LOCUS       NM_001105565            1695 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens smoothelin like 1 (SMTNL1), mRNA.
ACCESSION   NM_001105565 XM_005273819 XM_937286
VERSION     NM_001105565.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Major,E., Gyory,F., Horvath,D., Keller,I., Tamas,I., Uray,K.,
            Fulop,P. and Lontay,B.
  TITLE     Smoothelin-Like Protein 1 Regulates Development and Metabolic
            Transformation of Skeletal Muscle in Hyperthyroidism
  JOURNAL   Front Endocrinol (Lausanne) 12, 751488 (2021)
   PUBMED   34675885
  REMARK    GeneRIF: Smoothelin-Like Protein 1 Regulates Development and
            Metabolic Transformation of Skeletal Muscle in Hyperthyroidism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Lontay,B., Bodoor,K., Sipos,A., Weitzel,D.H., Loiselle,D., Safi,R.,
            Zheng,D., Devente,J., Hickner,R.C., McDonnell,D.P., Ribar,T. and
            Haystead,T.A.
  TITLE     Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote
            the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human
            and Mice
  JOURNAL   J Biol Chem 290 (29), 17985-17998 (2015)
   PUBMED   26048986
  REMARK    GeneRIF: Pregnancy promotes switching of skeletal muscle to a
            glycolytic phenotype through the smoothelin-like protein 1
            transcriptional cofactor.
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Ulke-Lemee,A., Turner,S.R., Mughal,S.H., Borman,M.A., Winkfein,R.J.
            and MacDonald,J.A.
  TITLE     Mapping and functional characterization of the murine
            smoothelin-like 1 promoter
  JOURNAL   BMC Mol Biol 12, 10 (2011)
   PUBMED   21352594
  REMARK    GeneRIF: The Smtnl1 proximal promoter enhances expression up to
            8-fold in smooth muscle cells and a second activating region lays
            500 bp further upstream.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Lontay,B., Bodoor,K., Weitzel,D.H., Loiselle,D., Fortner,C.,
            Lengyel,S., Zheng,D., Devente,J., Hickner,R. and Haystead,T.A.
  TITLE     Smoothelin-like 1 protein regulates myosin phosphatase-targeting
            subunit 1 expression during sexual development and pregnancy
  JOURNAL   J Biol Chem 285 (38), 29357-29366 (2010)
   PUBMED   20634291
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Ulke-Lemee,A., Ishida,H., Borman,M.A., Valderrama,A., Vogel,H.J.
            and MacDonald,J.A.
  TITLE     Tropomyosin-binding properties of the CHASM protein are dependent
            upon its calponin homology domain
  JOURNAL   FEBS Lett 584 (15), 3311-3316 (2010)
   PUBMED   20627103
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Borman,M.A., Freed,T.A., Haystead,T.A. and Macdonald,J.A.
  TITLE     The role of the calponin homology domain of smoothelin-like 1
            (SMTNL1) in myosin phosphatase inhibition and smooth muscle
            contraction
  JOURNAL   Mol Cell Biochem 327 (1-2), 93-100 (2009)
   PUBMED   19219534
REFERENCE   7  (bases 1 to 1695)
  AUTHORS   Wooldridge,A.A., Fortner,C.N., Lontay,B., Akimoto,T., Neppl,R.L.,
            Facemire,C., Datto,M.B., Kwon,A., McCook,E., Li,P., Wang,S.,
            Thresher,R.J., Miller,S.E., Perriard,J.C., Gavin,T.P.,
            Hickner,R.C., Coffman,T.M., Somlyo,A.V., Yan,Z. and Haystead,T.A.
  TITLE     Deletion of the protein kinase A/protein kinase G target SMTNL1
            promotes an exercise-adapted phenotype in vascular smooth muscle
  JOURNAL   J Biol Chem 283 (17), 11850-11859 (2008)
   PUBMED   18310078
REFERENCE   8  (bases 1 to 1695)
  AUTHORS   Borman,M.A., MacDonald,J.A. and Haystead,T.A.
  TITLE     Modulation of smooth muscle contractility by CHASM, a novel member
            of the smoothelin family of proteins
  JOURNAL   FEBS Lett 573 (1-3), 207-213 (2004)
   PUBMED   15327999
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002893.3.
            
            On or before Jun 27, 2020 this sequence version replaced
            XM_005273819.4, NM_001105565.2.
            
            Summary: The protein encoded by this gene is involved in the
            contraction of both striated and smooth muscle. During pregnancy,
            the encoded protein interacts with progesterone receptor to
            attenuate the expression of contractile and metabolic proteins.
