LOCUS       NM_014474               1866 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sphingomyelin phosphodiesterase acid like 3B
            (SMPDL3B), transcript variant 1, mRNA.
ACCESSION   NM_014474
VERSION     NM_014474.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Su,L., Hao,J., Zhang,N., Wu,S., Wu,X. and Wei,W.
  TITLE     SMPDL3B contributes to gastric adenocarcinoma cells progression by
            promoting the infiltration of M2 macrophages
  JOURNAL   Turk J Med Sci 53 (6), 1635-1647 (2023)
   PUBMED   38813495
  REMARK    GeneRIF: SMPDL3B contributes to gastric adenocarcinoma cells
            progression by promoting the infiltration of M2 macrophages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Francis,M., Ahmad,A., Bodgi,L., Azzam,P., Youssef,T., Abou
            Daher,A., Eid,A.A., Fornoni,A., Pollack,A., Marples,B. and
            Zeidan,Y.H.
  TITLE     SMPDL3b modulates radiation-induced DNA damage response in renal
            podocytes
  JOURNAL   FASEB J 36 (10), e22545 (2022)
   PUBMED   36094323
  REMARK    GeneRIF: SMPDL3b modulates radiation-induced DNA damage response in
            renal podocytes.
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Watanabe,S., Hidenori,U., Hashimoto,S., Riko,S., Aizawa,T.,
            Tsugawa,K., Imaizumi,T. and Tanaka,H.
  TITLE     Sphingomyelin Phosphodiesterase Acid-Like 3b is Essential for
            Toll-Like Receptor 3 Signaling in Human Podocytes
  JOURNAL   J Membr Biol 255 (1), 117-122 (2022)
   PUBMED   34739556
  REMARK    GeneRIF: Sphingomyelin Phosphodiesterase Acid-Like 3b is Essential
            for Toll-Like Receptor 3 Signaling in Human Podocytes.
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Waldbillig,F., Nitschke,K., Abdelhadi,A., von Hardenberg,J.,
            Nuhn,P., Nientiedt,M., Weis,C.A., Michel,M.S., Erben,P. and
            Worst,T.S.
  TITLE     Phosphodiesterase SMPDL3B Gene Expression as Independent Outcome
            Prediction Marker in Localized Prostate Cancer
  JOURNAL   Int J Mol Sci 21 (12), 4373 (2020)
   PUBMED   32575490
  REMARK    GeneRIF: Phosphodiesterase SMPDL3B Gene Expression as Independent
            Outcome Prediction Marker in Localized Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Abou Daher,A., Francis,M., Azzam,P., Ahmad,A., Eid,A.A.,
            Fornoni,A., Marples,B. and Zeidan,Y.H.
  TITLE     Modulation of radiation-induced damage of human glomerular
            endothelial cells by SMPDL3B
  JOURNAL   FASEB J 34 (6), 7915-7926 (2020)
   PUBMED   32293077
  REMARK    GeneRIF: Modulation of radiation-induced damage of human glomerular
            endothelial cells by SMPDL3B.
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Heinz,L.X., Baumann,C.L., Koberlin,M.S., Snijder,B., Gawish,R.,
            Shui,G., Sharif,O., Aspalter,I.M., Muller,A.C., Kandasamy,R.K.,
            Breitwieser,F.P., Pichlmair,A., Bruckner,M., Rebsamen,M., Bluml,S.,
            Karonitsch,T., Fauster,A., Colinge,J., Bennett,K.L., Knapp,S.,
            Wenk,M.R. and Superti-Furga,G.
  TITLE     The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate
            Immunity
  JOURNAL   Cell Rep 11 (12), 1919-1928 (2015)
   PUBMED   26095358
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Lopes,M.C., Hysi,P.G., Verhoeven,V.J., Macgregor,S., Hewitt,A.W.,
            Montgomery,G.W., Cumberland,P., Vingerling,J.R., Young,T.L., van
            Duijn,C.M., Oostra,B., Uitterlinden,A.G., Rahi,J.S., Mackey,D.A.,
            Klaver,C.C., Andrew,T. and Hammond,C.J.
