LOCUS       NM_001375584            5946 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SMG7 nonsense mediated mRNA decay factor (SMG7),
            transcript variant 11, mRNA.
ACCESSION   NM_001375584 XM_005245652
VERSION     NM_001375584.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5946)
  AUTHORS   Song,X., Ru,M., Steinsnyder,Z., Tkachuk,K., Kopp,R.P., Sullivan,J.,
            Gumus,Z.H., Offit,K., Joseph,V. and Klein,R.J.
  TITLE     SNPs at SMG7 Associated with Time from Biochemical Recurrence to
            Prostate Cancer Death
  JOURNAL   Cancer Epidemiol Biomarkers Prev 31 (7), 1466-1472 (2022)
   PUBMED   35511739
  REMARK    GeneRIF: SNPs at SMG7 Associated with Time from Biochemical
            Recurrence to Prostate Cancer Death.
REFERENCE   2  (bases 1 to 5946)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5946)
  AUTHORS   Boehm,V., Kueckelmann,S., Gerbracht,J.V., Kallabis,S.,
            Britto-Borges,T., Altmuller,J., Kruger,M., Dieterich,C. and
            Gehring,N.H.
  TITLE     SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6
            endonucleolytic activity
  JOURNAL   Nat Commun 12 (1), 3965 (2021)
   PUBMED   34172724
  REMARK    GeneRIF: SMG5-SMG7 authorize nonsense-mediated mRNA decay by
            enabling SMG6 endonucleolytic activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5946)
  AUTHORS   Ho,K., Luo,H., Zhu,W. and Tang,Y.
  TITLE     Critical role of SMG7 in activation of the ATR-CHK1 axis in
            response to genotoxic stress
  JOURNAL   Sci Rep 11 (1), 7502 (2021)
   PUBMED   33820915
  REMARK    GeneRIF: Critical role of SMG7 in activation of the ATR-CHK1 axis
            in response to genotoxic stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5946)
  AUTHORS   Yang,L., Kraft,V.A.N., Pfeiffer,S., Merl-Pham,J., Bao,X., An,Y.,
            Hauck,S.M. and Schick,J.A.
  TITLE     Nonsense-mediated decay factor SMG7 sensitizes cells to
            TNFalpha-induced apoptosis via CYLD tumor suppressor and the
            noncoding oncogene Pvt1
  JOURNAL   Mol Oncol 14 (10), 2420-2435 (2020)
   PUBMED   32602581
  REMARK    GeneRIF: Nonsense-mediated decay factor SMG7 sensitizes cells to
            TNFalpha-induced apoptosis via CYLD tumor suppressor and the
            noncoding oncogene Pvt1.
REFERENCE   6  (bases 1 to 5946)
  AUTHORS   Unterholzner,L. and Izaurralde,E.
  TITLE     SMG7 acts as a molecular link between mRNA surveillance and mRNA
            decay
  JOURNAL   Mol Cell 16 (4), 587-596 (2004)
   PUBMED   15546618
REFERENCE   7  (bases 1 to 5946)
  AUTHORS   Ohnishi,T., Yamashita,A., Kashima,I., Schell,T., Anders,K.R.,
            Grimson,A., Hachiya,T., Hentze,M.W., Anderson,P. and Ohno,S.
  TITLE     Phosphorylation of hUPF1 induces formation of mRNA surveillance
            complexes containing hSMG-5 and hSMG-7
  JOURNAL   Mol Cell 12 (5), 1187-1200 (2003)
   PUBMED   14636577
  REMARK    GeneRIF: Data show that phosphorylated hUPF1, the human ortholog of
            UPF1/SMG-2, forms a complex with human orthologs of the
            Caenorhabditis elegans proteins SMG-5 and SMG-7.
REFERENCE   8  (bases 1 to 5946)
  AUTHORS   Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
            Robinson,M.O. and Harrington,L.
  TITLE     Functional conservation of the telomerase protein Est1p in humans
  JOURNAL   Curr Biol 13 (8), 698-704 (2003)
   PUBMED   12699629
REFERENCE   9  (bases 1 to 5946)
  AUTHORS   Reichenbach,P., Hoss,M., Azzalin,C.M., Nabholz,M., Bucher,P. and
            Lingner,J.
