LOCUS       NM_001352885            3123 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens small integral membrane protein 31 (SMIM31), mRNA.
ACCESSION   NM_001352885 NR_038834 XR_109799
VERSION     NM_001352885.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Lu,X., Chen,L., Li,Y., Huang,R., Meng,X. and Sun,F.
  TITLE     Long non-coding RNA LINC01207 promotes cell proliferation and
            migration but suppresses apoptosis and autophagy in oral squamous
            cell carcinoma by the microRNA-1301-3p/lactate dehydrogenase
            isoform A axis
  JOURNAL   Bioengineered 12 (1), 7780-7793 (2021)
   PUBMED   34463208
  REMARK    GeneRIF: Long non-coding RNA LINC01207 promotes cell proliferation
            and migration but suppresses apoptosis and autophagy in oral
            squamous cell carcinoma by the microRNA-1301-3p/lactate
            dehydrogenase isoform A axis.
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Yu,L., Gao,Y., Ji,B., Feng,Z., Li,T. and Luan,W.
  TITLE     CTCF-induced upregulation of LINC01207 promotes gastric cancer
            progression via miR-1301-3p/PODXL axis
  JOURNAL   Dig Liver Dis 53 (4), 486-495 (2021)
   PUBMED   33495099
  REMARK    GeneRIF: CTCF-induced upregulation of LINC01207 promotes gastric
            cancer progression via miR-1301-3p/PODXL axis.
REFERENCE   3  (bases 1 to 3123)
  AUTHORS   Chi,D., Zhang,W., Jia,Y., Cong,D., Yu,K. and Hu,S.
  TITLE     LINC01207 Predicts Poor Prognosis and Suppresses Cell Growth and
            Metastasis via Regulating GSK-3beta/beta-Catenin Signaling Pathway
            in Malignant Glioma
  JOURNAL   Med Sci Monit 26, e923189 (2020)
   PUBMED   32533688
  REMARK    GeneRIF: LINC01207 Predicts Poor Prognosis and Suppresses Cell
            Growth and Metastasis via Regulating GSK-3beta/beta-Catenin
            Signaling Pathway in Malignant Glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3123)
  AUTHORS   Liu,C., Wang,J.O., Zhou,W.Y., Chang,X.Y., Zhang,M.M., Zhang,Y. and
            Yang,X.H.
  TITLE     Long non-coding RNA LINC01207 silencing suppresses AGR2 expression
            to facilitate autophagy and apoptosis of pancreatic cancer cells by
            sponging miR-143-5p
  JOURNAL   Mol Cell Endocrinol 493, 110424 (2019)
   PUBMED   30991076
  REMARK    GeneRIF: LINC01207 was highly expressed in pancreatic cancer.
            Functionally, LINC01207 can bind to miR-143. Its silencing
            down-regulated the expression of AGR2 by up-regulating miR-143.
            Moreover, silencing of LINC01207 and up-regulation of miR-143-5p
            promoted cell apoptosis and autophagy, corresponding to increased
            expression of autophagy- and apoptosis-related proteins, in
            addition to inhibited cell growth.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104620.5 and DA454469.1.
            
            On Jun 23, 2017 this sequence version replaced NR_038834.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095255.1, SRR11853565.22744.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000507311.1/ ENSP00000490699.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC104620.5         27111-27157
            48-594              DA454469.1         1-547
            595-3123            AC104620.5         74247-76775
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..3123
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
                     /note="small integral membrane protein 31"
                     /db_xref="GeneID:100505989"
                     /db_xref="HGNC:HGNC:49638"
     exon            1..281
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
                     /inference="alignment:Splign:2.1.0"
     exon            282..418
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..522
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
                     /note="long intergenic non-protein coding RNA 1207; human
                     epithelial cell program regulator"
                     /codon_start=1
                     /product="small integral membrane protein 31"
                     /protein_id="NP_001339814.1"
                     /db_xref="CCDS:CCDS87279.1"
                     /db_xref="GeneID:100505989"
                     /db_xref="HGNC:HGNC:49638"
                     /translation="MELPYTNLEMAFILLAFVIFSLFTLASIYTTPDDSNEEEEHEKK
                     GREKKRKKSEKKKNCSEEEHRIEAVEL"
     exon            419..3123
