LOCUS       NM_032947               1521 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens small integral membrane protein 3 (SMIM3), mRNA.
ACCESSION   NM_032947
VERSION     NM_032947.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1521)
  AUTHORS   Liu,Y., Chen,Y., Liu,Y., Li,M., Zhang,Y., Shi,L., Yang,L., Li,T.,
            Li,Y., Jiang,Z., Liu,Y., Wang,C. and Wang,S.
  TITLE     Downregulation of SMIM3 inhibits growth of leukemia via PI3K-AKT
            signaling pathway and correlates with prognosis of adult acute
            myeloid leukemia with normal karyotype
  JOURNAL   J Transl Med 20 (1), 612 (2022)
   PUBMED   36550462
  REMARK    GeneRIF: Downregulation of SMIM3 inhibits growth of leukemia via
            PI3K-AKT signaling pathway and correlates with prognosis of adult
            acute myeloid leukemia with normal karyotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1521)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1521)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   4  (bases 1 to 1521)
  AUTHORS   Vician,L., Silver,A.L., Farias-Eisner,R. and Herschman,H.R.
  TITLE     NID67, a small putative membrane protein, is preferentially induced
            by NGF in PC12 pheochromocytoma cells
  JOURNAL   J Neurosci Res 64 (2), 108-120 (2001)
   PUBMED   11288140
  REMARK    GeneRIF: Reports cloning of rat NID67 and discussion of mouse and
            human orthologs.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC106040.1.
            
            On Aug 11, 2020 this sequence version replaced NM_032947.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125286.1, AK027847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000526627.2/ ENSP00000436897.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1521              BC106040.1         465-1985
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..1521
                     /gene="SMIM3"
                     /gene_synonym="C5orf62; MST150; NID67"
                     /note="small integral membrane protein 3"
                     /db_xref="GeneID:85027"
                     /db_xref="HGNC:HGNC:30248"
                     /db_xref="MIM:608324"
     exon            1..216
                     /gene="SMIM3"
                     /gene_synonym="C5orf62; MST150; NID67"
                     /inference="alignment:Splign:2.1.0"
     exon            217..1521
                     /gene="SMIM3"
                     /gene_synonym="C5orf62; MST150; NID67"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..410
                     /gene="SMIM3"
                     /gene_synonym="C5orf62; MST150; NID67"
                     /note="NGF-induced differentiation clone 67 protein; small
                     membrane protein NID67; Uncharacterized protein C5orf62"
                     /codon_start=1
                     /product="small integral membrane protein 3"
                     /protein_id="NP_116565.3"
                     /db_xref="CCDS:CCDS47312.2"
                     /db_xref="GeneID:85027"
                     /db_xref="HGNC:HGNC:30248"
                     /db_xref="MIM:608324"
                     /translation="MDAVSQVPMEVVLPKHILDIWVIVLIILATIVIMTSLLLCPATA
                     VIIYRMRTHPILSGAV"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM3"
                     /gene_synonym="C5orf62; MST150; NID67"
                     /note="hexamer: AATAAA"
     polyA_site      1521
                     /gene="SMIM3"
                     /gene_synonym="C5orf62; MST150; NID67"
                     /note="major polyA site"
ORIGIN      
        1 gcattccaga gccagcagcg cgtcctggcc gctcctgcgc tctcccgcct cccggggctc
       61 ggaggagccg gggcacgttc caggagctgc ctagggctga ggttccaggc ctgggggtcg
      121 cttccagctg ccagatcccg tgcagtcctg gggaccctga gaagcaccga gccatccctg
      181 acccaggaac tttccgcaga ctcgccgcca tctgggagtg aagcaacatg gatgcagtca
      241 gccaagtccc catggaagtc gtgcttccca agcacatcct ggatatctgg gttattgtcc
      301 tcatcatcct ggccaccatt gtcatcatga cctcgttgtt gctgtgccca gccactgcag
      361 taatcatcta tcgcatgcgg actcatccga tccttagtgg ggctgtttga gagcctccca
      421 agagggccgg gtgagggatg aggacaggca tcctatcccc agcctcttcc tgtcttcaga
      481 aaagcagcag gagggacttt ggggcatgga cctgagttct ggttttgatt ctgccacgag
      541 ccagctgtgt gaatttggtc aagggaccta actctctgag ttccaggttc cttatctttc
      601 aaatggggat ggtgatccct gccctttcta cctcataggg atgtgagaac cacctgactt
      661 agtggatgtg aaagctgttt gtgatcagta aagctaccac agatataagg gtgttatgct
      721 gaatcctgag aagctttcaa gaaccagaga acctgattgc tgatgatggc cttaaaggtg
      781 gtgagggaga tactgggggc agagcagact ttgccagtgc ccctcaggtc aaaccaagcc
      841 aagagcaccc tgtccccatt ccaaggggcc agcagcactt tggcccaaag tattttcttt
      901 aaggtgccat tccttcatgt tttctcagtt tggagggtga tgggtagagc tttccagaac
      961 cttctccatt ccagaatctc tgcccctgtg taatctgaag gaaggctgtg ccatctttgg
     1021 gcactgccaa gggagttggg gtgatgggct tctttctgca ctggagtctc acatctgtta
     1081 gctttgacac tcaagcaatg ttggaaaatg cagggtgact gagttccctg cccagctttc
     1141 gggatctctg gcccccatcc ccttgtgtgt gtccctctgc ccagctcctg ctgtaattag
     1201 ctccacgtgt acccccttca ctccctccca ccagctctgc agccagccta tggcaattat
     1261 attttaagag gtgttcccag gacttttggg acctactaaa acaatgatgg ttattttaga
     1321 tgtgatgatt tatatttatg tagagatatt tctggaccac tcaagctctt cgataccaaa
     1381 atcaggagca tcttgggatt tattaaatta tgtaagaaga tagcacagat atcgggatat
     1441 tattgtgtga aaatgctgct tttactttga tgtgatctca ttgatgtaca caaccaagtt
     1501 ccaataaagt gctagaatgt g
//
