LOCUS       NM_018225               7136 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SMU1 DNA replication regulator and spliceosomal factor
            (SMU1), mRNA.
ACCESSION   NM_018225 XM_001128440 XM_001129811
VERSION     NM_018225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7136)
  AUTHORS   Qian,M., Liang,X., Zeng,Q., Zhang,C., He,N. and Ma,J.
  TITLE     SMU1 Knockdown Suppresses Gastric Carcinoma Growth, Migration, and
            Invasion and Modulates the Cell Cycle
  JOURNAL   Cancer Control 31, 10732748241281716 (2024)
   PUBMED   39236066
  REMARK    GeneRIF: SMU1 Knockdown Suppresses Gastric Carcinoma Growth,
            Migration, and Invasion and Modulates the Cell Cycle.
REFERENCE   2  (bases 1 to 7136)
  AUTHORS   von Elsner,L., Chai,G., Schneeberger,P.E., Harms,F.L., Casar,C.,
            Qi,M., Alawi,M., Abdel-Salam,G.M.H., Zaki,M.S., Arndt,F., Yang,X.,
            Stanley,V., Hempel,M., Gleeson,J.G. and Kutsche,K.
  TITLE     Biallelic FRA10AC1 variants cause a neurodevelopmental disorder
            with growth retardation
  JOURNAL   Brain 145 (4), 1551-1563 (2022)
   PUBMED   34694367
REFERENCE   3  (bases 1 to 7136)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7136)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7136)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7136)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
REFERENCE   7  (bases 1 to 7136)
  AUTHORS   Ficarro,S.B., Salomon,A.R., Brill,L.M., Mason,D.E.,
            Stettler-Gill,M., Brock,A. and Peters,E.C.
  TITLE     Automated immobilized metal affinity chromatography/nano-liquid
            chromatography/electrospray ionization mass spectrometry platform
            for profiling protein phosphorylation sites
  JOURNAL   Rapid Commun Mass Spectrom 19 (1), 57-71 (2005)
   PUBMED   15570572
REFERENCE   8  (bases 1 to 7136)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 7136)
  AUTHORS   Spike,C.A., Shaw,J.E. and Herman,R.K.
  TITLE     Analysis of smu-1, a gene that regulates the alternative splicing
            of unc-52 pre-mRNA in Caenorhabditis elegans
  JOURNAL   Mol Cell Biol 21 (15), 4985-4995 (2001)
   PUBMED   11438655
REFERENCE   10 (bases 1 to 7136)
  AUTHORS   Di Benedetto,A.J., Klick Stoddard,J. and Glavan,B.J.
  TITLE     Cloning and molecular characterization of a novel gene encoding a
            WD-repeat protein expressed in restricted areas of adult rat brain
  JOURNAL   Gene 271 (1), 21-31 (2001)
   PUBMED   11410362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162590.15 and AK001667.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018225.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.252816.1,
                                           SRR1803617.118968.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397149.4/ ENSP00000380336.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL162590.15        76569-76596         c
            29-1558             AK001667.1         1-1530
            1559-7049           AL162590.15        41774-47264         c
            7050-7136           AL162590.15        41687-41773         c
FEATURES             Location/Qualifiers
     source          1..7136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.1"
     gene            1..7136
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="SMU1 DNA replication regulator and spliceosomal
                     factor"
                     /db_xref="GeneID:55234"
                     /db_xref="HGNC:HGNC:18247"
                     /db_xref="MIM:617811"
     exon            1..92
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1608
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="functional spliceosome-associated protein 57;
                     brain-enriched WD-repeat protein; DNA replication
                     regulator and spliceosomal factor; smu-1 suppressor of
                     mec-8 and unc-52 protein homolog; smu-1 suppressor of
                     mec-8 and unc-52 homolog"
                     /codon_start=1
