LOCUS       NM_015327               4559 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SMG5 nonsense mediated mRNA decay factor (SMG5),
            transcript variant 1, mRNA.
ACCESSION   NM_015327
VERSION     NM_015327.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4559)
  AUTHORS   Yang,L., Wei,J., Ma,X., Cheng,R., Zhang,H. and Jin,T.
  TITLE     Pan-Cancer Analysis of the Prognostic and Immunological Role of
            SMG5: A Biomarker for Cancers
  JOURNAL   Oncology 102 (2), 168-182 (2024)
   PUBMED   37699361
  REMARK    GeneRIF: Pan-Cancer Analysis of the Prognostic and Immunological
            Role of SMG5: A Biomarker for Cancers.
REFERENCE   2  (bases 1 to 4559)
  AUTHORS   Wang,Y., Jin,Q., Zhang,S. and Wang,Y.
  TITLE     Overexpression of TMEM79 combined with SMG5 is related to
            prognosis, tumor immune infiltration and drug sensitivity in
            hepatocellular carcinoma
  JOURNAL   Eur J Med Res 28 (1), 490 (2023)
   PUBMED   37936239
  REMARK    GeneRIF: Overexpression of TMEM79 combined with SMG5 is related to
            prognosis, tumor immune infiltration and drug sensitivity in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4559)
  AUTHORS   Boehm,V., Kueckelmann,S., Gerbracht,J.V., Kallabis,S.,
            Britto-Borges,T., Altmuller,J., Kruger,M., Dieterich,C. and
            Gehring,N.H.
  TITLE     SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6
            endonucleolytic activity
  JOURNAL   Nat Commun 12 (1), 3965 (2021)
   PUBMED   34172724
  REMARK    GeneRIF: SMG5-SMG7 authorize nonsense-mediated mRNA decay by
            enabling SMG6 endonucleolytic activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4559)
  AUTHORS   Nicholson,P., Gkratsou,A., Josi,C., Colombo,M. and Muhlemann,O.
  TITLE     Dissecting the functions of SMG5, SMG7, and PNRC2 in
            nonsense-mediated mRNA decay of human cells
  JOURNAL   RNA 24 (4), 557-573 (2018)
   PUBMED   29348139
  REMARK    GeneRIF: The authors found no evidence for the existence of a
            physical or functional interaction between SMG5 and PNRC2.
REFERENCE   5  (bases 1 to 4559)
  AUTHORS   Jin,Y., Zhang,F., Ma,Z. and Ren,Z.
  TITLE     MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting
            SMG5 mRNA
  JOURNAL   BMC Mol Biol 17 (1), 17 (2016)
   PUBMED   27473591
  REMARK    GeneRIF: This study highlights that miR-433 represses nonsense
            mediated mRNA decay. The miR-433 targets 3'-UTR of SMG5 and
            represses the expression of SMG5, whereas nonsense-mediated mRNA
            decay activity is decreased when SMG5 is decreased.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4559)
  AUTHORS   Moriarty,T.J., Ward,R.J., Taboski,M.A. and Autexier,C.
  TITLE     An anchor site-type defect in human telomerase that disrupts
            telomere length maintenance and cellular immortalization
  JOURNAL   Mol Biol Cell 16 (7), 3152-3161 (2005)
   PUBMED   15857955
REFERENCE   7  (bases 1 to 4559)
  AUTHORS   Unterholzner,L. and Izaurralde,E.
  TITLE     SMG7 acts as a molecular link between mRNA surveillance and mRNA
            decay
  JOURNAL   Mol Cell 16 (4), 587-596 (2004)
   PUBMED   15546618
REFERENCE   8  (bases 1 to 4559)
  AUTHORS   Ohnishi,T., Yamashita,A., Kashima,I., Schell,T., Anders,K.R.,
            Grimson,A., Hachiya,T., Hentze,M.W., Anderson,P. and Ohno,S.
