LOCUS       NM_198274               4385 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SET and MYND domain containing 1 (SMYD1), transcript
            variant 1, mRNA.
ACCESSION   NM_198274 XM_097915
VERSION     NM_198274.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4385)
  AUTHORS   Wu,J.K., Lee,Y.Y., Hung,H., Chang,Y.P., Tai,M.H. and Fan,H.F.
  TITLE     Binding Behavior of Human Hepatoma-Derived Growth Factor on SMYD1
  JOURNAL   J Phys Chem B 128 (32), 7722-7735 (2024)
   PUBMED   39091133
  REMARK    GeneRIF: Binding Behavior of Human Hepatoma-Derived Growth Factor
            on SMYD1.
REFERENCE   2  (bases 1 to 4385)
  AUTHORS   Zhu,L., Brown,M.A., Sims,R.J., Tiwari,G.R., Nie,H., Mayfield,R.D.
            and Tucker,H.O.
  TITLE     Lysine Methyltransferase SMYD1 Regulates Myogenesis via skNAC
            Methylation
  JOURNAL   Cells 12 (13), 1695 (2023)
   PUBMED   37443729
  REMARK    GeneRIF: Lysine Methyltransferase SMYD1 Regulates Myogenesis via
            skNAC Methylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4385)
  AUTHORS   Shamloul,A., Steinemann,G., Roos,K., Liem,C.H., Bernd,J., Braun,T.,
            Zakrzewicz,A. and Berkholz,J.
  TITLE     The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of
            IL-6 in Endothelial Cells
  JOURNAL   Cells 10 (12), 3515 (2021)
   PUBMED   34944023
  REMARK    GeneRIF: The Methyltransferase Smyd1 Mediates LPS-Triggered
            Up-Regulation of IL-6 in Endothelial Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4385)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4385)
  AUTHORS   Becker,S., Steinemann,G., Karle,W., Roos,K., Liem,C.H.,
            Muralikumar,S., Volkamer,A., Munz,B., Zakrzewicz,A. and Berkholz,J.
  TITLE     Stability of Smyd1 in endothelial cells is controlled by
            PML-dependent SUMOylation upon cytokine stimulation
  JOURNAL   Biochem J 478 (1), 217-234 (2021)
   PUBMED   33241844
  REMARK    GeneRIF: Stability of Smyd1 in endothelial cells is controlled by
            PML-dependent SUMOylation upon cytokine stimulation.
REFERENCE   6  (bases 1 to 4385)
  AUTHORS   Yang,J. and Everett,A.D.
  TITLE     Hepatoma-derived growth factor represses SET and MYND domain
            containing 1 gene expression through interaction with C-terminal
            binding protein
  JOURNAL   J Mol Biol 386 (4), 938-950 (2009)
   PUBMED   19162039
  REMARK    GeneRIF: HDGF functions as a transcriptional repressor of the SMYD1
            gene through interaction with the transcriptional corepressor CtBP.
REFERENCE   7  (bases 1 to 4385)
  AUTHORS   Sims,R.J. 3rd, Weihe,E.K., Zhu,L., O'Malley,S., Harriss,J.V. and
            Gottlieb,P.D.
  TITLE     m-Bop, a repressor protein essential for cardiogenesis, interacts
            with skNAC, a heart- and muscle-specific transcription factor
  JOURNAL   J Biol Chem 277 (29), 26524-26529 (2002)
   PUBMED   12011100
REFERENCE   8  (bases 1 to 4385)
  AUTHORS   Gottlieb,P.D., Pierce,S.A., Sims,R.J., Yamagishi,H., Weihe,E.K.,
            Harriss,J.V., Maika,S.D., Kuziel,W.A., King,H.L., Olson,E.N.,
            Nakagawa,O. and Srivastava,D.
  TITLE     Bop encodes a muscle-restricted protein containing MYND and SET
            domains and is essential for cardiac differentiation and
            morphogenesis
  JOURNAL   Nat Genet 31 (1), 25-32 (2002)
   PUBMED   11923873
REFERENCE   9  (bases 1 to 4385)
  AUTHORS   Srivastava,D., Gottlieb,P.D. and Olson,E.N.
  TITLE     Molecular mechanisms of ventricular hypoplasia
  JOURNAL   Cold Spring Harb Symp Quant Biol 67, 121-125 (2002)
   PUBMED   12858532
  REMARK    GeneRIF: effects of gene mutations on ventricular development
REFERENCE   10 (bases 1 to 4385)
  AUTHORS   Hwang,I. and Gottlieb,P.D.