  TITLE     A human homolog of yeast Est1 associates with telomerase and uncaps
            chromosome ends when overexpressed
  JOURNAL   Curr Biol 13 (7), 568-574 (2003)
   PUBMED   12676087
REFERENCE   10 (bases 1 to 5946)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL449223.7 and AL137800.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 29, 2019 this sequence version replaced XM_005245652.3.
            
            Summary: This gene encodes a protein that is essential for
            nonsense-mediated mRNA decay (NMD); a process whereby transcripts
            with premature termination codons are targeted for rapid
            degradation by a mRNA decay complex. The mRNA decay complex
            consists, in part, of this protein along with proteins SMG5 and
            UPF1. The N-terminal domain of this protein is thought to mediate
            its association with SMG5 or UPF1 while the C-terminal domain
            interacts with the mRNA decay complex. This protein may therefore
            couple changes in UPF1 phosphorylation state to the degradation of
            NMD-candidate transcripts. Alternative splicing results in multiple
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.221341.1,
                                           SRR1660807.81080.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000688051.1/ ENSP00000510175.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AL449223.7         167418-167568
            152-183             AL137800.12        13381-13412
            184-301             AL137800.12        16418-16535
            302-434             AL137800.12        18232-18364
            435-606             AL137800.12        27140-27311
            607-678             AL137800.12        28500-28571
            679-829             AL137800.12        29436-29586
            830-965             AL137800.12        29942-30077
            966-1128            AL137800.12        33708-33870
            1129-1285           AL137800.12        34220-34376
            1286-1356           AL137800.12        37689-37759
            1357-1417           AL137800.12        38924-38984
            1418-1537           AL137800.12        41528-41647
            1538-1964           AL137800.12        42620-43046
            1965-2109           AL137800.12        44897-45041
            2110-2492           AL137800.12        45474-45856
            2493-2864           AL137800.12        46510-46881
            2865-3014           AL137800.12        47647-47796
            3015-3095           AL137800.12        49752-49832
            3096-3255           AL137800.12        50308-50467
            3256-3426           AL137800.12        51295-51465
            3427-3572           AL137800.12        51589-51734
            3573-5946           AL137800.12        52362-54735
FEATURES             Location/Qualifiers
     source          1..5946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..5946
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /note="SMG7 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:9887"
                     /db_xref="HGNC:HGNC:16792"
                     /db_xref="MIM:610964"
     exon            1..151
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..3686
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /EC_number="2.7.11.1"
                     /note="isoform 10 is encoded by transcript variant 11;
                     ever shorter telomeres 1C; EST1 telomerase component
                     homolog C; breast cancer-associated antigen SGA-56M;
                     EST1-like protein C; smg-7 homolog, nonsense mediated mRNA
                     decay factor; nonsense-mediated mRNA decay factor SMG7"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG7 isoform
