LOCUS       NM_001369201            5353 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens small integral membrane protein 38 (SMIM38),
            transcript variant 1, mRNA.
ACCESSION   NM_001369201 XR_001748284
VERSION     NM_001369201.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5353)
  AUTHORS   Mudge,J.M., Jungreis,I., Hunt,T., Gonzalez,J.M., Wright,J.C.,
            Kay,M., Davidson,C., Fitzgerald,S., Seal,R., Tweedie,S., He,L.,
            Waterhouse,R.M., Li,Y., Bruford,E., Choudhary,J.S., Frankish,A. and
            Kellis,M.
  TITLE     Discovery of high-confidence human protein-coding genes and exons
            by whole-genome PhyloCSF helps elucidate 118 GWAS loci
  JOURNAL   Genome Res 29 (12), 2073-2087 (2019)
   PUBMED   31537640
REFERENCE   2  (bases 1 to 5353)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003071.3.
            
            On Apr 5, 2021 this sequence version replaced NM_001369201.1.
            
            Transcript Variant: This variant (1) encodes the conserved protein.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038193.4570332.1, SRR14372079.363706.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000686237.1/
                                                ENSP00000509996.1
            NMD candidate                    :: translation inferred from
                                                conservation
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AP003071.3         170429-170608
            181-2358            AP003071.3         171668-173845
            2359-5353           AP003071.3         173940-176934
FEATURES             Location/Qualifiers
     source          1..5353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..5353
                     /gene="SMIM38"
                     /note="small integral membrane protein 38"
                     /db_xref="GeneID:107984345"
                     /db_xref="HGNC:HGNC:54074"
     exon            1..180
                     /gene="SMIM38"
                     /inference="alignment:Splign:2.1.0"
     exon            181..2358
                     /gene="SMIM38"
                     /inference="alignment:Splign:2.1.0"
     CDS             854..1009
                     /gene="SMIM38"
                     /codon_start=1
                     /product="small integral membrane protein 38"
                     /protein_id="NP_001356130.1"
                     /db_xref="CCDS:CCDS91523.1"
                     /db_xref="GeneID:107984345"
                     /db_xref="HGNC:HGNC:54074"
                     /translation="MTSWPGGSFGPDPLLALLVVILLARLILWSCLGTYIDYRLAQRR
                     PQKPKQD"
     exon            2359..5353
                     /gene="SMIM38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5335..5340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM38"
                     /note="hexamer: AATAAA"
     polyA_site      5353
                     /gene="SMIM38"
                     /note="major polyA site"
ORIGIN      
        1 ccagagctca acgttcccta agtgagtggc ctttgacagc agtgccaggc agcccagtgg
       61 gtgcagggca caccacagat ggaggaaggg ccaggcatgc ttcccagaca gcctctgcca
      121 gtccaggcag gggctccagg gtggctgcgg gaaggcagct taggcggtgc ccggcccaag
