LOCUS       NM_138428               5694 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens small integral membrane protein 12 (SMIM12),
            transcript variant 3, mRNA.
ACCESSION   NM_138428
VERSION     NM_138428.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5694)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 5694)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064320.1, AL122010.10 and AI467795.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138428.5.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.169908.1,
                                           SRR1803614.82929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521580.3/ ENSP00000428585.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1009              BC064320.1         31-1039
            1010-5607           AL122010.10        23214-27811
            5608-5694           AI467795.1         11-97               c
FEATURES             Location/Qualifiers
     source          1..5694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..5694
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /note="small integral membrane protein 12"
                     /db_xref="GeneID:113444"
                     /db_xref="HGNC:HGNC:25154"
     exon            1..73
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /inference="alignment:Splign:2.1.0"
     exon            74..5694
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..357
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /note="UPF0767 protein C1orf212; alternative protein
                     C1orf212"
                     /codon_start=1
                     /product="small integral membrane protein 12"
                     /protein_id="NP_612437.3"
                     /db_xref="CCDS:CCDS53295.1"
                     /db_xref="GeneID:113444"
                     /db_xref="HGNC:HGNC:25154"
                     /translation="MWPVFWTVVRTYAPYVTFPVAFVVGAVGYHLEWFIRGKDPQPVE
                     EEKSISERREDRKLDELLGKDHTQVVSLKDKLEFAPKAVLNRNRPEKN"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /note="hexamer: ATTAAA"
     polyA_site      1012
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /note="major polyA site"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /note="hexamer: AATAAA"
     polyA_site      2537
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
     regulatory      5675..5680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
                     /note="hexamer: ATTAAA"
     polyA_site      5694
                     /gene="SMIM12"
                     /gene_synonym="C1orf212"
ORIGIN      
        1 gcggcgactt ccgtgctccc ggcgagcggg cggagagcgg gggccgcact ggggagtgtg
       61 ggctgggccg cagatgtcat gtggcctgtg ttttggaccg tggttcgtac ctatgctcct
      121 tatgtcacat tccctgttgc cttcgtggtc ggggctgtgg gttaccacct ggaatggttc
      181 atcaggggaa aggaccccca gcccgtggag gaggaaaaga gcatctcaga gcgccgggag
      241 gatcgcaagc tggatgagct tctaggcaag gaccacacgc aggtggtgag ccttaaggac
      301 aagctagaat ttgccccgaa agctgtgctg aacagaaacc gcccagagaa gaattaatgg
      361 aggacacagg gccctatggt cctactgtgg gtggtgactt gtcctgctac catgttgaca
      421 gagccccaga acccacatct aattggcttt gttgcttatt ctggcccttc ccacaccaca
      481 cagccacaca aatactggct gctccttgat ggccaggcag acccagcagc agccgagggg
