LOCUS       NM_022739               6240 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SMAD specific E3 ubiquitin protein ligase 2 (SMURF2),
            mRNA.
ACCESSION   NM_022739
VERSION     NM_022739.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6240)
  AUTHORS   Ren,J., Yu,L., Zhang,Q., Ren,P., Cai,Y., Wang,X., Lan,K. and Wu,S.
  TITLE     AIMP2 restricts EV71 replication by recruiting SMURF2 to promote
            the degradation of 3D polymerase
  JOURNAL   Virol Sin 39 (4), 632-644 (2024)
   PUBMED   38945214
  REMARK    GeneRIF: AIMP2 restricts EV71 replication by recruiting SMURF2 to
            promote the degradation of 3D polymerase.
REFERENCE   2  (bases 1 to 6240)
  AUTHORS   Jiang,C., Yao,D., Liu,Z., Zheng,Y., Chen,M., Yim,W.Y., Zheng,Q.,
            Zhang,T., Fan,L., Fan,Z., Geng,B., Tian,R., Zhou,T., Qiao,W.,
            Shi,J., Li,F., Xu,L., Huang,Y. and Dong,N.
  TITLE     FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific
            aortic valve disease
  JOURNAL   Redox Biol 73, 103215 (2024)
   PUBMED   38810422
  REMARK    GeneRIF: FOXO1 regulates RUNX2 ubiquitination through SMURF2 in
            calcific aortic valve disease.
REFERENCE   3  (bases 1 to 6240)
  AUTHORS   Pi,Y., Feng,Q., Sun,F., Wang,Z., Zhao,Y., Chen,D., Liu,Y. and
            Lou,G.
  TITLE     Loss of SMURF2 expression enhances RACK1 stability and promotes
            ovarian cancer progression
  JOURNAL   Cell Death Differ 30 (11), 2382-2392 (2023)
   PUBMED   37828084
  REMARK    GeneRIF: Loss of SMURF2 expression enhances RACK1 stability and
            promotes ovarian cancer progression.
REFERENCE   4  (bases 1 to 6240)
  AUTHORS   Wang,L., Zha,H., Huang,J. and Shi,L.
  TITLE     Flavin containing monooxygenase 2 regulates renal tubular cell
            fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37800598
  REMARK    GeneRIF: Flavin containing monooxygenase 2 regulates renal tubular
            cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation.
REFERENCE   5  (bases 1 to 6240)
  AUTHORS   Yan,B., Jin,Y., Mao,S., Zhang,Y., Yang,D., Du,M. and Yin,Y.
  TITLE     Smurf2-Mediated Ubiquitination of FOXO4 Regulates Oxygen-glucose
            Deprivation/Reperfusion-induced Pyroptosis of Cortical Neurons
  JOURNAL   Curr Neurovasc Res 20 (4), 443-452 (2023)
   PUBMED   37861000
  REMARK    GeneRIF: Smurf2-Mediated Ubiquitination of FOXO4 Regulates
            Oxygen-glucose Deprivation/Reperfusion-induced Pyroptosis of
            Cortical Neurons.
REFERENCE   6  (bases 1 to 6240)
  AUTHORS   Asano,Y., Ihn,H., Yamane,K., Kubo,M. and Tamaki,K.
  TITLE     Impaired Smad7-Smurf-mediated negative regulation of TGF-beta
            signaling in scleroderma fibroblasts
  JOURNAL   J Clin Invest 113 (2), 253-264 (2004)
   PUBMED   14722617
REFERENCE   7  (bases 1 to 6240)
  AUTHORS   Bonni,S., Wang,H.R., Causing,C.G., Kavsak,P., Stroschein,S.L.,
            Luo,K. and Wrana,J.L.
  TITLE     TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase
            complex that targets SnoN for degradation
  JOURNAL   Nat Cell Biol 3 (6), 587-595 (2001)
   PUBMED   11389444
REFERENCE   8  (bases 1 to 6240)
  AUTHORS   Zhang,Y., Chang,C., Gehling,D.J., Hemmati-Brivanlou,A. and
            Derynck,R.