      181 gctccgtcct tcttccccgt ggtggcccca gcctccctgc caagcttccc ggcccccgcc
      241 ccatcccggg cctgctgctg cggagaccgt gggccggcgc tggacggcgc ggcctccaga
      301 agtgatagct aattggggag agaaagggcc caattgtctg gcggggccgg aagagccgcg
      361 tgggctgctg aaagcgtcgg gaggaggtgg ccgcttcgcc cagcagctgc cgccggggat
      421 gtttgcagat tacgtcagcg ctggcgagca gggggcgcgg ggacagcgag gggggcgggc
      481 tcccggcggc ctcccgcccc ccaggcccct ggacaatgct gtcattgtca gcacggagag
      541 tggttaattc tggatgaatg gtacacgggc ctcttgacca aggaggctgc tcgtcgtccc
      601 cagtctgtcc tctcacatgc cagggaggcc ccgggctgga gtctggcggg cagatctggc
      661 ctgcttggtg gcaccagaga gaacagggcg gtcccttggg ggcgccggct gcagaggccc
      721 caggctggac ggagcttcct gtcctgggtc tgcacagcag ccacttggca gtgccgggct
      781 agggtggcag ggccccactg catctcggtt ccagggcaga ggctgctgct gccctttggg
      841 gctgacttca ggcatgacct cctggccagg tggcagcttt ggccctgacc cgctcctggc
      901 cctgctggtg gtgatcctgc tagcacgcct catcctgtgg tcctgcctcg ggacctacat
      961 cgactacaga ctggcccagc ggcggcccca gaaacccaag caggactaag cctctgcagg
     1021 ctgcggcctc cacgcgccct gtcccgagac tcagccggcc cttccagtgg tggtgggagg
     1081 gaggggagca gggcaggcgc atgatcccca tgtcccaccc ctggggcagg agctcagaga
     1141 ggcctgagat ggatcgtgcc ttcccagact gaccagggct gtcccgtaga ggcagctggc
     1201 catgtgggga gatggagggg ccggccttgc aggtccatca ccaggttctg gggtccccgg
     1261 ttgcagggag tggtcctggg ggtgggtctt gctttaagac cttctctgcc tccaattcct
     1321 tataaatatg cctgcaggaa gagctgggta agccagagga ctcaggtgga ggtgccacag
     1381 agacaaatgt gacctcatca caagctggcc ctgttaccaa aggccacgtc ctgtctcagc
     1441 tcaccaccct cataactagt ctcctcctgc ctcccaaggg acgagataag tgccgatggc
     1501 tgtcctgatt tctccagagc agacccctgg gaagggtctc aggacgcact tgtgaggctg
     1561 agttgacaag ccagacgcac ttggctctgg ttgaccctct gcacactctc taacggtctg
     1621 aacagttagg gcacaatgat ccctgcctcc ctccctcagc aggatatcat gtaggggaca
     1681 atttagggga caagccaagg cacccatcaa tgccctctgt tcatctgttc ctgcaagtgt
     1741 gtggctggga agtgcccagg aaggctgaca gggcagggaa gttgatttga ggccaagcat
     1801 ccagtgctcc tgctccacct ccgtagcacg ttagccgtga tgccagtgac ttaacccaca
     1861 gcttggggaa gctcaaaggc tccacattcg agcctcttgg gggaaattcg gcaaacaccc
     1921 atgtccaagt tccacactgt atttcctggg atcgttccag cagatcgtgg attgcagcga
     1981 gggctgctga ctgcatgcgg aactgtgaga tggaagggac tgtgggcggc agctccaggg
     2041 aggagcatcg aaccagatat cgtctctggg aggctgggcc tggtgatgtg gcaacgtctt
     2101 gctccctgag aggtgatggg tatgctaggg atgctcgctc agggaacgtg ggccaagtcc
     2161 tctgaacacg aagctcgcag agggggtgat tcctgtgaat tctgaaagga cttgggggcg
     2221 tccagcaaga gcaggagctt agatggtggt tccagggctg gtgttgctga ctgggacgag
     2281 tggaccccca gggtgggcat ggagtggggc actggctggg agcctctgcc ttgctgtgtc
     2341 ctggctgaat gaacccagga cttgctgtgc tcagatcctc cattcaagag agctacagac
     2401 acgggggtgc tggtgagcag gagccgagac catctggggt gggaccgacc aagagtttga
     2461 ggtgtccagg gggtgacgtg aagatgacct attgcagagg gtcccttctc attcacgctc
     2521 tgaagtctgc acaggggcag gggctaccgt gctccatttc agtttggcct ctgttgtatc
     2581 agccagaggc cagcagaact ctatggtcac tcccccgtgt cacggacaat ttgccacctc
     2641 caccggcagc ccagggctct gcctgaatat tctcgcctga tcgtaggatt gtggggaggg
     2701 atattctcat tgatctctaa ggaaaatatt gttcgctttt taaaaacatg atctggtacc
