA.
ACCESSION   NM_052928 XM_056082
VERSION     NM_052928.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4405)
  AUTHORS   Zhou,Z., Chen,Z., Zhou,Q., Meng,S., Shi,J., Mui,S., Jiang,H.,
            Lin,J., He,G., Li,W., Zhang,J., Wang,J., He,C., Yan,Y. and Xiao,Z.
  TITLE     SMYD4 monomethylates PRMT5 and forms a positive feedback loop to
            promote hepatocellular carcinoma progression
  JOURNAL   Cancer Sci 115 (5), 1587-1601 (2024)
   PUBMED   38438251
  REMARK    GeneRIF: SMYD4 monomethylates PRMT5 and forms a positive feedback
            loop to promote hepatocellular carcinoma progression.
REFERENCE   2  (bases 1 to 4405)
  AUTHORS   Xiao,D., Wang,H., Hao,L., Guo,X., Ma,X., Qian,Y., Chen,H., Ma,J.,
            Zhang,J., Sheng,W., Shou,W., Huang,G. and Ma,D.
  TITLE     The roles of SMYD4 in epigenetic regulation of cardiac development
            in zebrafish
  JOURNAL   PLoS Genet 14 (8), e1007578 (2018)
   PUBMED   30110327
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4405)
  AUTHORS   O'Seaghdha,C.M., Yang,Q., Glazer,N.L., Leak,T.S., Dehghan,A.,
            Smith,A.V., Kao,W.H., Lohman,K., Hwang,S.J., Johnson,A.D.,
            Hofman,A., Uitterlinden,A.G., Chen,Y.D., Brown,E.M.,
            Siscovick,D.S., Harris,T.B., Psaty,B.M., Coresh,J., Gudnason,V.,
            Witteman,J.C., Liu,Y.M., Kestenbaum,B.R., Fox,C.S. and Kottgen,A.
  CONSRTM   GEFOS Consortium
  TITLE     Common variants in the calcium-sensing receptor gene are associated
            with total serum calcium levels
  JOURNAL   Hum Mol Genet 19 (21), 4296-4303 (2010)
   PUBMED   20705733
REFERENCE   4  (bases 1 to 4405)
  AUTHORS   Hu,L., Zhu,Y.T., Qi,C. and Zhu,Y.J.
  TITLE     Identification of Smyd4 as a potential tumor suppressor gene
            involved in breast cancer development
  JOURNAL   Cancer Res 69 (9), 4067-4072 (2009)
   PUBMED   19383909
  REMARK    GeneRIF: Smyd4, as a potential tumor suppressor, plays a critical
            role in breast carcinogenesis at least partly through inhibiting
            the expression of Pdgfr-alpha.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130689.8, AK095369.1, CR987176.1, DB219337.1, BC035077.2,
            CN352185.1, AV700545.1, AL137345.1 and BM676597.1.
            
            On May 17, 2019 this sequence version replaced NM_052928.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.99701.1,
                                           SRR1803616.38012.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305513.12/ ENSP00000304360.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC130689.8         122089-122109
            22-26               AK095369.1         1-5
            27-119              CR987176.1         1-93
            120-638             DB219337.1         57-575
            639-1728            AK095369.1         618-1707
            1729-2368           BC035077.2         1627-2266
            2369-2741           AK095369.1         2348-2720
            2742-2780           CN352185.1         693-731
            2781-3240           AV700545.1         1-460               c
            3241-4332           AL137345.1         268-1359
            4333-4355           BM676597.1         16-38               c
            4356-4405           AC130689.8         172457-172506
FEATURES             Location/Qualifiers
     source          1..4405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4405
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /note="SET and MYND domain containing 4"
                     /db_xref="GeneID:114826"
                     /db_xref="HGNC:HGNC:21067"
                     /db_xref="MIM:619134"
     exon            1..177
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            178..323
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2604
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /codon_start=1
                     /product="SET and MYND domain-containing protein 4"