  TITLE     Regulation of Smad degradation and activity by Smurf2, an E3
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 98 (3), 974-979 (2001)
   PUBMED   11158580
REFERENCE   9  (bases 1 to 6240)
  AUTHORS   Kavsak,P., Rasmussen,R.K., Causing,C.G., Bonni,S., Zhu,H.,
            Thomsen,G.H. and Wrana,J.L.
  TITLE     Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets
            the TGF beta receptor for degradation
  JOURNAL   Mol Cell 6 (6), 1365-1375 (2000)
   PUBMED   11163210
REFERENCE   10 (bases 1 to 6240)
  AUTHORS   Lin,X., Liang,M. and Feng,X.H.
  TITLE     Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent
            degradation of Smad2 in transforming growth factor-beta signaling
  JOURNAL   J Biol Chem 275 (47), 36818-36822 (2000)
   PUBMED   11016919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132812.9, CN370887.1, CN310238.1, CB267500.1, BP363931.1,
            AY014180.1, BC051283.1, BC009527.1, AK002019.1 and AC009994.10.
            
            On Nov 22, 2018 this sequence version replaced NM_022739.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY014180.1, BC093876.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262435.14/ ENSP00000262435.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC132812.9         99603-99641
            40-60               CN370887.1         1-21
            61-75               CN310238.1         19-33
            76-138              CB267500.1         47-109
            139-139             BP363931.1         138-138
            140-245             CN370887.1         101-206
            246-2772            AY014180.1         7-2533
            2773-2787           BC051283.1         2423-2437
            2788-2805           BC009527.1         983-1000
            2806-3166           BC009527.1         1002-1362
            3167-3296           BC051283.1         2815-2944
            3297-3441           BC051283.1         2946-3090
            3442-3905           AK002019.1         345-808
            3906-6240           AC009994.10        108579-110913
FEATURES             Location/Qualifiers
     source          1..6240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3-q24.1"
     gene            1..6240
                     /gene="SMURF2"
                     /note="SMAD specific E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:64750"
                     /db_xref="HGNC:HGNC:16809"
                     /db_xref="MIM:605532"
     exon            1..479
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..2674
                     /gene="SMURF2"
                     /EC_number="2.3.2.26"
                     /note="E3 ubiquitin ligase SMURF2; hSMURF2; SMAD
                     ubiquitination regulatory factor 2; HECT-type E3 ubiquitin
                     transferase SMURF2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SMURF2"
                     /protein_id="NP_073576.1"
                     /db_xref="CCDS:CCDS32707.1"
                     /db_xref="GeneID:64750"
                     /db_xref="HGNC:HGNC:16809"
                     /db_xref="MIM:605532"
                     /translation="MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGS
                     GQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSN
                     AINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLP
                     DGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA
                     TCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGV
                     STWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANL
                     HLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGH
                     CRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEML
                     NPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPF
                     YKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKP
                     NGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELEL
                     IICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVP
                     LQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE
                     ETCGFAVE"
     exon            480..518
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..627
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..761
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..827
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..912
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..996
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1199
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1284
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1443
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1639
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1743
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1858
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2037
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2175
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2296
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2498
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2574
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..6240
                     /gene="SMURF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3144..3149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMURF2"
                     /note="hexamer: AATAAA"
     polyA_site      3178
                     /gene="SMURF2"
     regulatory      6191..6196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMURF2"
                     /note="hexamer: AATAAA"
     polyA_site      6223
                     /gene="SMURF2"
     polyA_site      6240
                     /gene="SMURF2"
                     /note="major polyA site"
ORIGIN      
        1 agacaagagg gcgggtggag gaggaagcgg ccgagcccag agttctgctc cggcgccccc
       61 gagcaccgcc cgcttcagcc gaccagcccc gtcggctact gggcctcgcc gagacgagag
      121 gagggaaagg cctcggcggc cgcgaggagg cggcgggggc gcgggcggag gcggcgcggg
      181 cggccgcggc tgccgctttg ttgtgcggcc cgggccgagg aaggagaagt gggaggaggg
      241 gggagctcgg cgtcccgctc cctccgcggc tcatggcgac gactctcggc acatccggga
      301 ccctccggcc gtggcggccg aggcgccggc tgctcgggcc ccagccccgg ccgctgtggt
      361 gactccgccg cgcctcgccg tcgcccccgt gccgcccgcc gcccccgccg cccccgccgc
      421 cggggacatg tctaaccccg gaggccggag gaacgggccc gtcaagctgc gcctgacagt
      481 actctgtgca aaaaacctgg tgaaaaagga ttttttccga cttcctgatc catttgctaa
      541 ggtggtggtt gatggatctg ggcaatgcca ttctacagat actgtgaaga atacgcttga
      601 tccaaagtgg aatcagcatt atgacctgta tattggaaag tctgattcag ttacgatcag
      661 tgtatggaat cacaagaaga tccataagaa acaaggtgct ggatttctcg gttgtgttcg
      721 tcttctttcc aatgccatca accgcctcaa agacactggt tatcagaggt tggatttatg
      781 caaactcggg ccaaatgaca atgatacagt tagaggacag atagtagtaa gtcttcagtc