     2761 atttcattga tctctttaag gaagaaaaat cacatggttg tcatgagcat gtaccgacag
     2821 agctaggagg gccagctgtt ccgggttgcc cagggctgtc ttgtttttaa aatggaaagt
     2881 tcgatgtcct ggaaaacccc tcagtcctgg gcaaaccagg tcacgctgga tagaaggagt
     2941 tagacattca tatgatgtgc cgatgtcttg ccagttgtag agttttgtgt aaacctgtgt
     3001 gtggcctgcg tgtccacatg ggtgtgtagg atggcaccta cacacatacc tgaggtcacc
     3061 tcttggtcca gtgagccaga atcctgggac ttcatcatct tttttttttt tttttttgag
     3121 atggaatctc actctgtcac ccaggctgga gggcagtggc gcaatcttgg ctcactgcaa
     3181 cctccgcctc tggggctcaa gcaattctcc tgcctcagcc tcccgagtag ctgggattat
     3241 aggcgtgtgc caccacgccc tgctgatttt tgtatttttt agtagagatg gtgtttcact
     3301 atattggcca ggctggtctt gaactcctga cctcaagtga tctgcctgcc ttggcctccc
     3361 gaaatgctgg ggttacaggc atgagctacc atgcccggcc tcagaatcct gggacttctg
     3421 ctggagccag gggtcagaac agactcctct actgggactg cctggcaggg aggacagacg
     3481 ctcaaggcgg ccccatgaga acacagccac ctggaaaaat ggtggaaggg aagattctgc
     3541 caacctcctc cgactcccta tctcagttac actggtccat aatttctttt ctttttctta
     3601 agtctgtttc attggtttct gttcctggaa aatggacaca attctgatga attcatgtat
     3661 tctgcatcca cgtgtcagca tctccagcct tgtgacgcag tgcctggctc agaacaggca
     3721 atcaggccat ggcatctgaa tgaatgagag ggtgtgccct ggccgtatct caggcagcag
     3781 atgcattcag ctgcaggtaa cagacacgta gacaaacagt ggcttaaaaa agagaggctt
     3841 taaaagtatt ttgtttttct ttcttcacgt agcaagaagt ctggcatttg gcattcccag
     3901 gctgtggcgt gacagctttg tgaagttatc agggtctcag accctgacat atttctgctc
     3961 tgctaccctc agcatgtaga tttgatcttc acggctacaa gaaacctgct gctactgcag
     4021 gcatcttaca cgagttccag gcaggaagag aaaggaaagg gtgacagaga cagaaagcaa
     4081 tgtccccaga tacccttagt tttccatctc ataagccaga atgatgtcac gtggcatccc
     4141 tggatgcaca ggaggctgag agatagtggc gtttgttagc tggtctccta gccatcctga
     4201 atgccaagtt tgttataaag aaacagaggc aaaatggcga tcaggcaggc aactgggtgg
     4261 tctctgccac gggccccttg gccattcttt gtaatgatgg tctttgtctt ggaccctatt
     4321 ttggatattt gggcaccttt gtggtaccct tatgtgctgg ttttgctgtt gtctgccctt
     4381 caggaatagc agctgagtca agctgtcctt ggctgctcca atctggagtc agaggttgga
     4441 gatttccatg gctccccatg gctccttggg gcctcctaag aaaatgtttt aataaggaag
     4501 tccaaggctg agacagacat gctccttctt agagacacat gggaacatgc ctctgctcac
     4561 agctggtagc cacagatgta aaccgtagcc catggaacgg agacagtgaa gaattgatgg
     4621 ataaatgaat aatgatgatg gacagcagat gtataaaagg cataaaagga tagtgttagg
     4681 gctggaatgt cttcccccca attcatatgt tgaaccttta atgcctaata cttcagaaag
     4741 agactgtgtt tgaagatatg gtctttacag agggaataaa gttaaaataa ggtcattagg
     4801 gtgagcccta atccaaagga tgggtgtcct aatcagagga ggagattagg acccagacac
     4861 acacacacac acagagccag gtgaggacac agggagaaaa tggccacgta caagccaaga
     4921 tgagaggact caggaagaac cagccgactc cacccttcaa aactgtgaga acatagatgt
     4981 ctgctgtttg agccaccctg tctgcaagca gtcagcaagc attcattgag tgcttgcagt
     5041 attcaaggca ccacagatac aatgttgaat aaggcaaagc acctgccctc aggtagcttg
     5101 cagtcaggga ggtaagggta gtgggcagag agacctggaa acagatatta gacctgcact
     5161 aagcatgtgt ggttattgaa cagtaaaaat gccaccacaa attgcgatat gatgtaagta
     5221 aaatgcgtac tggctattga agacttggca cagaaaaata atgtaaaatc tcattagtaa
     5281 tggttttata ttgattacgc attgaaataa tactattttg gacagattgg gttaaataaa
     5341 atattaaatt tga
//
