LOCUS       NM_019108               5491 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens SMG9 nonsense mediated mRNA decay factor (SMG9), mRNA.
ACCESSION   NM_019108
VERSION     NM_019108.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5491)
  AUTHORS   Rahikkala,E., Urpa,L., Ghimire,B., Topa,H., Kurki,M.I., Koskela,M.,
            Airavaara,M., Hamalainen,E., Pylkas,K., Korkko,J., Savolainen,H.,
            Suoranta,A., Bertoli-Avella,A., Rolfs,A., Mattila,P., Daly,M.,
            Palotie,A., Pietilainen,O., Moilanen,J. and Kuismin,O.
  TITLE     A novel variant in SMG9 causes intellectual disability, confirming
            a role for nonsense-mediated decay components in neurocognitive
            development
  JOURNAL   Eur J Hum Genet 30 (5), 619-627 (2022)
   PUBMED   35087184
  REMARK    GeneRIF: A novel variant in SMG9 causes intellectual disability,
            confirming a role for nonsense-mediated decay components in
            neurocognitive development.
REFERENCE   2  (bases 1 to 5491)
  AUTHORS   Yang,Q., Qin,Z., Zhang,Q., Yi,S., Yi,S. and Luo,J.
  TITLE     Identification of a novel compound heterozygous SMG9 variants in a
            Chinese family with heart and brain malformation syndrome using
            whole exome sequencing
  JOURNAL   BMC Med Genomics 15 (1), 67 (2022)
   PUBMED   35321723
  REMARK    GeneRIF: Identification of a novel compound heterozygous SMG9
            variants in a Chinese family with heart and brain malformation
            syndrome using whole exome sequencing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5491)
  AUTHORS   Abdel-Salam,G.M.H., Duan,R., Abdel-Hamid,M.S., Sayed,I.S.M.,
            Jhangiani,S.N., Khan,Z., Du,H., Gibbs,R.A., Posey,J.E., Marafi,D.
            and Lupski,J.R.
  TITLE     Expanding the phenotypic and allelic spectrum of SMG8: Clinical
            observations reveal overlap with SMG9-associated disease trait
  JOURNAL   Am J Med Genet A 188 (2), 648-657 (2022)
   PUBMED   34761517
  REMARK    GeneRIF: Expanding the phenotypic and allelic spectrum of SMG8:
            Clinical observations reveal overlap with SMG9-associated disease
            trait.
REFERENCE   4  (bases 1 to 5491)
  AUTHORS   Han,L., Bai,L., Fang,X., Liu,J., Kang,R., Zhou,D., Tang,D. and
            Dai,E.
  TITLE     SMG9 drives ferroptosis by directly inhibiting GPX4 degradation
  JOURNAL   Biochem Biophys Res Commun 567, 92-98 (2021)
   PUBMED   34146907
  REMARK    GeneRIF: SMG9 drives ferroptosis by directly inhibiting GPX4
            degradation.
REFERENCE   5  (bases 1 to 5491)
  AUTHORS   Lopez-Perrote,A., Hug,N., Gonzalez-Corpas,A., Rodriguez,C.F.,
            Serna,M., Garcia-Martin,C., Boskovic,J., Fernandez-Leiro,R.,
            Caceres,J.F. and Llorca,O.
  TITLE     Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated
            mRNA decay factor DHX34, as evidenced by Cryo-EM
  JOURNAL   Elife 9, e63042 (2020)
   PUBMED   33205750
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5491)
  AUTHORS   Melero,R., Uchiyama,A., Castano,R., Kataoka,N., Kurosawa,H.,
            Ohno,S., Yamashita,A. and Llorca,O.
  TITLE     Structures of SMG1-UPFs complexes: SMG1 contributes to regulate
            UPF2-dependent activation of UPF1 in NMD
  JOURNAL   Structure 22 (8), 1105-1119 (2014)
   PUBMED   25002321
REFERENCE   7  (bases 1 to 5491)
  AUTHORS   Takeda,S., Fujimoto,A., Yamauchi,E., Hiyoshi,M., Kido,H.,
            Watanabe,T., Kaibuchi,K., Ohta,T. and Konishi,H.
  TITLE     Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to
            IQGAP and the NMD complex
  JOURNAL   Biochem Biophys Res Commun 410 (1), 29-33 (2011)
   PUBMED   21640080
  REMARK    GeneRIF: IQGAP1 protein, an actin cytoskeleton modifier acts as a
            binding partner with SMG-9 and this binding is regulated by
            phosphorylation of SMG-9 at Tyr-41.
REFERENCE   8  (bases 1 to 5491)
  AUTHORS   Fernandez,I.S., Yamashita,A., Arias-Palomo,E., Bamba,Y.,
            Bartolome,R.A., Canales,M.A., Teixido,J., Ohno,S. and Llorca,O.
