LOCUS       NM_001135674            3704 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens small integral membrane protein 19 (SMIM19),
            transcript variant 1, mRNA.
ACCESSION   NM_001135674
VERSION     NM_001135674.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090739.13 and DB519016.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001135674.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All variants (1-4) encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.73938.1,
                                           SRR1803615.50026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417410.7/ ENSP00000405694.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-789               AC090739.13        157630-158418       c
            790-927             AC090739.13        153397-153534       c
            928-1052            AC090739.13        151223-151347       c
            1053-1466           AC090739.13        147046-147459       c
            1467-1506           DB519016.1         415-454
            1507-3704           AC090739.13        144808-147005       c
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..3704
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /note="small integral membrane protein 19"
                     /db_xref="GeneID:114926"
                     /db_xref="HGNC:HGNC:25166"
     exon            1..789
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /inference="alignment:Splign:2.1.0"
     exon            790..927
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /inference="alignment:Splign:2.1.0"
     CDS             794..1117
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0697 protein C8orf40"
                     /codon_start=1
                     /product="small integral membrane protein 19 isoform 1"
                     /protein_id="NP_001129146.1"
                     /db_xref="CCDS:CCDS6133.2"
                     /db_xref="GeneID:114926"
                     /db_xref="HGNC:HGNC:25166"
                     /translation="MAGGYGVMGDDGSIDYTVHEAWNEATNVYLIVILVSFGLFMYAK
                     RNKRRIMRIFSVPPTEETLSEPNFYDTISKIRLRQQLEMYSISRKYDYQQPQNQADSV
                     QLSLE"
     exon            928..1052
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..3704
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /note="hexamer: AATAAA"
     polyA_site      1489
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /note="major polyA site"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /note="hexamer: AATAAA"
     polyA_site      2129
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /note="hexamer: AATAAA"
     polyA_site      2978
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
                     /note="hexamer: AATAAA"
     polyA_site      3704
                     /gene="SMIM19"
                     /gene_synonym="C8orf40"
ORIGIN      
        1 gaaggcagag ggcgtccagg tccgctcggt aaccgtttcc cgcgcgcccg gccccgactc
       61 cggggtaaag agccccggag cggagcagcg ctggccgcgt gccgcctccg gagccggcag
      121 cgtgagtggc cccgcgtccc cgcttctccc ggtccccggc ggggccgcgt cacccggccc
      181 cgccccgcgc cgcccgcccc gccccggacg cgggggtaag gggggtggcc gcccgcctgc
      241 cctcggtccc gtgcggtccc cgaaactccg agcacccgcc cggtcccggc gcggagcccc
      301 tcggcgtcgc gtggagctgc gagtcgcccg cttccggaag cgcacacggg ccagttgcgg
      361 cggcccatct gccggggcgg cgggggctcg gcgggagggt tgaggctgaa tcacgcgcag
      421 cctgcgggcg gcggaaacgt ccctagagcc tcgccgccct gggacccggg ctgcttcctg
      481 ggagaggatt acattttctc cctgctccac ttgactttct tccggaagga gcaggtctcg
      541 caggatcggg gccaagactg gaagagttca ggtttgggag tcgtgtgtat aacagccccg
      601 cgcctccacg cccaggcctg tgtggctttg gacaagttat ataaccaccg ccgccacccc
      661 agtttcttct cctgtaaaat ggagctttag tgccgcccag cagggttgtt gggataattc
