LOCUS       NM_001048249            2888 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens small integral membrane protein 15 (SMIM15), mRNA.
ACCESSION   NM_001048249 XM_926525 XM_938936
VERSION     NM_001048249.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA039277.1, BX538015.1 and AC008498.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001048249.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.208459.1, BX538015.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339020.8/ ENSP00000339324.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               DA039277.1         8-538
            532-2014            BX538015.1         534-2016
            2015-2840           AC008498.3         76646-77471
            2841-2883           BX538015.1         2847-2889
            2884-2888           AC008498.3         77515-77519
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..2888
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="small integral membrane protein 15"
                     /db_xref="GeneID:643155"
                     /db_xref="HGNC:HGNC:33861"
     exon            1..252
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            253..392
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            393..2888
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..645
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="UPF0542 protein C5orf43"
                     /codon_start=1
                     /product="small integral membrane protein 15"
                     /protein_id="NP_001041714.1"
                     /db_xref="CCDS:CCDS34165.1"
                     /db_xref="GeneID:643155"
                     /db_xref="HGNC:HGNC:33861"
                     /translation="MFDIKAWAEYVVEWAAKDPYGFLTTVILALTPLFLASAVLSWKL
                     AKMIEAREKEQKKKQKRQENIAKAKRLKKD"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="hexamer: ATTAAA"
     polyA_site      1827
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="major polyA site"
     regulatory      1966..1971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="hexamer: AATAAA"
     polyA_site      1990
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="major polyA site"
     polyA_site      2454
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="hexamer: AATAAA"
     regulatory      2862..2867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
                     /note="hexamer: AATAAA"
     polyA_site      2880
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
     polyA_site      2888
                     /gene="SMIM15"
                     /gene_synonym="C5orf43"
ORIGIN      
        1 gccttcctgc ttccggtctg gcggtgagtg gggagtggga tccgatcccg tggggctatg
       61 taggggaagt tggtggctgc agctgccgtg gttttctcct ggtgtccagc agaaacggcg
      121 gcggcgcaag gtgtggctgg gccaacccag gatctcccag gaccctccgc tctgcgcgac
      181 aaggggcccg cgcttgccaa ggccgacggg caggagtgaa cgtggcctcc gtgggtctgc
      241 agccccgata ggccaattgt acagaattta aaccgtctct cagatgtgta cagtagaact
      301 caagaagaca gactaccaag ggtcatctga agtcgtgatt gggtcactaa taacaccagg
      361 acaaagttaa gggatcacta ctcaagcata agccccagtt ttcataagac tgctgtgaag
      421 atgtttgata taaaggcttg ggctgagtat gttgtggaat gggctgcaaa ggacccctat
      481 ggcttcctta caaccgttat tttggccctt actccactgt tcctagcaag tgctgtactg
      541 tcttggaaat tggccaagat gattgaggcc agggagaagg agcaaaagaa gaagcaaaaa
      601 cgccaagaaa acattgcaaa agctaaacga ctaaaaaagg attgaaggac tgaacaggct
      661 ttgcaaccag aggaaaatca tttggaaaat tacacagctt tggaagaatc cactaaagtt
      721 tcttctttgg atttcttgac agtatgattt agtaaatgaa atttgaccaa atggaagaat
      781 catgttagtt ctgacctcaa tactatagta acttttaggc gtgggtgtag aagtttatag
      841 gtttctattg acagttattg taaattagca tttactgtgg tacaaattct ttataactga
      901 cttagtcatt tgccgcttag cagtttatat actgaaatga aaacatcttg tggggaaaag
      961 tgactttaga ttatgaactc aattcaaatg aactctattt aaaatggggt cctattttgg
     1021 acaaaggaaa ttaagaatgt aaaagtcaga acagtcttga ggtaaaaagt gtgctttggc
     1081 ttaaaaggga tacagtatat taattacatc ttttattatt attgtttatt tcttagaatc
     1141 atttctggct ttctcaaaac aaaataatat taatgagtac ttctatttgc tgcatttttc
     1201 ttattacagc ctttgagaca gctggtaatt ataagtcatt ttccattttt taaaacataa
     1261 ttttataaag aattctctta tctcgactat gtagaatacc acctactgga cagaacaatt
     1321 tttgtactca caaacactgc cattttctta gagatggctt gagaggagta acactatggt
     1381 ttaaagcttg cagtaaaaat gccaaacact gtagtacctt ggaacccagt ttattcttgt
     1441 gctaagcaga actgtaaaat agttaaaatg tcttatcaag taattcgccg attacaaaga
     1501 caccatttgt tttttatttc attctttgtt ttaactcatg tggtagtgat atttaatact
     1561 ttctgatcaa acaggttcaa agtaaaacgt taaatttcac atttctttta aagaactctt
     1621 aaagtgtaac agttacgcca tacttcataa gtggtaaaga aaggtataaa atttggaaac
     1681 attttgttgg gcatagtagt gattgggtga aaaggataaa ttatatcaaa atgagaatgt
     1741 gctgtaattg gaagtaggga gctaaaggat gtttctttca gtttagtaga actggaacgt
     1801 tttactatta aacatggctt ttataaatgc atggtccaat aattttattc actgttagta
     1861 tttaattcac tgtcagctta ttaatgtttt ctgtacccat taatgaattt taaattacaa
     1921 aaaattgtct agcagctaca gtttaaaaat gaaactagac attaaaataa atttgataat
     1981 tttttataaa gaggtcctgg attttttttt tttttttgga ggaactaaca ttttaagtta
     2041 cattatgtta tgcaagttag aatttcagtt acagctaagc atacttgtaa aatttcagga
     2101 ctgtatctct cagaacctaa ggaccactga gaatgtttat ggaccagttt gaataacact
     2161 taatgctatt cttttagatt atcagtctct acttggtgcc agtgtgagca acacattata
     2221 actcaaggca ctgaaattat tcagtgttaa gatatatcta taatatgttt ggttttctgc
     2281 aatcaagctg ttcatggaaa gaatttatgt acatgtttta cttagggtca cattttagag
     2341 taaaagtatt gaagcaaagg atatagtcat aattctcagt tacctactaa agttatggtt
     2401 tcatcagttc tgttgtaaca acttaaaggt atttaaaggt ctgtttttct ataatttatt
     2461 agtcttaaca catgccagtt ttgtatttgt ttgacatatg cttttttttt ccactttttt
     2521 ccatcattta gagagccttt ctatatatgt gagattcata ctttacagtg tgtgtgtgtg
     2581 tgtgtgtgtg tgtgtgtgtg taaggggctg gagtatagag aatattgtga ggtttgggat
     2641 tcttcagaaa aatcacctct cactgcaaca gagtactgtt gttaaagaat cccatttgct
     2701 attatctaga atacttttaa gaaattgttt acttattaca ttgtttctga agttctgaga
     2761 actaagtaca atcaattacc attctaaagc tggtcttggg ggagaaagaa agctgtcccc
     2821 tggctgcctc taacaaacat tttatcaaaa atcagcaaat aaataaaagt ttgtatgtca
     2881 gaacttga
//