  TITLE     Characterization of SMG-9, an essential component of the
            nonsense-mediated mRNA decay SMG1C complex
  JOURNAL   Nucleic Acids Res 39 (1), 347-358 (2011)
   PUBMED   20817927
REFERENCE   9  (bases 1 to 5491)
  AUTHORS   Yamashita,A., Izumi,N., Kashima,I., Ohnishi,T., Saari,B.,
            Katsuhata,Y., Muramatsu,R., Morita,T., Iwamatsu,A., Hachiya,T.,
            Kurata,R., Hirano,H., Anderson,P. and Ohno,S.
  TITLE     SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate
            remodeling of the mRNA surveillance complex during
            nonsense-mediated mRNA decay
  JOURNAL   Genes Dev 23 (9), 1091-1105 (2009)
   PUBMED   19417104
REFERENCE   10 (bases 1 to 5491)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY084349.1, AL136606.1,
            AC004780.1 and BQ180848.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_019108.3.
            
            Summary: This gene encodes a regulatory subunit of the SMG1
            complex, which plays a critical role in nonsense-mediated mRNA
            decay (NMD). Binding of the encoded protein to the SMG1 complex
            kinase scaffold protein results in the inhibition of its kinase
            activity. Mutations in this gene cause a multiple congenital
            anomaly syndrome in human patients, characterized by brain
            malformation, congenital heart disease and other features.
            [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1119794.1,
                                           SRR1163655.59815.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270066.11/ ENSP00000270066.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                HY084349.1         55-104
            51-2320             AL136606.1         5-2274
            2321-4897           AC004780.1         5454-8030           c
            4898-5477           BQ180848.1         16-595              c
            5478-5491           AC004780.1         4860-4873           c
FEATURES             Location/Qualifiers
     source          1..5491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..5491
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="SMG9 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:56006"
                     /db_xref="HGNC:HGNC:25763"
                     /db_xref="MIM:613176"
     exon            1..309
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            310..465
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1878
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="protein smg-9 homolog"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG9"
                     /protein_id="NP_061981.2"
                     /db_xref="CCDS:CCDS33043.2"
                     /db_xref="GeneID:56006"
                     /db_xref="HGNC:HGNC:25763"
                     /db_xref="MIM:613176"
                     /translation="MSESGHSQPGLYGIERRRRWKEPGSGGPQNLSGPGGRERDYIAP
                     WERERRDASEETSTSVMQKTPIILSKPPAERSKQPPPPTAPAAPPAPAPLEKPIVLMK
                     PREEGKGPVAVTGASTPEGTAPPPPAAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPA
                     AMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKS
                     MVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSP
                     SILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFL
                     QTAEMVKPSTPSPSHESSSSSGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMID
                     QLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDSEAESENPPRAGPGS
                     SPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRK
                     SSALAEYSRLLA"
     exon            466..540
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            541..805
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            806..903
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1016
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1128
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1224
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1310