                     10"
                     /protein_id="NP_001362513.1"
                     /db_xref="CCDS:CCDS91123.1"
                     /db_xref="GeneID:9887"
                     /db_xref="HGNC:HGNC:16792"
                     /db_xref="MIM:610964"
                     /translation="MSLQSAQYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKML
                     VTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFY
                     TQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGD
                     IARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFP
                     FPAASTNLQKALSKALESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKL
                     EEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLAL
                     FMSFLGILCKCPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPW
                     LISLLNSFHPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQ
                     QRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQE
                     TSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKENIKTREVNRDQGRSFPP
                     KEVRRDYSKGITVTKNDGKKDNNKRKTETKKCTLEKLQETGKQNVAVQVKSQTELRKT
                     PVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSG
                     YTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPS
                     QQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQYQQADASK
                     QLWNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVMQQQPLEKKMKPFPMEP
                     YNHNPSEVKVPEFYWDSSYSMADNRSVMAQQANIDRRGKRSPGVFRPEQDPVPRMPFE
                     DPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLFKSLLEKPS
                     ELMSHSSSFLSLTGFSLNQERYPNNSMFNEVYGKNLTSSSKAELSPSMAPQETSLYSL
                     FEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSVPFSNFGPIGTPDNR
                     DRRTADRWKTDKPAMGGFGIDYLSATSSSESSWHQASTPSGTWTGHGPSMEDSSAVLM
                     ESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH"
     exon            152..183
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            184..301
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            302..434
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            435..606
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            607..678
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            679..829
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            830..965
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1128
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1285
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1356
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1417
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1537
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1964
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2109
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2492
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2864
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3014
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3095
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3255
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3426
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3572
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..5946
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5923..5928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /note="hexamer: ATTAAA"
     polyA_site      5946
                     /gene="SMG7"
                     /gene_synonym="C1orf16; EST1C; SGA56M"
                     /note="major polyA site"
ORIGIN      
