LOCUS       NM_001253794             628 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens small integral membrane protein 22 (SMIM22),
            transcript variant 4, mRNA.
ACCESSION   NM_001253794
VERSION     NM_001253794.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 628)
  AUTHORS   Polycarpou-Schwarz,M., Gross,M., Mestdagh,P., Schott,J.,
            Grund,S.E., Hildenbrand,C., Rom,J., Aulmann,S., Sinn,H.P.,
            Vandesompele,J. and Diederichs,S.
  TITLE     The cancer-associated microprotein CASIMO1 controls cell
            proliferation and interacts with squalene epoxidase modulating
            lipid droplet formation
  JOURNAL   Oncogene 37 (34), 4750-4768 (2018)
   PUBMED   29765154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020663.1, BI767985.1, AA507469.1 and CK903133.1.
            
            On May 17, 2019 this sequence version replaced NM_001253794.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. This results in a longer protein (isoform 2),
            compared to isoform 1. Both variants 2 and 4 encode the same
            isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138519.494149.1,
                                           DRR138512.372518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586005.6/ ENSP00000464748.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC020663.1         88130-88138
            10-52               BI767985.1         1-43
            53-96               AA507469.1         329-372             c
            97-97               AC020663.1         88491-88491
            98-264              AA507469.1         161-327             c
            265-265             AC020663.1         88748-88748
            266-418             AA507469.1         7-159               c
            419-628             CK903133.1         320-529
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..628
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /note="small integral membrane protein 22"
                     /db_xref="GeneID:440335"
                     /db_xref="HGNC:HGNC:48329"
     exon            1..81
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..225
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..368
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="small integral membrane protein 22 isoform 2"
                     /protein_id="NP_001240723.1"
                     /db_xref="CCDS:CCDS59259.1"
                     /db_xref="GeneID:440335"
                     /db_xref="HGNC:HGNC:48329"
                     /translation="MAVSTEELEATVQEVLGRLKSHQFFQSTWDTVAFIVFLTFMGTV
                     LLLLLLVVAHCCCCSSPGPRRESPRKVSPWKERPKGVDNLALEP"
     exon            226..326
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..628
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      395..400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /note="hexamer: AACAAA"
     polyA_site      418
                     /gene="SMIM22"
                     /gene_synonym="CASIMO1"
                     /note="major polyA site"
ORIGIN      
        1 aggtggtgtg gagccggaag caggaagcag cctgtgctcc ccaggacctg cctggttggg
       61 ggaattggag gcttctagga ggtggcacgg tgcacgccaa gatggctgtg tccacagagg
      121 agctggaggc cacggttcag gaagtcctgg ggagactgaa gagccaccag tttttccagt
      181 ccacatggga cactgttgcc ttcattgttt tcctcacctt catgggcacc gtgctgctcc
      241 tgctgctgct ggtcgtcgcc cactgctgct gctgcagctc ccccgggccc cgcagggaaa
      301 gccccaggaa ggtgagcccc tggaaggaaa gacccaaggg agtggataac ttggccctgg
      361 aaccctgacc ctgtgtctcc tgcccggtgg cagtaacaaa gccttctgtc tgcccagagc
      421 ctgagtctgc agtgtcttcc agtccccgtc tgggtgggtg acgcgggact cgccgcccca
      481 ctcaggtggc cacctggcct ctccaagcct tcagtcagca cgactgtgcc aggtcatcct
      541 cagtcaccta gctgggaggg gagctggtct caggccgggc gcggtggctc acacctataa
      601 tcccagcact ttgggaggcc gaggtggg
//