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
                     /inference="alignment:Splign:2.1.0"
     regulatory      638..643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
                     /note="hexamer: ATTAAA"
     polyA_site      657
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
     polyA_site      1196
                     /gene="SMIM31"
                     /gene_synonym="h.EPR; LINC01207"
                     /note="major polyA site"
ORIGIN      
        1 gtttccttct tgatccttca caagggaaga ttttcttttt tagaggtaca gattcctctt
       61 agtcaagtcc tgattaaaac tccagctaag acattagtaa gccttggtta gtgaagtggc
      121 atcaggaagt gcctacattt tcatggcctg gtagcgttca gtgaaaatgt tcattaacag
      181 acacaggcca ttcagtcccg aatcccaaga cactgaagac tctgtttgaa tcagactcac
      241 gggttccttc ctagccactc tcagggacag gaatgcttct ggtgaagaag ttttcggtgg
      301 tggttcatgg agcttcccta caccaacttg gaaatggcat tcattttatt ggcttttgtt
      361 atcttttcct tatttaccct ggcttccatc tacactactc cggatgacag taatgaagag
      421 gaagaacatg aaaaaaaggg aagggaaaag aaaaggaaaa agtctgaaaa gaagaaaaat
      481 tgctcagagg aagagcacag aattgaagct gttgagctat gatctcatag ccaccgatat
      541 ttctcgctaa gaagacagag gaagcaatcc atgggaacta cttatccaca gttacacaag
      601 aggaggggat aatgaagaaa gttaaaatca cttactgatt aaacacgatg ataataacca
      661 ttaatgaact caatactcgg gaaaggcttc acatttctgg gactcagcat tatccaaaat
      721 atctattaag agccatacac cattctagct gcaattgatt atacaaaaaa aaaaagacca
      781 aagtggttac aataataaaa tagaacacag agaaagaaga aaactacatg tgttacaatt
      841 tggtaagata aacaaacaaa caaaaaattt aatcactttt tttggtcctg cgacacacat
      901 gataattttt gtcttaattc tcctaacaaa tgataatgaa aagctataag taactgtgtt
      961 attgcttccg tatctgaaat aggtgaaaga gggaaaaaac actatatatt ttttcagctt
     1021 tacagaagaa attttgaaag gtttacattc aatggaaata ttagcattgc ctcagtaagc
     1081 tttaaaacac aaatgtctac gttttctgaa gcaatatggt ttacagagac atgagtgttt
     1141 gtaaatctct cgtcccaata ctatgtaaat ccttaatgtg taagcatcca ggaaaatttg
     1201 tcattctgtg tcctttattc atcctaaaag ttgaaagttt tctgttattt atattttttt
     1261 ttttttaatt tgagagagag gctgggtgca gtggctcacg cctgtaatcc cagcactttg
     1321 ggaggccgag gtgggcagat cacgaggtca ggagattgag accatcctag ctaacacagt
     1381 gaaaccccgt ctctactaaa aatacaaaaa attagccgag cgtggtggcg ggcgcctata
     1441 gtcccatctt ctcgggaagc tgaggcagga gaatggtgtg aacccgggag gcggaggttg
     1501 caatgagctg agatcatgcc actgcactcc agcctgggcg acagagcaag actctgtctc
     1561 aaaagaaaaa aaacaaagag agagagaggg tctcgctttg tcaccgaggc tggagtgcag
     1621 tggtgtaatc atagctcact gcaaccttaa gttcctgggc tcaggtgatc ctcttgcttc
     1681 agcctcccaa gtaactgtga ctacaagcat gtgtcatcac agccagctaa tttttgtaat
     1741 tgtttgtaga accaaggcct ctctatgttg cctaggctgg tctccaaatc ctggactcaa
     1801 gcgatcctct gccttagcct cccaaagcac tgggattaca cgcatgagcc accatgcctg
     1861 gcctgttatt tataactctt acaaacatta aaccatcaca atcaatgctg gcagcattat
     1921 cgtggcagga aggaatccac aatacaacca aagataccta cctgcatctc ataagaatca
     1981 tagctcaggt ctccattgcc acagagtttc agtcatgtga gagactccct ttatctgtac
     2041 ttacccctta ctgctcactt tcaagaaaga ttcaataaag atggctttct gccatacaga
     2101 gataggcata ctagtgtaaa cagaatgctt acaaagttaa ccaagtagtc acccaggtca
     2161 gagtactaaa catttaaaag ggctcactaa gttagagagg acagagaatg ggctttggag
     2221 atgagcagat ctgggtttga gtctgctcca acctttcctt attatatgac cttgggcaaa
     2281 gtacttaatt tctctgagcc ttggtgttct ctctgaaaaa atgagcattt taaaaaatct
     2341 ttgctgggct gacaaatgga tgagagatag tataagtaaa atgtgtaact cagtgcctag
     2401 gatcgttgct gaataacgct acctattatt attggaaagc attttgggac atttggactt
     2461 ttaagtttac tgatacgttt tttcagaaaa gcagaaaaat caacaacatg gtttcaaata
     2521 cttggatgag gctccattca ctcccttagc ccatcttaca tatattactg cattgactgg
     2581 aaatgggagg cacttcacaa ttaggaatat tgtcaggtca gccaggcgcc gtgggcatgc
     2641 ttatagtcca agctactcac aaggctgagg caggaggatc gcttgagcct gggagtttga
     2701 ggctgcagtg agctccagcc tgggtgaaag agaagaccct atctcaaaaa ataaaaaatt
     2761 ttaaaaacct gtcaagttag atgttaaaga ggacatgtaa aataaaatct ccctaacatg
     2821 tttatgaaat agctgcaaaa ggctgagcgt ggtggctcac gtctgaaatc ccagcacttt
     2881 gtgaagccga ggtgggtgga tcacctgagg tcaagagtta gagaccagcc tggccaagat
     2941 ggtgaaacct cctctctact aaaaatacaa aaattagcca ggcgtggtgg tccatgcctg
     3001 taatcctagc tactcaggag gctgaggcag gagaatcact tgaacctggg aggcggaggt
     3061 tgtagtgagc caagattgcg ccattgctct ccagcctggg gagcaaatgc aaaactccat
     3121 ttc
//