  TITLE     Phosphorylation of hUPF1 induces formation of mRNA surveillance
            complexes containing hSMG-5 and hSMG-7
  JOURNAL   Mol Cell 12 (5), 1187-1200 (2003)
   PUBMED   14636577
  REMARK    GeneRIF: Data show that phosphorylated hUPF1, the human ortholog of
            UPF1/SMG-2, forms a complex with human orthologs of the
            Caenorhabditis elegans proteins SMG-5 and SMG-7.
REFERENCE   9  (bases 1 to 4559)
  AUTHORS   Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
            Robinson,M.O. and Harrington,L.
  TITLE     Functional conservation of the telomerase protein Est1p in humans
  JOURNAL   Curr Biol 13 (8), 698-704 (2003)
   PUBMED   12699629
REFERENCE   10 (bases 1 to 4559)
  AUTHORS   Reichenbach,P., Hoss,M., Azzalin,C.M., Nabholz,M., Bucher,P. and
            Lingner,J.
  TITLE     A human homolog of yeast Est1 associates with telomerase and uncaps
            chromosome ends when overexpressed
  JOURNAL   Curr Biol 13 (7), 568-574 (2003)
   PUBMED   12676087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT000143.1, AB029012.2 and BC038296.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015327.2.
            
            Summary: SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi
            et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038296.1, SRR1803612.64849.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361813.5/ ENSP00000355261.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CT000143.1         66-77
            13-4123             AB029012.2         19-4129
            4124-4559           BC038296.1         4129-4564
FEATURES             Location/Qualifiers
     source          1..4559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..4559
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /note="SMG5 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:23381"
                     /db_xref="HGNC:HGNC:24644"
                     /db_xref="MIM:610962"
     exon            1..219
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3196
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /note="isoform 1 is encoded by transcript variant 1; ever
                     shorter telomeres 1B; EST1 telomerase component homolog B;
                     protein SMG5; Est1p-like protein B; LPTS interacting
                     protein; EST1-like protein B; smg-5 homolog, nonsense
                     mediated mRNA decay factor; nonsense-mediated mRNA decay
                     factor SMG5"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG5 isoform
                     1"
                     /protein_id="NP_056142.2"
                     /db_xref="CCDS:CCDS1137.1"
                     /db_xref="GeneID:23381"
                     /db_xref="HGNC:HGNC:24644"
                     /db_xref="MIM:610962"
                     /translation="MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAY
                     QEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIH
                     SRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSAS
                     GKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQL
                     GTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSP
                     GKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLS
                     LASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLV
                     NHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKS
                     RKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAF
                     DAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASN
                     LQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGS
                     ESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSL
                     WNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPL
                     RAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQ
                     SEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPY
                     LVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFK
                     KGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTI
                     ITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG"
     exon            220..318
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            319..442
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            443..599
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            600..689
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            690..779
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            780..858
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            859..984
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1053
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1262
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1400
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..2000
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2176
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2252
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2428
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2587
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2647
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2807
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2898
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..2973
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3112
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..4559
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4540..4545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /note="hexamer: AATAAA"
     polyA_site      4559
                     /gene="SMG5"
                     /gene_synonym="EST1B; LPTS-RP1; LPTSRP1; SMG-5"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcgggca gccgcctcac agcgatggcg gccgagcagg gccggtggcg gcggcggctg
       61 cggctacggc cggagacggc agtgttggcg gtagtggtgg gtggcagggg cctgtgaccg
      121 ggagctgccc ccggacccgg gcaccatgag ccaaggcccc cccacagggg agagcagcga
      181 gcccgaagca aaagtcctcc acactaagcg gctttaccgg gctgtggtgg aggctgtgca
      241 tcgacttgac ctcatccttt gcaacaaaac tgcttatcaa gaagtattca aaccagaaaa
      301 cattagcctg aggaacaagc tgcgtgagct ctgcgtcaag cttatgttcc tgcacccagt
      361 ggactatggg agaaaggctg aggagctgct gtggagaaag gtatactatg aagttatcca
      421 gcttatcaag actaacaaaa agcacatcca cagccggagc actttggaat gtgcctacag
      481 gacgcacctg gttgctggta ttggcttcta ccagcatctc cttctctata tccagtccca
      541 ctaccagctg gaactgcagt gctgcatcga ctggacccat gtcactgacc ccctcatagg
      601 atgcaagaag ccagtgtctg cctcagggaa ggagatggat tgggcacaga tggcatgtca
      661 ccgatgtctg gtgtatctgg gggatttgtc ccgatatcag aatgaattag ctggcgtaga
      721 taccgagctg ctagccgaga gattttacta ccaagccctg tcagtagctc ctcagattgg
      781 aatgcccttc aatcagctgg gcaccctggc aggcagcaag tactataatg tggaagccat
      841 gtattgctac ctgcgctgca tccagtcaga agtgtccttt gagggagcct atgggaacct
      901 caagcggctg tatgacaagg cagccaaaat gtaccaccaa ctgaagaagt gtgagactcg
      961 gaaactgtct cctggcaaaa agcgatgtaa agacattaaa aggttgctag tgaactttat
     1021 gtatctgcaa agcctcctac agcccaaaag cagctccgtg gactcagagc tgacctcact
     1081 ttgccagtca gtcctggagg acttcaacct ctgcctcttc tacctgccct cctcacccaa
     1141 cctcagcctg gccagtgagg atgaggagga gtatgagagt ggatatgctt tcctcccgga
     1201 ccttctcatc tttcaaatgg tcatcatctg ccttatgtgt gtgcacagct tggagagagc
     1261 aggatccaag cagtacagtg cagccattgc cttcaccctg gccctctttt cccacctcgt
     1321 caatcatgtc aacatacggc tgcaggctga gctggaagag ggcgagaatc ccgtcccggc
     1381 attccagagt gatggcacag atgaaccaga gtccaaggaa cctgtggaga aagaggagga
     1441 gccagatcct gagcctcctc ctgtaacacc ccaagtgggt gagggcagaa agagccgtaa
