LOCUS       NM_001034852            3679 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens SPARC related modular calcium binding 1 (SMOC1),
            transcript variant 1, mRNA.
ACCESSION   NM_001034852
VERSION     NM_001034852.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3679)
  AUTHORS   Aoki,H., Takasawa,A., Yamamoto,E., Niinuma,T., Yamano,H.O.,
            Harada,T., Kubo,T., Yorozu,A., Kitajima,H., Ishiguro,K., Kai,M.,
            Katanuma,A., Shinohara,T., Nakase,H., Sugai,T., Osanai,M. and
            Suzuki,H.
  TITLE     Downregulation of SMOC1 is associated with progression of
            colorectal traditional serrated adenomas
  JOURNAL   BMC Gastroenterol 24 (1), 91 (2024)
   PUBMED   38429655
  REMARK    GeneRIF: Downregulation of SMOC1 is associated with progression of
            colorectal traditional serrated adenomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3679)
  AUTHORS   Wang,Y., Gu,J., Du,A., Zhang,S., Deng,M., Zhao,R., Lu,Y., Ji,Y.,
            Shao,Y., Sun,W. and Kong,X.
  TITLE     SPARC-related modular calcium binding 1 regulates aortic valve
            calcification by disrupting BMPR-II/p-p38 signalling
  JOURNAL   Cardiovasc Res 118 (3), 913-928 (2022)
   PUBMED   33757126
  REMARK    GeneRIF: SPARC-related modular calcium binding 1 regulates aortic
            valve calcification by disrupting BMPR-II/p-p38 signalling.
REFERENCE   3  (bases 1 to 3679)
  AUTHORS   Lyubchenko,T., Collins,H.K., Vang,K.A., Leung,D.Y.M. and Goleva,E.
  TITLE     SMOC1 and IL-4 and IL-13 Cytokines Interfere with Ca2+ Mobilization
            in Primary Human Keratinocytes
  JOURNAL   J Invest Dermatol 141 (7), 1792-1801 (2021)
   PUBMED   33484701
  REMARK    GeneRIF: SMOC1 and IL-4 and IL-13 Cytokines Interfere with Ca(2+)
            Mobilization in Primary Human Keratinocytes.
REFERENCE   4  (bases 1 to 3679)
  AUTHORS   Delgado Lagos,F., Elgheznawy,A., Kyselova,A., Meyer Zu
            Heringdorf,D., Ratiu,C., Randriamboavonjy,V., Mann,A.W.,
            Fisslthaler,B., Siragusa,M. and Fleming,I.
  TITLE     Secreted modular calcium-binding protein 1 binds and activates
            thrombin to account for platelet hyperreactivity in diabetes
  JOURNAL   Blood 137 (12), 1641-1651 (2021)
   PUBMED   33529332
  REMARK    GeneRIF: Secreted modular calcium-binding protein 1 binds and
            activates thrombin to account for platelet hyperreactivity in
            diabetes.
REFERENCE   5  (bases 1 to 3679)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3679)
  AUTHORS   Choi,Y.A., Lim,J., Kim,K.M., Acharya,B., Cho,J.Y., Bae,Y.C.,
            Shin,H.I., Kim,S.Y. and Park,E.K.
  TITLE     Secretome analysis of human BMSCs and identification of SMOC1 as an
            important ECM protein in osteoblast differentiation
  JOURNAL   J Proteome Res 9 (6), 2946-2956 (2010)
   PUBMED   20359165
  REMARK    GeneRIF: Analyzed the secretory protein profiles of BMSCs grown in
            osteogenic medium (OSM) and identified SPARC-related modular
            calcium-binding protein 1 (SMOC1), a member of the SPARC family, as
            a regulator of osteoblast differentiation of BMSCs.
REFERENCE   7  (bases 1 to 3679)
  AUTHORS   Sherva,R., Miller,M.B., Lynch,A.I., Devereux,R.B., Rao,D.C.,
            Oberman,A., Hopkins,P.N., Kitzman,D.W., Atwood,L.D. and Arnett,D.K.
  TITLE     A whole genome scan for pulse pressure/stroke volume ratio in
            African Americans: the HyperGEN study
  JOURNAL   Am J Hypertens 20 (4), 398-402 (2007)
   PUBMED   17386346
  REMARK    GeneRIF: SMOC-1 is of physiological interest because it codes a
            secreted glycoprotein with five domains, each containing regions
            homologous to those on other proteins that mediate cell-matrix
            interactions.
REFERENCE   8  (bases 1 to 3679)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   9  (bases 1 to 3679)
  AUTHORS   Vannahme,C., Smyth,N., Miosge,N., Gosling,S., Frie,C., Paulsson,M.,
            Maurer,P. and Hartmann,U.
