LOCUS       NM_001114974            2295 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens smoothelin like 2 (SMTNL2), transcript variant 1,
            mRNA.
ACCESSION   NM_001114974
VERSION     NM_001114974.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Hachimi,M., Grabowski,C., Campanario,S., Herranz,G., Baonza,G.,
            Serrador,J.M., Gomez-Lopez,S., Barea,M.D., Bosch-Fortea,M.,
            Gilmour,D., Bagnat,M., Rodriguez-Fraticelli,A.E. and
            Martin-Belmonte,F.
  TITLE     Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin
            Cortex during Epithelial Morphogenesis
  JOURNAL   Curr Biol 31 (4), 696-706 (2021)
   PUBMED   33275893
  REMARK    GeneRIF: Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the
            Apical Actin Cortex during Epithelial Morphogenesis.
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Saxena,R., Plenge,R.M., Bjonnes,A.C., Dashti,H.S., Okada,Y., Gad El
            Haq,W., Hammoudeh,M., Al Emadi,S., Masri,B.K., Halabi,H.,
            Badsha,H., Uthman,I.W., Margolin,L., Gupta,N., Mahfoud,Z.R.,
            Kapiri,M., Dargham,S.R., Aranki,G., Kazkaz,L.A. and Arayssi,T.
  TITLE     A Multinational Arab Genome-Wide Association Study Identifies New
            Genetic Associations for Rheumatoid Arthritis
  JOURNAL   Arthritis Rheumatol 69 (5), 976-985 (2017)
   PUBMED   28118524
  REMARK    GeneRIF: Variants of SMTNL2 were associated with rheumatoid
            arthritis in an Arab population.
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Gordon,E.A., Whisenant,T.C., Zeller,M., Kaake,R.M., Gordon,W.M.,
            Krotee,P., Patel,V., Huang,L., Baldi,P. and Bardwell,L.
  TITLE     Combining docking site and phosphosite predictions to find new
            substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun
            N-terminal kinase (JNK) substrate
  JOURNAL   Cell Signal 25 (12), 2518-2529 (2013)
   PUBMED   23981301
  REMARK    GeneRIF: Study describes a novel JNK substrate that emerged from
            analysis of the human genome, the functionally uncharacterized
            protein smoothelin-like 2 (SMTNL2). SMTNL2 protein bound with
            high-affinity to multiple MAPKs including JNK1-3 and ERK2; SMTNL2
            protein was expressed in many mammalian tissues, with a notably
            high expression in skeletal muscle.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118754.6, BC110859.1, DA822419.1, BC105050.1 and DB557882.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001114974.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110859.1, DRR138525.488730.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389313.9/ ENSP00000373964.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC118754.6         76604-76613         c
            11-502              BC110859.1         1-492
            503-850             DA822419.1         145-492
            851-1507            BC105050.1         394-1050
            1508-2290           BC110859.1         1498-2280
            2291-2295           DB557882.1         436-440
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2295
                     /gene="SMTNL2"
                     /note="smoothelin like 2"
                     /db_xref="GeneID:342527"
                     /db_xref="HGNC:HGNC:24764"
     exon            1..476
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1463
                     /gene="SMTNL2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     smoothelin-like protein 2"
                     /codon_start=1
                     /product="smoothelin-like protein 2 isoform 1"
                     /protein_id="NP_001108446.1"
                     /db_xref="CCDS:CCDS45583.1"
                     /db_xref="GeneID:342527"
                     /db_xref="HGNC:HGNC:24764"
                     /translation="MEPAPDAQEARTVREALGRYEAALEGAVRALHEDMRGLQRGVER
                     RVAEAMRLAGPLARTVADLQRDNQRLQAQLERLTRQVEALGLASGMSPVPGTPGTPSP
