LOCUS       NM_001163438            1483 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens small integral membrane protein 10 (SMIM10), mRNA.
ACCESSION   NM_001163438 XM_001715907 XM_927661 XM_939025
VERSION     NM_001163438.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Lubrano,S., Comelli,L., Piccirilli,C., Marranci,A., Dapporto,F.,
            Tantillo,E., Gemignani,F., Gutkind,J.S., Salvetti,A., Chiorino,G.,
            Cozza,G., Chiariello,M., Galli,A., Poliseno,L. and Cervelli,T.
  TITLE     Development of a yeast-based system to identify new hBRAFV600E
            functional interactors
  JOURNAL   Oncogene 38 (8), 1355-1366 (2019)
   PUBMED   30237439
  REMARK    GeneRIF: Therefore, these data suggest that SMIM10 exerts an
            oncosuppressive role in melanoma cells.Taken together, our results
            unveil the potential of S. cerevisiae to study hBRAFV600E, to
            populate the network of its functional interactors and, in doing
            so, to uncover new cancer-associated genes with therapeutic
            potential
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008642.1, AA630048.1 and BQ016562.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001163438.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.921325.1,
                                        SRR3476690.164392.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330288.6/ ENSP00000328335.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-739               BC008642.1         54-792
            740-938             AA630048.1         1-199               c
            939-1483            BQ016562.1         17-561              c
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1483
                     /gene="SMIM10"
                     /gene_synonym="CXorf69"
                     /note="small integral membrane protein 10"
                     /db_xref="GeneID:644538"
                     /db_xref="HGNC:HGNC:41913"
     exon            1..1483
                     /gene="SMIM10"
                     /gene_synonym="CXorf69"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..357
                     /gene="SMIM10"
                     /gene_synonym="CXorf69"
                     /codon_start=1
                     /product="small integral membrane protein 10"
                     /protein_id="NP_001156910.1"
                     /db_xref="CCDS:CCDS55502.1"
                     /db_xref="GeneID:644538"
                     /db_xref="HGNC:HGNC:41913"
                     /translation="MEALGSGHYVGGSIRSMAAAALSGLAVRLSRPQGTRGSYGAFCK
                     TLTRTLLTFFDLAWRLRKNFFYFYILASVILNVHLQVYI"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM10"
                     /gene_synonym="CXorf69"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="SMIM10"
                     /gene_synonym="CXorf69"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMIM10"
                     /gene_synonym="CXorf69"
                     /note="hexamer: ATTAAA"
     polyA_site      1483
                     /gene="SMIM10"
                     /gene_synonym="CXorf69"
                     /note="major polyA site"
ORIGIN      
        1 ccgccttgca gcgcagctcg gatcagcagc agcccaggag gcctcccgcc cgtactttcc
       61 cgcgtccatc cctctgtccc acggtcggtg agtcagcgga gcctgatgga ggccttgggc
      121 tctgggcact atgtgggagg cagcatcagg tccatggcgg cggcggccct gtctggcctg
      181 gcggtgcggc tgtcgcgccc gcaggggacc cgcggctctt acggcgcctt ctgcaagacg
      241 ctcacgcgca cgctgctcac cttcttcgac ctggcctggc ggctgcgcaa gaacttcttt
      301 tacttctata ttctggcctc ggtgattctc aacgtccacc tgcaggtata tatttagagc
      361 cactaacttt gtggcatttg ggggctcctc gtcaggatgg ctgacttcca cccacctgct
      421 cacccaccct agagcaaagc gaccaactcc gctcctgcat gcagacttgc cactcattct
      481 ttccattgcc tcatctttta gtataaatgg gtggcaaaaa aagaaaaaaa cagcatttgt
      541 ggaaagcctg aaatataacc caaatcgtct aagatagaat gaaaaattga ctctcaagga
      601 aatatttgaa ggaacagaat acagcttaaa aatttgaaaa tccttaaaaa tatctgagaa
      661 gtttttgcat ccgtaaaaca gaaaacagca cgaactttag gaaatgacaa tgggcacaga
      721 atgcaataaa aaaaaaaaac ggggaaaggt aactaaaaac ttaaggaaag ataaactgaa
      781 caagaatggc tcagacagca ggcaaatctc cccaattaga aacgaagtga atagacccaa
      841 ttgaatgaga tgaattctaa gcaatagatg gattgaataa taagctggag gacattaata
      901 acatgttctg gaaggcatac atttcttcaa cccaaaggaa aaaaaatgac agaaagaaac
      961 tacagggaag aacattaaaa actgtgcaag aaacttatgt ttcacatatg aagcaacctc
     1021 agatgtggca tggttttgaa cagttgccga aagtgtgaga aagggaatct gtttgaatat
     1081 tggcacatgg atcaagactc tggagtcggt gatgagaaaa tccaatcaga gcattccact
     1141 ttgctattca ttgaaccagg tagccaacag aagagttaaa aattagtgat atgactatat
     1201 tcagggggaa ggagagctga ggggggcggc aggaagtcag cagaaaatgc ctcatgtcat
     1261 taagtcaaga aatagtaata aaggcatgtt attgaaaaag ggggtgtaat ctctaaacaa
     1321 gcacgtgtag aagtttgtgt ttctgatttg gggaagcaag agttgagaag gagggacagt
     1381 tctattactt ttcattatat gtcctttttc tactgtttga tttttaaaaa ctatacacat
     1441 gtattgcttt tgcttcgatt aaaaatcaag acattaaaat gaa
//
