LOCUS       NM_001166412            3082 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens SPARC related modular calcium binding 2 (SMOC2),
            transcript variant 2, mRNA.
ACCESSION   NM_001166412
VERSION     NM_001166412.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3082)
  AUTHORS   Huang,Q., Sun,Y., Huang,W., Zhang,F., He,H., He,Y. and Huang,F.
  TITLE     FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in
            Human Stem Cells from the Apical Papilla under Inflammatory
            Microenvironment
  JOURNAL   Int J Mol Sci 25 (7), 4045 (2024)
   PUBMED   38612855
  REMARK    GeneRIF: FTO Positively Regulates Odontoblastic Differentiation via
            SMOC2 in Human Stem Cells from the Apical Papilla under
            Inflammatory Microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3082)
  AUTHORS   Xu,H., Lu,G., Zhou,S. and Fang,F.
  TITLE     MicroRNA-19a-3p Acts as an Oncogene in Gastric Cancer and Exerts
            the Effect by Targeting SMOC2
  JOURNAL   Appl Biochem Biotechnol 194 (9), 3833-3842 (2022)
   PUBMED   35543855
  REMARK    GeneRIF: MicroRNA-19a-3p Acts as an Oncogene in Gastric Cancer and
            Exerts the Effect by Targeting SMOC2.
REFERENCE   3  (bases 1 to 3082)
  AUTHORS   Feng,D., Gao,P., Henley,N., Dubuissez,M., Chen,N., Laurin,L.P.,
            Royal,V., Pichette,V. and Gerarduzzi,C.
  TITLE     SMOC2 promotes an epithelial-mesenchymal transition and a
            pro-metastatic phenotype in epithelial cells of renal cell
            carcinoma origin
  JOURNAL   Cell Death Dis 13 (7), 639 (2022)
   PUBMED   35869056
  REMARK    GeneRIF: SMOC2 promotes an epithelial-mesenchymal transition and a
            pro-metastatic phenotype in epithelial cells of renal cell
            carcinoma origin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3082)
  AUTHORS   Alabiad,M.A., Harb,O.A., Hefzi,N., Ahmed,R.Z., Osman,G.,
            Shalaby,A.M., Alnemr,A.A. and Saraya,Y.S.
  TITLE     Prognostic and clinicopathological significance of TMEFF2, SMOC-2,
            and SOX17 expression in endometrial carcinoma
  JOURNAL   Exp Mol Pathol 122, 104670 (2021)
   PUBMED   34339705
  REMARK    GeneRIF: Prognostic and clinicopathological significance of TMEFF2,
            SMOC-2, and SOX17 expression in endometrial carcinoma.
REFERENCE   5  (bases 1 to 3082)
  AUTHORS   Hyun,C.L., Park,S.J., Kim,H.S., Song,H.J., Kim,H.U., Lee,C.,
            Lee,D.H., Maeng,Y.H., Kim,Y.S. and Jang,B.
  TITLE     The Intestinal Stem Cell Marker SMOC2 Is an Independent Prognostic
            Marker Associated With Better Survival in Gastric Cancer
  JOURNAL   Anticancer Res 41 (7), 3689-3698 (2021)
   PUBMED   34230168
  REMARK    GeneRIF: The Intestinal Stem Cell Marker SMOC2 Is an Independent
            Prognostic Marker Associated With Better Survival in Gastric
            Cancer.
REFERENCE   6  (bases 1 to 3082)
  AUTHORS   Birlea,S.A., Gowan,K., Fain,P.R. and Spritz,R.A.
  TITLE     Genome-wide association study of generalized vitiligo in an
            isolated European founder population identifies SMOC2, in close
            proximity to IDDM8
  JOURNAL   J Invest Dermatol 130 (3), 798-803 (2010)
   PUBMED   19890347
  REMARK    GeneRIF: SMOC2 is a risk locus for generalized vitiligo and perhaps
            other autoimmune diseases
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3082)
  AUTHORS   Wilk,J.B., Herbert,A., Shoemaker,C.M., Gottlieb,D.J. and
            Karamohamed,S.
  TITLE     Secreted modular calcium-binding protein 2 haplotypes are
            associated with pulmonary function
  JOURNAL   Am J Respir Crit Care Med 175 (6), 554-560 (2007)
   PUBMED   17204727
  REMARK    GeneRIF: We tested association between SMOC2 polymorphisms and
            FEV(1) and FVC. SMOC2 might play an important role in the
            determination of FEV(1) and FVC
REFERENCE   8  (bases 1 to 3082)
  AUTHORS   Rocnik,E.F., Liu,P., Sato,K., Walsh,K. and Vaziri,C.