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1417
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1525
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1654
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1799
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..5491
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="hexamer: AATAAA"
     polyA_site      2320
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="major polyA site"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="hexamer: AATACA"
     polyA_site      2528
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
     regulatory      4869..4874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="hexamer: AATAAG"
     polyA_site      4891
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
     regulatory      5458..5463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="hexamer: AATAAA"
     regulatory      5470..5475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
                     /note="hexamer: AATACA"
     polyA_site      5477
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
     polyA_site      5491
                     /gene="SMG9"
                     /gene_synonym="C19orf61; F17127_1; HBMS; NEDITPO"
ORIGIN      
        1 attcagttct cgagctccag ccctcagcgc atgcgcagga cgagtcgcct gagggaactg
       61 atctcagctc gggcccgcgt tacatcctcc tcctcttctt ccttcggccc agctttcctt
      121 aggggctgca acccggacgc cgaggccggt ttcggagtgg ggagtgccca ttttctctcc
      181 ttcccacgtt cctggccccc agacgccatt tgcaggcggg tggcttgggt cagcctcccc
      241 gcccccaccc gactcccgtc acgggagagc gcacaccgcg ccccgagaac caatcagcag
      301 ccgcgttagg taaccatgtc tgagtctgga cacagtcagc ctggactcta tgggatagag
      361 cggcggcgac ggtggaagga gcctggctct ggtggccccc agaatctctc tgggcctggt
      421 ggtcgggaga gggactacat tgcaccatgg gaaagagaga gaagggatgc cagcgaagag
      481 acaagcactt ccgtcatgca gaaaaccccc atcatcctct caaaacctcc agcagagcgg
      541 tcaaaacagc caccacctcc aacagcccct gctgccccgc ctgctccagc ccctctggag
      601 aagcccatcg ttctcatgaa gccacgggag gaggggaagg ggcctgtggc cgtgacaggt
      661 gcctctaccc ctgagggcac cgccccacca ccccctgcag cccctgcgcc acccaagggg
      721 gagaaggagg ggcagagacc cacacagcct gtgtaccaga tccagaaccg gggcatgggc
      781 actgccgcac cagcagccat ggaccctgtc gtgggtcagg ccaaactact gcccccagag
      841 cgcatgaagc acagcatcaa gttggtggat gaccagatga attggtgtga cagtgccatc
      901 gagtacctgt tggatcagac tgatgtgttg gtggttggtg tcctgggcct ccaggggaca
      961 ggcaagtcca tggtcatgtc attgttgtca gccaacactc cagaggagga ccagaggact
     1021 tatgttttcc gggcccagag cgctgaaatg aaggaacgag ggggcaacca gaccagtggc
     1081 atcgacttct ttattaccca agaacggatt gttttcctgg acacacagcc catcctgagc
     1141 ccttctatcc tagaccatct catcaataat gaccgcaaac tgcctccaga gtacaacctt
     1201 ccccacactt acgttgaaat gcagtcactc cagattgctg ccttcctttt cacggtctgc
     1261 catgtggtga ttgttgtcca ggactggttc acagacctca gtctctacag gttcctgcag
     1321 acagcagaga tggtgaagcc ctccacccca tcccccagcc acgagtccag cagctcatcg
     1381 ggctccgatg aaggcaccga gtactacccc cacctagtct tcttgcagaa caaagctcgc
     1441 cgagaggact tctgtcctcg gaagctgcgg cagatgcacc tgatgattga ccagctcatg
     1501 gcccactccc acctgcgtta caagggaact ctgtccatgt tacaatgcaa tgtcttcccg
     1561 gggcttccac ctgacttcct ggactctgag gtcaacttat tcctggtacc cttcatggac
     1621 agtgaagcag agagtgaaaa cccaccaaga gcaggacctg gttccagccc actcttctcc
     1681 ctgctgcctg ggtatcgtgg ccaccccagt ttccagtcct tggtgagcaa gctccggagc
     1741 caagtgatgt ccatggcccg gccacagctg tcacacacga tcctcaccga gaagaactgg
     1801 ttccactacg ctgcccggat ctgggatggg gtgagaaagt cctctgctct ggcagagtac
     1861 agccgcctgc tggcctgagg ccaaggagag gaatgtcatg caggggacct cctgggtccg
     1921 cagtgtactg cgagggagca cagatgtcca tcccccgctg gggtggagag cggcagcagg
     1981 cctgatggat gagggatcgt ggcttcccgg cccagagaca tgaggtgtcc agggccaggc
     2041 cccccaccct cagttggggc tgttccgggg gtgactgtga gcgatcccac cccaaacctg
     2101 agatggggta gcccgtcctg tgtcctccac agggacaagc agtgggagga gtctgaatgg
     2161 tcaccaggaa gcccgggctc catcttgacc tcctttttca gggacaggag caacaggccc
     2221 ctcttccctg actctaagcc cttccctgta aggtgaggca gggtctggag agctctttat
