LOCUS       NM_001395940            1540 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens small integral membrane protein 45 (SMIM45),
            transcript variant 1, mRNA.
ACCESSION   NM_001395940 NR_024355 XM_001724192 XM_001725635 XM_001726821
            XM_001726822 XM_934917 XM_945995
VERSION     NM_001395940.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1540)
  AUTHORS   An,N.A., Zhang,J., Mo,F., Luan,X., Tian,L., Shen,Q.S., Li,X.,
            Li,C., Zhou,F., Zhang,B., Ji,M., Qi,J., Zhou,W.Z., Ding,W.,
            Chen,J.Y., Yu,J., Zhang,L., Shu,S., Hu,B. and Li,C.Y.
  TITLE     De novo genes with an lncRNA origin encode unique human brain
            developmental functionality
  JOURNAL   Nat Ecol Evol 7 (2), 264-278 (2023)
   PUBMED   36593289
REFERENCE   2  (bases 1 to 1540)
  AUTHORS   Zhang,X., Feng,Y., Gao,Y. and Hu,J.
  TITLE     Long Noncoding RNA LINC00634 Functions as an Oncogene in Esophageal
            Squamous Cell Carcinoma Through the miR-342-3p/Bcl2L1 Axis
  JOURNAL   Technol Cancer Res Treat 19, 1533033820928508 (2020)
   PUBMED   32583748
  REMARK    GeneRIF: Long Noncoding RNA LINC00634 Functions as an Oncogene in
            Esophageal Squamous Cell Carcinoma Through the miR-342-3p/Bcl2L1
            Axis.
REFERENCE   3  (bases 1 to 1540)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z99716.4.
            
            On Sep 3, 2021 this sequence version replaced NR_024355.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068568.1, SRR3476690.839781.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381348.5/ ENSP00000499702.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               Z99716.4           95390-95661
            273-1540            Z99716.4           100912-102179
FEATURES             Location/Qualifiers
     source          1..1540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..1540
                     /gene="SMIM45"
                     /gene_synonym="BK250D10.8; LINC00634"
                     /note="small integral membrane protein 45"
                     /db_xref="GeneID:339674"
                     /db_xref="HGNC:HGNC:27930"
     exon            1..272
                     /gene="SMIM45"
                     /gene_synonym="BK250D10.8; LINC00634"
                     /inference="alignment:Splign:2.1.0"
     exon            273..1540
                     /gene="SMIM45"
                     /gene_synonym="BK250D10.8; LINC00634"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..493
                     /gene="SMIM45"
                     /gene_synonym="BK250D10.8; LINC00634"
                     /note="long intergenic non-protein coding RNA 634; protein
                     SMIM45"
                     /codon_start=1
                     /product="small integral membrane protein 45"
                     /protein_id="NP_001382869.1"
                     /db_xref="CCDS:CCDS93175.1"
                     /db_xref="GeneID:339674"
                     /db_xref="HGNC:HGNC:27930"
                     /translation="MPHFLDWFVPVYLVISVLILVGFGACIYYFEPGLQEAHKWRMQR
                     PLVDRDLRKTLMVRDNLAFGGPEV"
     regulatory      1514..1519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM45"
                     /gene_synonym="BK250D10.8; LINC00634"
                     /note="hexamer: AATAAA"
     polyA_site      1540
                     /gene="SMIM45"
                     /gene_synonym="BK250D10.8; LINC00634"
                     /note="major polyA site"
ORIGIN      
        1 ctctgatggg cagggagaga taccagggtg ctgagccagt ccaggactgc cccctcctgg
       61 cccactcaga gcccctgggt gtgagaagct cgtctcccgt gggttgcatt ggctctgccc
      121 tatctctgcc tccagcaccc agggcggccg cagatggcag tgtctctggg gacagcagct
      181 gcgaatgagt ccacgggcca atgctgagct gctcaggctg aggcggtgtg ctcagcacag
      241 agcccccgga actggcatct gcagggcgtg agccaaggcc gccgcgatgc cgcacttcct
      301 ggactggttc gtgccggtct acttggtcat ctcggtcctc attctggtgg gcttcggcgc
      361 ctgcatctac tacttcgagc cgggcctgca ggaggcgcac aagtggcgca tgcagcgccc
      421 cctggtggac cgcgacctcc gcaagacgct aatggtgcgc gacaacctgg ccttcggcgg
      481 cccggaggtc tgagccgact tgcaaagggg ataggcgggc ggcaccgggc gccctccccc
      541 agcccgcccc gcccgcccag cccggagacc cccaaggcag agggaggccg gcctgttggc
      601 cctccacgct atccctctgc agcctgggcc ctcccgacag aggccccagg tgcgctggca
      661 gtggaggtgg ggcacttagg tgcctggctg gcccagggct tgctctccgt gtcaagccga
      721 ctcacccaga gcccaccctc ccaagctcag gggcatcctc cgctgggccc cagtgccttt
      781 gcgctgcgca gcactctgcc ctccactgga ctcaggcatg tctatggctg cctgtcctga
      841 ggctccggag ccctcatttc ttcgtgaagt ccccagctcc cctgcctcca ctcaatggca
      901 ccggccctgc aactttaggc aggtcgaagc caacccaagg aaagaaccta agaacctcgt
      961 ttggagggat gtcagcttgg gccagaccag ccgcaccccg cggggctcag gcttggaact
     1021 ggtgagggtg tgtggtgggg gtatgcagag ggataagacc gtggtagagg agagggttgg
     1081 tgaggagaga gagagagaga gagagagagt ctggggggag cgggcaagca tggggagatg
     1141 agatgtgtat atgtgagaga gagtgtgggg gccccaggca gggcaggagg tggtggaaac
     1201 ggggtgaact ccgtgggctg tgtgaggact gtccatagtg ggtcccaacc ccctccctct
     1261 gctggagttt cctagccctt ccccctcccc aagactgtgg cagcaggcag gagcccctgc
     1321 cctccctccc tgtcctgtgc cacacttctg gggccaaacc cagccccctt gagccaggcc
     1381 ctgccagact ccaagcccac cctagaaccc tcctcctgtg tggagactct gttgccccac
     1441 tttggacaca gattggcaac ctgcctcacc ccgcccccct tcgctggggc ttccatctta
     1501 atttattctc aataataaag acttcatgat gatctctgca
//
