LOCUS       NM_020197               1745 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SET and MYND domain containing 2 (SMYD2), mRNA.
ACCESSION   NM_020197 XM_937363
VERSION     NM_020197.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Jin,L., Qian,D., Tang,X., Huang,Y., Zou,J. and Wu,Z.
  TITLE     SMYD2 Imparts Gemcitabine Resistance to Pancreatic Adenocarcinoma
            Cells by Upregulating EVI2A
  JOURNAL   Mol Biotechnol 66 (10), 2920-2933 (2024)
   PUBMED   37812330
  REMARK    GeneRIF: SMYD2 Imparts Gemcitabine Resistance to Pancreatic
            Adenocarcinoma Cells by Upregulating EVI2A.
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Li,M., Zhang,Z., He,L., Wang,X., Yin,J., Wang,X., You,Y., Qian,X.,
            Ge,X. and Shi,Z.
  TITLE     SMYD2 induced PGC1alpha methylation promotes stemness maintenance
            of glioblastoma stem cells
  JOURNAL   Neuro Oncol 26 (9), 1587-1601 (2024)
   PUBMED   38721826
  REMARK    GeneRIF: SMYD2 induced PGC1alpha methylation promotes stemness
            maintenance of glioblastoma stem cells.
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Hou,X., Yang,Y., Wang,C., Huang,Z., Zhang,M., Yang,J., Li,N.,
            Yang,H., Yang,L. and Wu,K.
  TITLE     H3K36 methyltransferase SMYD2 affects cell proliferation and
            migration in Hirschsprung's disease by regulating METTL3
  JOURNAL   J Cell Physiol 239 (9), e31402 (2024)
   PUBMED   39109795
  REMARK    GeneRIF: H3K36 methyltransferase SMYD2 affects cell proliferation
            and migration in Hirschsprung's disease by regulating METTL3.
REFERENCE   4  (bases 1 to 1745)
  AUTHORS   Richard,A., Berthelet,J., Judith,D., Advedissian,T., Espadas,J.,
            Jannot,G., Amo,A., Loew,D., Lombard,B., Casanova,A.G., Reynoird,N.,
            Roux,A., Berlioz-Torrent,C., Echard,A., Weitzman,J.B. and
            Medjkane,S.
  TITLE     Methylation of ESCRT-III components regulates the timing of
            cytokinetic abscission
  JOURNAL   Nat Commun 15 (1), 4023 (2024)
   PUBMED   38740816
  REMARK    GeneRIF: Methylation of ESCRT-III components regulates the timing
            of cytokinetic abscission.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1745)
  AUTHORS   Li,J., Hong,Z., Zhang,J., Zheng,S., Wan,F., Liu,Z. and Dai,B.
  TITLE     Lysine methyltransferase SMYD2 enhances androgen receptor signaling
            to modulate CRPC cell resistance to enzalutamide
  JOURNAL   Oncogene 43 (10), 744-757 (2024)
   PUBMED   38243079
  REMARK    GeneRIF: Lysine methyltransferase SMYD2 enhances androgen receptor
            signaling to modulate CRPC cell resistance to enzalutamide.
REFERENCE   6  (bases 1 to 1745)
  AUTHORS   Abu-Farha,M., Lambert,J.P., Al-Madhoun,A.S., Elisma,F.,
            Skerjanc,I.S. and Figeys,D.
  TITLE     The tale of two domains: proteomics and genomics analysis of SMYD2,
            a new histone methyltransferase
  JOURNAL   Mol Cell Proteomics 7 (3), 560-572 (2008)
   PUBMED   18065756
  REMARK    GeneRIF: The combination of the SMYD2 interactome with the gene
            expression data suggests that some of the genes regulated by SMYD2
            are closely associated with SMYD2-interacting proteins.
REFERENCE   7  (bases 1 to 1745)
  AUTHORS   Huang,J., Sengupta,R., Espejo,A.B., Lee,M.G., Dorsey,J.A.,
            Richter,M., Opravil,S., Shiekhattar,R., Bedford,M.T., Jenuwein,T.
            and Berger,S.L.
  TITLE     p53 is regulated by the lysine demethylase LSD1
  JOURNAL   Nature 449 (7158), 105-108 (2007)
   PUBMED   17805299
REFERENCE   8  (bases 1 to 1745)
  AUTHORS   Huang,J., Perez-Burgos,L., Placek,B.J., Sengupta,R., Richter,M.,
            Dorsey,J.A., Kubicek,S., Opravil,S., Jenuwein,T. and Berger,S.L.
  TITLE     Repression of p53 activity by Smyd2-mediated methylation
  JOURNAL   Nature 444 (7119), 629-632 (2006)
   PUBMED   17108971
REFERENCE   9  (bases 1 to 1745)
  AUTHORS   Brown,M.A., Sims,R.J. 3rd, Gottlieb,P.D. and Tucker,P.W.
  TITLE     Identification and characterization of Smyd2: a split SET/MYND
            domain-containing histone H3 lysine 36-specific methyltransferase
            that interacts with the Sin3 histone deacetylase complex
  JOURNAL   Mol Cancer 5, 26 (2006)
   PUBMED   16805913
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1745)
  AUTHORS   Kobayashi,H., Uetake,H., Higuchi,T., Enomoto,M. and Sugihara,K.
