LOCUS       NM_024104               1360 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens small integral membrane protein 7 (SMIM7), transcript
            variant 2, mRNA.
ACCESSION   NM_024104
VERSION     NM_024104.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL702263.1 and BC001680.2.
            
            On May 21, 2020 this sequence version replaced NM_024104.3.
            
            Transcript Variant: This variant (2) contains an alternate 3'
            terminal exon, resulting in a novel 3' coding region and 3' UTR. It
            encodes isoform 2, which has a shorter and distinct C-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.127334.1, BG703640.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000487416.7/ ENSP00000417147.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AL702263.1         15-229
            216-1360            BC001680.2         1-1145
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1360
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /note="small integral membrane protein 7"
                     /db_xref="GeneID:79086"
                     /db_xref="HGNC:HGNC:28419"
     exon            1..60
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..262
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; UPF0608 protein C19orf42"
                     /codon_start=1
                     /product="small integral membrane protein 7 isoform 2
                     precursor"
                     /protein_id="NP_077009.2"
                     /db_xref="CCDS:CCDS12348.2"
                     /db_xref="GeneID:79086"
                     /db_xref="HGNC:HGNC:28419"
                     /translation="MIGDILLFGTLLMNAGAVLNFKLKKKDTQGFGEESREPSTGDNI
                     REFLLSLRYFRIFIALWNIFMMFCMIVLFGS"
     exon            61..102
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            103..155
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            156..246
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /inference="alignment:Splign:2.1.0"
     exon            247..1360
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      919..924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /note="hexamer: AATAAA"
     polyA_site      949
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /note="major polyA site"
     regulatory      1337..1342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /note="hexamer: AATAAA"
     polyA_site      1360
                     /gene="SMIM7"
                     /gene_synonym="C19orf42"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggtt ctgacggacg cttcggccgt aacgatgatc ggagacatcc tgctgttcgg
       61 gacgttgctg atgaatgccg gggcggtgct gaactttaag ctgaaaaaga aggacacgca
      121 gggctttggg gaggagtcca gggagcccag cacaggtgac aacatccggg aattcttgct
      181 gagcctcaga tactttcgaa tcttcatcgc cctgtggaac atcttcatga tgttctgcat
      241 gattgtgctg ttcggctctt gaatcccagc gatgaaacca ggaactcact ttcccgggat
      301 gccgagtctc cattcctcca ttcctgatga cttcaagaat gtttttgacc agaaaaccga
      361 caaccttccc agaaagtcca agctcgtggt gggtggaaaa gtgttcgccg aggtgtgcat
      421 ggtttcccag ccacgtccct gttttcaaag atagtttcac tttggtctct gaattgaaat
      481 gctgtctact gaaagggttt caggagcgtt tatgtaaggg gctgtgatga aattgcattc
      541 cccatagata aaagaaaaat catttctatc cagagatctg agcagaagga ttggcttgtt
      601 agtttaacac agccgtattt ttggacattc agtgttactt gctgagtctg acagcctctg
      661 ggcccggcca ggggccctgt taacaaactg ctttcacatc ccaacagggt ctgcttggcc
      721 actcagtgca gctgcgatta accctaaagg ctttaaggaa cgggccacct gtaacagaga
      781 caccagcctt cctgtataga cactaaattg ttagcaagag tgttgagcta gttcctggtg
      841 aagtgtttcc acagaagaca tgtggagcag ttgtggggat attaagggaa actttcctct
      901 gccttgaccc ctttgttaaa taaaatgact ttgggagcca ttcattgtac agttgcagga
      961 atgagagtga ttttatgatg tggtacattg ggaccatgtt ctaaaacctt gggtttctga
     1021 gtctgctttt tgagtaggtg attttgaggt tgaaaaacca ggggccttca tctaggaaat
     1081 acagcatttt ccagaagctt ctttgaaagg gaatcctggt tttgttgcca aaatgaaacg
     1141 cccggggttg gcgctgaatc ccacaactgt gtgatttgct tgttgagttt tttgttgtct
     1201 ggtttttttg tttgtttgtt tataccaata agaatgagcc tgaatgttgg tggtttttga
     1261 aatcctgact tggaggtaaa cctggaggaa ggaaaaaaag taaatatgca ggcttttagg
     1321 actgagtagc cttgaaaata aacctcattt ctaaaaagga
//
