LOCUS       NM_001348957             490 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens small integral membrane protein 26 (SMIM26),
            transcript variant 1, mRNA.
ACCESSION   NM_001348957
VERSION     NM_001348957.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Meng,K., Lu,S., Li,Y.Y., Hu,L.L., Zhang,J., Cao,Y., Wang,Y.,
            Zhang,C.Z. and He,Q.Y.
  TITLE     LINC00493-encoded microprotein SMIM26 exerts anti-metastatic
            activity in renal cell carcinoma
  JOURNAL   EMBO Rep 24 (6), e56282 (2023)
   PUBMED   37009826
  REMARK    GeneRIF: LINC00493-encoded microprotein SMIM26 exerts
            anti-metastatic activity in renal cell carcinoma.
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Konina,D., Sparber,P., Viakhireva,I., Filatova,A. and Skoblov,M.
  TITLE     Investigation of LINC00493/SMIM26 Gene Suggests Its Dual
            Functioning at mRNA and Protein Level
  JOURNAL   Int J Mol Sci 22 (16), 8477 (2021)
   PUBMED   34445188
  REMARK    GeneRIF: Investigation of LINC00493/SMIM26 Gene Suggests Its Dual
            Functioning at mRNA and Protein Level.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 490)
  AUTHORS   Yeasmin,F., Imamachi,N., Tanu,T., Taniue,K., Kawamura,T., Yada,T.
            and Akimitsu,N.
  TITLE     Identification and analysis of short open reading frames (sORFs) in
            the initially annotated noncoding RNA LINC00493 from human cells
  JOURNAL   J Biochem 169 (4), 421-434 (2021)
   PUBMED   33386847
  REMARK    GeneRIF: Identification and analysis of short open reading frames
            (sORFs) in the initially annotated noncoding RNA LINC00493 from
            human cells.
REFERENCE   4  (bases 1 to 490)
  AUTHORS   Cogill,S.B. and Wang,L.
  TITLE     Co-expression Network Analysis of Human lncRNAs and Cancer Genes
  JOURNAL   Cancer Inform 13 (Suppl 5), 49-59 (2014)
   PUBMED   25392693
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK024594.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001348957.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024594.1, CB105385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000411646.2/ ENSP00000485316.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               AK024594.1         4-493
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..490
                     /gene="SMIM26"
                     /gene_synonym="LINC00493"
                     /note="small integral membrane protein 26"
                     /db_xref="GeneID:388789"
                     /db_xref="HGNC:HGNC:43430"
     exon            1..165
                     /gene="SMIM26"
                     /gene_synonym="LINC00493"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..335
                     /gene="SMIM26"
                     /gene_synonym="LINC00493"
                     /note="isoform 1 is encoded by transcript variant 1; long
                     intergenic non-protein coding RNA 493"
                     /codon_start=1
                     /product="small integral membrane protein 26 isoform 1"
                     /protein_id="NP_001335886.1"
                     /db_xref="CCDS:CCDS86936.1"
                     /db_xref="GeneID:388789"
                     /db_xref="HGNC:HGNC:43430"
                     /translation="MYRNEFTAWYRRMSVVYGIGTWSVLGSLLYYSRTMAKSSVDQKD
                     GSASEVPSELSERPKGFYVETVVTYKEDFVPNTEKILNYWKSWTGGPGTEP"
     exon            166..490
                     /gene="SMIM26"
                     /gene_synonym="LINC00493"
                     /inference="alignment:Splign:2.1.0"
     regulatory      468..473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM26"
                     /gene_synonym="LINC00493"
                     /note="hexamer: AATAAA"
     polyA_site      490
                     /gene="SMIM26"
                     /gene_synonym="LINC00493"
                     /note="major polyA site"
ORIGIN      
        1 gcctctgccg tgggcctgcg agaatcgagg cactcgctgg cgtacccatg tatcgaaatg
       61 agttcacggc ctggtaccgg cggatgtcgg tggtctacgg gatcggcacc tggtctgtgt
      121 tgggctcact gctttactat agccggacaa tggcgaagtc gtcagtagac caaaaggatg
      181 gctcagcaag tgaagtaccc agtgaactct ctgaacgccc aaaaggattt tatgtggaaa
      241 cagttgtcac atataaagaa gattttgttc caaatacaga aaagatcctc aactattgga
      301 aatcatggac tggtggccct ggtacagaac catgactggc tgctgaattc tgaaaaccag
      361 gacttggttc aacatttaaa tttgatagtt gccctgattc ccattttggg tttgtgaaaa
      421 gtgtatgtat ttaaatttgc tgtaaaacat aatcactaat aatatgcaat aaatattttc
      481 ttgaaggaaa
//
