LOCUS       NM_001395421            1374 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens small integral membrane protein 36 (SMIM36), mRNA.
ACCESSION   NM_001395421
VERSION     NM_001395421.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006269.13.
            
            On May 5, 2022 this sequence version replaced NM_001395421.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.4430.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000636752.2/ ENSP00000490644.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               AC006269.13        26816-27389
            575-695             AC006269.13        58688-58808
            696-747             AC006269.13        59455-59506
            748-931             AC006269.13        70940-71123
            932-1374            AC006269.13        87970-88412
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..1374
                     /gene="SMIM36"
                     /note="small integral membrane protein 36"
                     /db_xref="GeneID:101927367"
                     /db_xref="HGNC:HGNC:53654"
     exon            1..574
                     /gene="SMIM36"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..400
                     /gene="SMIM36"
                     /codon_start=1
                     /product="small integral membrane protein 36"
                     /protein_id="NP_001382350.1"
                     /db_xref="CCDS:CCDS92361.1"
                     /db_xref="GeneID:101927367"
                     /db_xref="HGNC:HGNC:53654"
                     /translation="MEFYLEIDPVTLNLIILVASYVILLLVFLISCVLYDCRGKDPSK
                     EYAPEATLEAQPSIRLVVMHPSVAGPHWPKGPGLSLGDPAPLGKKSTMV"
     exon            575..695
                     /gene="SMIM36"
                     /inference="alignment:Splign:2.1.0"
     exon            696..747
                     /gene="SMIM36"
                     /inference="alignment:Splign:2.1.0"
     exon            748..931
                     /gene="SMIM36"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1374
                     /gene="SMIM36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1216..1221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM36"
                     /note="hexamer: TATAAA"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM36"
                     /note="hexamer: AATAAT"
     polyA_site      1249
                     /gene="SMIM36"
     polyA_site      1269
                     /gene="SMIM36"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM36"
                     /note="hexamer: AATAAA"
     polyA_site      1367
                     /gene="SMIM36"
                     /note="major polyA site"
ORIGIN      
        1 gtatttttac tccagagcca atgtagctat tccgatgctc taagatctgc tctctgcaat
       61 gcccaaactg accccaattg cctttctcta gacccacttc tccaccgtgg gagaagtgat
      121 ggaattctac ttggagatcg accctgttac cttgaacctg atcatcctag ttgcgagcta
      181 cgtcatcttg ctcctggtct tcctcatctc ctgcgtgcta tacgactgcc gaggcaagga
      241 tcccagtaag gagtacgcgc ccgaggccac tctcgaggcc cagccctcca tccggttggt
      301 ggtgatgcac ccaagtgtcg ctgggcccca ctggccaaag gggcctggcc tttctttggg
      361 ggatcctgct ccactaggaa agaaaagcac catggtatga ggctggctaa gggacactgg
      421 ggagagacca ctagactttc catagagaca aactgctccc tatcgtggct ccaattctct
      481 cagcacatgt atcccgcttg atgaaggaag tgagagctct gtcttacttg ctgttttctc
      541 gtcaccttct ttgtgacaaa agtaactgtt taagatggag tctcactctg ttgcccaggc
      601 tggagcgcaa tggtgcaatc tcagctcact gcaacctctg cctactggtt caagcaattc
      661 tcctgcctca gcctcccgag tagctgggat tacaggtgtc tgaggagctc cacaaaggtg
      721 tcttaagaga cactgcaaag aaacaaggtg atggaactga ctggccccaa tagaaattag
      781 actgacagct aataaaaaga agcttttgaa tctatagctc ttaacaagcc ccactgctct
      841 ttctgcctgc tgtggcttac tgtcatggga aaccatcctt agggacattt cgtggcctct
      901 ggatgtgggc agacattata acaaacactg taagccagga gtatgaaatc aaggtgtcag
      961 aggggctgta ctccctccga aggctgcagg agaaaatcta ttgcttgcct cttctacctt
     1021 ttggtggttc caggagttcc ttggcttgtg atcacatcac tgaaatctta acctacctgg
     1081 tcatactgct gcctcttctt ctctctcaaa acttctcctg cctctcttca tacttgtgat
     1141 tgcatttagg gtccatctgg gtactccagg aaaaactcct actgtcaaga tttaacttaa
     1201 tcatatctta tgtcatataa agtcatgttc aatattttac aacataaaat aatagtcaca
     1261 gtttctggag ataaggacat gggcgtgtct tttgggggat catccttcaa tccattgcat
     1321 ctatctatca gtgatcaccc caacccaaat aaacccgcat aatattttca ggta
//