  TITLE     The novel SPARC family member SMOC-2 potentiates angiogenic growth
            factor activity
  JOURNAL   J Biol Chem 281 (32), 22855-22864 (2006)
   PUBMED   16774925
  REMARK    GeneRIF: SMOC-2 is a novel angiogenic factor that potentiates
            angiogenic effects of growth factors
REFERENCE   9  (bases 1 to 3082)
  AUTHORS   Vannahme,C., Gosling,S., Paulsson,M., Maurer,P. and Hartmann,U.
  TITLE     Characterization of SMOC-2, a modular extracellular calcium-binding
            protein
  JOURNAL   Biochem J 373 (Pt 3), 805-814 (2003)
   PUBMED   12741954
  REMARK    GeneRIF: identification of gene, chromosome mapping
REFERENCE   10 (bases 1 to 3082)
  AUTHORS   Nishimoto,S., Hamajima,Y., Toda,Y., Toyoda,H., Kitamura,K. and
            Komurasaki,T.
  TITLE     Identification of a novel smooth muscle associated protein, smap2,
            upregulated during neointima formation in a rat carotid
            endarterectomy model
  JOURNAL   Biochim Biophys Acta 1576 (1-2), 225-230 (2002)
   PUBMED   12031507
  REMARK    GeneRIF: Although this study specifies rat, the authors studied and
            discussed the human gene in this study as well.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC028420.1 and AI032288.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001166412.1.
            
            Summary: This gene encodes a member of the SPARC family (secreted
            protein acidic and rich in cysteine/osteonectin/BM-40), which are
            highly expressed during embryogenesis and wound healing. The gene
            product is a matricellular protein which promotes matrix assembly
            and can stimulate endothelial cell proliferation and migration, as
            well as angiogenic activity. Associated with pulmonary function,
            this secretory gene product contains a Kazal domain, two
            thymoglobulin type-1 domains, and two EF-hand calcium-binding
            domains. The encoded protein may serve as a target for controlling
            angiogenesis in tumor growth and myocardial ischemia. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            This results in a shorter protein (isoform 2), compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.210283.1, BC047583.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356284.7/ ENSP00000348630.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3080              BC028420.1         37-3116
            3081-3082           AI032288.1         4-5                 c
FEATURES             Location/Qualifiers
     source          1..3082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..3082
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /note="SPARC related modular calcium binding 2"
                     /db_xref="GeneID:64094"
                     /db_xref="HGNC:HGNC:20323"
                     /db_xref="MIM:607223"
     exon            1..271
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1528
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; smooth muscle associated protein 2;
                     thyroglobulin type-1 repeat containing protein; secreted
                     modular calcium-binding protein 2; SPARC-related modular
                     calcium-binding protein 2; SMAP-2; SMOC-2"
                     /codon_start=1
                     /product="SPARC-related modular calcium-binding protein 2
                     isoform 2 precursor"
                     /protein_id="NP_001159884.1"
                     /db_xref="CCDS:CCDS55076.1"
                     /db_xref="GeneID:64094"
                     /db_xref="HGNC:HGNC:20323"
                     /db_xref="MIM:607223"
                     /translation="MLLPQLCWLPLLAGLLPPVPAQKFSALTFLRVDQDKDKDCSLDC
                     AGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQAR
                     KEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEK
                     LPQREGTGKTDDAAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQ
                     EHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRY
                     EQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSS
                     SGRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKF
                     VEYCDVNNDKSISVQELMGCLGVAKEDGKADTKKRHTPRGHAESTSNRQPRKQG"
     exon            272..443
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..650
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..698
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..749
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..824
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1011
