LOCUS       NM_015092              16062 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens SMG1 nonsense mediated mRNA decay associated PI3K
            related kinase (SMG1), mRNA.
ACCESSION   NM_015092 NM_014006
VERSION     NM_015092.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16062)
  AUTHORS   Leeksma,A.C., Derks,I.A.M., Garrick,B., Jongejan,A., Colombo,M.,
            Bloedjes,T., Trowe,T., Leisten,J.C., Howarth,M., Malek,M.,
            Mortensen,D.S., Blease,K., Groza,M.C., Narla,R.K., Loos,R.,
            Kersten,M.J., Moerland,P.D., Guikema,J.E.J., Kater,A.P.,
            Eldering,E. and Filvaroff,E.H.
  TITLE     SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a
            candidate therapeutic target in multiple myeloma
  JOURNAL   Mol Oncol 17 (2), 284-297 (2023)
   PUBMED   36400430
  REMARK    GeneRIF: SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a
            candidate therapeutic target in multiple myeloma.
REFERENCE   2  (bases 1 to 16062)
  AUTHORS   Bamberger,C., Pankow,S. and Yates,J.R. 3rd.
  TITLE     SMG1 and CDK12 Link DeltaNp63alpha Phosphorylation to RNA
            Surveillance in Keratinocytes
  JOURNAL   J Proteome Res 20 (12), 5347-5358 (2021)
   PUBMED   34761935
  REMARK    GeneRIF: SMG1 and CDK12 Link DeltaNp63alpha Phosphorylation to RNA
            Surveillance in Keratinocytes.
REFERENCE   3  (bases 1 to 16062)
  AUTHORS   Guo,L.W., Li,X.G., Yang,Y.S., Lu,X.X., Han,X.C., Lang,G.T.,
            Chen,L., Shao,Z.M. and Hu,X.
  TITLE     Large-scale genomic sequencing reveals adaptive opportunity of
            targeting mutated-PI3Kalpha in early and advanced HER2-positive
            breast cancer
  JOURNAL   Clin Transl Med 11 (11), e589 (2021)
   PUBMED   34842356
  REMARK    GeneRIF: Large-scale genomic sequencing reveals adaptive
            opportunity of targeting mutated-PI3Kalpha in early and advanced
            HER2-positive breast cancer.
REFERENCE   4  (bases 1 to 16062)
  AUTHORS   Lopez-Perrote,A., Hug,N., Gonzalez-Corpas,A., Rodriguez,C.F.,
            Serna,M., Garcia-Martin,C., Boskovic,J., Fernandez-Leiro,R.,
            Caceres,J.F. and Llorca,O.
  TITLE     Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated
            mRNA decay factor DHX34, as evidenced by Cryo-EM
  JOURNAL   Elife 9, e63042 (2020)
   PUBMED   33205750
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 16062)
  AUTHORS   Langer,L.M., Gat,Y., Bonneau,F. and Conti,E.
  TITLE     Structure of substrate-bound SMG1-8-9 kinase complex reveals
            molecular basis for phosphorylation specificity
  JOURNAL   Elife 9, e57127 (2020)
   PUBMED   32469312
  REMARK    GeneRIF: Structure of substrate-bound SMG1-8-9 kinase complex
            reveals molecular basis for phosphorylation specificity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16062)
  AUTHORS   Denning,G., Jamieson,L., Maquat,L.E., Thompson,E.A. and Fields,A.P.
  TITLE     Cloning of a novel phosphatidylinositol kinase-related kinase:
            characterization of the human SMG-1 RNA surveillance protein
  JOURNAL   J Biol Chem 276 (25), 22709-22714 (2001)
   PUBMED   11331269
REFERENCE   7  (bases 1 to 16062)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   8  (bases 1 to 16062)
  AUTHORS   Carmeliet,P., Lampugnani,M.G., Moons,L., Breviario,F.,
            Compernolle,V., Bono,F., Balconi,G., Spagnuolo,R., Oosthuyse,B.,
            Dewerchin,M., Zanetti,A., Angellilo,A., Mattot,V., Nuyens,D.,
            Lutgens,E., Clotman,F., de Ruiter,M.C., Gittenberger-de Groot,A.,
            Poelmann,R., Lupu,F., Herbert,J.M., Collen,D. and Dejana,E.
  TITLE     Targeted deficiency or cytosolic truncation of the VE-cadherin gene
            in mice impairs VEGF-mediated endothelial survival and angiogenesis
  JOURNAL   Cell 98 (2), 147-157 (1999)
   PUBMED   10428027
REFERENCE   9  (bases 1 to 16062)
  AUTHORS   Sanchez,P., De Carcer,G., Sandoval,I.V., Moscat,J. and
            Diaz-Meco,M.T.
