LOCUS       NM_001167740            1565 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SET and MYND domain containing 3 (SMYD3), transcript
            variant 1, mRNA.
ACCESSION   NM_001167740
VERSION     NM_001167740.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Geng,W., An,J., Dong,K., Zhang,H., Zhang,X., Liu,Y., Xu,R., Liu,Y.,
            Huang,X., Song,H., Yan,W., Sun,A., He,F., Wang,J., Gao,H. and
            Tian,C.
  TITLE     ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by
            Recruiting SMYD3 in Breast Cancer
  JOURNAL   Adv Sci (Weinh) 11 (40), e2404904 (2024)
   PUBMED   39225541
  REMARK    GeneRIF: ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by
            Recruiting SMYD3 in Breast Cancer.
REFERENCE   2  (bases 1 to 1565)
  AUTHORS   Wang,Z.H., Wang,J., Liu,F., Sun,S., Zheng,Q., Hu,X., Yin,Z.,
            Xie,C., Wang,H., Wang,T., Zhang,S. and Wang,Y.P.
  TITLE     THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes
            mitochondrial respiration in hepatocellular carcinoma
  JOURNAL   FEBS Lett 598 (12), 1513-1531 (2024)
   PUBMED   38664231
  REMARK    GeneRIF: THAP3 recruits SMYD3 to OXPHOS genes and epigenetically
            promotes mitochondrial respiration in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1565)
  AUTHORS   Sajic,T., Ferreira Gomes,C.K., Gasser,M., Caputo,T., Bararpour,N.,
            Landaluce-Iturriria,E., Augsburger,M., Walter,N., Hainard,A.,
            Lopez-Mejia,I.C., Fracasso,T., Thomas,A. and Gilardi,F.
  TITLE     SMYD3: a new regulator of adipocyte precursor proliferation at the
            early steps of differentiation
  JOURNAL   Int J Obes (Lond) 48 (4), 557-566 (2024)
   PUBMED   38148333
  REMARK    GeneRIF: SMYD3: a new regulator of adipocyte precursor
            proliferation at the early steps of differentiation.
REFERENCE   4  (bases 1 to 1565)
  AUTHORS   Yu,L., Wei,Y., Lu,T., Li,Z., Lai,S., Yan,Y., Chen,C. and Wen,W.
  TITLE     The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2
            differentiation in CRSwNP via positive feedback
  JOURNAL   Cell Commun Signal 21 (1), 345 (2023)
   PUBMED   38037054
  REMARK    GeneRIF: The SMYD3-dependent H3K4me3 status of IGF2 intensifies
            local Th2 differentiation in CRSwNP via positive feedback.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1565)
  AUTHORS   Nigam,N., Bernard,B., Sevilla,S., Kim,S., Dar,M.S., Tsai,D.,
            Robbins,Y., Burkitt,K., Sievers,C., Allen,C.T., Bennett,R.L.,
            Tettey,T.T., Carter,B., Rinaldi,L., Lingen,M.W., Sater,H.,
            Edmondson,E.F., Moshiri,A., Saeed,A., Cheng,H., Luo,X., Brennan,K.,
            Koparde,V., Chen,C., Das,S., Andresson,T., Abdelmaksoud,A.,
            Murali,M., Sakata,S., Takeuchi,K., Chari,R., Nakamura,Y.,
            Uppaluri,R., Sunwoo,J.B., Van Waes,C., Licht,J.D., Hager,G.L. and
            Saloura,V.
  TITLE     SMYD3 represses tumor-intrinsic interferon response in HPV-negative
            squamous cell carcinoma of the head and neck
  JOURNAL   Cell Rep 42 (7), 112823 (2023)
   PUBMED   37463106
  REMARK    GeneRIF: SMYD3 represses tumor-intrinsic interferon response in
            HPV-negative squamous cell carcinoma of the head and neck.
REFERENCE   6  (bases 1 to 1565)
  AUTHORS   Hamamoto,R., Silva,F.P., Tsuge,M., Nishidate,T., Katagiri,T.,
            Nakamura,Y. and Furukawa,Y.
  TITLE     Enhanced SMYD3 expression is essential for the growth of breast
            cancer cells
  JOURNAL   Cancer Sci 97 (2), 113-118 (2006)
   PUBMED   16441421
  REMARK    GeneRIF: Enhanced SMYD3 expression is associated with growth of
            breast cancer
REFERENCE   7  (bases 1 to 1565)
  AUTHORS   Tsuge,M., Hamamoto,R., Silva,F.P., Ohnishi,Y., Chayama,K.,
            Kamatani,N., Furukawa,Y. and Nakamura,Y.
  TITLE     A variable number of tandem repeats polymorphism in an E2F-1
            binding element in the 5' flanking region of SMYD3 is a risk factor
            for human cancers
  JOURNAL   Nat Genet 37 (10), 1104-1107 (2005)
   PUBMED   16155568
  REMARK    GeneRIF: The common variable number of tandem repeats polymorphism
            in SMYD3 is a susceptibility factor for some types of human cancer.
REFERENCE   8  (bases 1 to 1565)
  AUTHORS   Zhou,Z., Ren,X., Huang,X., Lu,L., Xu,M., Yin,L., Li,J. and Sha,J.