      721 agtgactctg tggactgccc agcacctgtg aattgctttc ctggatgttg ggtgaaggcc
      781 tgtgagcttc cccatggctg ggggttatgg agtgatgggt gacgatggtt ctattgatta
      841 tactgttcac gaagcctgga atgaagccac caatgtttac ttgatagtta tccttgttag
      901 cttcggtctc ttcatgtatg ccaaaaggaa caaaaggaga attatgagga tattcagtgt
      961 gccacctaca gaggaaactt tgtcagagcc caacttttat gacacgataa gcaagattcg
     1021 tttaagacaa caactggaaa tgtattccat ttcaagaaag tacgactatc agcagccaca
     1081 aaaccaagct gacagtgtgc aactctcatt ggaatgaaac ctcagaaaaa gagcaacaga
     1141 agtaattgtt tcaagctcct gattctttct actaaatcat gaacagcttt aaaaacattt
     1201 ctgtctgcat aaaattattt tacttgtaac ttttccccaa ttgttctgtg cattgttttg
     1261 cctttttaaa ttacatctcc aagtggctca aaaggccttg acacagggaa cctgcacata
     1321 tccaggatat gtgtaaccag cgatggtgac ttgaccttgc caagacctgt gattccttca
     1381 ggatacaatc agtgagaaat aaaaacacat cttgggaagt gggaatcctg gagtttatgc
     1441 catttgcaat attaaaaaat aaaaatgcaa gttattattt caataataac ttcctgtttc
     1501 attgtattct gtgagtgata agtgtcagat caataacaga ttaatttgtt gttaacagct
     1561 cttttttttt tttttttttt gagacagagt ctgttgccca gactggagtg cagtggcaca
     1621 atctctgctc actgcaactt ccacctcccg ggtttaaacg attctcctgc cacagcctcc
     1681 tgaatattct gttaacagct ctttaattaa tgatctttgc ttcttcagaa cttgtatggt
     1741 agaccgtctt ttctacagca tgatgcatac tcctgtgcta attttagaag ctttctgtaa
     1801 ctagattttt cctcattatg ctcccaggag cgagtttgtt tttatccccg tttcatttct
     1861 accaggtagc tctactttag gccatactgg ggacctgctg ttgaataaat ggatgcctgt
     1921 gtattggtgt tggcaactct gcggtagtag tgctaccact ggcgaggcag tattactgcc
     1981 actggtgaat gttgctgtct ggttactgct gcatttttgg catgctaagc tttcctaaag
     2041 agcctcatat cttttcccat gctgtactgt acaatgaaat gtttttacct aatttttcat
     2101 gtttatttaa ataaaagctg actgggtaat agtggggaag tttaattgtc cacataagtc
     2161 aaaagaatcc gtttttgaac tagagctatt ttcaattata agagtgagct ggctgggcac
     2221 ggtggctcac gcctgaaatc ccagcacttt gggaggccaa ggtgggagga tcacgaggtc
     2281 aggagtttga gaccagcctg gccaacgtgg ttaaacccaa tctctacgaa gaatacaaaa
     2341 attcgctggg tgtggtggca tgcgcctgta atcccagcta ctcaggaggc tgaggcagga
     2401 gaattgctcg aatctgagag gtggaggttg caatgagcca agatcacacc actgcattcc
     2461 agcctaggcg acagagcaag acttcgtctc agaaaaaaaa aaaaaagtta ataatggctt
     2521 caagtatttc attttcccct tattgtgaaa taaactatat acattttaaa tggaaattaa
     2581 ggtttagacc aaataaaatc attcagggaa attgcattta cttttaaaaa tgtgttgttc
     2641 aaaaatgtat atatagtaca aagtgaattg accaaacaga ataattctta actcacaaag
     2701 gagtttgagc gcacttccta catgttgaat ttaaatctga ctaaaggatt gtaaacagtt
     2761 gtaattatgg gttgtagtaa cagagcaaca aggggacaat cttctaaact tgcctttgcc
     2821 taggagagct actgtatatt tccacaagtg aatttaatca gcagtaggag tggtttactc
     2881 gtcactgaca tgtggcacaa tctggacaaa ttacacaaac tggctatctc agatgtgtaa
     2941 aattaatgta cataaataaa cgtaagtcac acaatgaatt tcctttgtgt ccactagata
     3001 gagatggtcc taactacaaa ctagtagatt atttgatgag catcaagccc tggcaagtga
     3061 caggagatga attcctctcc gttttttcct taaagcaaac tgatgggaat tgcacacacc
     3121 ccactggcag gaacaacagc aagccggctt tgaagtctct tccctgcttc aacagctgaa
     3181 ttggggagag cgcaagccct gcagccacac ttcaaagcgg cgctgactgg ctgtcctgct
     3241 tctacccaac atccacctga gactcaacag aactgttttc tttggaagaa aaatggaact
     3301 actaataagc tagtaattaa cccttgtatt ctttttctgg tttcatcttc ctgttttaat
     3361 gtgtaagata ttcagcagta agcactggtc agcctgccct ggtgcacagc ttgagtgtgt
     3421 taaataactg gctgtttagc tgatgccagc cagctgcgtg aaggggagaa ggccgcctcc
     3481 aaggacacag atgtttgctg ttgacctcac gctgtgtctg gttgagttat tcatgattca
     3541 tcagaaaatg acatgcaagg tttatggtaa aactgctgta caatcagaag tattttaagt
     3601 atgcattaga agtaagataa aatagtaata aaaatagttt cagatgttaa gatgatacaa
     3661 gaataaattt aacctagaaa ataaagggag aaggaataaa agaa
//