  TITLE     JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary
            metastases of colorectal cancer in rats
  JOURNAL   BMC Cancer 5, 26 (2005)
   PUBMED   15743541
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929236.4, BG723585.1, BC098276.1 and AW474469.1.
            
            On Nov 24, 2018 this sequence version replaced NM_020197.2.
            
            Summary: SET domain-containing proteins, such as SMYD2, catalyze
            lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied
            by OMIM, Nov 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039890.1, AF226053.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366957.10/ ENSP00000355924.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL929236.4         40219-40281
            64-74               BG723585.1         128-138
            75-1448             BC098276.1         1-1374
            1449-1745           AW474469.1         8-304               c
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..1745
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /note="SET and MYND domain containing 2"
                     /db_xref="GeneID:56950"
                     /db_xref="HGNC:HGNC:20982"
                     /db_xref="MIM:610663"
     exon            1..269
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1398
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /EC_number="2.1.1.354"
                     /note="zinc finger, MYND domain containing 14; SET and
                     MYND domain-containing protein 2; lysine
                     N-methyltransferase 3C; histone methyltransferase SMYD2"
                     /codon_start=1
                     /product="N-lysine methyltransferase SMYD2"
                     /protein_id="NP_064582.2"
                     /db_xref="CCDS:CCDS31022.1"
                     /db_xref="GeneID:56950"
                     /db_xref="HGNC:HGNC:20982"
                     /db_xref="MIM:610663"
                     /translation="MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLT
                     VNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNP
                     SETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFY
                     SKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYK
                     GTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAK
                     VEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFED
                     SNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLY
                     MGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH"
     exon            270..333
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            334..444
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            445..505
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            506..630
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            631..698
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            699..801
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            802..912
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1033
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1208
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1317
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1745
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /note="hexamer: ATTAAA"
     polyA_site      1745
                     /gene="SMYD2"
                     /gene_synonym="HSKM-B; KMT3C; ZMYND14"
                     /note="major polyA site"
ORIGIN      
        1 accccgcccc ccgcagctct aggtgacgcg tctccaataa cagctcgccg ggagccgcag
       61 ctcgggcaca gccggcggcc gcgccccgcc gccaccatga gggccgaggg cctcggcggc
      121 ctggagcgct tctgcagccc gggcaaaggc cgggggctgc gggctctgca gcccttccag
      181 gtgggggact tgctgttctc ctgcccggcc tatgcctacg tgctcacggt caacgagcgg
      241 ggcaaccact gcgagtactg cttcaccagg aaagaaggat tgtccaaatg tggaagatgc
      301 aagcaggcat tttactgcaa tgtggagtgt cagaaagaag attggcccat gcacaagctg
      361 gaatgttctc ccatggttgt ttttggggaa aactggaatc cctcggagac tgtaagacta
      421 acagcaagga ttctggccaa acagaaaatc cacccagaga gaacaccttc ggaaaaattg
      481 ttagctgtga aggagtttga atcacatctg gataagttag acaatgagaa gaaggatttg
      541 attcagagtg acatagctgc tctccatcac ttttactcca agcatctcgg attccctgac
      601 aatgatagcc tcgtagtact ctttgcacag gttaactgta atggcttcac aattgaagat
      661 gaagaacttt ctcatttggg atcagcgata tttcctgatg ttgcattgat gaatcatagc
      721 tgttgcccca atgtcattgt gacctacaaa gggaccctgg cagaagtcag agctgtacag
      781 gaaatcaagc cgggagagga ggtttttacc agctatattg atctcctgta cccaacggaa
      841 gatagaaatg accggttaag agattcttat ttctttacct gtgagtgcca ggagtgtacc
      901 accaaggaca aggataaggc caaggtggaa atccggaagc tcagcgatcc cccaaaggca
      961 gaagccatcc gagacatggt cagatatgca cgcaacgtca ttgaagagtt ccggagggcc
     1021 aagcactata aatcccctag tgagctgctg gagatctgcg agctcagcca ggagaagatg
     1081 agctctgtgt ttgaggacag taacgtgtac atgttgcaca tgatgtacca ggccatgggt
     1141 gtctgcttgt acatgcagga ctgggaagga gccctgcaat atggacagaa aatcattaag
     1201 ccctacagta agcactatcc tttgtactcc ctcaacgtgg cctccatgtg gttgaagcta
     1261 gggagactct acatgggcct ggaacacaaa gccgcagggg agaaagccct gaagaaggcc
     1321 attgcaatca tggaagtagc tcacggcaaa gatcatccat atatttctga gatcaaacag
     1381 gaaattgaaa gccactgaaa ctatgcagca tttcagtttt catttaaaca cttagttcag
     1441 aaaccttaaa ggatttgaat atttcaaatt gcacacgtca ctccagcatc tctgtaaaat
     1501 aattggaatg aaaatacttc ttgcacttaa acactgcaca tgccgtactt tgaggttagt
     1561 ctgaatcttg aactttaata ccaaattaat tttgaatgct tttgtttcct aagagataat
     1621 ggcatggttt catatgttat actttggaca gacagagttt taaaaatgga attatttttt
     1681 ctttcatgcc tcttgtaatg ttctgaacaa acttgaatga tgaaagtatt aaagagatat
     1741 cagta
//
