LOCUS       XM_047420635            5945 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SMAD specific E3 ubiquitin protein ligase 1
            (SMURF1), transcript variant X2, mRNA.
ACCESSION   XM_047420635
VERSION     XM_047420635.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000007.14) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
     gene            1..5945
                     /gene="SMURF1"
                     /note="SMAD specific E3 ubiquitin protein ligase 1;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 5 mRNAs, 27 ESTs, 910 long SRA reads, and
                     98% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:57154"
                     /db_xref="HGNC:HGNC:16807"
                     /db_xref="MIM:605568"
     CDS             1053..2801
                     /gene="SMURF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SMURF1 isoform X2"
                     /protein_id="XP_047276591.1"
                     /db_xref="GeneID:57154"
                     /db_xref="HGNC:HGNC:16807"
                     /db_xref="MIM:605568"
                     /translation="MEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRG
                     SLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGG
                     DAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFT
                     DPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQ
                     PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLL
                     CHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGG
                     FTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQ
                     HELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ
                     KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTG
                     STRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLY
                     EKLLTAVEETCGFAVE"
ORIGIN      
        1 ctttgactct taccatctca gaattcaagg tctaaattga catatttggg aagagcaggg
       61 tgttggggaa acagaactgg taagtagatg gttttcctct cccatctgac tcagtgttag
      121 agaactctgt tggagacagt gttaatttca atatcttgat gcccgatttt atcgttacag
      181 acatcctgtt atacagaata gcttatttgc tctcttaata gaaatcttgt aaagaaaatc
      241 catcttcctt atttcactgt ttctttccct aaaagttttt gtataccacc cctttatcaa
      301 gaattaagat gttggggaaa aaaaaaaaac aaatcttttt gggctaaata atgccagctt
      361 cacttccctc aatgatgaca catttatctg tattttaaag ttgttttttt ttttttctcc
      421 ctttcccact acactgctct gcatgtgggt tccctagctg agaagctgcc attgatggtg
      481 aaagacttta atctaaattt agattctctt cagaggtttc gtggaatact tccttaaatt
      541 aagccacaga ctgcaaaagc tgctgctgag tggggcttcc agtgttatgt gccaagaacc
      601 ttgcaaagaa agacttcttc aggctccctg acccttttgc aaagattgtc gtggatgggt
      661 ctgggcagtg ccactcaacc gacactgtga aaaacacatt ggacccaaag tggaaccagc
      721 actatgatct atatgttggg aaaacggatt cgataaccat tagcgtgtgg aaccataaga
      781 aaattcacaa gaaacaggga gctggcttcc tgggctgtgt gcggctgctc tccaatgcca
      841 tcagcagatt aaaagatacc ggataccagc gtttggatct atgcaaacta aacccctcag
      901 atactgatgc agttcgtggc cagatagtgg tcagtttaca gacacgagac agaataggaa