                     /product="WD40 repeat-containing protein SMU1"
                     /protein_id="NP_060695.2"
                     /db_xref="CCDS:CCDS6534.1"
                     /db_xref="GeneID:55234"
                     /db_xref="HGNC:HGNC:18247"
                     /db_xref="MIM:617811"
                     /translation="MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSI
                     ESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDP
                     MIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSR
                     LMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVE
                     CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT
                     EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH
                     GLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGS
                     TAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCAL
                     SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLL
                     KLWKP"
     exon            93..303
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..456
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..567
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..696
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..816
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..933
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1061
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1188
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1356
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1509
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..7136
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1731..1736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="hexamer: AATAAT"
     polyA_site      1732
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="major polyA site"
     regulatory      2327..2332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="hexamer: AATAAA"
     polyA_site      2351
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="major polyA site"
     regulatory      3897..3902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="hexamer: ATTAAA"
     regulatory      3910..3915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3920
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="major polyA site"
     polyA_site      3931
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
     regulatory      4154..4159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="hexamer: AATAAT"
     polyA_site      4179
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
     regulatory      7027..7032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="hexamer: ATTATA"
     polyA_site      7049
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
     regulatory      7102..7107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
                     /note="hexamer: AGTAAA"
     polyA_site      7136
                     /gene="SMU1"
                     /gene_synonym="BWD; fSAP57; SMU-1"
ORIGIN      
        1 gtcgttggtg tgttgcgcga ctggccttga gggagagctg gggcctgctc ccggagagat
       61 acggctatgt cgatcgaaat cgaatcttcg gatgtgatcc gccttattat gcagtacttg
      121 aaggagaaca gtttacatcg ggcgttagcc accttgcagg aggagactac tgtgtctctg
      181 aatactgtgg acagcattga gagttttgtg gctgacatta acagtggcca ttgggatact
      241 gtgttgcagg ctatacagtc tctgaaattg ccagacaaaa ccctcattga cctctatgaa
      301 caggttgttc tggaattgat agagctccgt gaattgggtg ctgccaggtc acttttgaga
      361 cagactgatc ccatgatcat gttaaaacaa acacagccag agcgatatat tcatctggag
      421 aaccttttgg ccaggtctta ctttgatcct cgtgaggcat acccagatgg aagtagcaaa
      481 gaaaagagaa gagcagcaat tgcccaggcc ttagctggcg aagtcagtgt ggtgcctcca
      541 tctcgtctca tggcattgct gggacaggca ctgaagtggc agcagcatca gggattgctt
      601 cctcctggta tgaccataga tttgtttcga ggcaaggcag ctgtcaaaga tgtggaagaa
      661 gaaaagtttc ctacacaact gagcaggcat attaagtttg gtcagaaatc acatgtggag
      721 tgtgctcgat tttctccaga tggtcagtat ttggtcactg ggtctgttga tggattcatt