      841 cagagaccga ataggcacag gaggacaagt tgtggactgc agtcgtttat ttgataacga
      901 tttaccagac ggctgggaag aaaggagaac cgcctctgga agaatccagt atctaaacca
      961 tataacaaga actacgcaat gggagcgccc aacacgaccg gcatccgaat attctagccc
     1021 tggcagacct cttagctgct ttgttgatga gaacactcca attagtggaa caaatggtgc
     1081 aacatgtgga cagtcttcag atcccaggct ggcagagagg agagtcaggt cacaacgaca
     1141 tagaaattac atgagcagaa cacatttaca tactcctcca gacctaccag aaggctatga
     1201 acagaggaca acgcaacaag gccaggtgta tttcttacat acacagactg gtgtgagcac
     1261 atggcatgat ccaagagtgc ccagggatct tagcaacatc aattgtgaag agcttggtcc
     1321 attgcctcct ggatgggaga tccgtaatac ggcaacaggc agagtttatt tcgttgacca
     1381 taacaacaga acaacacaat ttacagatcc tcggctgtct gctaacttgc atttagtttt
     1441 aaatcggcag aaccaattga aagaccaaca gcaacagcaa gtggtatcgt tatgtcctga
     1501 tgacacagaa tgcctgacag tcccaaggta caagcgagac ctggttcaga aactaaaaat
     1561 tttgcggcaa gaactttccc aacaacagcc tcaggcaggt cattgccgca ttgaggtttc
     1621 cagggaagag atttttgagg aatcatatcg acaggtcatg aaaatgagac caaaagatct
     1681 ctggaagcga ttaatgataa aatttcgtgg agaagaaggc cttgactatg gaggcgttgc
     1741 cagggaatgg ttgtatctct tgtcacatga aatgttgaat ccatactatg gcctcttcca
     1801 gtattcaaga gatgatattt atacattgca gatcaatcct gattctgcag ttaatccgga
     1861 acatttatcc tatttccact ttgttggacg aataatggga atggctgtgt ttcatggaca
     1921 ttatattgat ggtggtttca cattgccttt ttataagcaa ttgcttggga agtcaattac
     1981 cttggatgac atggagttag tagatccgga tcttcacaac agtttagtgt ggatacttga
     2041 gaatgatatt acaggtgttt tggaccatac cttctgtgtt gaacataatg catatggtga
     2101 aattattcag catgaactta aaccaaatgg caaaagtatc cctgttaatg aagaaaataa
     2161 aaaagaatat gtcaggctct atgtgaactg gagattttta cgaggcattg aggctcaatt
     2221 cttggctctg cagaaaggat ttaatgaagt aattccacaa catctgctga agacatttga
     2281 tgagaaggag ttagagctca ttatttgtgg acttggaaag atagatgtta atgactggaa
     2341 ggtaaacacc cggttaaaac actgtacacc agacagcaac attgtcaaat ggttctggaa
     2401 agctgtggag ttttttgatg aagagcgacg agcaagattg cttcagtttg tgacaggatc
     2461 ctctcgagtg cctctgcagg gcttcaaagc attgcaaggt gctgcaggcc cgagactctt
     2521 taccatacac cagattgatg cctgcactaa caacctgccg aaagcccaca cttgcttcaa
     2581 tcgaatagac attccaccct atgaaagcta tgaaaagcta tatgaaaagc tgctaacagc
     2641 cattgaagaa acatgtggat ttgctgtgga atgacaagct tcaaggattt acccaggact
     2701 ctatttatac aaccctgact gacagcctcc tttcagcaga gtttcaaaga atatgctgaa
     2761 atacaggaaa acactccccc cccccccctt tttttttttt tttttacatt ttaggacact
     2821 gtgaggggaa aggacaattt tgaaattcct tttcaaggaa aaaaaaggtc tttatgcttt
     2881 gccatgaggc cacattcagc tgctatttaa acttaatatc ttgaacctaa agaatgctga
     2941 cttttcctac atttccagag ttaggcagta ttctacactt aaagactact actattttta
     3001 taaaaggtaa tctattcaaa tttcttcaca gatttcaagt ctctcaaaca tcaagacaac
     3061 ttcagcagtc ggtacaagtc acatttcatt ttgattgaat acatgatctt gaacagctcc
     3121 tgtacttgct ctttgtaaaa aaaaataaaa ttattttgaa ttattctacc tttgtaaaca
     3181 attggctaaa agaatcatct ttaagaaatt aagccattta catgtttgtg tttttctata
     3241 gcagagcatt atattttgca ttatatgttt caacctagtc taagtgggtc ttttttacat
     3301 ttttcaagaa cggatttcct ggaatacagc gatataattt tggttgtcaa attcctaatg
     3361 caaccattta gtctaaactt agtcatttat ttgtgacaat aagatgtgtt caggggctcc
     3421 ctgtttttaa gagactcttt taaaaaaaaa aaaacctaat gtttttatct tgagtcaata
     3481 tgattaggta ttttggattt acttttaatc ttaaaatact gcatttttat agcttctcag