      961 ccggcggctc ggtggtggac tgcagaggac tgttagaaaa tgaaggaacg gtgtatgaag
     1021 actccgggcc tgggaggccg ctcagctgct tcatggagga accagcccct tacacagata
     1081 gcaccggtgc tgctgctgga ggagggaatt gcaggttcgt ggagtcccca agtcaagatc
     1141 aaagacttca ggcacagcgg cttcgaaacc ctgatgtgcg aggttcacta cagacgcccc
     1201 agaaccgacc acacggccac cagtccccgg aactgcccga aggctacgaa caaagaacaa
     1261 cagtccaggg ccaagtttac tttttgcata cacagactgg agttagcacg tggcacgacc
     1321 ccaggatacc aagtccctcg gggaccattc ctgggggaga tgcagctttt ctatacgaat
     1381 tccttctaca aggccataca tctgagccca gagaccttaa cagtgtgaac tgtgatgaac
     1441 ttggaccact gccgccaggc tgggaagtca gaagtacagt ttctgggagg atatattttg
     1501 tagatcataa taaccgaaca acccagttta cagacccaag gttacaccac atcatgaatc
     1561 accagtgcca actcaaggag cccagccagc cgctgccact gcccagtgag ggctctctgg
     1621 aggacgagga gcttcctgcc cagagatacg aaagagatct agtccagaag ctgaaagtcc
     1681 tcagacacga actgtcgctt cagcagcccc aagctggtca ttgccgcatc gaagtgtcca
     1741 gagaagaaat ctttgaggag tcttaccgcc agataatgaa gatgcgaccg aaagacttga
     1801 aaaaacggct gatggtgaaa ttccgtgggg aagaaggttt ggattacggt ggtgtggcca
     1861 gggagtggct ttacttgctg tgccatgaaa tgctgaatcc ttattacggg ctcttccagt
     1921 attctacgga caatatttac atgttgcaaa taaatccgga ttcttcaatc aaccccgacc
     1981 acttgtctta tttccacttt gtggggcgga tcatggggct ggctgtgttc catggacact
     2041 acatcaacgg gggcttcaca gtgcccttct acaagcagct gctggggaag cccatccagc
     2101 tctcagatct ggaatctgtg gacccagagc tgcataagag cttggtgtgg atcctagaga
     2161 acgacatcac gcctgtactg gaccacacct tctgcgtgga acacaacgcc ttcgggcgga
     2221 tcctgcagca tgaactgaaa cccaatggca gaaatgtgcc agtcacagag gagaataaga
     2281 aagaatacgt ccggttgtat gtaaactgga ggtttatgag aggaatcgaa gcccagttct
     2341 tagctctgca gaaggggttc aatgagctca tccctcaaca tctgctgaag ccttttgacc
     2401 agaaggaact ggagctgatc ataggcggcc tggataaaat agacttgaac gactggaagt
     2461 cgaacacgcg gctgaagcac tgtgtggccg acagcaacat cgtgcggtgg ttctggcaag
     2521 cggtggagac gttcgatgaa gaaaggaggg ccaggctcct gcagtttgtg actgggtcca
     2581 cgcgagtccc gctccaaggc ttcaaggctt tgcaaggttc tacaggcgcg gcagggcccc
     2641 ggctgttcac catccacctg atagacgcga acacagacaa ccttccgaag gcccatacct
     2701 gctttaaccg gatcgacatt ccaccatatg agtcctatga gaagctctac gagaagctgc
     2761 tgacagccgt ggaggagacc tgcgggtttg ctgtggagtg aaaagcaacc aaaggcaaca
     2821 gagtctagct catggccacc agaccaaaag catccagctt ctgtgcacct cctgcaaagc
     2881 tggcagaggc cctggaattc cagatcacct gaggggaaag ggttgtctct ctcctttctg
     2941 ttgggggagg gggatggggg acttttgttg gtggctccca cccatatatc cctcctttac
     3001 catagtactc ccacccactt ccatcaccca tccaataaaa tgcagccagg tttagccttt
     3061 ggctttggtc acacaggata ttctgctgtg ttgcaaccca tgtggtgata aggctcacag
     3121 ccctgagctc tttacgggag catcaactca cagttagggg actgggcgtg gctgattgag
     3181 ggtttggaac tggtggctat gccagctatt ccatctcaaa acagccttga ggcccctttt
     3241 caatttgagc agctgctaga tatcttatca gagctcagat tccagatttc acatcccagc
     3301 agccggttct gggtagcaga tcaatttcca actggaaaat aactatataa tgtatgctta
     3361 ttggaattct gccacagcag gaagcttgag tcaaaatgtg tttccccttt gaaaggagaa
     3421 ggaattggag cagcttttcc tggaggccca ggatatttct tttctgggta tcttggctga
