LOCUS       NM_017575               5974 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens SMG6 nonsense mediated mRNA decay factor (SMG6),
            transcript variant 1, mRNA.
ACCESSION   NM_017575 NM_025023 XM_930587 XM_942731
VERSION     NM_017575.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5974)
  AUTHORS   Langer,L.M., Kurscheidt,K., Basquin,J., Bonneau,F., Iermak,I.,
            Basquin,C. and Conti,E.
  TITLE     UPF1 helicase orchestrates mutually exclusive interactions with the
            SMG6 endonuclease and UPF2
  JOURNAL   Nucleic Acids Res 52 (10), 6036-6048 (2024)
   PUBMED   38709891
  REMARK    GeneRIF: UPF1 helicase orchestrates mutually exclusive interactions
            with the SMG6 endonuclease and UPF2.
REFERENCE   2  (bases 1 to 5974)
  AUTHORS   Sun,X., Xiao,T., Qin,J., Song,Y., Lu,K., Ding,R., Shi,W. and
            Bian,Q.
  TITLE     Mechanism of circRNA_SMG6 mediating lung macrophage ECM degradation
            via miR-570-3p in microplastics-induced emphysema
  JOURNAL   Environ Int 187, 108701 (2024)
   PUBMED   38685156
  REMARK    GeneRIF: Mechanism of circRNA_SMG6 mediating lung macrophage ECM
            degradation via miR-570-3p in microplastics-induced emphysema.
REFERENCE   3  (bases 1 to 5974)
  AUTHORS   Sanderlin,E.J., Keenan,M.M., Mense,M., Revenko,A.S., Monia,B.P.,
            Guo,S. and Huang,L.
  TITLE     CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated
            endonucleolytic decay pathway
  JOURNAL   Nat Commun 13 (1), 2344 (2022)
   PUBMED   35487895
  REMARK    GeneRIF: CFTR mRNAs with nonsense codons are degraded by the
            SMG6-mediated endonucleolytic decay pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5974)
  AUTHORS   Annibaldis,G., Domanski,M., Dreos,R., Contu,L., Carl,S., Klay,N.
            and Muhlemann,O.
  TITLE     Readthrough of stop codons under limiting ABCE1 concentration
            involves frameshifting and inhibits nonsense-mediated mRNA decay
  JOURNAL   Nucleic Acids Res 48 (18), 10259-10279 (2020)
   PUBMED   32941650
  REMARK    GeneRIF: Readthrough of stop codons under limiting ABCE1
            concentration involves frameshifting and inhibits nonsense-mediated
            mRNA decay.
REFERENCE   5  (bases 1 to 5974)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5974)
  AUTHORS   Ohnishi,T., Yamashita,A., Kashima,I., Schell,T., Anders,K.R.,
            Grimson,A., Hachiya,T., Hentze,M.W., Anderson,P. and Ohno,S.
  TITLE     Phosphorylation of hUPF1 induces formation of mRNA surveillance
            complexes containing hSMG-5 and hSMG-7
  JOURNAL   Mol Cell 12 (5), 1187-1200 (2003)
   PUBMED   14636577
REFERENCE   7  (bases 1 to 5974)
  AUTHORS   Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
            Robinson,M.O. and Harrington,L.
  TITLE     Functional conservation of the telomerase protein Est1p in humans
  JOURNAL   Curr Biol 13 (8), 698-704 (2003)
   PUBMED   12699629
REFERENCE   8  (bases 1 to 5974)
  AUTHORS   Reichenbach,P., Hoss,M., Azzalin,C.M., Nabholz,M., Bucher,P. and
            Lingner,J.
  TITLE     A human homolog of yeast Est1 associates with telomerase and uncaps
            chromosome ends when overexpressed
  JOURNAL   Curr Biol 13 (7), 568-574 (2003)
   PUBMED   12676087
  REMARK    GeneRIF: associated with most or all active telomerase in HeLa cell
            extracts; overexpression of hEST1A induces anaphase bridges due to
            chromosome-end fusions, and telomeric DNA persists at the fusion
            points
REFERENCE   9  (bases 1 to 5974)
  AUTHORS   Chiu,S.Y., Serin,G., Ohara,O. and Maquat,L.E.
  TITLE     Characterization of human Smg5/7a: a protein with similarities to
            Caenorhabditis elegans SMG5 and SMG7 that functions in the
            dephosphorylation of Upf1
  JOURNAL   RNA 9 (1), 77-87 (2003)
   PUBMED   12554878
REFERENCE   10 (bases 1 to 5974)
  AUTHORS   Hoff,C., Seranski,P., Mollenhauer,J., Korn,B., Detzel,T.,
            Reinhardt,R., Ramser,J. and Poustka,A.