        1 gaggagccgg aggagaggaa gatggcggcg gccgccagca cccgcggtgc cgcggggccg
       61 ctccgaggag cctgagagac ccacggaggc ttcgcgggaa gacgcggcgg cggcggcgga
      121 ggatgagcct gcagagcgcg cagtacctcc ggcaggcaga agtcctgaag gctgacatga
      181 cagattctaa gctgggtcca gctgaagtct ggacatccag gcaggctctg caggacctgt
      241 accagaaaat gctagttacc gatttggaat acgctttaga caagaaagta gaacaggatc
      301 tctggaatca cgcctttaag aatcagatca caacactgca aggccaggca aagaatcgag
      361 caaatccgaa tcggagtgaa gttcaggcaa acctttctct gttcctagag gcagctagtg
      421 gcttctatac tcagttatta caagaactgt gtacagtatt taatgtagat ttaccatgcc
      481 gtgtgaagtc ttcccaattg ggaattatca gcaataaaca gacgcatacc agcgccatag
      541 tgaagccaca gtctagctcc tgttcctata tctgccagca ctgcctcgtc caccttggag
      601 acattgctcg atacagaaac cagaccagcc aggcagagtc ctactatagg catgcagctc
      661 agcttgtccc ctccaatggt cagccttata atcagttggc tatcttagct tcttccaaag
      721 gagaccatct gaccacaatt ttctactact gcagaagcat tgctgtgaag ttccctttcc
      781 cagctgcctc cactaatctg caaaaagcac tttctaaagc actggaaagc cgagatgagg
      841 tgaaaaccaa gtggggtgtt tctgacttca tcaaggcctt tattaaattc cacggtcatg
      901 tgtacctgag taagagcttg gaaaagttga gccctcttcg agagaaattg gaagaacagt
      961 ttaagaggct gctattccaa aaagctttca actctcagca gttagttcat gtcactgtca
     1021 ttaacctgtt tcaacttcat caccttcgtg actttagcaa tgaaaccgag cagcacactt
     1081 atagccaaga tgagcagcta tgttggacac agttgctggc cctctttatg tcttttcttg
     1141 gcatcctgtg caagtgtcct ctacagaatg agtctcagga ggagtcctac aatgcctatc
     1201 ctcttccagc agtcaaggtc tccatggact ggctaagact cagacccagg gtctttcagg
     1261 aggcagtggt ggatgaaaga cagtacattt ggccctggtt gatttctctt ctgaatagtt
     1321 tccatcccca tgaagaggac ctctcaagta ttagtgcgac accacttcca gaggagtttg
     1381 aattacaagg atttttggca ttgagacctt ctttcaggaa cttggatttt tccaaaggtc
     1441 accagggtat tacaggggac aaagaaggcc agcaacgacg aatacgacag caacgcttga
     1501 tctctatagg caaatggatt gctgataatc agccaaggct gattcagtgt gaaaatgagg
     1561 tagggaaatt gttgtttatc acagaaatcc cagaattaat actggaagac cccagtgaag
     1621 ccaaagagaa cctcattctg caagaaacat ctgtgataga gtcgctggct gcagatggga
     1681 gcccagggct aaaatcagtg ctatctacaa gccgaaattt aagcaacaac tgtgacacag
     1741 gagagaagcc agtggttacc ttcaaagaaa acattaagac acgagaagtg aacagagacc
     1801 aaggaagaag ttttcctccc aaagaggtga gaagggacta tagcaaagga ataactgtaa
     1861 ctaagaatga tggaaagaag gacaacaaca agaggaaaac tgaaaccaag aaatgcacct
     1921 tagaaaagtt acaggaaaca ggaaagcaga atgtggcagt gcaggtaaaa tcccagacag
     1981 aactaagaaa gactccagtg tctgaagcca gaaaaacacc tgtaactcaa accccaactc
     2041 aagcaagtaa ctcccagttc atccccattc atcaccctgg agccttccct cctcttccca
     2101 gcaggccagg gtttccgccc ccaacatatg ttatcccccc gcctgtggca ttttctatgg
     2161 gctcaggtta caccttccca gctggtgttt ctgtcccagg aacctttctt cagcctacag
     2221 ctcactctcc agcaggaaac caggtgcaag ctgggaaaca gtcccacatt ccttacagcc
     2281 agcaacggcc ctctggacca gggccaatga accagggacc tcaacaatca cagccacctt
     2341 cccagcaacc ccttacatct ttaccagctc agccaacagc acagtctaca agccagctgc
     2401 aggttcaagc tctaactcag caacaacaat cccctacaaa agctgtgccg gctttgggga
     2461 aaagcccgcc tcaccactct ggattccagc agtatcaaca ggcagatgcc tccaaacagc
     2521 tgtggaatcc ccctcaggtt caaggcccat tagggaaaat tatgcctgtg aaacagccct
     2581 actaccttca gacccaagac cccataaaac tgtttgagcc gtcattgcaa cctcctgtaa
     2641 tgcagcagca gcctctagaa aaaaaaatga agccttttcc catggagcca tataaccata
     2701 atccctcaga agtcaaggtc ccagaattct actgggattc ttcctacagc atggctgata
     2761 acagatctgt aatggcacag caagcaaaca tagaccgcag gggcaaacgg tcaccaggag
     2821 tcttccgtcc agagcaggat cctgtaccca gaatgccgtt tgaggacccc aagagctccc
     2881 ctctgcttcc tccggacctg ttaaagagtc tggctgcctt ggaggaagag gaagagctga
     2941 ttttttctaa ccctcctgat ctttacccgg ctctgctggg gcctctcgcc tctcttcctg
