LOCUS       NM_001384332            2295 bp    mRNA    linear   PRI 11-JAN-2024
DEFINITION  Homo sapiens small integral membrane protein 43 (SMIM43),
            transcript variant 1, mRNA.
ACCESSION   NM_001384332
VERSION     NM_001384332.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Fu H, Wang T, Kong X, Yan K, Yang Y, Cao J, Yuan Y, Wang N, Kee K,
            Lu ZJ and Xi Q.
  TITLE     A Nodal enhanced micropeptide NEMEP regulates glucose uptake during
            mesendoderm differentiation of embryonic stem cells
  JOURNAL   Nat Commun 13 (1), 3984 (2022)
   PUBMED   35810171
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P,
            Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell
            GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H,
            Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak
            A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P,
            Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M,
            Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T,
            Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS,
            Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K,
            McLellan MD, Meyer R, Randall-Maher J, Tomlinson C,
            Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid
            S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C,
            Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam
            AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW,
            Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L,
            Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL,
            Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli
            FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X,
            McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy
            SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P,
            Suyama M, Torrents D, Waterston RH and Wilson RK.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079341.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047657.1, SRR1803615.200397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643802.2/ ENSP00000495721.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AC079341.6         24656-25003         c
            349-457             AC079341.6         23603-23711         c
            458-529             AC079341.6         22566-22637         c
            530-592             AC079341.6         21669-21731         c
            593-750             AC079341.6         21377-21534         c
            751-2295            AC079341.6         18769-20313         c
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..2295
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /note="small integral membrane protein 43"
                     /db_xref="GeneID:132332"
                     /db_xref="HGNC:HGNC:55077"
     exon            1..348
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..251
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /note="protein TMEM155; transmembrane protein 155; Nodal
                     Enhanced MEsendoderm Peptide"
                     /codon_start=1
                     /product="small integral membrane protein 43"
                     /protein_id="NP_001371261.1"
                     /db_xref="CCDS:CCDS93616.1"
                     /db_xref="GeneID:132332"
                     /db_xref="HGNC:HGNC:55077"
                     /translation="MEWELNLLLYLALFFFLLFLLFLLLFVVIKQLKNSVANTAGALQ
                     PGRLSVHREPWGFSREQAV"
     exon            349..457
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /inference="alignment:Splign:2.1.0"
     exon            458..529
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /inference="alignment:Splign:2.1.0"
     exon            530..592
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /inference="alignment:Splign:2.1.0"
     exon            593..750
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /inference="alignment:Splign:2.1.0"
     exon            751..2295
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /note="hexamer: AATAAA"
     polyA_site      2292
                     /gene="SMIM43"
                     /gene_synonym="NEMEP; TMEM155"
                     /note="major polyA site"
ORIGIN      
        1 gccctccagc tgcagcccgc gccgagcgcg cagggccagc gagcgccggc gcctccagca
       61 tggagtggga actcaacttg ctgctctacc tggcgctctt cttcttcctg ctcttcttac
      121 ttttcctcct gctcttcgtg gtcatcaagc agctgaagaa ctccgtggcc aacacggccg
      181 gggcgctcca gcccgggcgc ctctcggtgc accgcgagcc ttggggcttc tcccgagagc
      241 aagcggtgtg acccgagtgc gggcactggc gggagggcac cgagctgcgc gggcgctggg
      301 ctgggtctcc gcctcgattc tccgtcctcg cggcctccca gcttccagag ccgagctgct
      361 gcccttgact ggtgctcagg ggaccacagc tgcaatgaca gtttgggcct gcaaaaagaa
      421 ggctggaaca acgggagatg gaagctttct gcaaatgcag caccactggt atccatgaat
      481 ttaacctgcc catcattctt cctaaacaag agactattga aaagtcaggg tgttcaaaat
      541 ggcttcagat cttatcagga caatcttggc tgttgcacta atttccaaac ttggcacagc
      601 tgtagatgca gaactgatgc catctggtgc gattctacag aataagagag aaaatttacc
      661 cagagtgtgc catgcactgg cttttctggg aatggcaagg tgccaggatt tgtttttggt
      721 tcgcttgcag gggtggaaac ttggaactag gttccaagat ggtccccgca gcaccccaca
      781 agaagaagga ggaagcccac agagaaaacg gggcatgcca gttcaaatcc acttcctttt
      841 aaagagcttc ctcagcagcc caataacttt tgccttcatc tcattggcca gaactgtgtc
      901 attggctact gctatctgca agattgtctg agaaatgtag tttttgtagc tggatatata
      961 actgcctttg acaaaaatcc agtttctctt gatgaagaag aagatgatgg tggatcttgg
     1021 gaggacaact aacattttat gccctggcta cagaatacag ttgcagagga gcataaagtt
     1081 caaaaagatc aaaactctag ttccttcaca actgtcaaag ctccaagcag cactgctccc
     1141 ctctgacaga gtgagcagag tgaaggcatg tcaggtgttc tcacaaaact cttgacaggg
     1201 ctgacctctc tcagtcaata tccttgtccc acatcaggat tttctagagg gccctgggta
     1261 cctgtgcact tccttggtgg ccgtaacctc tttgtggagg gttggtgtag gataaagaat
     1321 gttctattac gctgctccct catctgtatc atttctctcc tctctaattt tcctgtcagt
     1381 tatattttgg tggagtctgg gtttgtgtat ttgattccta tagaaagacc atcgctttca
     1441 tgcatggagg aggggaatct acgcaaagaa aggctacctt actcctttct gtgactccac
     1501 caccagtcta ggaatatcct gggagaagaa ttgcctctca aagctgcttc tataagcagc
     1561 ctacatccta gctaagcaaa gaagaaacac ttcccacatc tagggctgtc taaaagaact
     1621 ttctgtgatg acagaaatgt tctatatctg cagtgtccaa tatggtaacc atataggcac
     1681 atgtggctag tgaacacttg aaatgtggct agtgtgactg aggaaggaaa atttaaattt
     1741 tgtttaattg taattaattt aaattcagat agccaaatgg ggctactagc tattgtgtta
     1801 gatagcacgg tatactttat tctctttctt gtgttgtaga accagctggg agaggtgtgg
     1861 gtcagtcatg ggcttggtat cccctggtct tcactattct agcttgccat tgaatttgtc
     1921 tcccagagga aaagaaagaa tggtatttgg aattaaattc aagatgttaa cttgacatct
     1981 atatattgca catattcctg tatagtgaat ggatgacctc ctgggaatag ttcctgtgac
     2041 tgattttagt gataattgat catgaagaaa tggcagtact gctccacttc accttcctag
     2101 tgactattat gtgttcctag tcagagtgac tcagcagaga ttattttgtt ctcttgtgca
     2161 atttattctg tgtcatttta tttttgtaat attgtggcag ctaaatgatt attctgtgta
     2221 tgtttttcaa aatattaggt ggcttatatt ttttaaaagg ctatgaaata aaaataaact
     2281 atacgtaaca cagtt
//