     2281 tggaacagat ctggtggttc aaataaacac agtcatgcaa gcctgttctt atgttccact
     2341 tactcctcta cccaccatgc agctctggga agcaggacaa attggacacc cagcccttgc
     2401 gggcagatgg agatcagtct ctgctaagaa gtccctagaa ggggttattc tgtttcctgg
     2461 ggtggcatca agcctcccct gtgtatgttt tggatgggaa aatacactgg tgcagctgag
     2521 tacagcaact accctcgtgt cttctgctct cacttaaaga cagttacctg cctttgggtt
     2581 aaatgcccag ttaaatacag tgcctaggct gggcatggtg gctcacgtct ataatcctag
     2641 cactttggga ggccgaggca ggcggatcac ttgagatcag gagttcgaga ccagcctggc
     2701 caacatggtg agaccctgtc tctactaaaa atacaaaaaa aaattagctg ggcgtggtgg
     2761 cgcacgcctg taatcctagc tacttgggag gctgaggtgg gagaactgct tgaacccggg
     2821 aggcagaggt tgcagtgagc caagatcacg ccactgcact ctccagcttg ggcaacagag
     2881 cgagactccg tctcaaaaaa aaaaaaaaag cctacttttg acttaagaaa cagaacttgt
     2941 ccttaaatgt agtaagtact tacccttaat ccaaatacca tgcctcaccc gtacagacag
     3001 tgccttctgt tggttaaata cagtggcttt cctctcgtaa acctcatcta ctcttgctta
     3061 gaaatggcaa ccctcacctt taatgtaaat ccagaaccta ccctcagtta aatccactct
     3121 gcgatttggt acagtaccaa ccctcatctg ctcagttaaa tacagtacat gatcttagtt
     3181 tgaggtttcc caaagtatgt ctccaaattg gtctcgccac cccaaattaa tccatcgttc
     3241 agtaaagcag tcagctccag tccagctggc tgagtctgtt catccattgc cctcccccac
     3301 cccctgccgc ccgtggcaca tatttgtctc cctggtttcc tcctgctttc aagcatccca
     3361 tacagccctg gtgtttcata ccatggggat ccagggcctt gtgagaaaca actgaagtga
     3421 gggggggcgg ggggtcagtg aagaaagcac tcagcagggc cagagaaggt caggccagaa
     3481 gtggatagaa tgccagtctc tacagagggc tgaggcctgg gagacaggag gcccagcaca
     3541 ggctctggca cagccacttc ctgaccgact gtagtaggca aggagcctcc cctctctggc
     3601 cattattcca acatttaaga tcatcctcga ggcccttcag agctgtgaca ttcactgccc
     3661 ttttaccgaa atgcttctaa atcctttgcc ccactgtcgt gatctctaca gaaccctcct
     3721 gaccatcctc tccagctaga taacccagct cttccctgcc ttgtcaaaat gtctgcccca
     3781 agtctcatcc ccacccctgc ttccccaggg ggtcttcctg ctggttgatt tgggggtttg
     3841 ccagagtagg aaaggtggtg ggggcaacgg ccagagaaag atgggagacc caaggcaaga
     3901 cggcaccaga cagcatgcaa ctcagtccag gagagttgga gcttcagttt cttccatccc
     3961 agcccctttc agcacaaggc tggggacaga gagaactgtg ccctcccagc cctaacctac
     4021 cacctcctgc tggcccagct cagggctgag attgttgatt ggattcacct gtgatcttgt
     4081 ggtcagtgtt gccaaggaag gtctgaatca gcacactctt ggtgtccctg gctgccaaat
     4141 ccaggggcgt gtgaagcatc cggtagatgg tggtgaagga ggtgctgcag gtgaccagga
     4201 tgcccggatg ggtgaaatga ggcactctgg aaatccggcc tagcgtttcc accaccacca
     4261 ccgtggtgat ctggtgacct tggtccaaag gccctgtccc acctccaggg ttttgtgcag
     4321 gggctggctc gttgaggcag tttgacagag gagtcaaact ggcagtagcc ttctgaacag
     4381 tgggtaagta tgtaccggtc acccgccacc ccctttacat ccagcagagg actcaggctg
     4441 atgctgccag caggccactg tggacaccag ctagatatac tgctgcaggg aggccttctg
     4501 ctctaggatg ggctgcaaga tgggcctggc caccaggaat gcctgctgct tgtggctctc
     4561 cagtcccttc atcattccca gcaggtggaa ctcacgcttt tcaattcaga cacaggaata
     4621 cattggtatc cttctcaccc tccactgcag gaaacatgag caccgctcaa tcagcttcta
     4681 cactggagca ggccatgttg tgctggcagc tgcctgggct caagcgcctg tcatgagcgc
     4741 agcacttggc ctaagaatgt cagccctgca gccaggctgc ctatgttcag atcccagcct
     4801 tgccatctac cacctgtgtg gcattggaca agttgctaaa gcttgctggg catctgtttt
     4861 gtctgcaaaa taaggtgatg attgtaccta cctcctaggg gtgttgtggt gattaattga
     4921 gttcataatg gtgtctgttt tagtcggttc ttgcattgct gtaaggaaat acctgagact
     4981 gggtaattta taaagaaaag gggtttaatt ggctcagagt tctgcaggct gaaccagaag
     5041 catggtgctg gcatctgctc ggcttctggg gaggcctcag gaaacttaca atcatggcgg
     5101 aaggtgaact gggagcaggt acttcacatg cccagagcag gagcaagagg gggcaggtgg
     5161 cacacacttt gaaaccacga gctcttacaa cagattcact attgtgagga cagtaccaag
     5221 gggctggcgc tgaaccatga gaaaccaccc ccatgatgcc gtccctcccg ccaggcccca
     5281 cctccaacag tggtgactac aaactacaag ttgacatgag atctggtggg gacacagatc
     5341 caaaccatat cagtgcctga cctatgctga gcctcaataa atgttaaatg ccaccatcat
     5401 ccacaggtgc caggtctgca ttgggcacat agcattttgc aatcctctaa ctttgcaaat
     5461 aaatgagcca atacatactc tttctcctta a
//
