LOCUS       NM_001037331            1834 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens small integral membrane protein 21 (SMIM21),
            transcript variant 1, mRNA.
ACCESSION   NM_001037331 XM_378756
VERSION     NM_001037331.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Bossini-Castillo,L., de Kovel,C., Kallberg,H., van 't Slot,R.,
            Italiaander,A., Coenen,M., Tak,P.P., Posthumus,M.D., Wijmenga,C.,
            Huizinga,T., van der Helm-van Mil,A.H., Stoeken-Rijsbergen,G.,
            Rodriguez-Rodriguez,L., Balsa,A., Gonzalez-Alvaro,I.,
            Gonzalez-Gay,M.A., Gomez-Vaquero,C., Franke,B., Vermeulen,S., van
            der Horst-Bruinsma,Ie., Dijkmans,B.A., Wolbink,G.J., Ophoff,R.A.,
            Maehlen,M.T., van Riel,P., Merriman,M., Klareskog,L., Lie,B.A.,
            Merriman,T., Crusius,J.B., Brouwer,E., Martin,J., de Vries,N.,
            Toes,R., Padyukov,L. and Koeleman,B.P.
  CONSRTM   LifeLines Cohort Study
  TITLE     A genome-wide association study of rheumatoid arthritis without
            antibodies against citrullinated peptides
  JOURNAL   Ann Rheum Dis 74 (3), e15 (2015)
   PUBMED   24532677
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Daviss,W.B., O'Donnell,L., Soileau,B.T., Heard,P., Carter,E.,
            Pliszka,S.R., Gelfond,J.A., Hale,D.E. and Cody,J.D.
  TITLE     Mood disorders in individuals with distal 18q deletions
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (8), 879-888 (2013)
   PUBMED   24006251
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Mark,P.R., Radlinski,B.C., Core,N., Fryer,A., Kirk,E.P. and
            Haldeman-Englert,C.R.
  TITLE     Narrowing the critical region for congenital vertical talus in
            patients with interstitial 18q deletions
  JOURNAL   Am J Med Genet A 161A (5), 1117-1121 (2013)
   PUBMED   23495172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093452.1 and AC116003.7.
            
            On Jan 7, 2015 this sequence version replaced NM_001037331.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093452.1, BC107486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579022.5/ ENSP00000462106.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               AK093452.1         1-299
            300-300             AC116003.7         163800-163800       c
            301-666             AK093452.1         301-666
            667-667             AC116003.7         155557-155557       c
            668-1471            AK093452.1         668-1471
            1472-1651           AC116003.7         154573-154752       c
            1652-1834           AK093452.1         1654-1836
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..1834
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /note="small integral membrane protein 21"
                     /db_xref="GeneID:284274"
                     /db_xref="HGNC:HGNC:27598"
     exon            1..269
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..446
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="small integral membrane protein 21 isoform 1"
                     /protein_id="NP_001032408.1"
                     /db_xref="CCDS:CCDS32845.1"
                     /db_xref="GeneID:284274"
                     /db_xref="HGNC:HGNC:27598"
                     /translation="MDQYVSTAPPRFPIAQLGTFKQDSAGMGRIFKGNLLQKKALTTF
                     ENEHHIRFFTLLVLFHVMVLLRNHSRIQGVSEDWKRANSIFRNFLRLKSSRNTAEAE"
     exon            270..400
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /inference="alignment:Splign:2.1.0"
     exon            401..1834
                     /gene="SMIM21"
                     /gene_synonym="C18orf62"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatacccaga tcttcaaggt tggcaaagaa gagaaaagct ccttgggaac ttagttacca
       61 ggtcttatag caccagctct gtgtcctcag agtcgctgtc atcaaggaga cctctcactg
      121 gtcaccgccg cagcccccac atggaccagt atgtgtccac agctcctccc cgattcccta
      181 tagcacagct gggaacattt aaacaagact ctgcaggaat gggacggata ttcaagggga
      241 atttgctgca gaagaaagca cttaccacat ttgaaaatga acaccatatt cgtttcttca
      301 cattgttggt tcttttccat gtgatggtgt tgctgaggaa tcatagcagg atacaagggg
      361 tttctgaaga ctggaaaagg gccaacagca tatttcgaaa ctttctacgt ttgaagtcat
      421 ccaggaacac agcagaagca gaataaatga cactacgttt ctctctcatg gccttcatac
      481 catggatttc ccctgctcaa gatgaaaaga aattaagagg aaatcagatt gcttagagat
      541 agcagattat tgctcacttt ttaaaaggag ctccacagag agaatgaaga acgtgtaact
      601 ttttgcaatg ataatgtctg ctttgttctt gaggggcact cttccttttt ctgttcagga
      661 atattccgga ggagagctgc agatgccacc caaccctgcg aaatctgccc tgcgtgtcga
      721 aacagatcca gcagtgcaaa gaacttcttc attaggacat caagcctgta gtcatatttt
      781 caattgctgc tgtaactttt tccttgcaag tgctttcact tatttcggga ccacctaagg
      841 ctctgtgtgg tatacagcaa cacagtttga gatatttctg tgatgttctg tatatcatat
      901 agttgctaac aacctgtcaa agtcatcctg acaccaaact gagaagctga tggtttgggt
      961 aacatattag aggagatgaa aaaaccgaca gtcctcatta ctgtaataaa accagcagag
     1021 acacactgag aatcaattac tgattgtgac ctaatgaact aaccctcagt caagtagaaa
     1081 actgcaccaa gcctcttaca ttatcaaatg atttaggatg gagcactgtc tgaagacggg
     1141 caacaagtcg aggcagatga gttttcttat attgtggctg acttaattac cttgttcctg
     1201 agtgcagaga tcaaattgag caacttaagg tgctaaagct ctgtgccagc tggaaatgaa
     1261 aaggaaataa ttaacaccaa caagagctac gtctaaggtt gtggcacctc ctgacagaag
     1321 caaggagact caaagttaag gcggctgcaa agtccttgac gaggtgagcc ctgctctatc
     1381 cgcctggctg gattcgtcca ggttgcctgt ggcagctgtg cactgaagag tccggctggg
     1441 gagccaggga ttcagaactc acagtgcagc ctgacgacca aagggcaaat ccacctgagg
     1501 acctgagtgc agatggctgg gctccccgga acaaagtgga ggaatgacag aggtgtaact
     1561 cttacaccac agcctccatc tgtgtgtcgc agagaaaaat actataatgg agactattct
     1621 tacacacata cacacacaca cacacacaca gagttcttgt caccgatgga acagtctgtc
     1681 tttgtctttc atctcccaca ttcatgtcca gatcccattg cgctgcatca cacgtgaacc
     1741 cagtgaggtc aacaatgaat ggatggtgtt cacaaagaaa ccagcttatg gaaggggacc
     1801 tgttacaatt ctttgaatta agttcttgga agcc
//
