LOCUS       NM_001162997            1140 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens endoregulin (ERLN), mRNA.
ACCESSION   NM_001162997 XM_001717994 XM_001719297
VERSION     NM_001162997.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Rathod,N., Bak,J.J., Primeau,J.O., Fisher,M.E.,
            Espinoza-Fonseca,L.M., Lemieux,M.J. and Young,H.S.
  TITLE     Nothing Regular about the Regulins: Distinct Functional Properties
            of SERCA Transmembrane Peptide Regulatory Subunits
  JOURNAL   Int J Mol Sci 22 (16), 8891 (2021)
   PUBMED   34445594
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087749.12, BC062771.1, AL041162.1 and AI167865.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001162997.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062771.1, SRR5189667.64574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579469.2/ ENSP00000463361.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AC087749.12        90737-91051
            316-854             BC062771.1         5-543
            855-1137            AL041162.1         41-323              c
            1138-1140           AI167865.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1140
                     /gene="ERLN"
                     /gene_synonym="C17orf110; ELN; SMIM6"
                     /note="endoregulin"
                     /db_xref="GeneID:100130933"
                     /db_xref="HGNC:HGNC:40032"
                     /db_xref="MIM:620531"
     exon            1..536
                     /gene="ERLN"
                     /gene_synonym="C17orf110; ELN; SMIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1140
                     /gene="ERLN"
                     /gene_synonym="C17orf110; ELN; SMIM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             543..731
                     /gene="ERLN"
                     /gene_synonym="C17orf110; ELN; SMIM6"
                     /note="small integral membrane protein 6"
                     /codon_start=1
                     /product="endoregulin"
                     /protein_id="NP_001156469.1"
                     /db_xref="CCDS:CCDS54166.1"
                     /db_xref="GeneID:100130933"
                     /db_xref="HGNC:HGNC:40032"
                     /db_xref="MIM:620531"
                     /translation="MDQLVFKETIWNDAFWQNPWDQGGLAVIILFITAVLLLILFAIV
                     FGLLTSTENTQCEAGEEE"
     regulatory      1116..1121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ERLN"
                     /gene_synonym="C17orf110; ELN; SMIM6"
                     /note="hexamer: AATAAA"
     polyA_site      1140
                     /gene="ERLN"
                     /gene_synonym="C17orf110; ELN; SMIM6"
                     /note="major polyA site"
ORIGIN      
        1 attcacccca caacacagga agtgagccct acgccagtcc cagccccagg gcttcctgag
       61 ctcggggcag gtccgcagtc cacacgtcac ccagacagag gacagcccag cccagccaca
      121 ggtgaggcgg cctgatggcc tggggcaaag gccctcggtc cagtctcttc cccgtccacc
      181 ccaagtctga cttctctcag gagggactca tgaacacgtg ccctgagcac ccccaaaatg
      241 acatcacaca agggcagaaa ggagctgaag ggggaacgtg aaaggcagaa agggagccgt
      301 ggttgccagg caaccagccc tagcccacct ttgtttgttt ggtgacagca actaaggtct
      361 ggtcagggcc gcttggccac gctcatgcct tttcctctca acagttgctt ctttgagtca
      421 gggtgcagct ctggtcacct ggcggcctct tcagctcagc cctccacaaa gtgtgagcct
      481 gaaggaccac cctgaattgc ccttgtagga cccagaacag ctaccagcag aatcagattc
      541 tcatggacca actggtattc aaagagacaa tctggaatga tgcgttctgg cagaacccct
      601 gggaccaggg gggcctggca gtgattatct tattcatcac cgctgtcctg cttctcatct
      661 tatttgccat cgtgtttggt ttactcactt ccacagaaaa cactcagtgt gaagcgggtg
      721 aagaggagtg acctgacttg ctggggactg agatggcagc aggggaggcg agctgacctg
      781 cccccattcc agtggtgggc cccttcgcgg ttccctctgg ctcaggggcc aagccctggt
      841 gtcttccttt cccatcagga aaaagtctag taaaatactg tatctggctt agggttggtc
      901 agactagtaa gatggggagg ctggtctgag accaattctg gctccttgac cctattgttt
      961 ttagggttcc ccgaccagaa ccctaaaagc acatggagag gatggctcca ctgcctcagg
     1021 tggaaggagc tatggctaac aaggttctct aacaggctca caggcccagc cagcaatttc
     1081 acaaatcctt gacagagaaa gacacaacca aatgaaataa aaattccttt tcaaatctgc
//