  TITLE     Characterization of SMOC-1, a novel modular calcium-binding protein
            in basement membranes
  JOURNAL   J Biol Chem 277 (41), 37977-37986 (2002)
   PUBMED   12130637
  REMARK    GeneRIF: isolation of the novel gene SMOC-1 encoding a secreted
            modular protein containing an EF-hand calcium-binding domain;
            localization within basement membranes in kidney and skeletal
            muscle and expression in the zona pellucida surrounding the oocyte
REFERENCE   10 (bases 1 to 3679)
  AUTHORS   Bardakjian,T., Weiss,A. and Schneider,A.
  TITLE     Microphthalmia/Anophthalmia/Coloboma Spectrum - RETIRED CHAPTER,
            FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA805236.1, BC011548.1,
            AJ249900.1, AK098441.1 and BQ183777.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001034852.2.
            
            Summary: This gene encodes a multi-domain secreted protein that may
            have a critical role in ocular and limb development. Mutations in
            this gene are associated with microphthalmia and limb anomalies.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289988.1, BC011548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361956.8/ ENSP00000355110.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               DA805236.1         20-359
            341-1953            BC011548.1         331-1943
            1954-2489           AJ249900.1         1943-2478
            2490-2948           AK098441.1         586-1044
            2949-3678           AJ249900.1         2939-3668
            3679-3679           BQ183777.1         19-19               c
FEATURES             Location/Qualifiers
     source          1..3679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..3679
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /note="SPARC related modular calcium binding 1"
                     /db_xref="GeneID:64093"
                     /db_xref="HGNC:HGNC:20318"
                     /db_xref="MIM:608488"
     exon            1..362
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1571
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; secreted modular calcium-binding protein 1"
                     /codon_start=1
                     /product="SPARC-related modular calcium-binding protein 1
                     isoform 1 precursor"
                     /protein_id="NP_001030024.1"
                     /db_xref="CCDS:CCDS32110.1"
                     /db_xref="GeneID:64093"
                     /db_xref="HGNC:HGNC:20318"
                     /db_xref="MIM:608488"
                     /translation="MLPARCARLLTPHLLLVLVQLSPARGHRTTGPRFLISDRDPQCN
                     LHCSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQA
                     LEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSG
                     SVTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNI
                     RNSEKVYSCDQERQSALEEAQQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDT
                     GRPLPGTSTRYVMPSCESDARAKTTEADDPFKDRELPGCPEGKKMEFITSLLDALTTD
                     MVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDSNSSNDINKREMKPFKRYVK
                     KKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEVGRLV"
     exon            363..528
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            529..641
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            642..741
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            742..789
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            790..846
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            847..927
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1120
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1203
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1309
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1554
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..3679
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /note="hexamer: AATATA"
     polyA_site      1953
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /note="major polyA site"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /note="hexamer: AATAAA"
     polyA_site      3679
                     /gene="SMOC1"
                     /gene_synonym="OAS"
                     /note="major polyA site"
ORIGIN      
        1 aggcgtccaa cctgctgccg cctgggcccc gccgagcgga gctagcgccg cgcgcagagc
       61 acacgctcgc gctccagctc ccctcctgcg cggttcatga ctgtgtcccc tgaccgcagc
