LOCUS       NM_001303482            2576 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens small integral membrane protein 21 (SMIM21),
            transcript variant 2, mRNA.
ACCESSION   NM_001303482
VERSION     NM_001303482.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2576)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2576)
  AUTHORS   Bossini-Castillo,L., de Kovel,C., Kallberg,H., van 't Slot,R.,
            Italiaander,A., Coenen,M., Tak,P.P., Posthumus,M.D., Wijmenga,C.,
            Huizinga,T., van der Helm-van Mil,A.H., Stoeken-Rijsbergen,G.,
            Rodriguez-Rodriguez,L., Balsa,A., Gonzalez-Alvaro,I.,
            Gonzalez-Gay,M.A., Gomez-Vaquero,C., Franke,B., Vermeulen,S., van
            der Horst-Bruinsma,Ie., Dijkmans,B.A., Wolbink,G.J., Ophoff,R.A.,
            Maehlen,M.T., van Riel,P., Merriman,M., Klareskog,L., Lie,B.A.,
            Merriman,T., Crusius,J.B., Brouwer,E., Martin,J., de Vries,N.,
            Toes,R., Padyukov,L. and Koeleman,B.P.
  CONSRTM   LifeLines Cohort Study
  TITLE     A genome-wide association study of rheumatoid arthritis without
            antibodies against citrullinated peptides
  JOURNAL   Ann Rheum Dis 74 (3), e15 (2015)
   PUBMED   24532677
REFERENCE   3  (bases 1 to 2576)
  AUTHORS   Daviss,W.B., O'Donnell,L., Soileau,B.T., Heard,P., Carter,E.,
            Pliszka,S.R., Gelfond,J.A., Hale,D.E. and Cody,J.D.
  TITLE     Mood disorders in individuals with distal 18q deletions
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (8), 879-888 (2013)
   PUBMED   24006251
REFERENCE   4  (bases 1 to 2576)
  AUTHORS   Mark,P.R., Radlinski,B.C., Core,N., Fryer,A., Kirk,E.P. and
            Haldeman-Englert,C.R.
  TITLE     Narrowing the critical region for congenital vertical talus in
            patients with interstitial 18q deletions
  JOURNAL   Am J Med Genet A 161A (5), 1117-1121 (2013)
   PUBMED   23495172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093452.1, BC037871.2, AC116003.7, BX117297.1 and AW118572.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001303482.1.
            
            Transcript Variant: This variant (2) uses an alternate 3' terminal
            exon compared to variant 1. The encoded isoform (2) is shorter, and
            contains a distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037871.2, BI828108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK093452.1         1-25
            26-518              BC037871.2         5-497
            519-1925            AC116003.7         161582-162988       c
            1926-2283           BX117297.1         35-392
            2284-2490           BC037871.2         2263-2469
            2491-2576           AW118572.1         4-89                c
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..2576
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /note="small integral membrane protein 21"
                     /db_xref="GeneID:284274"
                     /db_xref="HGNC:HGNC:27598"
     exon            1..269
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..404
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="small integral membrane protein 21 isoform 2"
                     /protein_id="NP_001290411.1"
                     /db_xref="CCDS:CCDS77200.1"
                     /db_xref="GeneID:284274"
                     /db_xref="HGNC:HGNC:27598"
                     /translation="MDQYVSTAPPRFPIAQLGTFKQDSAGMGRIFKGNLLQKKALTTF