     3541 agcatgtgga tgggatggga ttttcgttat tttgctgggt cagcttatct ttaatatatg
     3601 gactattcct ataaaccaaa gtctctgaca agtgcaccta atttatattg tattttaact
     3661 acagtgtaag tttccattaa caaaaccatc ctaaagcgtt aactgctcat aattttaatc
     3721 agctacagtt atgaaaaagg aagaattttg ctctaaagat tattaataag cttagaaaat
     3781 cctgctttta cctaacagaa tgaagtgggg ttgaggggcg gtagtatgaa cagtgattct
     3841 aactctatgg cgtaaattac tttgaagagt tcattttgga agtaagggaa tcccgcttcc
     3901 cttggtgttg aagatctgca tctgattttg aaacgtccag atttagcttt caaggtgcgt
     3961 gcatgttgaa tgatccagaa gcaacgaaaa ctctggggtg agggattgaa aaaatctgaa
     4021 atcacagttg gatttttaaa ttcaaccatc aaaaatatgt actatcagtt tttttttaca
     4081 ttgatgtgaa ataagcaaat tttcatgata attaagctgc aaaatttaaa gttatcaagt
     4141 aaataggtcc tctgtgttct gtttcatgtg atggagtggg tttcagtctg tgttcttgga
     4201 gccaaagggt tcctcagggg tgcctcagga gtaatggttt aagagaagag gggcaatgag
     4261 agggagcgag ggggaaggcc tagttggtat ttgagcaggg gccttaggct ccatatcccc
     4321 acccccttta cccagaacag cccatttttc ttatgtatat tggaatttca agtaagcttt
     4381 catggggtgc agtggggcgg ggaggaatgg atgggataaa aaaagtggag attttgctgc
     4441 tttaaaaaag ttgagaacta cttgtgtagt ttttaagtat tttaatgtat ttcatttggc
     4501 caaattcaac tgccacaagc aagctagtca tagttgtaac tgtgcagtgg taatatgctt
     4561 atgcctacct ttttcctctc aaacaatttg ttttttttac attgcattct gagtactgaa
     4621 gagcatcttg aaatgtatgg aagtggtttc tatgctattt gataatcagt aatgttcagc
     4681 tgtcatgata gtactttact ggttgcagac ccatctctct tttatattaa agcactagtg
     4741 cagtttataa ttgtgcctac ttttaaaatc tttcagtaaa aaagtacata atgaatacag
     4801 aaatcataac tgacagggat acagtaataa tgaaatgcta ctatcactta ttttaatata
     4861 caatataaag caggcaaata ccattgcttt ttgagtgcct ttttaacttt atactaatga
     4921 cttaatagag ctttaaaaga aagaaattgg ctgggcatgg tggctcacac ctgtaatccc
     4981 agcactttgg gaggccgagg tgggcggatc acctgaggtc aggagttcga gaccagcctg
     5041 gccaacgtgg tgaaaccctg tctctactaa aaatacaaaa tttagccggg catggtggcg
     5101 cactcctgta atccaactac ttgggaggct gaggcaggag aattgcttga atctgggagg
     5161 cagagattgc agtgagccga gatcgcacca ctgcactcca gcctgggcga caagagtgag
     5221 actccgtccc cgcccaaaaa aaaaaaaaaa agaaattact ctccataaca gtctatgtta
     5281 tcaccaacat atataaaaac atgatttaga tttccatttc aaagttacat tacccgatta
     5341 cttccaaata ggtgctaagc aaaaaccccc aatgtattat tgaaccatgg acttgcacct
     5401 catgtttaat gtgaatattt atttccatgt ccctcttaac tggttttttc ttgtcttccc
     5461 tctagctgta ttgttatttc agatatgtga tatctgtttt catactcttg cctttccatc
     5521 atgaatgctt agttatgaac agagattcct ttgtagagct cataggcagt acagagaggt
     5581 aagtcttgcc tcagagggcc ttgtatcttg gtgtagtttt taaatagtgc atagtgtata
     5641 gtgtatagtg tacattttgt tttgcacata gtttgttgcc ccgaatgggt tttttaccaa
     5701 gccttttttt ctttcatgta tttacagtcc ggagcacaag attctcttct ttcaaataca
     5761 atgtaattcg ctttacttta caacactaaa tctgggcttt gaatttccag tgcattggac
     5821 tgattggatt gttgggagtt agaggctgtt ccaaccatcc ttagtttggg agagtggctc
     5881 cttctgcttg ttttctaagc gtacagtcaa cgggtgccat ttgtggtatt taacatgtta
     5941 ggatgattgt tccaaatgct gagttgtttt atttctagat gtaattagtt cactttatgt
     6001 aatattcttc tctcagactg actttaaaaa caaagtttta tcattttcat tgtatttgta
     6061 tttattacag agtgttttag ctttgatatt ctttgtattt tcattcattt gttacatgag
     6121 ctttatcagt aacatctgta taaatggttt ttaaaaatta actatgtatg tgcccatgcc
     6181 gaagtcgagc aataaaatca atgctgtttg cactgtcaca gcatcaacgt ttttaaagaa
//
