LOCUS       NM_012390                666 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens submaxillary gland androgen regulated protein 3A
            (SMR3A), mRNA.
ACCESSION   NM_012390 XM_496699
VERSION     NM_012390.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 666)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 666)
  AUTHORS   Grunow,J., Rong,C., Hischmann,J., Zaoui,K., Flechtenmacher,C.,
            Weber,K.J., Plinkert,P. and Hess,J.
  TITLE     Regulation of submaxillary gland androgen-regulated protein 3A via
            estrogen receptor 2 in radioresistant head and neck squamous cell
            carcinoma cells
  JOURNAL   J Exp Clin Cancer Res 36 (1), 25 (2017)
   PUBMED   28166815
  REMARK    GeneRIF: Results show prominent SMR3A expression in head and neck
            squamous cell carcinoma, which was accompanied by an up-regulation
            of ESR2. These data suggest a critical role of ESR2 in
            radio-resistance and that SMR3A might serve as a surrogate marker
            for active ESR2 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 666)
  AUTHORS   Thierauf,J., Veit,J.A., Grunow,J., Doscher,J., Weissinger,S.,
            Whiteside,T., Beutner,D., Quaas,A., Plinkert,P., Hoffmann,T.K. and
            Hess,J.
  TITLE     Expression of Submaxillary Gland Androgen-regulated Protein 3A
            (SMR3A) in Adenoid Cystic Carcinoma of the Head and Neck
  JOURNAL   Anticancer Res 36 (2), 611-615 (2016)
   PUBMED   26851015
  REMARK    GeneRIF: High SMR3A expression is associated with aberrant
            differentiation into mucosal- or glandular-like cells in Adenoid
            Cystic Carcinoma of the Head and Neck.
            Erratum:[Anticancer Res. 2016 Mar;36(3):1445.. Quaas, Alexander
            [added]. PMID: 26977049]
REFERENCE   4  (bases 1 to 666)
  AUTHORS   Tong,Y., Tar,M., Melman,A. and Davies,K.
  TITLE     The opiorphin gene (ProL1) and its homologues function in erectile
            physiology
  JOURNAL   BJU Int 102 (6), 736-740 (2008)
   PUBMED   18410445
  REMARK    GeneRIF: All members of the human opiorphin family of genes can
            potentially modulate erectile physiology. Both hSMR3 and ProL1 are
            down-regulated in the corpora of men with ED, and therefore both
            genes can potentially act as markers of ED.
REFERENCE   5  (bases 1 to 666)
  AUTHORS   Tong,Y., Tar,M., Monrose,V., DiSanto,M., Melman,A. and Davies,K.P.
  TITLE     hSMR3A as a marker for patients with erectile dysfunction
  JOURNAL   J Urol 178 (1), 338-343 (2007)
   PUBMED   17512016
  REMARK    GeneRIF: Results suggest that hSMR3A can act as a marker for
            erectile dysfunction associated with both diabetic and non-diabetic
            etiologies.
REFERENCE   6  (bases 1 to 666)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   7  (bases 1 to 666)
  AUTHORS   Isemura,S. and Saitoh,E.
  TITLE     Nucleotide sequence of gene PBI encoding a protein homologous to
            salivary proline-rich protein P-B
  JOURNAL   J Biochem 121 (6), 1025-1030 (1997)
   PUBMED   9354371
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106884.5, CD722957.1 and CA946421.1.
            
            On May 17, 2019 this sequence version replaced NM_012390.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK429967.1, CK429935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226460.5/ ENSP00000226460.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC106884.5         101264-101279
            17-178              CD722957.1         1-162
            179-220             CA946421.1         62-103
            221-614             AC106884.5         107217-107610
            615-666             AC106884.5         107611-107662
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..666
                     /gene="SMR3A"
                     /gene_synonym="P-B1; PBI; PRL5; PROL5"
                     /note="submaxillary gland androgen regulated protein 3A"
                     /db_xref="GeneID:26952"
                     /db_xref="HGNC:HGNC:19216"
                     /db_xref="MIM:618340"
     exon            1..83
                     /gene="SMR3A"
                     /gene_synonym="P-B1; PBI; PRL5; PROL5"
                     /inference="alignment:Splign:2.1.0"
     exon            84..151
                     /gene="SMR3A"
                     /gene_synonym="P-B1; PBI; PRL5; PROL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..502
                     /gene="SMR3A"
                     /gene_synonym="P-B1; PBI; PRL5; PROL5"
                     /note="proline rich 5 (salivary); protein homologous to
                     salivary proline-rich protein P-B; proline- rich protein
                     5; proline-rich protein PBI; submaxillary gland androgen
                     regulated protein 3 homolog A"
                     /codon_start=1
                     /product="submaxillary gland androgen-regulated protein 3A
                     precursor"
                     /protein_id="NP_036522.3"
                     /db_xref="CCDS:CCDS34000.1"
                     /db_xref="GeneID:26952"
                     /db_xref="HGNC:HGNC:19216"
                     /db_xref="MIM:618340"
                     /translation="MKSLTWILGLWALAACFTPGESQRGPRGPYPPGPLAPPPPPCFP
                     FGTGFVPPPHPPPYGPGRFPPPLSPPYGPGRIPPSPPPPYGPGRIQSHSLPPPYGPGY
                     PQPPSQPRPYPPGPPFFPVNSPTDPALPTPAP"
     exon            152..666
                     /gene="SMR3A"
                     /gene_synonym="P-B1; PBI; PRL5; PROL5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacctttatt ttctgtcttt caactggcaa gagtcatttt gaccagcagg ttaatcaact
       61 ctaagacaga tcctcacgca aagaggcaac tgaaaggatg aaatcactga cttggatctt
      121 gggcctttgg gctcttgcag cgtgtttcac acctggtgag agtcaaagag gccccagggg
      181 accatatcca cctggaccac tggctcctcc tcctccacca tgttttcctt ttggaacagg
      241 atttgttcca ccaccccatc ctccacccta tggtccaggg agatttccac cacccctttc
      301 tccaccctat ggtccaggga gaatcccacc atcccctcct ccaccctatg gtccagggag
      361 aattcaatca cactctcttc ctcctcctta tggcccaggt tatccacagc caccttccca
      421 accaagaccc tatccacctg gacctccatt tttccctgta aattctccaa ctgatcctgc
      481 cctccctact cctgcaccct aaatacagac aactgcaaca ggtgccacca cccacaaaag
      541 acaacactac cctcgtaact actgcttcta ctacccaaaa ataagaattt caacactact
      601 tccaagagac ttttagataa aatcacttcc atttttggat gagaataaag atttccaaag
      661 cactga
//