      541 ccagtgaaga ggaaggccgc atctgttgtg tggtggccac aagcactcag gcatctgagt
      601 ttactggtgc actgctggga ggagagttat gagatgaaca ttggctgtca atctctgtgg
      661 gcaggcggtt tggcctctag tgggaatggc tgggatttgg gcgttgcctt taggagggat
      721 acctgcatgt ctagttccag tctgcactgg aaagaattca aatatgcacc tggctccctt
      781 cactattttg ccctatcctt tgtgctcatt cttactgaaa tctgtcttgt cagctcagga
      841 atgggattcc cccaggaagg aaagcacttt tctgttctgg gaagcccaga ctgttcactt
      901 tggggcaggg acgaacatgt gcctcgtgaa tttgcttgaa aacagtcacc atcttctacc
      961 cccatcactg tatagtgaaa aacctgatta aagtggtatc tgagaaccat aatgatcgaa
     1021 tcttatcatc caggtggtat ttgggggtct tcttaggagt taggcaagta caggcatttt
     1081 agagcaggat aacattggta ttaaagggtg ccaaggagcc ctggaaactg ctttactagt
     1141 gcggttgcac tgaaccctgg aggcacagat tcccaggaac ctttttacca ttattacaat
     1201 tggctgcagc accttcaagt ctaaatggag gtagacctca catacacaca catagacgcc
     1261 tttccctata aaagtatata cgcacattca agaaaatttg gtagggattt taaaaaggtc
     1321 acccatgttc ccagctcgtt aataacaacc gttaacattt tgttgtcttt tactaattct
     1381 ctgcataggt tttagagata gttatcatta ctgtacattt aattttatat acttttctca
     1441 ctattatcat tttcccattt tacatggtca tcataattgg ttttttggag acagggtctc
     1501 actctgtcac acaggctgga gtgcagtaca attacggctc agtgcaacct tgacctcctg
     1561 ggctcaagtg atcctctcac ttcagctcct caagtagatg ggactacagg agtatgccac
     1621 catgcccagc taattttttt atttttttgt agaaccaggt ctcactatgt tgcccaggct
     1681 agtctcaaac tcctgggctc aagtgatcct ccggccttgg cctgtagttt cttttttctt
     1741 tttttttgga gatggactct cattctgtca cccgggctgg agtgcagtgg cgtgatcttg
     1801 gctgactgca acttctgcct cctgggttca agcgattctc ctacctcagc ttcctaagta
     1861 gctgggatta caggcgtgcg ccatcgtgcc tggctagttt ttgtgttttt agtaaagaca
     1921 ggggtttcac catcttggcc aggctggtct cgaactcctg acctcaagcg atcccatctg
     1981 cctcggcctc ccaaagtgct gggattacag gtgtgaggca ccgtgcctgg cagtctgtag
     2041 tttttttttg ttgttgttgt tgttgttgtt ttaaatatgg agtctcgctg tattgcccag
     2101 gctggagtgc agtggcgcga tcttggttca ctgcaacctc cacctcttgg gttcaagcga
     2161 ttctcctgcc tcagcctcct gagtagctgg gattacaggt gtgcgccgct acgcctggct
     2221 aatttttgta tttttagtag agacagggtt tcaccatgtt ggtcaggctg gtctcaaact
     2281 tctgaccttg tgatctgcct gccttggcct cctaaagtgc tgggattaca ggcgtgagcc
     2341 accgtgcctg gctgtagttg tttataatag caacataatt gtctatcaag tgggagtatg
     2401 acataagttt atcctggaca atttccatat tgctggacat ttgaattgtt tctggttggt
     2461 cactcgttta gatactgcaa cgaatatctt atatgaagct tttcctgcgt tttggaataa
     2521 acagtaaaaa tagtaaatgt cattttggat gaaatgggat aaatgagcag ttttgaggat
     2581 ctcatgcata acaccaaatg tctttccaaa agggctctag gagtttctac taaatcttac
     2641 cactgaagac gttgctggta aggctgtgag gggagtaaaa gcagagagca ggaagaagca
     2701 taagaagctg ttgcctcttg aagcctactg atgtttaact aaagtcagca cagggcagta
     2761 gtgagcattt gatgaattga tctgcctcta aaagggagtg ggtattggcc ctgcttctta
     2821 ggttctctct cgtgaggcct gatggtgtcc acaggtgggt gagggtggag ttcctgaaca
     2881 gttagagggg ccagctgtga agaggtgcca gctggaggtg ccttccagga cctggtggtg
     2941 gcctgagagg agggagcagg ttgagtcgtt ggcttcttct aaggctccct gaggcctagt
     3001 gggaatgcgg aaatgagctg ctgttgcttc ccagggaaca aatcggatgg aacttgggaa
     3061 gagactgtca gctaccaagt aaggagattt ctggttctgg ctgcaggttc tggctgatga