                     PPAPGVPDRAPRLGSARFASHATFSLSGRGQSLDHDEASESEMRKTSNSCIMENGHQP
                     GAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQPVTAITRVSDRFSGETSAAALSP
                     MSAATLGGLNPSPSEVITPWTPSPSEKNSSFTWSVPSSGYGAVTASKHSNSPPLVTPP
                     QSPVSPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGE
                     ARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHS
                     FFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYV
                     QSLYNHLRRFE"
     exon            477..564
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..807
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..883
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1066
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1184
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1336
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..2295
                     /gene="SMTNL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMTNL2"
                     /note="hexamer: CATAAA"
     polyA_site      2295
                     /gene="SMTNL2"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcggcc cggagctgcg gagctcggat cttctccccc gtctggcccg ctctcgaccc
       61 gcgcgctctg ctgggccatg gagccggccc ccgacgccca ggaggcgcgc actgtgcgcg
      121 aggcgctggg ccgctacgag gcggcgctgg agggtgcggt gcgcgcgctg cacgaggaca
      181 tgcgggggct gcagcgcggc gtggagcggc gagtggcaga ggcgatgcgc ctggccggcc
      241 ccctggcgcg cacggtggcc gacctgcagc gggacaacca gcggctgcag gcgcagctcg
      301 agcgcctgac gcgccaggtg gaggcgctgg gcttggccag cgggatgtcc ccggtgcccg
      361 gcactcccgg cacgcccagc cccccgcccg cgcccggggt tcccgaccgc gcgccccgcc
      421 tgggcagcgc acgcttcgcc agccacgcca ccttctcgct gtccggccgc ggccagagtt
      481 tggatcacga tgaggccagt gagtcggaga tgagaaagac ctcaaactcc tgcatcatgg
      541 aaaatgggca ccagccgggg gcaggtccag gcgatggacc ccctgagatt gcccaaaact
      601 tctcagcacc agatcccccc aggcctcgtc ctgtgagcct ctccttgcgg ctgccccacc
      661 agccagtcac ggccatcacc cgagtctctg acaggttctc tggggagacc tcagctgcgg
      721 ctctatcacc catgtctgct gccaccctgg ggggcctcaa cccaagcccc agcgaggtca
      781 tcacgccctg gactcccagt cctagcgaga agaattcctc tttcacgtgg tctgtgccaa
      841 gctctggcta tggggcagtg acagcaagca aacacagcaa tagcccaccg ctggtgacac
      901 caccccagtc gcccgtgtcc ccgcagccgc cagccataac tcaggtccat cggcaggggg
      961 agcgtcgcag ggagctggtg aggtcgcaga cgctgccccg cacctcggag gcgcaggccc
     1021 ggaaagcatt gtttgagaag tgggagcagg aaacggcggc cggcaagggg aaaggcgagg
     1081 cccgggccag gctgaagcgg tcgcagagct tcggcgtggc cagcgccagc agcatcaagc
     1141 agatcctgct cgagtggtgc cgcagcaaga cgctgggcta ccagcacgtg gacctgcaga
     1201 acttctcctc cagctggagc gacggcatgg ccttctgcgc cctggtacac tccttcttcc
     1261 ccgatgcctt tgactacaac tccctgagcc ccacgcagag gcagaagaac ttcgagctgg
     1321 ctttcaccat ggccgagaat ctggccaact gtgagcgcct catcgaagtg gaggacatga
     1381 tggtgatggg ccgcaagccg gaccccatgt gtgtcttcac ctacgtccag tcgctgtaca
     1441 accacctgcg tcgcttcgag taaagcccct gagcctggat tgccaaagag cagccccagg
     1501 aagaggccgg gggtccgctt gcgattcccc agccaggatg cccccaggag ccttgccgtt
     1561 tggtgtgagc gcgctgtttg ttctgtggca tgtgacggca ctccccttcg agcccagctg
     1621 tgttactgat taaaagtact gctgagctgt ggtccgacag cactgatcac agccaagggc
     1681 ttggaggaaa aggaaaaatt atgagagaga gagagacatt ggtgctaagt aatgatcttc
     1741 ctaaagaaat gcttgtgttt atagcttcca gaatgctaat ctacaatttt ccctctggtg
     1801 aattcgatac atcggcttta cagggttaca gtgattacca agtgtttttt tttatcaaaa
     1861 tacccagagt tttttacttc ctcacgcgat tgtaggttcc tctcctccct ccctctgggc
     1921 cactgccagg aaacagagag accgcttaat cagcagcttg acaaagaaga cctcaagtct
     1981 tgggaagaaa cagtttaatc actcccaagt cctgggcaac agatgacctt caagtcacct
     2041 ccgctctccg gggagatggg aaggctctcc tctcggtccc aaagtcctcc tgttcttccc
     2101 aggaggcccc acaagtgttt ggctaagcac aggctctcgg gaatttaaca cttttgggga
     2161 aggaataggc cctttgtgct gagagagagt ttttattcac atctttttta ggggatttgc
     2221 tgcagatatt tataaaaagt aactccctct gtaccactga cccatttata cataaaaaag
     2281 atgtgttgaa ttttg
//