  TITLE     Bop: a new T-cell-restricted gene located upstream of and opposite
            to mouse CD8b
  JOURNAL   Immunogenetics 42 (5), 353-361 (1995)
   PUBMED   7590968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC126191.1, AL832035.1, AC092836.4 and BX647878.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198274.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647878.1, SRR1803612.106784.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419482.7/ ENSP00000393453.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               BC126191.1         46-399
            355-1871            AL832035.1         317-1833
            1872-4342           AC092836.4         44056-46526
            4343-4385           BX647878.1         4307-4349
FEATURES             Location/Qualifiers
     source          1..4385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..4385
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /note="SET and MYND domain containing 1"
                     /db_xref="GeneID:150572"
                     /db_xref="HGNC:HGNC:20986"
                     /db_xref="MIM:606846"
     exon            1..177
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1513
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /EC_number="2.1.1.354"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger, MYND domain containing 18; CD8 beta opposite; SET
                     and MYND domain-containing protein 1; histone-lysine
                     N-methyltransferase SMYD1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SMYD1 isoform
                     1"
                     /protein_id="NP_938015.1"
                     /db_xref="CCDS:CCDS33240.1"
                     /db_xref="GeneID:150572"
                     /db_xref="HGNC:HGNC:20986"
                     /db_xref="MIM:606846"
                     /translation="MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVF
                     DSLVNFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNE
                     NIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPP
                     QSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNN
                     GNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTC
                     EHCQKKLKDDLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRE
                     CLEKQEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL
                     GMAVMRAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRM
                     FRQNEFMYYKMREAALNNQPMQVMAEPSNEPSPALFHKKQ"
     exon            178..354
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            355..568
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            569..699
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            700..738
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            739..928
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1021
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1185
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1354
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..4385
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4359..4364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /note="hexamer: ATTAAA"
     polyA_site      4385
                     /gene="SMYD1"
                     /gene_synonym="BOP; KMT3D; ZMYND18; ZMYND22"
                     /note="major polyA site"
ORIGIN      
        1 agtgttaaat aactgccgcg ctggcctgac agtctctgag atgacaatag ggagaatgga
       61 gaacgtggag gtcttcaccg ctgagggcaa aggaaggggt ctgaaggcca ccaaggagtt
      121 ctgggctgca gatatcatct ttgctgagcg ggcttattcc gcagtggttt ttgacagcct
      181 tgttaatttt gtgtgccaca cctgcttcaa gaggcaggag aagctccatc gctgtgggca
      241 gtgcaagttt gcccattact gcgaccgcac ctgccagaag gatgcttggc tgaaccacaa
      301 gaatgaatgt tcggccatca agagatatgg gaaggtgccc aatgagaaca tcaggctggc
      361 ggcgcgcatc atgtggcggg tggagagaga aggcaccggg ctcacggagg gctgcctggt
      421 gtccgtggac gacttgcaga accacgtgga gcactttggg gaggaggagc agaaggacct
      481 gcgggtggac gtggacacat tcttgcagta ctggccgccg cagagccagc agttcagcat
      541 gcagtacatc tcgcacatct tcggagtgat taactgcaac ggttttactc tcagtgatca
      601 gagaggcctg caggccgtgg gcgtaggcat cttccccaac ctgggcctgg tgaaccatga
      661 ctgttggccc aactgtactg tcatatttaa caatggcaat catgaggcag tgaaatccat
      721 gtttcatacc cagatgagaa ttgagctccg ggccctaggc aagatctcag aaggagagga
      781 gctgactgtg tcctatattg acttcctcaa cgttagtgaa gaacgcaaga ggcagctgaa