                     /protein_id="NP_443160.2"
                     /db_xref="CCDS:CCDS11013.1"
                     /db_xref="GeneID:114826"
                     /db_xref="HGNC:HGNC:21067"
                     /db_xref="MIM:619134"
                     /translation="MDLPVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLL
                     QPEDELFLKRLSKGYLVGKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNT
                     EDMSLCHANRSAALFHLGQYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQ
                     EASQTISDLERNFTATPALADVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLED
                     AALREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPP
                     PHHGLDSKWDTRVTNGDLYCHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTE
                     CPLGGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLN
                     YGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSAL
                     CRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTT
                     IQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKG
                     QEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCG
                     APMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQRLSG
                     CQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPSSVEM
                     GHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQKMKSCLLDLPPT
                     PVGPAL"
     exon            324..468
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            469..558
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1726
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1909
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2073
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2209
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2326
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2450
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..4405
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4317..4322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /note="hexamer: AATAAA"
     polyA_site      4353
                     /gene="SMYD4"
                     /gene_synonym="ZMYND21"
                     /note="major polyA site"
ORIGIN      
        1 acccatggtc ccaagcgagg cctggcgcgg gacgccggac gcggtgcggg gcggagcggg
       61 gcgccaaggg gcgcgccagg agctgcgcgg gcgctgggag ggagaccagg gcgcagttcc
      121 gggcgcgtct gagcggttct cgaggcgttc tcgcctcggt ctctggcgag tgcacggatc
      181 aaaagcagca tggatctgcc tgtggatgaa tggaaatcat atctgcttca aaagtgggct
      241 tcactcccga cgtctgttca ggtcacaatt tctacagcag agaccttgag ggatatcttt
      301 cttcactcct cttcacttct tcaacctgag gatgagctgt ttctaaaaag actttctaaa
      361 ggttacttgg tgggaaagga ctcggacgct cctcttttct acagagaaga aggaaacaaa
      421 aaatttcagg agaaagatta cacaggagct gcagtgctgt actctaaggg agtgtcacat
      481 tcaaggccta acactgagga catgtcactg tgtcatgcta accgctcggc agccctcttc
      541 cacctgggtc agtatgagac gtgtcttaaa gacattaaca gagcacagac acatgggtat
      601 ccagaaaggt tgcaacccaa gattatgtta cgtaaagcag aatgtctggt ggccctgggg
      661 agactgcagg aggcaagcca gaccatcagt gatcttgaaa ggaacttcac agccacacca
      721 gccctagcag atgtcctccc tcagactctg cagagaaacc tccatcgtct gaaaatgaag
      781 atgcaagaaa aggacagtct cacagaaagc ttcccagcag ctctggccaa aacccttgag
      841 gatgcagcgc tgagggagga gaatgaacaa ctttccaatg cctcatcatc catcggctta
      901 tgcgtagatc ctttaaaagg tcgctgtctc gttgccacaa aagatattct cccaggagag
      961 ctcctggtgc aggaggatgc ttttgtgagt gttctcaacc caggagaact gccaccaccg
     1021 catcacggcc tagacagcaa atgggacacc agagtcacca atggggacct ctattgtcac
     1081 cgatgtttga agcacacttt ggccacagtt ccgtgtgacg gatgcagtta tgccaagtat
     1141 tgcagccagg agtgtttgca gcaggcctgg gagctctacc acaggacaga atgtcctctg
     1201 ggagggctgc ttctcacact gggtgtcttt tgccacattg ccctgaggtt gactcttttg
     1261 gtgggatttg aggatgttcg caaaatcata acgaagcttt gtgataagat tagtaacaag