      781 gaagtatgga actttactac tggaaaaatc agaaaggatc ttaagtacca ggcccaagat
      841 aactttatga tgatggatga tgctgtcctc tgcatgtgtt tcagcagaga tacagaaatg
      901 ttagcaactg gggcccaaga tggaaaaatc aaggtgtgga agattcagag tggacaatgt
      961 ttaaggagat ttgagagggc acacagtaag ggtgtcacct gtctaagctt ttctaaggat
     1021 agcagtcaga tccttagtgc ttcttttgac cagacaatta gaattcatgg tttaaaatct
     1081 gggaaaaccc tgaaggaatt tcgtggccat tcctcctttg ttaacgaagc aacatttaca
     1141 caagatggac attacattat tagtgcatcc tctgatggca ctgtaaagat ctggaatatg
     1201 aagaccacag aatgttcaaa tacctttaaa tccctgggca gcaccgcagg gacagatatt
     1261 accgtcaaca gtgtgattct acttcctaaa aaccctgagc actttgtggt gtgcaacaga
     1321 tcaaacacgg tggtcatcat gaacatgcag gggcagattg tcagaagctt cagttctggt
     1381 aaaagagaag gtggggactt tgtttgctgt gccctctctc cccgtggtga atggatctac
     1441 tgtgtagggg aggactttgt gctctactgt ttcagtacag tcactggcaa actggagaga
     1501 actttgacag tgcacgagaa ggatgtgatt ggtattgcac atcaccctca tcagaacctg
     1561 attgctacct acagtgaaga tggactccta aagctctgga aaccataatt caacttttct
     1621 ttttaaatca gctcgaaagc atgtacttaa atgaagcata ttcatgtaat gtgctttttt
     1681 ttttttttgc cagcttttct aagcaaatag attgtctgaa ttagtcacag aataattttg
     1741 tgaaaattca tgtttaagta gcaactaccc tttctttttt tatatatttt taaggtatta
     1801 gtttatcttc ttctaactgg tgcagtcact taatgttttc attaatcttc gacctggaga
     1861 gtgaaatact gatatttcta gaaaaaaatt ctactcctct gattatttga aatgctgagg
     1921 aaaatgtccc tcccatagta aaacttgtaa ataaggaact atatcatatt cagtagctgt
     1981 gttctgttcc atcttttttt ttttttttga gatggagttt tgcttgttgc ccaggctgga
     2041 gtgcagcggc acgatcttgg ttcactgcaa cctccgcctc ccaggttcaa gcgattctct
     2101 tgcctcagcc tcccgagtag ctggggacta caggtgtgcg acaccatgcc tggctaattt
     2161 ttttgtattt ttagtagaga tggggtttca ccatgttggc caggctggtc tcaaactcct
     2221 gacctcaaag gatccacccg ccttggcctc ccaaagtgct gggatcacag gcgtgagcca
     2281 ccatgcccgg cccatctttt tttttttttt tttttttaaa gatgttaata aactttatac
     2341 ctttctggag actttgttct aaaatgtaca taaatgctca tctagttaac atatttactt
     2401 agaatgtggg aggaggagtc acattattat ccctgaatct caagtacagc agaagtgaat
     2461 tcctgggata gtaggataga ctaacatgta aaaaggccag gtgatgcata ggttctcatt
     2521 tcactgccct cagccttcct ctccttctga gctgtgcctt ctcacatgtt cagtcaactc
     2581 cagggaatat tgtctccatc ttctggatag aactagttgc aggatccgtt acaagaattc
     2641 agagttttgg catctcccct ttgtatgttg taggagaagg tttggcattg aaaatgtgct
     2701 gttgttccaa agaaaaatta gcaaaggact tgagatttag aaaagtctcc tttgtaatgt
     2761 gcatcattac cagttatcta aagaaaaaca tgtaaaagcc aacaaaaccc ttgaaaatat
     2821 tttgcatatg gatgtctgtt tcacgtttca actgaagatg tatagagcac ctctgatgat
     2881 gaggaagata ccatgctagg cagtactttc aagaacgtga gttcttattt ctgcaggcct
     2941 tttgtgcccc cttttaaatg ttagcattta ttaggtacaa actagtgggg aaggtttttt
     3001 taaaaagttt tgcagtcttg taatttacct ttttaaaaaa tttattttat ttttctgaga
     3061 tggagtcttg ctctgttgcc caggctggag tgcagtggtg ccatctcagc taactgcaac
     3121 ttccacttcc caggttcaag cgattctcct gccttagcct cccaagtagc tgggactaca
     3181 ggcgcatgcc agcatgcctg gctaattttt gtatttttag tagagcgggg gttttgccat
     3241 gttggccagg ctggtcttga actcctgacc tcaggtgatc cgcctgccct ggcctcccaa
     3301 agtgctggga ttacaggcat gagccactgc gcccagcctt gtaatttacc tttgatggtg
     3361 acctgaaatg cagtatgatc ctatatgtgg cacgtagtaa tgttcagtgt ttgctgaatt
     3421 aattctgggc agcactaaga aatccctctt tcccagtcat attctataac acatttccca
     3481 tttgccacaa aacctgcagc tttttggtcc aggtaatgac atttgctgcc attttgatga
     3541 tttaaaaatg gtcgtgggag ttgaacatag tcatgaattc aggattcctg agcatgtaga
     3601 cagtcatccc agtggaaaga cacgttcact taagagaagt ttaagttaga ggaaacagtt
     3661 tatgctaaaa aaatttttag aaaagtcctt gagaattttt gatttagtct tgacctcatg
     3721 aagctggtag ttatgatgtg catagtttgt atcaccgttt atgaagatgg agaatctagt
     3781 cagcacgtgt tggtttattc taggaatttt tagggaacac ttctgttgct ggcaccaggt
     3841 gatgaatatg gttaaaaaaa gactcgtttc tgcctaaaca tagggaagaa gagcaaatta
     3901 aaaggagtaa ttaaaactga taaaagctca agttaccttt gtgatgatga ggcgggcagt
