LOCUS       NM_001387564             360 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens small integral membrane protein 27 (SMIM27),
            transcript variant 5, mRNA.
ACCESSION   NM_001387564
VERSION     NM_001387564.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 360)
  AUTHORS   Chen,J., Brunner,A.D., Cogan,J.Z., Nunez,J.K., Fields,A.P.,
            Adamson,B., Itzhak,D.N., Li,J.Y., Mann,M., Leonetti,M.D. and
            Weissman,J.S.
  TITLE     Pervasive functional translation of noncanonical human open reading
            frames
  JOURNAL   Science 367 (6482), 1140-1146 (2020)
   PUBMED   32139545
REFERENCE   2  (bases 1 to 360)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353671.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW594246.1, HY229246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692500.1/ ENSP00000508648.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AL353671.6         90281-90433
            154-360             AL353671.6         90755-90961
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.1"
     gene            1..360
                     /gene="SMIM27"
                     /gene_synonym="C9orf133; TOPORS-AS1"
                     /note="small integral membrane protein 27"
                     /db_xref="GeneID:100129250"
                     /db_xref="HGNC:HGNC:31420"
     exon            1..153
                     /gene="SMIM27"
                     /gene_synonym="C9orf133; TOPORS-AS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..276
                     /gene="SMIM27"
                     /gene_synonym="C9orf133; TOPORS-AS1"
                     /note="TOPORS antisense RNA 1 (non-protein coding)"
                     /codon_start=1
                     /product="small integral membrane protein 27"
                     /protein_id="NP_001374493.1"
                     /db_xref="CCDS:CCDS87647.1"
                     /db_xref="GeneID:100129250"
                     /db_xref="HGNC:HGNC:31420"
                     /translation="MKPVSRRTLDWIYSVLLLAIVLISWGCIIYASMVSARRQLRKKY
                     PDKIFGTNENL"
     exon            154..360
                     /gene="SMIM27"
                     /gene_synonym="C9orf133; TOPORS-AS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      338..343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM27"
                     /gene_synonym="C9orf133; TOPORS-AS1"
                     /note="hexamer: AATAAA"
     polyA_site      360
                     /gene="SMIM27"
                     /gene_synonym="C9orf133; TOPORS-AS1"
                     /note="major polyA site"
ORIGIN      
        1 gtgcccggct aaaagatggc tgctggcgcc tggcagccac cgcctgggag gttactgtaa
       61 ggcccgcagc tcccgccagc tcccgcggac tgctgccgcc tccttaccat gaagccagta
      121 agtcgtcgca cgctggactg gatttattca gtgttgctgc ttgccatcgt tttaatctcc
      181 tggggctgca tcatctatgc ttcgatggtg tctgcaagac gacagctaag gaagaaatac
      241 ccagacaaaa tctttgggac gaatgaaaat ttgtaactct tctggattta attatctgaa
      301 aatacagttc tttccctcat gcttatgtag atataaaaat aaaattcata atgcaaagtt
//