     3121 gcaggcctta tcggcacacc agtgctgcca ccctatggca gtcctgggca ttaccaagcc
     3181 tgcagtcact tccctgggct aaaccaaaca ctagtgctga cagaggtcag gtgacaaatg
     3241 agccaccacg ctggcagaaa gtatagacct gccgaaaggg ggcagtggtg actcaccttc
     3301 caatctgctg ctcatccagt ggtaccagat ttttgaattt ttctaaaaga tgttctaaga
     3361 gctccagagg gggtaaaaaa aaaaaaatga agagatgcta gaaattcagg gttttttggt
     3421 gtgtgtaacc ttctgatttt caagtgttga taattcatta tacaaaattc taagcatgct
     3481 atcatacccg tggggttaat ttgacccagt ggctgccaat ttgtgacctc tcaaactgcc
     3541 tcctccttct gatgacacct ataattatgg tttttttttt tttttttttt ttggcgatct
     3601 aacaacttgt tacaaatatt agatcccaga attggtttcc ctcaaaacac ttttgggcat
     3661 cctgtacaaa ggcagcttaa taacctaaga aaaatgtgag gatggaaagc ctacagaaat
     3721 aatagcaaac acatttccca tggacatttt tggattttca gatcttttaa aatatccctg
     3781 tcaccacccg ttggcctcca cttggtgtct ggtcgagaga gccctatctt tgggaatcca
     3841 ggtggctccc ttcttccagt ctcactttga ttgtgccccc ttttaaattc ttttctttcc
     3901 tttccaaggg cactttgtca ctgaattctt cctctagcaa gtctattagt gttctcagct
     3961 agatctttct ttcccacagg ctggctgaaa tcagccgttg cggtggctgt aagatagtat
     4021 atgtgctctt gcctctgctc gggtgacatt agatagcaag gtttatgtgg acgtgggtat
     4081 agacaggtca gggttgctgg gatgaaccaa ggtgcagacc ggttttcttc catgcttgct
     4141 gattcacctt ggaggcatgt gaccctcttt ttgactggcc ttccagtcac agttcactga
     4201 aacacatgag tgagtggatg tgcttggggc tttttgctcc ccgcttaccc ccgtctcttc
     4261 ccagcccaat gatggtggtg gctttagtat agggtcctct ccgagcacgg caggaatcac
     4321 ttctctccct gcagcggttc agtgtctggt gcttttccac tctttctaga ctctttcctg
     4381 tgcctgttgc tgtgttagca caagtcggct gggcagctgc cagaacaagc ctgccaggga
     4441 gccttttgac tctggtcagc tccccagggc tccaggctgg tgggactgcc gctgagtgaa
     4501 acatcatgga attagccttg ccagagtctg ggttgggagc caggcagtga aaatgtaaaa
     4561 gcccctccgt cttgctcact tttccttttc tactttgctt tagatctcta agcacttgta
     4621 gggtagggag ccagggcagt gtagcagagg aaaaataaag tggattctag agtctgacag
     4681 gctcgagtta tgaatactgc cttaacaatt aactggatga ccttgggcaa gtcacttagc
     4741 ccttctgaac ctcaatatcc tcacctgtaa aataggggta agaatttttg ttgggttgtt
     4801 gtgaggatga ggtaattatg taaggttctt agcatagtac gctaagaact ttatatacat
     4861 tgtcacagac tgtgctaaaa ctttacatac attacctcat cctcacaaca accagtaggt
     4921 actcagtaaa tgttagcagc tttaattgta ttgcaggaag aacctatgtt tcctgcaata
     4981 gttgtgtgta tccttgtgac cctggtgagg tggggatcta ggggagagag cagccttggc
     5041 tgagggacaa cagggaccct catagacctg gtggttgagg gctgcttaga aatatttcac
     5101 agagagaact ggcttgcata agaaccaaga agcacaagct ggtcaggaga ttgcaggctc
     5161 cacacctgcc ttagtggtag ttccatcagt gcagtctgca aagtcagagg gaagcagatt
     5221 ggccagaatg cccaggaggt cacagatcag gagaattggg aggggaaaga gccttggact
     5281 tggaggcaag cgatctgagt gatgacctgg ggtatgccgc ttcacctcta ctggccttgg
     5341 tttccctgca aaatggggaa cgtgttccct gctgatcgtg tgaaaagagt gagacaacca
     5401 gtttagagtg ctctgaaaac atgcaagtgc tagatattac agcccagtaa aacctccttt
     5461 atctagttgg gatggcagcc agtctgaata ataaaataca aatacatgtg ctattatttc
     5521 tttcctgtac agagcgtatt ttatagtatt tgctaagtag aagtctttag gggaatcagt
     5581 ttgaagagtg aagagtaatt agtaaccggt gtatcagttt tcatcctgtt ccagcagtgc
     5641 ctctggtact taaaaaacag tttattcttt ttgaattaaa cttgttaaca tcaa
//