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1094
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1197
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1472
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1510
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..3082
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3060..3065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /note="hexamer: AATAAA"
     polyA_site      3082
                     /gene="SMOC2"
                     /gene_synonym="bA270C4A.1; bA37D8.1; dJ421D16.1; DTDP1;
                     MST117; MSTP117; MSTP140; SMAP2"
                     /note="major polyA site"
ORIGIN      
        1 aacgcggagg acctctgggt gcctgcaggg gagctgctcc agccgggccg ccgggagcgg
       61 tggggagagc atcgcggagc cgcccctcca cgcgcccgcc cagccgcgct cgcccactgg
      121 gctctcccgg ctgcagtgcc agggcgcagg acgcggccga tctcccgctc ccgccacctc
      181 cgccaccatg ctgctccccc agctctgctg gctgccgctg ctcgctgggc tgctcccgcc
      241 ggtgcccgct cagaagttct cggcgctcac gtttttgaga gtggatcaag ataaagacaa
      301 ggattgtagc ttggactgtg cgggttcgcc ccagaaacct ctctgcgcat ctgacggaag
      361 gaccttcctt tcccgttgtg aatttcaacg tgccaagtgc aaagatcccc agctagagat
      421 tgcatatcga ggaaactgca aagacgtgtc caggtgtgtg gccgaaagga agtataccca
      481 ggagcaagcc cggaaggagt ttcagcaagt gttcattcct gagtgcaatg acgacggcac
      541 ctacagtcag gtccagtgtc acagctacac gggatactgc tggtgcgtca cgcccaacgg
      601 gaggcccatc agcggcactg ccgtggccca caagacgccc cggtgcccgg gttccgtaaa
      661 tgaaaagtta ccccaacgcg aaggcacagg aaaaacagat gatgccgcag ctccagcgtt
      721 ggagactcag cctcaaggag atgaagaaga tattgcatca cgttacccta ccctttggac
      781 tgaacaggtt aaaagtcggc agaacaaaac caataagaat tcagtgtcat cctgtgacca
      841 agagcaccag tctgccctgg aggaagccaa gcagcccaag aacgacaatg tggtgatccc
      901 tgagtgtgcg cacggcggcc tctacaagcc agtgcagtgc cacccctcca cggggtactg
      961 ctggtgcgtc ctggtggaca cggggcgccc cattcccggc acatccacaa ggtacgagca
     1021 gccgaaatgt gacaacacgg ccagggccca cccagccaaa gcccgggacc tgtacaaggg
     1081 ccgccagcta caaggttgtc cgggtgccaa aaagcatgag tttctgacca gcgttctgga
     1141 cgcgctgtcc acggacatgg tccacgccgc ctccgacccc tcctcctcgt caggcaggct
     1201 ctcagaaccc gaccccagcc ataccctaga ggagcgggtg gtgcactggt acttcaaact
     1261 actggataaa aactccagtg gagacatcgg caaaaaggaa atcaaaccct tcaagaggtt
     1321 ccttcgcaaa aaatcaaagc ccaaaaaatg tgtgaagaag tttgttgaat actgtgacgt
     1381 gaataatgac aaatccatct ccgtacaaga actgatgggc tgcctgggcg tggcgaaaga
     1441 ggacggcaaa gcggacacca agaaacgcca cacccccaga ggtcatgctg aaagtacgtc
     1501 taatagacag ccaaggaaac aaggataaat ggctcatacc ccgaaggcag ttcctagaca
     1561 catgggaaat ttccctcacc aaagagcaat taagaaaaca aaaacagaaa cacatagtat
     1621 ttgcactttg tactttaaat gtaaattcac tttgtagaaa tgagctattt aaacagactg
     1681 ttttaatctg tgaaaatgga gagctggctt cagaaaatta atcacataca atgtatgtgt
     1741 cctcttttga ccttggaaat ctgtatgtgg tggagaagta tttgaatgca tttaggctta
     1801 atttcttcgc cttccacatg ttaacagtag agctctatgc actccggctg caatcgtatg
     1861 gctttctcta acccctgcag tcacttccag atgcctgtgc ttacagcatt gtggaatcat
     1921 gttggaagct ccacatgtcc atggaagttt gtgatgtacg gccgacccta caggcagtta
     1981 acatgcatgg gctggtttgt ttcttgggat tttctgttag tttgtcttgt tttgctttcc
     2041 agagatcttg ctcatacaat gaatcacgca accactaaag ctatccagtt aagtgcaggt
     2101 agttcccctg gaggaaataa tattttcaaa ctgtcgttgg tgtgatactt tggctcaaag
     2161 gatctttgct tttccatttt aagcttctgt tttgagtttt gccctggggc ttgaatgagt
     2221 cccagagagt cgttcggatg gtgggaggct gcctaggagg cagtaaatcc agtcacagtg
     2281 cctgggaggg gcccatcctt ccaaaatgta aatccagtcg cggtgtgacc gagctggcta
     2341 acaggcttgt ctgcctggtt ttcctcctac acgtggacat tattctcctg atcctcctac
     2401 ctggtccacc ccagggctac cggaaggtaa aatcttcacc tgaaccaatt atgagcagtc
     2461 tccttactga aggtacagcc ggatacgtgg tgcccccggg gctggtgttg gcagccgggg
     2521 ggaggtgcct gagggtcccc acggttcctt tctgcttttc tgaatgcatc aagggtacga
     2581 gaacttgcca atgggaaatt catccgagtg gcactggcag agaaggatag gagtggaatg
     2641 cccacacagt gaccaacaga actggtctgc gtgcataacc agctgccacc ctcaggcctg
     2701 ggccccagag ctcagggcac ccagtgtctt aaggaaccat ttggaggaca gtctgagagc
     2761 aggaacttca agctgtgatt ctatctcggc tcagactttt ggttggaaaa agatcttcat
     2821 ggccccaaat cccctgagac atgccttgta gaatgatttt gtgatgttgt gatgcttgtg
     2881 gagcatcgcg taaggcttct tgcttattta aactgtgcaa ggtaaaaatc aagcctttgg
     2941 agccacagaa ccagctcaag tacatgccaa tgttgtttaa gaaacagtta tgatcctaaa
     3001 ctttttggat aatcttttat atttctgacc tttgaattta atcattgttc ttagattaaa
     3061 ataaaatatg ctattgaaac ta
//
