LOCUS       NM_006685                732 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens submaxillary gland androgen regulated protein 3B
            (SMR3B), mRNA.
ACCESSION   NM_006685
VERSION     NM_006685.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 732)
  AUTHORS   Giri,K., Maity,S. and Ambatipudi,K.
  TITLE     Targeted proteomics using parallel reaction monitoring confirms
            salivary proteins indicative of metastatic triple-negative breast
            cancer
  JOURNAL   J Proteomics 267, 104701 (2022)
   PUBMED   35995384
  REMARK    GeneRIF: Targeted proteomics using parallel reaction monitoring
            confirms salivary proteins indicative of metastatic triple-negative
            breast cancer.
REFERENCE   2  (bases 1 to 732)
  AUTHORS   Kazemi,E., Zargooshi,J., Dehpahni,M.F., Mohammadi Motlagh,H.R.,
            Kaboudi,M., Kahrizi,D., Khazaie,H., Mahaki,B., Mohammadian,Y. and
            Yazdani,L.
  TITLE     Androgen regulated protein and pyruvate dehydrogenase kinase 4 in
            severe erectile dysfunction: A gene expression analysis, and
            computational study of protein structure
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (2), 89-94 (2021)
   PUBMED   34817334
  REMARK    GeneRIF: Androgen regulated protein and pyruvate dehydrogenase
            kinase 4 in severe erectile dysfunction: A gene expression
            analysis, and computational study of protein structure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 732)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 732)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 732)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 732)
  AUTHORS   Isemura,S.
  TITLE     Nucleotide sequence of gene PBII encoding salivary proline-rich
            protein P-B
  JOURNAL   J Biochem 127 (3), 393-398 (2000)
   PUBMED   10731710
REFERENCE   7  (bases 1 to 732)
  AUTHORS   Isemura,S. and Saitoh,E.
  TITLE     Molecular cloning and sequence analysis of cDNA coding for the
            precursor of the human salivary proline-rich peptide P-B
  JOURNAL   J Biochem 115 (6), 1101-1106 (1994)
   PUBMED   7982889
REFERENCE   8  (bases 1 to 732)
  AUTHORS   Ramasubbu,N., Reddy,M.S., Bergey,E.J., Haraszthy,G.G., Soni,S.D.
            and Levine,M.J.
  TITLE     Large-scale purification and characterization of the major
            phosphoproteins and mucins of human submandibular-sublingual saliva
  JOURNAL   Biochem J 280 (Pt 2) (Pt 2), 341-352 (1991)
   PUBMED   1747107
REFERENCE   9  (bases 1 to 732)
  AUTHORS   Isemura,S., Saitoh,E. and Sanada,K.
  TITLE     Isolation and amino acid sequences of proline-rich peptides of
            human whole saliva
  JOURNAL   J Biochem 86 (1), 79-86 (1979)
   PUBMED   479131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC094707.1, BX487896.1 and BC015327.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006685.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB956862.1, CB956975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304915.8/ ENSP00000302400.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BC094707.1         1-66
            67-594              BX487896.1         70-597
            595-732             BC015327.1         583-720
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..732
                     /gene="SMR3B"
                     /gene_synonym="P-B; PBII; PRL3; PROL3; SMR1B"
                     /note="submaxillary gland androgen regulated protein 3B"
                     /db_xref="GeneID:10879"
                     /db_xref="HGNC:HGNC:17326"
                     /db_xref="MIM:611593"
     exon            1..82
                     /gene="SMR3B"
                     /gene_synonym="P-B; PBII; PRL3; PROL3; SMR1B"
                     /inference="alignment:Splign:2.1.0"
     exon            83..150
                     /gene="SMR3B"
                     /gene_synonym="P-B; PBII; PRL3; PROL3; SMR1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..336
                     /gene="SMR3B"
                     /gene_synonym="P-B; PBII; PRL3; PROL3; SMR1B"
                     /note="salivary proline-rich protein; proline rich 3;
                     proline-rich protein 3; proline-rich peptide P-B;
                     submaxillary gland androgen regulated protein 3 homolog B"
                     /codon_start=1
                     /product="submaxillary gland androgen-regulated protein 3B
                     precursor"
                     /protein_id="NP_006676.1"
                     /db_xref="CCDS:CCDS3540.1"
                     /db_xref="GeneID:10879"
                     /db_xref="HGNC:HGNC:17326"
                     /db_xref="MIM:611593"
                     /translation="MKSLTWILGLWALAACFTPGESQRGPRGPYPPGPLAPPQPFGPG
                     FVPPPPPPPYGPGRIPPPPPAPYGPGIFPPPPPQP"
     exon            151..732
                     /gene="SMR3B"
                     /gene_synonym="P-B; PBII; PRL3; PROL3; SMR1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      713..718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMR3B"
                     /gene_synonym="P-B; PBII; PRL3; PROL3; SMR1B"
                     /note="hexamer: AATAAA"
     polyA_site      732
                     /gene="SMR3B"
                     /gene_synonym="P-B; PBII; PRL3; PROL3; SMR1B"
                     /note="major polyA site"
ORIGIN      
        1 acctttattt gccgtctttc aactggcaag agtcattttg accagcagat taatcaactg
       61 taagacagat cctcacacaa agaggcaact gaaaggatga aatcactgac ttggatcttg
      121 ggcctttggg ctcttgcagc gtgtttcaca cctggtgaga gtcaaagagg ccccagggga
      181 ccatatccac ctggaccgct ggctcctcct caaccttttg gcccaggatt tgttccacca
      241 cctcctcctc caccctatgg tccagggaga atcccacctc ctcctcccgc accctatggt
      301 ccagggatat ttccaccacc ccctcctcaa ccctaaggtc caccactcca tcctgatgcc
      361 ccaggttatc cacagcctcc ttcccgacca agaccctatc cacctggacc tccatttttc
      421 cctgtaaatt ctccaactga tcctaccctc cctactcctg caccccaaat atgaacaact
      481 gcagcaggtg ccaccaccac cacaaaagac accactaccc ttgtaactac tgcttctact
      541 acccaaaata tgaattccaa cactgcttcc aagagacatt tacataaaat tgcttccatt
      601 tttggatgag aatgaaaaat tccaaaagtg ctgagctttg gggagaaata atcttagaaa
      661 gaaattgtag aaaaaaccca tgcagacata acatttatac caatgaggca aaaataaaga
      721 attgagcacc aa
//
