LOCUS       NM_001145432             919 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens small integral membrane protein 20 (SMIM20),
            transcript variant 1, mRNA.
ACCESSION   NM_001145432 XR_040593 XR_040594 XR_040595
VERSION     NM_001145432.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 919)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 919)
  AUTHORS   Yuan,T., Sun,Z., Zhao,W., Wang,T., Zhang,J. and Niu,D.
  TITLE     Phoenixin: A Newly Discovered Peptide with Multi-Functions
  JOURNAL   Protein Pept Lett 24 (6), 472-475 (2017)
   PUBMED   28176660
  REMARK    Review article
REFERENCE   3  (bases 1 to 919)
  AUTHORS   Dennerlein,S., Oeljeklaus,S., Jans,D., Hellwig,C., Bareth,B.,
            Jakobs,S., Deckers,M., Warscheid,B. and Rehling,P.
  TITLE     MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint
            during Cytochrome c Oxidase Assembly
  JOURNAL   Cell Rep 12 (10), 1644-1655 (2015)
   PUBMED   26321642
  REMARK    GeneRIF: MITRAC7 affects the biogenesis pathway by stabilizing
            newly synthesized COX1 in assembly intermediates, concomitantly
            preventing turnover.
            GeneRIF: SMIM20 (MITRAC7) is a COX1 specific chaperone which is
            necessary for cytochrome c oxidase biogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133961.3.
            
            On Apr 1, 2021 this sequence version replaced NM_001145432.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086307.1, BQ574842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000506197.3/ ENSP00000427407.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC133961.3         118606-118808
            204-260             AC133961.3         132699-132755
            261-919             AC133961.3         133540-134198
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..919
                     /gene="SMIM20"
                     /gene_synonym="C4orf52; MITRAC7; PNX"
                     /note="small integral membrane protein 20"
                     /db_xref="GeneID:389203"
                     /db_xref="HGNC:HGNC:37260"
                     /db_xref="MIM:617465"
     exon            1..203
                     /gene="SMIM20"
                     /gene_synonym="C4orf52; MITRAC7; PNX"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..298
                     /gene="SMIM20"
                     /gene_synonym="C4orf52; MITRAC7; PNX"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial translation regulation assembly intermediate
                     of cytochrome c oxidase protein of 7 kDa; phoenixin"
                     /codon_start=1
                     /product="small integral membrane protein 20 isoform 1"
                     /protein_id="NP_001138904.1"
                     /db_xref="CCDS:CCDS47038.1"
                     /db_xref="GeneID:389203"
                     /db_xref="HGNC:HGNC:37260"
                     /db_xref="MIM:617465"
                     /translation="MSRNLRTALIFGGFISLIGAAFYPIYFRPLMRLEEYKKEQAINR
                     AGIVQEDVQPPGLKVWSDPFGRK"
     exon            204..260
                     /gene="SMIM20"
                     /gene_synonym="C4orf52; MITRAC7; PNX"
                     /inference="alignment:Splign:2.1.0"
     exon            261..919
                     /gene="SMIM20"
                     /gene_synonym="C4orf52; MITRAC7; PNX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM20"
                     /gene_synonym="C4orf52; MITRAC7; PNX"
                     /note="hexamer: ATTAAA"
     polyA_site      919
                     /gene="SMIM20"
                     /gene_synonym="C4orf52; MITRAC7; PNX"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccgag cggggtcacg gcccggccgt cggtaacctg gtttccgaga gtgccgggcg
       61 gtcggcgggt cagggcagcc cggggcctga cgccatgtcc cggaacctgc gcaccgcgct
      121 cattttcggc ggcttcatct ccctgatcgg cgccgccttc tatcccatct acttccggcc
      181 cctaatgaga ttggaggagt acaagaagga acaagctata aatcgggctg gaattgttca
      241 agaggatgtg cagccaccag ggttaaaagt gtggtctgat ccatttggca ggaaatgaga
      301 gggctgtcat cagctctgat taagaaagga gatttcttca tgctttcgat tctgcatggg
      361 gtacagccag tcacctcacc agagaatgac ggctggagaa gaaaactctg taataccata
      421 aataagagtg cttgtaataa aagactgtgc acaaggatta atatttccct tcttaagtat
      481 caaaagaact ctggaacaaa ttataccatt aggaaggttt tcatgattca gttgattttc
      541 caaaaatgaa gctatctcac ccagctgggt ttggaggagc aatctgctta ttattctgtc
      601 gttaccactt actcaagcga gctgtgatat gaatacaagc aaccagtggg ctcgggaagg
      661 tccgggtctc ttctgccatc ttccagataa gagatttcag taaaaaactg ccatgctgag
      721 ctgccttata gagctcttcg aaaatgttcg agttgataaa gctctttgag gacaaggtac
      781 ttcgtgcacc tcatgctgaa gattgcaccg tgttggaaaa taaatatgaa gcaagtcaaa
      841 ctagatgcat acacttgtgt agaaatcaat aatcaattaa tagaagtgaa aaaatagaca
      901 ttaaaatgat ttatttcta
//