            [provided by RefSeq, Jul 2016].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138525.168604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527972.6/ ENSP00000432651.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AP002893.3         108092-108139
            49-782              AP002893.3         113138-113871
            783-915             AP002893.3         114121-114253
            916-967             AP002893.3         114366-114417
            968-1123            AP002893.3         116378-116533
            1124-1238           AP002893.3         116730-116844
            1239-1390           AP002893.3         116998-117149
            1391-1695           AP002893.3         120465-120769
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1695
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /note="smoothelin like 1"
                     /db_xref="GeneID:219537"
                     /db_xref="HGNC:HGNC:32394"
                     /db_xref="MIM:613664"
     exon            1..48
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            49..782
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1535
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /note="calponin homology-associated smooth muscle protein"
                     /codon_start=1
                     /product="smoothelin-like protein 1"
                     /protein_id="NP_001099035.2"
                     /db_xref="CCDS:CCDS44599.2"
                     /db_xref="GeneID:219537"
                     /db_xref="HGNC:HGNC:32394"
                     /db_xref="MIM:613664"
                     /translation="MEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINE
                     GPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE
                     ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKP
                     EPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEP
                     DGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWP
                     ESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPERR
                     VSAPARPRGPRAQNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMT
                     KKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLA
                     DCAQLLDVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK"
     exon            783..915
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            916..967
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1123
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1238
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1390
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1695
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /note="hexamer: ATTAAA"
     polyA_site      1695
                     /gene="SMTNL1"
                     /gene_synonym="CHASM"
                     /note="major polyA site"
ORIGIN      
        1 agctggagca aagagacagc tcccaagcca caggcagaag ccccacagag atggagcaga
       61 aggaagggaa gctctctgag gatgggacca ccgtctcccc agctgcggac aaccctgaga
      121 tgtcaggagg tggagcccct gcagaggaga ccaaaggcac agctggaaag gccatcaatg
      181 aggggcctcc cactgagtca ggaaagcagg aaaaggcacc agccgaggac ggcatgtcag
      241 cagaactcca gggggaagca aatggattag atgaggtcaa agtggaatct cagagggagg
      301 ctggtgggaa agaggatgct gaggctgaac ttaaaaagga ggatggtgag aaggaagaga
      361 ccactgtggg ttctcaggag atgactggca ggaaagaaga gaccaaatct gaacccaaag
      421 aggctgagga aaaggagagc acgctggcct ctgagaagca gaaggctgag gagaaagagg
      481 ccaaacctga atctgggcag aaagccgatg ccaatgacag agacaagcct gaacctaagg
      541 caacagttga ggaggaggac gccaagacag cctctcagga ggagacaggc cagaggaaag
      601 agtgcagcac tgaacccaag gagaaggcta ctgatgaaga ggccaaggct gaatcgcaga
      661 aggctgttgt ggaggatgag gctaaggctg aacccaagga gcccgatggg aaagaggagg
      721 ccaaacatgg tgcaaaagag gaggctgatg caaaagagga ggcggaggat gcagaggagg
      781 cagagccagg cagtcccagc gaagagcagg agcaggacgt ggaaaaagag ccagagggag
      841 gggcaggggt gattcccagc tccccagagg agtggcctga gagccccact ggggaggggc
      901 acaacctcag cacagatggg ctgggtccag actgtgtagc ttccggacag accagtcctt
      961 cagccagtga gtcttcaccc agcgacgtgc cccagagtcc ccctgagtcc ccttcctcag
     1021 gggagaagaa ggagaaggca ccagagcgca gggtatcagc ccctgctcgg ccccgggggc
     1081 cccgggcaca gaaccgcaaa gccatcgtgg acaagtttgg cggggcagct tccggcccca
     1141 cggccttgtt ccgcaacact aaggcagccg gggcagccat tggtggtgtc aagaacatgc
     1201 tcttggagtg gtgccgagcc atgacaaaaa aatacgagca tgtggacatc cagaacttct
     1261 cctccagctg gagcagtggt atggccttct gtgccctcat ccacaagttc ttccctgacg
     1321 cctttgacta cgcagagctg gatcccgcaa agcgccggca caacttcacc ctggccttct
     1381 ccacagcaga gaaactggct gactgtgctc agctgctgga cgtggatgac atggtgcggt
     1441 tggctgtgcc cgactccaag tgcgtctaca catacatcca ggaactgtac cgcagccttg
     1501 tgcagaaagg actggtgaag accaagaaga agtgaggagg tgactggctc tgtgggcaga
     1561 gatgggcagg gtgcccagct cagcagccac ggcccggggg ttcccttctg ctccatggag
     1621 gcaccagagc caggggctta ggcaagggtg tgtggcgttg gttttaactg cattaaaagt
     1681 acttttgtaa aatcc
//