     1321 gacatctgtt tacctgaaag caacaatcag gtcaagacac ttaattatgg cctaggggag
     1381 agtgagaaaa atggcaacat cgttgagacc ccaattcctg gatgcgatat taatgggaag
     1441 tatgaaaata attataatgc tgtcttcaac cttttgcccc acactgaaaa ccatagccca
     1501 gagcacaaat tcctctgtgc tctctgtgtt tctgcactgt gcagacagct agaagcagcc
     1561 agtttacagg ccatcccaac tgagaggatt gtgaactcct ctcagcttaa agcagcagtg
     1621 acacctgaat tgtgtcctga cgtgactatt tggggagtgg cgatgctgag acacatgtta
     1681 cagcttcagt gtaacgctca ggcgatgacc accatacaac acacaggacc taaagggagc
     1741 atcgttaccg acagcaggca ggtgcgcctt gccacaggca tcttccctgt tatcagcctc
     1801 ctgaaccact cctgtagccc caacaccagc gtgtccttca ttagcactgt cgccaccatc
     1861 cgggcgtcac agcggattag aaaggggcaa gagattctcc actgctatgg gcctcacaag
     1921 agccggatgg gggttgccga aaggcagcag aagctgaggt ctcagtattt ctttgactgc
     1981 gcctgtccag cttgtcaaac tgaggcacac aggatggctg cagggcccag gtgggaagca
     2041 ttctgttgca acagttgcgg agcgcccatg cagggagatg acgtgctgcg ctgtggcagc
     2101 agatcttgtg cagaatccgc cgtcagcagg gaccacctgg tctctcggtt acaggaccta
     2161 cagcagcagg tcagagtggc ccagaagctt ctcagagatg gtgaactaga gcgagctgtt
     2221 cagcggctgt cggggtgcca gcgtgacgcc gagagcttcc tgtgggcaga gcacgccgtg
     2281 gtgggagaga tcgcggatgg cctggcccgg gcctgtgctg ccttaggaga ctggcaaaag
     2341 tcagccaccc atctacagag gagtctctac gtggtggagg ttcgccacgg gccgtccagt
     2401 gttgaaatgg gccatgagct cttcaaattg gcccagatct ttttcaacgg gtttgcagta
     2461 cccgaagccc tgagcacaat acagaaagct gaggaggttc tgtcgctgca ctgtggccca
     2521 tgggacgatg aaatccagga gctccagaag atgaaatcct gtttgttgga cttaccaccc
     2581 acccctgtag ggcctgcatt gtagggttcc aggaggattt tgacccacag aaaaggagcc
     2641 catggaacac aagttaaaga ggttttgctg gccaggtatg gtggctcacg cctgtaatcc
     2701 cagcactttg ggaggctaag gtgggcggat cacctgatgt caggagttca agaccagcct
     2761 ggccaacatg gtgaaacccc atctttacta aaaatacaaa aaactagcca ggcgtggtgg
     2821 tgggcacctg taatcccagc tacttgggag gctgaggcag gagaatctct tgaacccagg
     2881 aggcggaggt tgcagtgagc cgagatcgct ccactgcact ccagcccagg tgacagtgtg
     2941 agactccatc tcaaaaaaaa aaataagagg ccgggtgcgg tggctcaagc ctgtaatccc
     3001 agcactttgg gaggccgagg caggcagatc acgaggtcag gagatccaga ccatcctggc
     3061 taacacggtg aaaccccgtc tctactaaaa atacaaaaaa attagtcggg cgtggtggcg
     3121 gacgcctgta ttcacagcta ctcgggaggt tgaggcagga gaatggggtg aacccgggag
     3181 gaagagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggtg acagagccag
     3241 actccatctc aaagaaaaaa aaaaaatatt aagaggttct gctgccagat gtgggttctg
     3301 tgggtcgggt gtgggttctg tgggtcgggt gtgggttctg cagaccaggt gcggattctg
     3361 tgtaggttct gcaggcccag tgtagaggct cacacctgta atcccagtac tttgagacgc
     3421 tgaggtggga ggatcacttg agcccaggag ttcaaaacca gcctgggcaa tatagtgaga
     3481 ccgtatcact acaaaaaagt ttttttagtt caccgagcat ggtggcacat gcctgtagtc
     3541 ccacctactc gagaagctga gatagggtca cctgagcctg gtaggctgag gctgcagtga
     3601 gccaagatcg cactactgca ctccagcctg ggtgacagag taagaccctg tctcaacaaa
     3661 aaaataacag gttctgttgc tgctgagctt tcgtcaggaa gataagactt tcccaacagt
     3721 ccgaagccta ggatatgagg gctgaggagg actcaaaccg ttgcagtcag agagacacct
     3781 attttggtga atattttttg aaatagttaa gtggcctcca gtacaaactc ccagttccca
     3841 gaaaagactt aaaactagta tctggagatt ccaagtcctt taaaaggatt ttagctgatc
     3901 tgcaggcatc tggatgttag cctggggttt tggctggatt ccacctcgct cagtgatgat
     3961 agtctgtttc cctggaacat tcctgtggtt ttagtagtaa tgagatgtgt gcaccactcc
     4021 agtgggaact gaagctctta gtagttacat tgtaattaaa aaagaattat aaaacaagaa
     4081 atcagcaagc ctgcttacct ccagagacac accgttccac ttacagtatc tagcttcctc
     4141 gactcctttg ttaaaatcgt ggagtatgaa ccgtgaccag agaagtaaat atggagccgt
     4201 tttattgagc agtttcctcc agggatgacg gctgtcagtg tgtttcctgc cagttttcca
     4261 gtccttactc tctgcccttc attctgtact cttggcagag tcagtaacca accactaata
     4321 aaatcaaagt tgtagtaaag actttataac acatatgcct ccttctgagt tgttggtttt
     4381 gttttgtttt gttttgtttt gtttt
//