                     ENEHHIRFFTLLVLFHVMVLLRNHSRIQGVSEDWKRANSIFRK"
     exon            270..400
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /inference="alignment:Splign:2.1.0"
     exon            401..2576
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatacccaga tcttcaaggt tggcaaagaa gagaaaagct ccttgggaac ttagttacca
       61 ggtcttatag caccagctct gtgtcctcag agtcgctgtc atcaaggaga cctctcactg
      121 gtcaccgccg cagcccccac atggaccagt atgtgtccac agctcctccc cgattcccta
      181 tagcacagct gggaacattt aaacaagact ctgcaggaat gggacggata ttcaagggga
      241 atttgctgca gaagaaagca cttaccacat ttgaaaatga acaccatatt cgtttcttca
      301 cattgttggt tcttttccat gtgatggtgt tgctgaggaa tcatagcagg atacaagggg
      361 tttctgaaga ctggaaaagg gccaacagca tatttcgaaa gtaaaaaact ccttctttct
      421 cccactgtag gctttttgtg ttttcaacat acccagcctc actcggaaaa ataaaaataa
      481 aaataaagca cccactcaca tgagcagcca agtttcagat accagtgggc acaagctctt
      541 ccaaatgtct cctgttctgg agatgttcac agtcctcaca tcaaaactga aacaagcaaa
      601 caaaaaaata aaaagcttac taccaaatac cctaggaata agacttaaac tctatttgga
      661 aattgaattt cttccatagt caatcaatat ttaataaaga gagaaaagga gctcattaca
      721 aagaccatct tgtttctcca caagtcatct atgtgagatt ccagaatttc agggcgataa
      781 gttcttaatt ggaacattat atattctctt tgcagccagt aagtacgcat cacttcacga
      841 gaaagcactg cggccaacat ttctcctggt ctgctctggg tttcagtgaa gggcaggcct
      901 ggaagcacct tgggaaatga ggtagagcca agctaaccct agagagccgt tgagcttacg
      961 gagggttgag tgattacgca ggcatagtct tgagttttat tttcagtttg aatactgcta
     1021 actagtctgt acagtcacag gcttactata gggagtttat tctacatcag ctatattctc
     1081 tcttccttag cagcacttaa tgagttggct ggaaagttgt tcccagccaa gccaatatcc
     1141 catgagttat aaatgacatt tcatgctcat atgcagattt tctgcaccga agtgaattat
     1201 ttacaaggta ggccttatgg attccaacag tcagctgcct gagatttaca cctacccgtt
     1261 ctctctactc tcttgctggg agaatgtgac gtctcccact gccctttaac atctgaagat
     1321 ttagcgggag ctgcccttcc tgaggcaggt gctcccttgc ttgagatggc aactggaaag
     1381 gccatgcacc ctggaagctg gaaggtaaac tgaggctctc ccagaggtgc ttctcctgcc
     1441 cggggaggat gctgtccgca tgcaaatgca cacgaggagc accaggaaga atttaagttc
     1501 tggggaggcc ttcctgccca ttaacaggga ttttattacc ttgggtttta gctacttagt
     1561 ttaataattt cttcctgaat gtgcgaaaat ccaaattttc tcctaaagga agctctgtgt
     1621 tcagcagtgt gctctgtcct ctgtggaaca gaagaaccaa catgtcgttt ctacctccca
     1681 ggaactccag gggttgaaaa gcctcccaac ttacagcaag gatgatgaaa atataagtaa
     1741 gagttcggca ccagacaaat ccaccaatgg aacaaaaaaa gcagcacaga caccagacac
     1801 caagttaagt acacaagggt ctctaatcta tgataaaatc agcatttaaa attagcaaaa
     1861 agtatggttt tttaaatatg ttgaatgaga acaactgact atgcatttgg aaaaagtaag
     1921 atgaagatcc ctaccttata ttatcaacaa aaatacatgt atgttgaatc aaagacctaa
     1981 atgtaaaaat aaaatccaaa gaatactgga agaaaagatg gaggaacatt tctgtagcct
     2041 tgcagtgaga gtaaacaaaa ggaaagaagg gacttaccaa attttataaa ctttttccca
     2101 ataaaaacca gactaaacaa aattaaaacg taagtgacaa acaagggagg gaaaacattt
     2161 acaactgact attaatatcc catattcaga gaaatccaac tcattggaag aaaatgacag
     2221 acaataccct aaagggataa agaatactta taggcaaaaa agaagtacac acggcaaata
     2281 aatctgtgaa aagatgctca accacggtat tgattaaagg aataaggaag tgaataacaa
     2341 caaaatagtt tttgccaaat ctgattgtca acatgtcata tattgttaac attgattgct
     2401 gtcgaggctg tgaaaaacta ggcagcttca taattgttgg caggaacaac caactgctac
     2461 aaacattttg ggggcaattt ggaattatct aataaaatat atttgcatac cctttggcca
     2521 tgccatttca cttttacgga tctaacaaaa aataaaataa aaacattata aaggta
//
