LOCUS       NM_058182                840 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens small integral membrane protein 11 (SMIM11),
            transcript variant 1, mRNA.
ACCESSION   NM_058182 NM_001042401
VERSION     NM_058182.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 840)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 840)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   3  (bases 1 to 840)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
REFERENCE   4  (bases 1 to 840)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000320.1 and AP000321.1.
            
            On Nov 22, 2019 this sequence version replaced NM_058182.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1099135.1,
                                           SRR5189658.175550.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399292.8/ ENSP00000382231.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AP000320.1         20724-20784
            62-150              AP000321.1         327-415
            151-317             AP000321.1         6376-6542
            318-840             AP000321.1         9527-10049
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..840
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /note="small integral membrane protein 11"
                     /db_xref="GeneID:54065"
                     /db_xref="HGNC:HGNC:1293"
     exon            1..61
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /inference="alignment:Splign:2.1.0"
     exon            62..150
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..315
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /note="protein FAM165B; family with sequence similarity
                     165, member B; small integral membrane protein 11A"
                     /codon_start=1
                     /product="small integral membrane protein 11"
                     /protein_id="NP_478062.1"
                     /db_xref="CCDS:CCDS33550.1"
                     /db_xref="GeneID:54065"
                     /db_xref="HGNC:HGNC:1293"
                     /translation="MNWKVLEHVPLLLYILAAKTLILCLTFAGVKMYQRKRLEAKQQK
                     LEAERKKQSEKKDN"
     exon            151..317
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /inference="alignment:Splign:2.1.0"
     exon            318..840
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      818..823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /note="hexamer: AATAAA"
     polyA_site      840
                     /gene="SMIM11"
                     /gene_synonym="C21orf51; FAM165B; SMIM11A; SMIM11B"
                     /note="major polyA site"
ORIGIN      
        1 aggacggtag aagtcgtggt ttgtgcgcgg ccaggcgctg gagcctccgc tgccgggagc
       61 aatcagacct tccagctgcc tctcatgtac ttgtctgttg ggggcttgtg ttgatcagga
      121 gtgaattcac agtctaccat gaattggaag gttcttgagc acgtgcccct gctgctgtat
      181 atcttggcag caaaaacatt aattctctgc ctgacatttg ctggggtgaa aatgtatcaa
      241 agaaaaaggt tggaggcaaa acaacaaaaa ctggaggctg aaaggaagaa gcaatcagag
      301 aaaaaagata actgaagatt ctgccatgta aatgtcagct tgagtggact ccagctgaga
      361 agaaagagaa gaaagactta attattgaat aatttgtcag aggataaact cccaacctag
      421 acctttcact taaaatagtg tgaatttgta tatgttttta aaagaaccag tactggccgg
      481 gtatgctggc ttttacctga aatcccagca ctttgggagg ccgaggcgag tggatcgcct
      541 gagatcggga gtttgagacc agcctggcca acatggtaaa atcctgtctc tactaaaaat
      601 ataaaaatta gccaggtgta gtggcgcgcg tctgtaatcc cagctactcg ggaggctgag
      661 gcaggagaat tgcttgaatc cgggaggtgg aggttgcagt gagcctaggt cgtgccactg
      721 ccctccagcc tgggtgacag agcgactgcg tctccaaaaa aaaaaaggta aaattaaaat
      781 taaaaaaaat aataataacc agtattttgt ttactaaaat aaaatgcctt tgtaaaaaaa
//