     3001 gacgaagcct ttttaaatcc ttattggaga agccctcaga gctcatgtca cattcatcct
     3061 ctttcctgtc cctcaccgga ttctctctca atcaggaaag atacccaaat aatagtatgt
     3121 tcaatgaggt atatgggaaa aacctgacat ccagctccaa agcagaactc agtccctcaa
     3181 tggcccccca ggaaacatct ctgtattccc tttttgaagg gactccgtgg tctccatcac
     3241 ttcctgccag ttcagatcat tcaacaccag ccagccagtc tcctcattcc tctaacccaa
     3301 gcagcctacc cagctctcct ccaacacaca accataattc tgttccattc tccaattttg
     3361 gacccattgg gactccagat aacagggata gaaggactgc agatcggtgg aaaactgata
     3421 agccagccat gggtgggttt ggcattgatt atctctcagc aacgtcatcc tctgagagca
     3481 gttggcatca ggccagcact ccgagtggca cctggacagg ccatggccct tccatggagg
     3541 attcctctgc tgtcctcatg gaaagcctaa agtctatctg gtccagttcc atgatgcatc
     3601 ctggaccttc tgctctggag cagctgttaa tgcagcagaa gcagaaacag caacggggac
     3661 aaggcaccat gaaccctcca cactgaggcc aaagtggcaa cctgggaatg aaggctccat
     3721 aaaccatggc atgttgggtt tgcaggactg gcccacacag tcccctgcag gtggcagccc
     3781 tcttttctgt ttctcgctgt caagagggtg taagtattcc accagcccgc tgagtgtgca
     3841 cgaaatgttc gcagtgcaac aaaaagaaaa atccatcagg aactctccgt ccccccgggg
     3901 ccctccggag ggagagagag aggaactgct gtttatctca ctcagttact tggtatcacc
     3961 gcctctcacc ttctccatcg tgcatgtccc cagccacatg ggaagtgaaa gctgagaagg
     4021 gaaggcagat gggagaagcc aatgggaact tctcagtcct tttttcctct ttggggaata
     4081 aaataggaat ccattaatga ttgctttgct gactgagaat gtagttgaaa ttattcttaa
     4141 acatctttta ttattattac tctcagtagt aaaatatcac actgaattct tccatacaca
     4201 ggtgtgcttc tagtcagtgt gtagcaagga aagccccgtt cactgctcct gtgagaggtt
     4261 ggtggtgaca ggatggggaa ccgacctctt cagccagtgg aaatgttcca taagggagag
     4321 ttcaaggcct gtcagaaggc tctggtaggc cttcctctgg ccaggagact ccagcaggga
     4381 atgcccttca ctctgtaggt gctcgagccc caatcgagga tacagtgtgg gtggtggtgc
     4441 tgggctggac tagcaggtag actgctgtag gatttcaaat tacgtttttg attcctgtac
     4501 attttacagt cgcacagcaa gcagtctcac agaaggcagg ctagtccatt cacagcctga
     4561 cacgttctaa taggtagaag ctttcagtgt ggttattttt tctttggttg gtttttgtgc
     4621 ccccattcta cttcccaccc tcctgcccca tctccatccc ttcttttacc caatgctgta
     4681 tgctagtaat tgtttttatt cctaatgtgt gcaacatcac atctccccaa gaagcaacag
     4741 catggggtcc agcagttggg gcccaaaaga cagtctgaag aggaaggaag cagcagtatc
     4801 tgcgtagccc acagagggcc caggcccctg cccagctgca gtctcccagc ctccactttc
     4861 agagtgaaat tcaaggcagc acggacatgt gcccatcagg cacagaagaa aacacgacgt
     4921 cgtccatttt ggaagagacg aaagaaagga aaataaactc tttgtatgat atttattagg
     4981 aggaaagagg actgaaaatg ttcttgtgta gaaacagaag gacagcattt ctgttagtca
     5041 tttcctggaa aagtaatatt ttaaggggaa attatggaaa caatctaatt gttcaattgc
     5101 tgtgctagtg gtagggttta ttttctggga ggtctctcct ttgtgtgtct gtatgtttgt
     5161 gtacacacac gtgcccatct gctgtcccag aggggagggg ttgtgtgtgc gagtgtatgg
     5221 agttagtgtg gaacttaaga gctggaagac agctgtagag caaagcacat ccaggagccc
     5281 cagttgtcac tgcagtctgg gcaaccccag caatgaaaag gggtgagata acgctcattg
     5341 ctcttcagag agagtggttg gagccccccc cgccccgtat gcttacatta ttgctctttt
     5401 agtttgacat ggtgtttggg ttttgttttt ttgaaaggtc tgaaaaggtg aagcccccta
     5461 cccaatggca atatgaaacc ttttgtgctt ctcttcagcc ccttccctgt gtccaccttt
     5521 ctctcctctt cccaagcctt tttcctacta cctttaccca gtttgtgtgt ttgagctctg
     5581 cattcaggca gctgcaacat tccagtgttt gaactgtcac tgattcttgc gccctagaca
     5641 agctaaccag gtttaccatc tcactcccag taatacccag ctcctatcta aagccccatt
     5701 ctgcatgaga atttggtgtt tggaatgttt tctgactctt ggggcgggat tcctcgcctt
     5761 atcatcctca ctgtggagta atgaggggga ggagaatctt tatcagaaac tggttttgtg
     5821 tagtaaactt tcttttgtgg ttttttgttt tgttttctgg gttttgtttt ttgtttttgt
     5881 ctgtgcaaga cctgcagctg ctgaaaatca gctttgcctt taattaaacc atgttctctc
     5941 caacca
//