      121 ctctgcgagc ccccgccgca ggaccacggc ccgctccccg ccgccgcgag ggccccgagc
      181 gaaggaagga agggaggcgc gctgtgcgcc ccgcggagcc cgcgaacccc gctcgctgcc
      241 ggctgcccag cctggctggc accatgctgc ccgcgcgctg cgcccgcctg ctcacgcccc
      301 acttgctgct ggtgttggtg cagctgtccc ctgctcgcgg ccaccgcacc acaggcccca
      361 ggtttctaat aagtgaccgt gacccacagt gcaacctcca ctgctccagg actcaaccca
      421 aacccatctg tgcctctgat ggcaggtcct acgagtccat gtgtgagtac cagcgagcca
      481 agtgccgaga cccgaccctg ggcgtggtgc atcgaggtag atgcaaagat gctggccaga
      541 gcaagtgtcg cctggagcgg gctcaagccc tggagcaagc caagaagcct caggaagctg
      601 tgtttgtccc agagtgtggc gaggatggct cctttaccca ggtgcagtgc catacttaca
      661 ctgggtactg ctggtgtgtc accccggatg ggaagcccat cagtggctct tctgtgcaga
      721 ataaaactcc tgtatgttca ggttcagtca ccgacaagcc cttgagccag ggtaactcag
      781 gaaggaaaga tgacgggtct aagccgacac ccacgatgga gacccagccg gtgttcgatg
      841 gagatgaaat cacagcccca actctatgga ttaaacactt ggtgatcaag gactccaaac
      901 tgaacaacac caacataaga aattcagaga aagtctattc gtgtgaccag gagaggcaga
      961 gtgccctgga agaggcccag cagaatcccc gtgagggtat tgtcatccct gaatgtgccc
     1021 ctgggggact ctataagcca gtgcaatgcc accagtccac tggctactgc tggtgtgtgc
     1081 tggtggacac agggcgcccg ctgcctggga cctccacacg ctacgtgatg cccagttgtg
     1141 agagcgacgc cagggccaag actacagagg cggatgaccc cttcaaggac agggagctac
     1201 caggctgtcc agaagggaag aaaatggagt ttatcaccag cctactggat gctctcacca
     1261 ctgacatggt tcaggccatt aactcagcag cgcccactgg aggtgggagg ttctcagagc
     1321 cagaccccag ccacaccctg gaggagcggg tagtgcactg gtatttcagc cagctggaca
     1381 gcaatagcag caacgacatt aacaagcggg agatgaagcc cttcaagcgc tacgtgaaga
     1441 agaaagccaa gcccaagaaa tgtgcccggc gtttcaccga ctactgtgac ctgaacaaag
     1501 acaaggtcat ttcactgcct gagctgaagg gctgcctggg tgttagcaaa gaagtaggac
     1561 gcctcgtcta aggagcagaa aacccaaggg caggtggaga gtccagggag gcaggatgga
     1621 tcaccagaca cctaaccttc agcgttgccc atggccctgc cacatcccgt gtaacataag
     1681 tggtgcccac catgtttgca cttttaataa ctcttacttg cgtgttttgt ttttggtttc
     1741 attttaaaac accaatatct aataccacag tgggaaaagg aaagggaaga aagactttat
     1801 tctctctctt attgtaagtt tttggatctg ctactgacaa cttttagagg gttttggggg
     1861 ggtgggggag ggtgttgttg gggctgagaa gaaagagatt tatatgctgt atataaatat
     1921 atatgtaaat tgtatagttc ttttgtacag gcattggcat tgctgtttgt ttatttctct
     1981 ccctctgcct gctgtgggtg gtgggcactc tggacacata gtccagcttt ctaaaatcca
     2041 ggactctatc ctgggcctac taaacttctg tttggagact gacccttgtg tataaagacg
     2101 ggagtcctgc aattgtactg cggactccac gagttctttt ctggtgggag gactatattg
     2161 ccccatgcca ttagttgtca aaattgataa gtcacttggc tctcggcctt gtccagggag
     2221 gttgggctaa ggagagatgg aaactgccct gggagaggaa gggagtccag atcccatgaa
     2281 tagcccacac aggtaccggc tctcagaggg tccgtgcatt cctgctctcc ggacccccaa
     2341 agggcccagc attggtgggt gcaccagtat cttagtgacc ctcggagcaa attatccaca
     2401 aaggatttgc attacgtcac tcgaaacgtt ttcatccatg cttagcatct actctgtata
     2461 acgcatgaga ggggaggcaa agaagaaaaa gacacacaga agggccttta aaaaagtaga
     2521 tatttaatat ctaagcaggg gaggggacag gacagaaagc ctgcactgag gggtgcggtg
     2581 ccaacaggga aactcttcac ctccctgcaa acctaccagt gaggctccca gagacgcagc
     2641 tgtctcagtg ccaggggcag attgggtgtg acctctccac tcctccatct cctgctgttg
     2701 tcctagtggc tatcacaggc ctgggtgggt gggttggggg aggtgtcagt caccttgttg
     2761 gtaacactaa agttgttttg ttggtttttt aaaaacccaa tactgaggtt cttcctgttc
     2821 cctcaagttt tcttatgggc ttccaggctt taagctaatt ccagaagtaa aactgatctt
     2881 gggtttccta ttctgcctcc cctagaaggg caggggtgat aacccagcta cagggaaatc
     2941 ccggcccagc tttccacagg catcacaggc atcttccgcg gattctaggg tgggctgccc
     3001 agccttctgg tctgaggcgc agctccctct gcccaggtgc tgtgcctatt caagtggcct
     3061 tcaggcagag cagcaagtgg cccttagcgc cccttcccat aagcagctgt ggtggcagtg
     3121 agggaggttg ggtagccctg gactggtccc ctcctcagat cacccttgca aatctggcct
     3181 catcttgtat tccaacccga catccctaaa agtacctcca cccgttccgg gtctggaagg
     3241 cgttggcacc acaagcactg tccctgtggg aggagcacaa ccttctcggg acaggatctg
     3301 atggggtctt gggctaaagg aggtccctgc tgtcctggag aaagtcctag aggttatctc
     3361 aggaatgact ggtggccctg ccccaacgtg gaaaggtggg aaggaagcct tctcccatta
     3421 gccccaatga gagaactcaa cgtgccggag ctgagtgggc cttgcacgag acactggccc
     3481 cactttcagg cctggaggaa gcatgcacac atggagacgg cgcctgcctg tagatgtttg
     3541 gatcttcgag atctccccag gcatcttgtc tcccacagga tcgtgtgtgt aggtggtgtt
     3601 gtgtggtttt cctttgtgaa ggagagaggg aaactatttg tagcttgttt tataaaaaat
     3661 aaaaaatggg taaatcttg
//
