LOCUS       NM_001352688            1011 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens small integral membrane protein 30 (SMIM30),
            transcript variant 2, mRNA.
ACCESSION   NM_001352688 NR_015442
VERSION     NM_001352688.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1011)
  AUTHORS   Shi,T.T., Huang,Y., Li,Y., Dai,X.L., He,Y.H., Ding,J.C., Ran,T.,
            Shi,Y., Yuan,Q., Li,W.J. and Liu,W.
  TITLE     MAVI1, an endoplasmic reticulum-localized microprotein, suppresses
            antiviral innate immune response by targeting MAVS on mitochondrion
  JOURNAL   Sci Adv 9 (35), eadg7053 (2023)
   PUBMED   37656786
REFERENCE   2  (bases 1 to 1011)
  AUTHORS   Yang,J.E., Zhong,W.J., Li,J.F., Lin,Y.Y., Liu,F.T., Tian,H.,
            Chen,Y.J., Luo,X.Y. and Zhuang,S.M.
  TITLE     LINC00998-encoded micropeptide SMIM30 promotes the G1/S transition
            of cell cycle by regulating cytosolic calcium level
  JOURNAL   Mol Oncol 17 (5), 901-916 (2023)
   PUBMED   36495128
  REMARK    GeneRIF: LINC00998-encoded micropeptide SMIM30 promotes the G1/S
            transition of cell cycle by regulating cytosolic calcium level.
REFERENCE   3  (bases 1 to 1011)
  AUTHORS   Pang,Y., Liu,Z., Han,H., Wang,B., Li,W., Mao,C. and Liu,S.
  TITLE     Peptide SMIM30 promotes HCC development by inducing SRC/YES1
            membrane anchoring and MAPK pathway activation
  JOURNAL   J Hepatol 73 (5), 1155-1169 (2020)
   PUBMED   32461121
  REMARK    GeneRIF: Peptide SMIM30 promotes HCC development by inducing
            SRC/YES1 membrane anchoring and MAPK pathway activation.
REFERENCE   4  (bases 1 to 1011)
  AUTHORS   Chen,J., Brunner,A.D., Cogan,J.Z., Nunez,J.K., Fields,A.P.,
            Adamson,B., Itzhak,D.N., Li,J.Y., Mann,M., Leonetti,M.D. and
            Weissman,J.S.
  TITLE     Pervasive functional translation of noncanonical human open reading
            frames
  JOURNAL   Science 367 (6482), 1140-1146 (2020)
   PUBMED   32139545
REFERENCE   5  (bases 1 to 1011)
  AUTHORS   Ye,N., Rao,S., Du,T., Hu,H., Liu,Z., Shen,Y. and Xu,Q.
  TITLE     Intergenic variants may predispose to major depression disorder
            through regulation of long non-coding RNA expression
  JOURNAL   Gene 601, 21-26 (2017)
   PUBMED   27940106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX537645.1 and BU630382.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001352688.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.241495.1,
                                           SRR1660809.126565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397764.8/ ENSP00000490095.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1006              BX537645.1         2-1007
            1007-1011           BU630382.1         17-21               c
FEATURES             Location/Qualifiers
     source          1..1011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.1"
     gene            1..1011
                     /gene="SMIM30"
                     /gene_synonym="LINC00998; MAVI1"
                     /note="small integral membrane protein 30"
                     /db_xref="GeneID:401397"
                     /db_xref="HGNC:HGNC:48953"
     exon            1..27
                     /gene="SMIM30"
                     /gene_synonym="LINC00998; MAVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            28..121
                     /gene="SMIM30"
                     /gene_synonym="LINC00998; MAVI1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1011
                     /gene="SMIM30"
                     /gene_synonym="LINC00998; MAVI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..330
                     /gene="SMIM30"
                     /gene_synonym="LINC00998; MAVI1"
                     /note="long intergenic non-protein coding RNA 998;
                     putative transmembrane protein LINC00998; microprotein in
                     antiviral immunity 1"
                     /codon_start=1
                     /product="small integral membrane protein 30 precursor"
                     /protein_id="NP_001339617.1"
                     /db_xref="CCDS:CCDS87543.1"
                     /db_xref="GeneID:401397"
                     /db_xref="HGNC:HGNC:48953"
                     /translation="MTSVSTQLSLVLMSLLLVLPVVEAVEAGDAIALLLGVVLSITGI
                     CACLGVYARKRNGQM"
     regulatory      986..991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM30"
                     /gene_synonym="LINC00998; MAVI1"
                     /note="hexamer: TATAAA"
     polyA_site      1011
                     /gene="SMIM30"
                     /gene_synonym="LINC00998; MAVI1"
                     /note="major polyA site"
ORIGIN      
        1 attcctgtaa tggctgcttc ctagaaggtc gtgtcacgtg gaacctctta atctcagcat
       61 ccggagctcc aggaagggaa aatttcaagt cagatagaat tctatatata ccatttcttt
      121 ggaaccttca gccctcaaga ttccaacatc atgacctcag tttcaacaca gttgtcctta
      181 gtcctcatgt cactgctttt ggtgctgcct gttgtggaag cagtagaagc cggtgatgca
      241 atcgcccttt tgttaggtgt ggttctcagc attacaggca tttgtgcctg cttgggggta
      301 tatgcacgaa aaagaaatgg acagatgtga ctttgaaagg cctactgagt caaacctcac
      361 cctgaaaacc tttgcgcttt agaggctaaa cctgagattt ggtgtgtgaa aggttccaag
      421 aatcagtaaa taagggagtt tcacattttt cattgtttcc atgaaatggc aacaaacata
      481 catttataaa ttgaaaaaaa aatgttttct ttacaacaaa taatgcacag aaaaatgcag
      541 cctataattt gctagttagg tagtcaaaga agtaagatgg ctgaaattta cataagtaat
      601 atttcataat cttagaattc tctcaaagca tgtgaaatag gaagaaggaa gttcttgccc
      661 agaatcttag gaaatcacca ctgttcggtt ataatcactg cctcctgaat cgttgaggag
      721 tcttttaaat tagatttttg ttttgttgtc tcccaagtta atattatatt tagatatcag
      781 agagtcaggc aaaaaggaaa acttttatct ctagggaaaa aacatttaga aaaatgtatt
      841 cagtgtatct aatactgaaa tgcggaaaaa aatttaatgt taaaaaaaaa ctatagacat
      901 tgacatggaa aagagattta atgttttgaa aaaaaacttt atattaactg agtaacatcc
      961 tcctgatgag aagtactata ttaaatataa acccattatg ttataagtta a
//