  TITLE     Physical and transcriptional mapping of the 17p13.3 region that is
            frequently deleted in human cancer
  JOURNAL   Genomics 70 (1), 26-33 (2000)
   PUBMED   11087658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450226.1, AB018275.2,
            AY168921.1 and AC090617.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017575.4.
            
            Summary: This gene encodes a component of the telomerase
            ribonucleoprotein complex responsible for the replication and
            maintenance of chromosome ends. The encoded protein also plays a
            role in the nonsense-mediated mRNA decay (NMD) pathway, providing
            the endonuclease activity near the premature translation
            termination codon that is needed to initiate NMD. Alternatively
            spliced transcript variants encoding distinct protein isoforms have
            been described. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018275.2, SRR1803612.27011.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263073.11/ ENSP00000263073.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL450226.1         35423-35432
            11-153              AB018275.2         38-180
            154-158             AL450226.1         38544-38548
            159-4341            AY168921.1         1-4183
            4342-5974           AC090617.16        165639-167271
FEATURES             Location/Qualifiers
     source          1..5974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..5974
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /note="SMG6 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:23293"
                     /db_xref="HGNC:HGNC:17809"
                     /db_xref="MIM:610963"
     exon            1..153
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..4325
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1; ever
                     shorter telomeres 1A; EST1 telomerase component homolog A;
                     telomerase-binding protein EST1A; telomerase subunit
                     EST1A; smg-6 homolog, nonsense mediated mRNA decay factor;
                     nonsense mediated mRNA decay factor SMG6"
                     /codon_start=1
                     /product="telomerase-binding protein EST1A isoform 1"
                     /protein_id="NP_060045.4"
                     /db_xref="CCDS:CCDS11016.1"
                     /db_xref="GeneID:23293"
                     /db_xref="HGNC:HGNC:17809"
                     /db_xref="MIM:610963"
                     /translation="MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDN
                     RRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELN
                     NQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESA
                     SRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGK
                     RMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDN
                     GCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGR
                     GEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQ
                     ESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGG
                     TTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPY
                     YYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSP
                     EEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYE
                     RCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGS
                     DFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYRE
                     QASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNP
                     ILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIW
                     IHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPA
                     VAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAA
                     ALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWS
                     DWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTL
                     LILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLL
                     AFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRE
                     LRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLASL
                     ARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFES
                     RDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEE
                     PIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG"
     exon            154..1912
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2105
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2216
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2323
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2402
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2513
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2726
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2788
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2934
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3051
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3220
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3422
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3599
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3746
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3900
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4112
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4113..4194
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..5974
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5950..5955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /note="hexamer: AATAAA"
     polyA_site      5974
                     /gene="SMG6"
                     /gene_synonym="C17orf31; EST1A; hEST1A; hSMG5/7a; SMG-6"
                     /note="major polyA site"
ORIGIN      
        1 gtggtggttt cctggctgcg cgcggcggtg gcggagccgc tacggctgta gcagcagccg
       61 cgaagatggc ggaagggctg gagcgtgtgc ggatctccgc gtcggagctg cgcgggatcc
      121 tggctactct ggccccgcag gccgggagca gagaaaacat gaaggaatta aaggaggcca
      181 ggccgcgcaa agataacagg cgtccagatc tggaaatcta taagcctggc ctttctcggc
      241 taaggaacaa gcccaaaatc aaggaacccc ctgggagtga ggaattcaaa gatgaaattg
      301 ttaatgaccg agattgctct gctgttgaaa atggtacaca gcccgttaaa gatgtctgca
      361 aggaactgaa caaccaagag cagaatggtc ctatagaccc agaaaataat cggggacaag
      421 aatcctttcc taggactgct ggacaagagg atcgtagtct aaaaattatc aaaagaacaa
      481 agaaacccga cctgcagatc tatcagcctg gacgacgttt gcagactgtt agcaaagaat
      541 ccgccagtcg ggtggaggag gaagaagtcc tcaaccaggt agaacaactg agagtagagg
      601 aagatgagtg taggggaaat gttgcgaagg aggaagttgc gaataaacca gacagggctg
      661 agatagaaaa gagcccaggt ggtgggagag taggggctgc aaaaggagaa aaaggaaaga
      721 ggatgggaaa aggggagggg gtgagggaaa cccacgacga cccagcccgc gggaggccgg
      781 gctccgcaaa gcgctactcc cgctcagaca aacgaaggaa tcgctaccgc acgcgcagca
      841 ccagctcagc tggcagcaac aacagcgctg agggagctgg cctgacggat aatggatgtc
      901 gccgccgccg acaggatagg accaaggaga ggccacgact gaagaagcaa gtgtctgtgt
      961 cctcaaccga ttccttagac gaggacagaa ttgatgagcc tgatggatta ggacccagga
     1021 gaagttcaga aaggaagaga catttagaaa gaaactggtc tggccgtggg gagggtgagc
     1081 agaaaaacag tgctaaagaa tatcgaggca ctcttcgtgt cactttcgat gcagaagcca
     1141 tgaacaaaga gtctcccatg gtgaggtcag ccagggatga tatggataga ggaaagcctg
     1201 acaaaggctt gagcagtggg ggcaaaggct ctgagaagca ggagtccaaa aacccgaaac
     1261 aagaacttcg gggtcgtggt cgtggcattc tgattttgcc tgcccatacc accctatctg
     1321 tcaattcagc aggttctcca gagtccgcgc ctttgggacc tcggcttttg tttggatctg
     1381 gtagtaaggg atctcggagt tggggccgtg gaggcaccac acgccgattg tgggacccaa
     1441 acaatcctga tcagaaacct gctctaaaga ctcagacgcc ccagctacat ttcttggaca
     1501 ctgatgatga agtcagccct acatcttggg gtgactcacg ccaggctcag gcatcttact
     1561 ataagtttca aaactctgac aacccctatt attacccccg gacaccaggc cctgcctccc
     1621 agtatcccta tacgggctat aaccctctac agtacccagt gggccctacg aatggtgtgt
     1681 acccagggcc ttactaccca ggctacccga ctccgtcagg acagtatgtg tgtagccctc
     1741 tacctaccag caccatgagt cccgaggagg tagagcagca catgaggaac ctgcagcaac
     1801 aggagctgca caggcttctc cgggtggctg acaaccagga actgcagctc agcaacctgc
     1861 tctccaggga ccgcatcagt ccggagggcc tggagaagat ggcgcaactc agagctgaac
     1921 tgctgcagct atatgagcgc tgtattctat tagatattga gttctctgat aatcagaatg
     1981 tggatcagat cctgtggaag aatgctttct atcaggtgat tgagaagttc aggcaacttg
     2041 tcaaggatcc gaatgttgag aacccagaac agattcggaa cagacttttg gagctcttgg
     2101 atgagggtag tgacttcttt gatagtttgc ttcagaagct gcaggttact tacaagttca
     2161 aactggaaga ctacatggat ggtcttgcca ttcgcagcaa gccattacgc aagacagtaa
     2221 aatatgcctt gatcagtgcc cagcgatgca tgatatgcca aggagatatt gctaggtacc
     2281 gggagcaagc cagtgataca gcgaattatg ggaaagcacg cagttggtac ctgaaggccc
     2341 agcacattgc tcccaagaat gggcgcccct ataaccagtt ggctttgctg gcagtgtata
     2401 cgaggaggaa gcttgacgct gtctattact atatgcgcag tttagctgcc agcaacccta