  TITLE     Identification of a candidate gene for astigmatism
  JOURNAL   Invest Ophthalmol Vis Sci 54 (2), 1260-1267 (2013)
   PUBMED   23322567
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 1866)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK301349.1, AK316500.1, AL512288.19 and CA425405.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014474.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.975232.1,
                                           SRR3476690.949963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373894.8/ ENSP00000363001.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-971               AK301349.1         1-971
            972-1736            AK316500.1         943-1707
            1737-1737           AL512288.19        75699-75699         c
            1738-1834           AK316500.1         1709-1805
            1835-1835           AL512288.19        75601-75601         c
            1836-1866           CA425405.1         24-54               c
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..1866
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /note="sphingomyelin phosphodiesterase acid like 3B"
                     /db_xref="GeneID:27293"
                     /db_xref="HGNC:HGNC:21416"
                     /db_xref="MIM:617737"
     exon            1..245
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1552
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; acid sphingomyelinase-like phosphodiesterase
                     3b; ASM-like phosphodiesterase 3b"
                     /codon_start=1
                     /product="acid sphingomyelinase-like phosphodiesterase 3b
                     isoform 1 precursor"
                     /protein_id="NP_055289.2"
                     /db_xref="CCDS:CCDS30655.1"
                     /db_xref="GeneID:27293"
                     /db_xref="HGNC:HGNC:21416"
                     /db_xref="MIM:617737"
                     /translation="MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQV
                     CPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEK
                     LGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKP
                     WLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLE
                     DVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFG
                     HHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSL
                     KDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRY
                     YVYNSVSYSAGVCDEACSMQHVCAMRQVDIDAYTTCLYASGTTPVPQLPLLLMALLGL
                     CTLVL"
     exon            246..459
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     exon            460..557
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     exon            558..701
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     exon            702..874
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1055
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1189
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1866
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1844..1849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /note="hexamer: AACAAA"
     polyA_site      1866
                     /gene="SMPDL3B"
                     /gene_synonym="ASML3B"
                     /note="major polyA site"
ORIGIN      
        1 ataccctgct gggcaaagga ggaagagcca gaggatccag acgccttgga ggacttggaa
       61 cacctgtaac aggacaagga gttctgctca ggcacgtggc cacagaaaac tacttaggaa
      121 gcctgtggtg agaacaacaa cagtgcctga gaatcccacg gctctgggga agtgagcccc
      181 gaggatgagg ctgctcgcct ggctgatttt cctggctaac tggggaggtg ccagggctga
      241 accagggaag ttctggcaca tcgctgacct gcaccttgac cctgactaca aggtatccaa
      301 agaccccttc caggtgtgcc catcagctgg atcccagcca gtgcccgacg caggcccctg
      361 gggtgactac ctctgtgatt ctccctgggc cctcatcaac tcctccatct atgccatgaa
      421 ggagattgag ccagagccag acttcattct ctggactggt gatgacacgc ctcatgtgcc
      481 cgatgagaaa ctgggagagg cagctgtact ggaaattgtg gaacgcctga ccaagctcat
      541 cagagaggtc tttccagata ctaaagtcta tgctgctttg ggaaatcatg attttcaccc
      601 caaaaaccag ttcccagctg gaagtaacaa catctacaat cagatagcag aactatggaa
      661 accctggctt agtaatgagt ccatcgctct cttcaaaaaa ggtgccttct actgtgagaa
      721 gctgccgggt cccagcgggg ctgggcgaat tgtggtcctc aacaccaatc tgtactatac
      781 cagcaatgcg ctgacagcag acatggcgga ccctggccag cagttccagt ggctggaaga
      841 tgtgctgacc gatgcatcca aagctgggga catggtgtac attgtcggcc acgtgccccc
      901 ggggttcttt gagaagacgc aaaacaaggc atggttccgg gagggcttca atgaaaaata
      961 cctgaaggtg gtccggaagc atcatcgcgt catagcaggg cagttcttcg ggcaccacca
     1021 caccgacagc tttcggatgc tctatgatga tgcaggtgtc cccataagcg ccatgttcat
     1081 cacacctgga gtcaccccat ggaaaaccac attacctgga gtggtcaatg gggccaacaa
     1141 tccagccatc cgggtgttcg aatatgaccg agccacactg agcctgaagg acatggtgac
     1201 ctacttcatg aacctgagcc aggcgaatgc tcaggggacg ccgcgctggg agctcgagta
     1261 ccagctgacc gaggcctatg gggtgccgga cgccagcgcc cactccatgc acacagtgct
     1321 ggaccgcatc gctggcgacc agagcacact gcagcgctac tacgtctata actcagtcag
     1381 ctactctgct ggggtctgcg acgaggcctg cagcatgcag cacgtgtgtg ccatgcgcca
     1441 ggtggacatt gacgcttaca ccacctgtct gtatgcctct ggcaccacgc ccgtgcccca
     1501 gctcccgctg ctgctgatgg ccctgctggg cctgtgcacg ctcgtgctgt gacctgccag
     1561 gctcaccttc ttcctggtaa cgggtaacgg gggcagcgcc caggatcacc cagagctggg
     1621 ccttccacca tttcctccgc gcctgaggag tgaactgaaa taggacaacc gaatcaggaa
     1681 gcgaagcccc aggagctgca gccatccgtg atcgcgccac tgcactccag cctgggtgac
     1741 aaagccagac tctctccaaa aacaaaccag aaacagaaaa gaaatgacga cccaagaccc
     1801 ccctacaagc atacttcttt tgcgtattat gtttaactca caaaacaaag ctcatcatgc
     1861 gtttga
//