     1501 gttctctcgc ctctcctgtc tccgccgtcg ccgccaccca cccaaagttg gtgatgacag
     1561 tgacctgagt gaaggctttg aatcggactc aagccatgac tcagcccggg ccagtgaggg
     1621 ctcagacagt ggctctgaca agagtcttga aggtggggga acggcctttg atgctgaaac
     1681 agactcggaa atgaatagcc aggagtcccg atcagacttg gaagatatgg aggaagagga
     1741 ggggacacgg tcaccaaccc tggagccccc tcggggcaga tcagaggctc ccgattccct
     1801 caatggccca ctgggcccca gtgaggctag cattgccagc aatctacaag ccatgtccac
     1861 ccagatgttc cagactaagc gctgcttccg actggccccc acctttagca acctgctcct
     1921 ccagcccacc accaaccctc atacctcggc cagccacagg ccttgcgtca atggggatgt
     1981 agacaagcct tcagagccag cctctgagga gggctctgag tcggagggga gtgagtccag
     2041 tggacgctcc tgtcggaatg agcgcagcat ccaggagaag cttcaggtcc tgatggccga
     2101 aggtctgctt cctgctgtga aagtcttcct ggactggctt cggaccaacc ccgacctcat
     2161 catcgtgtgt gcgcagagct ctcaaagtct gtggaaccgc ctgtctgtgt tgctgaatct
     2221 gttgcctgct gctggtgaac tccaggagtc tggcctggcc ttgtgtcctg aggtccaaga
     2281 tcttcttgaa ggttgtgaac tgcctgacct cccctctagc cttctgctcc cagaggacat
     2341 ggctcttcgt aacctgcccc cgctccgagc tgcccacaga cgctttaact ttgacacgga
     2401 tcggcccctg ctcagcacct tagaggagtc agtggtgcgc atctgctgca tccgcagctt
     2461 tggtcatttc atcgcccgcc tgcaaggcag catcctgcag ttcaacccag aggttggcat
     2521 cttcgtcagc attgcccagt ctgagcagga gagcctgctg cagcaggccc aggcacagtt
     2581 ccgaatggca caggaggaag ctcgtcggaa caggctcatg agagacatgg ctcagctacg
     2641 acttcagctc gaagtgtctc agctggaggg cagcctgcag cagcccaagg cccagtcagc
     2701 catgtctccc tacctcgtcc ctgacaccca ggccctctgc caccatctcc ctgtcatccg
     2761 ccaactggcc accagtggcc gcttcattgt catcatccca aggacagtga tcgatggcct
     2821 ggatttgctg aagaaggaac acccaggggc ccgggatggg attcggtacc tggaggcaga
     2881 gtttaaaaaa ggaaacaggt acattcgctg ccagaaagag gtgggaaaga gctttgagcg
     2941 gcataagctg aagaggcagg atgcagatgc ctggactctc tataagatcc tagacagctg
     3001 caaacagctg actctggccc agggggcagg tgaggaggat ccgagtggca tggtgaccat
     3061 catcacaggc cttccactgg acaaccccag cgtgctttca ggccccatgc aggcagccct
     3121 gcaggccgct gcccacgcca gtgtggacat caagaatgtt ctggacttct acaagcagtg
     3181 gaaggaaatt ggttgatact gacccccagg ccctgcagtg gggctgactc cagatctctc
     3241 ctgccctccc tggcagccag gaccagcacc tgtagtcacc ccaccacacg cagactcatg
     3301 cacgcacaca ggagggaggc ctagctgctc agaggctgca gggagggccc aggagccggc
     3361 tgggagggtg gggtcccttt gttgccaaga cgttaggaaa gcgaggaaag tgcttggatt
     3421 aggagagtct tgtgggcccc tggccagcct tcctgcctca gctcccctgc tgtctccagg
     3481 ggcaggtggt aggcatgggt acctgcattt cactggaatg ggttcttgga tctctgaggg
     3541 gaaggaacag caaaagaggc ccttcttcct cacccaagat gcagggtggt tggggccagg
     3601 agtttggacc ctctaggtct tgggggaaga gctgggtaat acctggtgtc tgagtgattc
     3661 tctgcagacc cttcccctcc tcaaggatca cccatcctcc tttcagcccc ctttatgggg
     3721 accaggcagc tctggagcca gccacagggg ctgttagaga agcaaggcct ggagtggcct
     3781 gcaccgagta gcagggtcag ggttcgtgtg ctcctcctcc tgctgcaggg gctgcacatc
     3841 ccattgcccc acttctgctt tgtgtctccc tctgtctagc ttccagggca gggagcaggc
     3901 cccacctagg gctgcaggca gtctggcctg tgccagcacg gtctcctgtg cccaccagcc
     3961 ccacaggtgc tgtgctttgt gctcttggct gctgtgctgg gacagaatgg gatgccagga
     4021 agagaagaaa gggggtgcag tctgaggcca ccacccccct tcctatctaa gggagggctg
     4081 aagacaaggg gccggcattc agtgggcagc agaaaggaga ggctccttga agctgctcag
     4141 tcagaggccc ccgtccctcc ttttgccttc cgcaggactg aagacctgaa ggggctggct
     4201 tttggagtgt tgaggtgaat atctgggagc agagatcatg aatagctcag ggcagtgaat
     4261 ggcgcaccaa gagcagggct gtgtgtggga ggctgcagcc aggattgcct cagctcctcc
     4321 ccctcaggct gggaggatag cacaggctag gggctcgggg tggagggtct cagctctgct
     4381 gcccccaccc cagtactagc ctagcttccc aagctgtggc ttagaggata gttggcttcc
     4441 tgcctctctc ctctaaaata gcaagtctgg gaaatcctgg ggtgagtgga gtcaccccac
     4501 tcccagttgc tggcagagac tgagactaaa gcatcactta ataaaccccc caagcccaa
//