     2461 tcctgactgc caaggagagt ctcatgagct tgtttgaaga gaccaagcgg aaggcagaac
     2521 agatggaaaa gaagcaacat gaggaatttg acctgagccc tgaccagtgg cggaaaggaa
     2581 agaagtctac tttccggcat gttggagatg acaccactcg cctggagatc tggattcatc
     2641 catcccatcc acggtcttcc cagggcactg agtctgggaa ggattctgag caagagaatg
     2701 ggctgggcag cctgagtccc agtgatctga acaaaaggtt catcctcagt tttctccatg
     2761 cccatgggaa gctgtttacc cggattggga tggagacatt ccctgcagtg gctgagaagg
     2821 tcctcaagga gttccaggtg ttactgcagc acagcccctc tcccattgga agtacccgca
     2881 tgctgcagct tatgaccatc aatatgtttg cagtacacaa ctcccagctg aaagactgct
     2941 tctcggagga gtgccgctct gtgatccagg aacaagccgc agctctgggc ttggccatgt
     3001 tttctctact ggtccgccgc tgcacctgct tacttaagga gtccgccaaa gctcagctgt
     3061 cctctcctga ggaccaggat gaccaagacg acatcaaggt gtcttccttt gtcccggacc
     3121 tgaaggagct gctccccagt gtcaaagtct ggtcagattg gatgctcggc tacccggaca
     3181 cctggaatcc tcctcccaca tccctggatc tgccctcgca tgttgctgtg gatgtatggt
     3241 cgacgctggc tgatttctgt aacatactga ctgcagtgaa tcagtctgag gtgccactgt
     3301 acaaggaccc ggatgatgac ctcacccttc ttatcctgga agaggatcgg cttctctcgg
     3361 gctttgtccc cttgctggct gcccctcagg acccctgcta cgtggagaaa acctcggata
     3421 aggttattgc agctgactgc aaaagggtca cagtgctgaa gtattttctg gaagcccttt
     3481 gtggacaaga agagcctctg ctggcattca agggtggaaa gtatgtgtca gtggcacccg
     3541 tcccagacac catgggaaag gaaatgggaa gccaagaggg aacacgactg gaagatgagg
     3601 aggaggatgt ggtgattgaa gactttgagg aagattcaga ggctgaaggc agcggaggcg
     3661 aggatgacat cagggagctt cgggccaaga agctggctct ggccaggaag atagctgagc
     3721 agcagcgtcg ccaggaaaag atccaggctg tcctggagga ccacagtcag atgaggcaga
     3781 tggagctcga aatcagacct ttgttcctcg taccagacac caacggcttc attgaccacc
     3841 tggccagtct ggcgcggctg ctggagagca ggaagtacat cctggtggtg cccctcatcg
     3901 tgatcaatga gctggacggc ctggccaagg ggcaggagac agaccaccgg gctgggggct
     3961 acgcccgtgt ggtacaagag aaggcccgca agtccatcga gttcctcgag cagcgattcg
     4021 agagtcggga ctcttgcctg cgagccctga ccagccgtgg caatgaactc gaatccatcg
     4081 ccttccgcag tgaggacatc actggccagc tgggtaacaa cgatgatctc atcctgtcct
     4141 gctgcctcca ctactgcaaa gacaaggcta aggacttcat gcccgccagc aaagaggagc
     4201 caatccggct actgcgggag gtggtgctgt tgacggatga ccggaacctg cgtgtgaagg
     4261 cgctcacaag gaatgttcct gtacgggaca tcccagcctt cctcacgtgg gcccaggtgg
     4321 gctgagggag ccacactggg gccccccccc cgtggaaccg ttcctgaaag gccaccaggc
     4381 gcccagtgta gcacggaaga tgcccacgtg cctgagccac caatccaccc agacaataaa
     4441 ccatcctctt ccaacccacg ccacggccat gctgtggggg acctgctcct cacagagccc
     4501 ctcccaagga tcgggcggaa gctgctggga ccctcctggg ctgccaggat ttagcaggga
     4561 ggtggctggc tacagcaaca gcagctgggc aagccagata ggccgcccat gctctcagcc
     4621 tttctccctc ccccgtctca ttccaaggct gagggagggc cttctcgcct ggggacgcag
     4681 ccactttctc cagtggagac agggcagggg ttctgagttt ccgtcagatg cagtgaaatc
     4741 acagttccct ttcatcttca gaacctctgt cgtgaatgtg ttcaagaggc tttggttaag
     4801 tcaggaagaa gtgcccaggg tgtgtgtccc cagtctccct gaggcctgga ctcgcccatg
     4861 aacccaagtc ggcttctaga cagcatgtcc ctaacagcag ccctgggccc ccacctcttc
     4921 taccatccac cccagactta ccacacaccc ttcctgctgc tcctcttcct gcccttatca
     4981 acctgggtcc ctcacacttc gccagttgcg tccccgtgga cagtcatgag tctagaggaa
     5041 aggggcatct ggtctcaggc ccgtgctctc gggtggcctc cacctgctcc ctctctcctc
     5101 actggccttt ctttccgtct agcttcctct tcaggaaatg tcctgactcc cctcagctcc
     5161 cccttcaccc ctccttgccc gcctaccctc cctccagaat agcccctcac ccttcttccc
     5221 cttctagttg atccttttca cctccctgat ccccttcatt tcttcaccgc ggttcctcgt
     5281 cataggggtt ctcactctga actttccctc tctactaccc atggcaggaa cctagtacag
     5341 gtctcccacc cagggccttc caccctcggc tcctgtgctg ggagaaactt ccaggcgtgg
     5401 acagcccagc ctgaggcatt ccagtgctgg ggcaccgtcg cctaacctgg tttctagctt
     5461 tgccctcact ccccggaaaa actgacactg acacaggggc cctttccttg cccctttagc
     5521 tggtacctca gtggggaggc ttccttacca agaatgagtt cctgaaaccc agggccagag
     5581 acaaggacaa cttaggggaa gacggggttt tcggtggagc caggggcaaa tcttaatggg
     5641 accagtgggg gataccccag agcccatggc ctgactgcac agcctgcctg gaggatgggt
     5701 gcgcagctct gccctccctg aggcccagga ctatgccaga agcgatgggg taccgtgtag
     5761 gggagccaag gccagtagtt tgggggtagg agtcccctag agtctcagaa gactgggctc
     5821 tttggagtac agggtccccg gcctctcctt taagattctc tccccagctg gaaggccgat
     5881 gactgggtgg tcgggaggga gacccagctc tcctttctgt cccgtttgca gcactggttt
     5941 tgtttcctta ataaattttt agttatgaaa cata
//