      841 gaagcagtac tactttgact gcacatgtga acactgccag aaaaaactga aggatgacct
      901 cttcctgggg gtgaaagaca accccaagcc ctctcaggaa gtggtgaagg agatgataca
      961 attctccaag gatacattgg aaaagataga caaggctcgt tccgagggtt tgtatcatga
     1021 ggttgtgaaa ttatgccggg agtgcctgga gaagcaggag ccagtgtttg ctgacaccaa
     1081 catctacatg ctgcggatgc tgagcattgt ttcggaggtc ctttcctacc tccaggcctt
     1141 tgaggaggcc tcgttctatg ccaggaggat ggtggacggc tatatgaagc tctaccaccc
     1201 caacaatgcc caactgggca tggccgtgat gcgggcaggg ctgaccaact ggcatgctgg
     1261 taacattgag gtggggcacg ggatgatctg caaagcctat gccattctcc tggtgacaca
     1321 cggaccctcc caccccatca ctaaggactt agaggccatg cgggtgcaga cggagatgga
     1381 gctacgcatg ttccgccaga acgaattcat gtactacaag atgcgcgagg ctgccctgaa
     1441 caaccagccc atgcaggtca tggccgagcc cagcaatgag ccatccccag ctctgttcca
     1501 caagaagcaa tgaggactgc ccagtggagg aggggcgatg tggctgggga gctagggaga
     1561 gactctggag gtggtgggtc tctcgggaga cccctaatga ggaagttgag gtaatgctta
     1621 acattgttgc tgtgagaatt tactgcccta tgtttcccag agccattttg gctcaattca
     1681 agtctattca attcaagtta actctagccc agcccagatc aactcctcct acaaatatta
     1741 ttggatgata ggccctagaa cccaataaag gagctccaaa tgtcgttggg tggggaagca
     1801 aaatgtagag aaacatttaa agcacactgt aataataaat gcaattataa actatatgga
     1861 ggagggtgca gaggagggaa tgtgtctggt gtgtgatgtg tgtgtgtgca gtgggggtat
     1921 cacagagagt atgacatctg agttgagggt agcaggtgcc tggagtctca ggtggctgct
     1981 cacccatctg tgcaggtgtc tctggggctg ctggtctcac ctgtggtctg cagtagacac
     2041 aattggctga gcaggatatg tgatactgtg tggttggtgt ggagttttga agaaggggct
     2101 gtgtttgggc cacgtaggct ctactcagag acctgaaacc acttcagaat ggtgcatatg
     2161 tcgaaagagc tggctggggg ccttgcccaa accaactgag gtcttaaagt ccagggaaaa
     2221 aaagtctggg ttccaactag aattctagaa atatttctag aacacacaga gagggaataa
     2281 gtccctctat cacccttatt accaagcctt gtggttccct gtgattttag ataatgtctg
     2341 atatttttct ggctatttgc ctagtaggat ttaaaaaata ttttcaaagt gaagctgaga
     2401 gagaatcttg gaaacacaca tacctgttga tcatgggccc tgcagaattg gcccttgggg
     2461 gctttatttg gttacatgtg cctgggtggt ctttaccagc ttagactcta tcatgggccc
     2521 ccatgaagct ccattctcaa tactgaataa ttattacttc ccttgttgag tttctttttc
     2581 tgtcatgccc tgggggcttc tgctcttctc accagaaaga acatttgaat ctggattctt
     2641 gtacacctgg gttagaccct gttcagaggt gtggccaatt tatcccgatc tcctggaagg
     2701 ctgttgtgat ttccatctaa gaaatgaggg tcttgagaat caaccagtcc caagattagc
     2761 ctgttatcct gttatctact gagaccccaa atttctcacc aatgttttgg gagatcctgg
     2821 aaaagatccc ttcagtttgg ggtgtcacca agacttctac acaacccagg actaccattg
     2881 acctcagagc tgtaccccac atcttgaagt aaattgatcc caccaggtcc cacgtttgtt
     2941 atctctgcct aaatgttagc ttctccatcc tcaccacatg atgacctgct gtgtccctct
     3001 gagcactacc cagtggctga aaactctgca aatgggccac acttttgcaa aatacttgta
     3061 tctgacactt aggtcttgtt tgaagaattt cctttctgga aggttttaca agaagactga
     3121 tagtctttca agcccccaca tcacaggctt agggacggca ctaactttct cccagggatc
     3181 taactggcta gttcaaatta tcactctttt accttcatat aaaatgtctc ccccaaacct
     3241 ttttcccttc tttgtcattg ttatctgcta agcccctggt catttcccca tattcgtagt
     3301 ctttttttcc atcctatctt tctaatattt gttgtcttta acaaactgtg ttctgtgtct
     3361 gtgctcctcc ttccctctca gaccactgga atgcaagtcc ttcttccctt tggaatgtac
     3421 tctggatccc ttcccctgct ttgaccccca gactttgctc catctattat tgcttctcca
     3481 tcctggatcc ttgacatttg tcaccccact ggccttctca ggtgcaatca gtaaaaatgc
     3541 tgagaactct tggatcttaa tcttcatgac tgagtttttt ttagttgtat agttatcatc
     3601 tgcctttctt cactttgcat ttcttcttga atccattgca gattgacttc cactcccact
     3661 ccttcactaa aagggctctt accaagatca aatctaatgg gtacatttta gttcctatgt
     3721 gatttggcct ttcgatgtca atcatcactc ccagccattg attttggtga cccacttccc
     3781 tgtgatgatc ttctgatcta gtttctcagg ttccttcgct ggtccttttt ctttccctgc
     3841 ccctgacata ttgacatttc ctggagttgg ttttgtcctt gattcattct catgtcattc
     3901 tgcacacagt ctctgcatga actcaggcag acccttcatt taatgaccac cttagggctg
     3961 atgattctca aatctgtatt ccccgatctt gcatttgagc tccagcccca ctcatcctct
     4021 cggatgttct gcaggcccag caaactcatc atgtccaaag tgaaactttt tctctttcct
     4081 gtctcctctc ctctgatctg ttctttcttg gaacaccacc caagaacgtc acctcctcca
     4141 tcagattgtg agctcctgga gggcaggagc tgtgtccttc tattcatctt cctatcccca
     4201 gaaccttgca cagatcctgg aatgtggtag gtgctcagta aatgtgtgtt gaataaatga
     4261 atgaatgaat gaacaaatga atgaatttgc ttacttcaag gcaaaagaac catgaaactg
     4321 tattttgagt ttctatgtta tagcagtcag caaatcctat taaatacttt gtgtttccaa
     4381 gcaaa
//