  TITLE     SMYD3-NY, a novel SMYD3 mRNA transcript variant, may have a role in
            human spermatogenesis
  JOURNAL   Ann Clin Lab Sci 35 (3), 270-277 (2005)
   PUBMED   16081583
  REMARK    GeneRIF: SMYD3-NY is a novel transcript variant of the SMYD3 gene,
            and SMYD3-NY protein may influence transcriptional regulation
            during spermatogenesis via HTMase activity
REFERENCE   9  (bases 1 to 1565)
  AUTHORS   Hamamoto,R., Furukawa,Y., Morita,M., Iimura,Y., Silva,F.P., Li,M.,
            Yagyu,R. and Nakamura,Y.
  TITLE     SMYD3 encodes a histone methyltransferase involved in the
            proliferation of cancer cells
  JOURNAL   Nat Cell Biol 6 (8), 731-740 (2004)
   PUBMED   15235609
  REMARK    GeneRIF: SMYD3 encodes a histone methyltransferase involved in the
            proliferation of cancer cells.
REFERENCE   10 (bases 1 to 1565)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP231249.1, BI916760.1 and AB057595.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001167740.1.
            
            Summary: This gene encodes a histone methyltransferase which
            functions in RNA polymerase II complexes by an interaction with a
            specific RNA helicase. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.320946.1,
                                           SRR3476690.530681.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000490107.6/ ENSP00000419184.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BP231249.1         63-162
            101-484             BI916760.1         56-439
            485-1565            AB057595.1         518-1598
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1565
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /note="SET and MYND domain containing 3"
                     /db_xref="GeneID:64754"
                     /db_xref="HGNC:HGNC:15513"
                     /db_xref="MIM:608783"
     exon            1..226
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1349
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /EC_number="2.1.1.354"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein, subfamily 3A (MYND domain containing), 1;
                     zinc finger, MYND domain containing 1; SET and MYND
                     domain-containing protein 3; histone-lysine
                     N-methyltransferase SMYD3; zinc finger MYND
                     domain-containing protein 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SMYD3 isoform
                     1"
                     /protein_id="NP_001161212.1"
                     /db_xref="CCDS:CCDS53486.1"
                     /db_xref="GeneID:64754"
                     /db_xref="HGNC:HGNC:15513"
                     /db_xref="MIM:608783"
                     /translation="MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGS
                     RGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSV
                     RLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQ
                     DASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNG
                     PHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADML
                     TGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCA
                     MDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKN
                     LRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS"
     exon            227..290
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..398
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..456
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..593
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..661
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..764
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..875
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..963
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1138
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1247
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1565
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /note="hexamer: AATAAA"
     polyA_site      1565
                     /gene="SMYD3"
                     /gene_synonym="bA74P14.1; KMT3E; ZMYND1; ZNFN3A1"
                     /note="major polyA site"
ORIGIN      
        1 agcccgtgag acgcccgctg ctggacgcgg gtagccgtct gaggtgccgg agctgcggga
       61 ggatggagcc gctgaaggtg gaaaagttcg caaccgccaa gaggggaaac gggctgcgcg
      121 ccgtgacccc gctgcgcccc ggagagctac tcttccgctc ggatcccttg gcgtacacgg
      181 tgtgcaaggg gagtcgtggc gtcgtctgcg accgctgcct tctcgggaag gaaaagctga
      241 tgcgatgctc tcagtgccgc gtcgccaaat actgtagtgc taagtgtcag aaaaaagctt
      301 ggccagacca caagcgggaa tgcaaatgcc ttaaaagctg caaacccaga tatcctccag
      361 actccgttcg acttcttggc agagttgtct tcaaacttat ggatggagca ccttcagaat
      421 cagagaagct ttactcattt tatgatctgg agtcaaatat taacaaactg actgaagata
      481 agaaagaggg cctcaggcaa ctcgtaatga catttcaaca tttcatgaga gaagaaatac
      541 aggatgcctc tcagctgcca cctgcctttg acctttttga agcctttgca aaagtgatct
      601 gcaactcttt caccatctgt aatgcggaga tgcaggaagt tggtgttggc ctatatccca
      661 gtatctcttt gctcaatcac agctgtgacc ccaactgttc gattgtgttc aatgggcccc
      721 acctcttact gcgagcagtc cgagacatcg aggtgggaga ggagctcacc atctgctacc
      781 tggatatgct gatgaccagt gaggagcgcc ggaagcagct gagggaccag tactgctttg
      841 aatgtgactg tttccgttgc caaacccagg acaaggatgc tgatatgcta actggtgatg
      901 agcaagtatg gaaggaagtt caagaatccc tgaaaaaaat tgaagaactg aaggcacact
      961 ggaagtggga gcaggttctg gccatgtgcc aggcaatcat aagcagcaat tctgaacggc
     1021 ttcccgatat caacatctac cagctgaagg tgctcgactg cgccatggat gcctgcatca
     1081 acctcggcct gttggaggaa gccttgttct atggtactcg gaccatggag ccatacagga
     1141 tttttttccc aggaagccat cccgtcagag gggttcaagt gatgaaagtt ggcaaactgc
     1201 agctacatca aggcatgttt ccccaagcaa tgaagaatct gagactggct tttgatatta
     1261 tgagagtgac acatggcaga gaacacagcc tgattgaaga tttgattcta cttttagaag
     1321 aatgcgacgc caacatcaga gcatcctaag ggaacgcagt cagagggaaa tacggcgtgt
     1381 gtctttgttg aatgccttat tgaggtcaca cactctatgc tttgttagct gtgtgaacct
     1441 ctcctattgg aaattctgtt ccgtgtttgt gtaggtaaat aaaggcagac atggtttgca
     1501 aaccacaaga atcattagtt gtagagaagc acgattataa taaattcaaa acatttggtt
     1561 gagga
//