     3961 taacgcgaaa gggttgggaa aggcttcctg gagggactag ggggcggtct aagcacaggg
     4021 aacctaaccg gggactccag tgtggcacag cggcaaggta tgtgctgggc aaaatgatag
     4081 gtgtcttggg agaccaggca aagagagctg gattaggagc cgttaagtat atatttttct
     4141 tctttttaaa taaaataatg cactgggtga acatgtaaac gctaagttga aaatctgcct
     4201 ttcccaggta acccttgtta atctttctac aacttcattt cgtacaaacc tgaaaaacac
     4261 actgattttg tctttaaatg ggcacacgct gcttacactc ctcggcgcct agcctttctg
     4321 aagccccacg cggccgtccc tccagcattg aaggctgggg cagcccagct cccctccagc
     4381 gcccttacag ccagaccgcg gcggggtcgg gccgcgcacg cgcagggcgg acggccggat
     4441 ctggggcgcc gctgctccgg gtggtcggag gtaggagtcc catcttgggt ccagggccgg
     4501 tagagcccct taccgggggt agggagactg cgcacccgct agagccaact gtcagggcct
     4561 gcagacgtcg ggtgacgtca ctgttacaaa attggcggtc acatcgtctt aagggccggt
     4621 ggcagcggct gcgcgaacgg gagttggctg ccgggaatca gtgctcactt ccttctgaat
     4681 tgggcgtgtg cagtcggttc ctagggaagt gctctgctgc agccaccaga tttaacggat
     4741 gctgctctct agcacttaac atagaagcta aactacctgg cgttaaaatt aattccatga
     4801 gcataaggac atttgtccta tcccctattc tgctgttgaa ttaatgactg gaaaacattg
     4861 cgcggaggta tttgggagta gtatggcttt tttttttttt ttttttttaa cagcaaatgg
     4921 tataaatctc aggtacaatt cagtatcttc ttcaccagtt gttttttttc agcatgtatt
     4981 attactacca ctaacggcct ctgttgagcc cttccttgct atgtaagcag ccatatttaa
     5041 ttctcagaac aatgtaatga gggtgcgcaa atgcacatga agaaacaggt ttccagacgt
     5101 gaggcaccta actcagtcca acttgcacga agctcgcatt gaaaaccaga tgtgactccg
     5161 aagctaggtt ttttttctct cttgcctcac tctcaatatt gctgtcagtt cctcctcaat
     5221 ctttaggttt gggcagggac aaagaataca tggattgttc ctccacatgc tgcaaacaca
     5281 ttcacctaag cagagcacag gtagtgagat gagtagagag aactgaatta gaggattctg
     5341 gatgtcagtc tttgctgtca cttcttttgg cttgtgctag aacagtggtt cttacaagtg
     5401 tcacgtgata gacacattct aaggtcctat cccagaccta cagaatcaga aattggtggt
     5461 ggggcccagc aagcgtgctc aaatttgaga gcaggtagac tacagggtag tttccgcata
     5521 tacaaaaggt gttttaattc ttgctgtcag tctcagaagt ttcatgctga gataaccaaa
     5581 tttaaatgat aaaggtgcaa gactgactct taaaatcaca ttttttcaaa ttgccatagc
     5641 ttgctagtgt tctcattcac tgtgctttta cagcttcatt ttccactatt ttaagagaag
     5701 aaattgctat gaagtgtatg tccaagtgag gaagttccct ggtctgaggt tgtttaaaac
     5761 ttacaatagg ccgggcacgg tggctcaagc ctgtaatccc agcactttgg gaggccgagg
     5821 tgggtggatc acgaggtcag gagttcaaga ccaccctggc caacatggtg acaccctgtc
     5881 tctactaagg atacaaaatt agccgggcat ggtggcacac gcctgtagtc ccagctacct
     5941 aggaggctga ggcaggagaa tagctggaac ccgggaggca gaggttgcag tgagctgaga
     6001 ctgtgccact gcactccagc ctgggtgaca gagcaagact tggtctcaaa aacaaaaaac
     6061 aaaaaaacca aacttggaat agcaagggct gcccattatt taaccttcca cggcaatttt
     6121 aacagtggta ttctgttcca agtggttaat attaaatcca tgtgtcagtg ttggtggctt
     6181 tcaaccttgg ctgcgcataa tcattttgat gcttaggcta cacccagccg agttatacag
     6241 aatccctgga gggtgggacc tgatgagtgt tttaatgttt cccgggtaat tccaatggta
     6301 gccaaggtta agaaccagta ccgtacgtac aaaaaagttg agaagctaat ttcacgtaca
     6361 gaaaatttgc cactgttcca agagcactct caagcgacat aattggcctc tactcctatt
     6421 ccctacaagt atgaatgggc aggagaagca tcacagagaa agcagagtta gtgctggaac
     6481 ttgtattttt gtggatgatg accttggtta atgttttttc ataggctctg tttcataggc
     6541 tttgtttttt cataggctct ccctcattac attgttctga gaattaaata tggctgctta
     6601 catagtaatg aagggttcaa cagaggctgt tagtggtagt aataatacaa gctgaaaaac
     6661 tacacagaca aacctatcag tttctgcctc ttcaggatat aactattagg ttagtgcaaa
     6721 agtaattgcg gtttttgcca ttaaaagtaa tggcacatta cttttgcacc aaccgaccta
     6781 atatgacttt cttttagtgt tcttaggatt tttaattgta aaacatgtaa caaattttcc
     6841 taaacaattg tgcaattcag tggcattatt tacgatgtta cgcaaccact attgtatttc
     6901 caaaatgtca tcaccctaaa cagaagccct gtaacattgt caattaactt ctccttccct
     6961 tcccctcagc ctttggtact gtttctgcct caatgcattt gtctaagttt agttcatata
     7021 agtgaaatta tacaatactt gtcctttttt atctggctta tttcatttag catgttttaa
     7081 aggttcatcc atgtatcaaa cagtaaagtg cttcatattt gggggaagta taaaaa
//