     3481 aaattttgtt ttacatagag aaaaacgatc ttttaagggt cccttttgct gcattatctg
     3541 tccagtttga cttttttttc agtgaaaaca ccatgtcatg gagtgtagga aagagcagac
     3601 caaaatcagc cctagagcca accagtcagt cccaaagctg tgacctctgt gccactgttg
     3661 tccatagaag agcatcgact gtgtcactta aaatattagt aaaccatgat gcagcaactg
     3721 ctaagagcta aactaacaaa attgtgtcat catagctgct ggcttggtgt gaactcgctt
     3781 aaaagcaatg gtgaaaggat aacctcgatg atgtaaatcc acccaaagat actgttctac
     3841 aaaaagtagg gtgtggacgc aaacctgtga cagcagaggg ggacgacttc acactcactg
     3901 cctcatgtgg cccctttccc agtggcagct ggtgacacta acgattgcta ctcggttcac
     3961 ttgcccagat gtcttcatat gatgagcaag gccagaagca aggctagatt cgaagtttct
     4021 gacaccattt ccagtttgca caaaagtcag tattttatct taaagtggct tgatttccaa
     4081 tagctgaact tgggcagaaa acagcaggcc aatgttccta tgtggtttct ttgttgttgt
     4141 ttttgtttgg ggtgggggca agtacagggt aattcatgag caagacattt cactgctgtc
     4201 gaagtctctg ggatcccgct gtgggtctga gatggcctgg gaaggacctt gtggacaatg
     4261 gttttatctg ttctttttgt cactgttaat ttctgggctg ctgaggttct agaatagaag
     4321 ggctgccaaa tgaggtttgc tgcaggagga aagtttaatc ccccattcca aaagtccagg
     4381 ccaaatggtg ggcttagcct ctttgaaaag ttctgccttg cccccacagg tgggcacatc
     4441 ctgtgtctca ttcaccatga tgcttcctga gggtgttcta gaagcccgtt ccccagtggc
     4501 tgtatccagc ctttccttgc atcatcttcc tcttgaaggt gaggaagtga aaactacaga
     4561 cctcccccgg acagcccact ctctatcacg agcctaaccc gcgggaggcg gaagagacat
     4621 ccattcgaga actgaagcgg cctccgggat gaggtcagag gccccacctg attttcctgg
     4681 tggtggtatc caaaatcttc agtaactagg aaggaaacca gggtctcatg gtttaaaaga
     4741 ctttgaagca ggaatgttgc atttgacgcc tttaaaacta cctttttgct gttgggagga
     4801 gtcgggggcg agccttagca gctgcaccgc catccccatg ctggttggtg ctgccctgcc
     4861 tctcgtgccg ggtgttgctt cagcccagag ccagagggct gggtcccggg tcctccacag
     4921 gtgaccccgg tggacacacg cgttcccatc ctggcctccg tctctgcttt tccacttcta
     4981 cctgcgtgtg ggtttgccgc cttgtcatcg gttgtgtgag tgtcgcagac ctttccagag
     5041 ctccggttca ctctttccaa acaggcctcc ctgtcggtgg cactgcactc ctagaacctt
     5101 cagtttctac gatggtttgt ttggtccttt tgaaccaccc caaagaactc aacatggcaa
     5161 agcaaatggt aaaagcttcc cgactgttct actttgggtc cgcgcgaagc ccactcacgt
     5221 gtgatctgtg ttgcccctct cggtggtccc aggcgatcca gccatgcccc ctgcccctct
     5281 gcccagatgc ttcaggggcc cggcttttca ggcttgccct caccagcggc cgtcagccga
     5341 cactcaggga tgtagctaac accactccgc cagtgctttc agtaggaaga gctgaggctg
     5401 cctgggaggc ccggggcgac cggaaaaggg ctctctcaag ttctgaaaag agaatctgcc
     5461 accagatcga atttcgaccc ctgagcttgt tcggacgtat ggtccaaatt cagattaagg
     5521 tggtcaccca acccgagatg tcaggaaagg ccttctgcag agaaaatgtc cccccacccg
     5581 ccatctgcag ccaggtgtgt gccacacggc agccttcccg aaacatagta tggattttaa
     5641 aaatgtgttt atttttgttt ctcaaccact ttataacgta ttttttaatt tattttgtaa
     5701 tgtcttgttt tgaagtattg ctgctatcct tgttatcctt cccactgttt ttatcactga
     5761 tttattttgt gaaagttgta cactaatgtt ctatgtcaaa atcaaaagta tttaatgaaa
     5821 tactagttct atttaatgtg gttatggaac cagctggaaa cacaaaacaa acagtgattg
     5881 tacagcaggc tgggcccagg aggtcaggtt cattttgtta catatgcaat aaactcacga
     5941 cttta
//