  TITLE     Localization of atypical protein kinase C isoforms into
            lysosome-targeted endosomes through interaction with p62
  JOURNAL   Mol Cell Biol 18 (5), 3069-3080 (1998)
   PUBMED   9566925
REFERENCE   10 (bases 1 to 16062)
  AUTHORS   Diaz-Meco,M.T., Municio,M.M., Sanchez,P., Lozano,J. and Moscat,J.
  TITLE     Lambda-interacting protein, a novel protein that specifically
            interacts with the zinc finger domain of the atypical protein
            kinase C isotype lambda/iota and stimulates its kinase activity in
            vitro and in vivo
  JOURNAL   Mol Cell Biol 16 (1), 105-114 (1996)
   PUBMED   8524286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA433527.1, AW503964.1,
            DA854035.1, AB061371.1, BE079340.1, AY014957.1, AL833298.1,
            AC138811.3, BC037335.1, AK025794.1 and AW088221.1.
            
            On Nov 22, 2019 this sequence version replaced NM_015092.4.
            
            Summary: This gene encodes a protein involved in nonsense-mediated
            mRNA decay (NMD) as part of the mRNA surveillance complex. The
            protein has kinase activity and is thought to function in NMD by
            phosphorylating the regulator of nonsense transcripts 1 protein.
            Alternatively spliced transcript variants have been described, but
            their full-length nature has yet to be determined. [provided by
            RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB061371.1, SRR14038193.1419736.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446231.7/ ENSP00000402515.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               DA433527.1         6-221
            217-515             AW503964.1         218-516
            516-660             DA854035.1         20-164
            661-2201            AB061371.1         609-2149
            2202-2257           BE079340.1         407-462
            2258-5763           AY014957.1         133-3638
            5764-5826           AB061371.1         5712-5774
            5827-10098          AY014957.1         3702-7973
            10099-10410         AL833298.1         3433-3744
            10411-11058         AY014957.1         8286-8933
            11059-11059         AC138811.3         187965-187965       c
            11060-12983         AY014957.1         8935-10858
            12984-13161         AL833298.1         6317-6494
            13162-15171         BC037335.1         107-2116
            15172-15643         AK025794.1         1638-2109
            15644-16060         AW088221.1         2-418               c
            16061-16062         BC037335.1         3006-3007
FEATURES             Location/Qualifiers
     source          1..16062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..16062
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /note="SMG1 nonsense mediated mRNA decay associated PI3K
                     related kinase"
                     /db_xref="GeneID:23049"
                     /db_xref="HGNC:HGNC:30045"
                     /db_xref="MIM:607032"
     exon            1..459
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..11353
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /EC_number="2.7.11.1"
                     /note="PI-3-kinase-related kinase SMG-1; lambda/iota
                     protein kinase C-interacting protein; lambda-interacting
                     protein; smg-1 homolog, phosphatidylinositol
                     3-kinase-related kinase; SMG1 phosphatidylinositol
                     3-kinase-related kinase; nonsense mediated mRNA
                     decay-associated PI3K-related kinase SMG1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SMG1"
                     /protein_id="NP_055907.3"
                     /db_xref="CCDS:CCDS45430.1"
                     /db_xref="GeneID:23049"
                     /db_xref="HGNC:HGNC:30045"
                     /db_xref="MIM:607032"
                     /translation="MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKY
                     SSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRK
                     SLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRITRED
                     DRDRRLATVKQLKEFIQQPENKLVLVKQLDNILAAVHDVLNESSKLLQELRQEGACCL
                     GLLCASLSYEAEKIFKWIFSKFSSSAKDEVKLLYLCATYKALETVGEKKAFSSVMQLV
                     MTSLQSILENVDTPELLCKCVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPS
                     LTQQVSGWLQSLEPFWVADLAFSTTLLGQFLEDMEAYAEDLSHVASGESVDEDVPPPS
                     VSLPKLAALLRVFSTVVRSIGERFSPIRGPPITEAYVTDVLYRVMRCVTAANQVFFSE
                     AVLTAANECVGVLLGSLDPSMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIV
                     EQINTKLPSSFVEKLFIPSSKLLFLRYHKEKEVVAVAHAVYQAVLSLKNIPVLETAYK
                     LILGEMTCALNNLLHSLQLPEACSEIKHEAFKNHVFNVDNAKFVVIFDLSALTTIGNA
                     KNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSHCTRHDHFISSS
                     LSSSSPSLFDGAVISTVTTATKKHFSIILNLLGILLKKDNLNQDTRKLLMTWALEAAV
                     LMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSLHALSSSLPDDLLQRC
                     VDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQEISLALRSHMSKAPSNT
                     FHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRNLLKTDAVLWQ
                     WAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTTADNDEG
                     HGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRI
                     RLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELHCPEA
                     IQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSV
                     LTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADWAAVQ
                     EWQNAIHDLKKSTSSTSLNLKADFNYIKSLSSFESGKFVECTEQLELLPGENINLLAG
                     GSKEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENV
                     VKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLF
                     SEALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRG
                     NVSLATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTA
                     GQSTHAMEMLSSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQ
                     QNFTGLSTLSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSV
                     QAPEVAKSWAALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKER
                     IYGILGQAVCRPAGIQDEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESAT
                     EGVIKVWRKVVDRIFSLYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDM
                     IVMATLRLLRLLVKHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSIC
                     NLLCRVAQDSPHLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECE
                     GGSPPASQDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRV
                     TVLWDELWLGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKP
                     IVFALEHVRSITAAPAETPHEKWFQDNYGDAIENALEKLKTPLNPAKPGSSWIPFKEI
                     MLSLQQRAQKRASYILRLEEISPWLAAMTNTEIALPGEVSARDTVTIHSVGGTITILP
                     TKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHA
                     RHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPR
                     PSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTT
                     PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKS
                     LRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPL
                     VDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDE
                     MLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSHTLQHRYSE
                     HTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQMDLGPPS
                     YVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKA
                     IFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEMTLQR
                     YAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVIIS
                     ALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLV
                     PQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHE
                     LDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGELIQPR
                     NGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARS
                     TQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQ
                     IVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDII
                     AQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLV
                     RRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLH
                     TLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKE
                     SQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSEL
                     ELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLV
                     DNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNI
                     QTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNE
                     CSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTG
                     KSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYV
                     IKEATNLDNLAQLYEGWTAWV"
     exon            460..623
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            624..779
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            780..916
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            917..975
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1189
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1315
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1388
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1486
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1660
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1885
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1987
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2257
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2388
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2550
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2669
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2757
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2859
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3000
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3200
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3397
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3562
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3717
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3860
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4062
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4063..4172
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4320
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4480
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4601
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4602..4850
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..5135
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5136..5280
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5281..5419
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5420..5650
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5651..5828
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5829..5990
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            5991..6208
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6209..6363
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6364..6586
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6587..6833
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6834..7063
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7064..7312
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7313..7451
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7452..7561
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7562..7780
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7781..7971
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7972..8144
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8145..8424
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8425..8697
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8698..8932
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            8933..9159
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9160..9310
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9311..9500
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9501..9970
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            9971..10108
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10109..10261
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10262..10441
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10442..10669
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10670..10881
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10882..10988
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            10989..11168
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11169..11275
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     exon            11276..16062
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16040..16045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /note="hexamer: AATAAA"
     polyA_site      16062
                     /gene="SMG1"
                     /gene_synonym="61E3.4; ATX; LIP"
                     /note="major polyA site"
ORIGIN      
        1 agtggccgtg tgagcgtgag gagctgccgc caccgcctgc tcctcgtcgt cctcgtcctc
       61 cggggccccg gcgacgtggg ccgcgcacgg ccctggaaaa gacgtcgcct ccccttcatc
      121 cgcctctctc tcaccgcgcc gctcccgcct cctcgtcctg cgctgcgggc tcaggcggaa
      181 cccggaacgg ccgtcctctt cccccgccct ccgccgcctc ctccttctcc tcctcctcct
      241 cctcctcctc cttctcggct tcctcctcag ccccgggccg gagcggggtg tcggcggcgg
      301 ccggttcggg cggcgactcg cgcttctttg ggcggcggcg cttggccatg tcgtgtcggg
      361 gaaggtaatg agccgcagag ccccggggtc tcggctgagc agcggcggcg gcggcggcgg
      421 caccaagtat ccgcggagct ggaatgactg gcaacccaga actgatagtg catcagccga
      481 cccagataat ttaaaatatt cttcatccag agatagaggt ggttcttcct cttatggact
      541 gcaaccttca aattcagctg tggtgtctcg gcaaaggcac gatgatacca gagtccacgc
      601 tgacatacag aatgacgaaa agggtggcta cagtgtcaat ggaggatctg gggaaaatac
      661 ttatggtcgg aagtcgttgg ggcaagagct gagggttaac aatgtgacca gccctgagtt
      721 caccagtgtt cagcatggca gtcgtgcttt agccaccaaa gacatgagga aatcacagga
      781 gagatcgatg tcttattctg atgagtctcg actgtcgaat cttcttcgga ggatcacccg
      841 ggaagacgac agagaccgaa gattggctac tgtaaagcag ttgaaagaat ttattcagca
      901 accagaaaat aagctggtac tagttaaaca attggataat atcttggctg ctgtacatga
      961 cgtgcttaat gaaagtagca aattgcttca ggagttgaga caggagggag cttgctgtct
     1021 tggccttctt tgtgcttctc tgagctatga ggctgagaag atcttcaagt ggatttttag
     1081 caaatttagc tcatctgcaa aagatgaagt taaactcctc tacttatgtg ccacctacaa
     1141 agcactagag actgtaggag aaaagaaagc cttttcatct gtaatgcagc ttgtaatgac
     1201 cagcctgcag tctattcttg aaaatgtgga tacaccagaa ttgctttgta aatgtgttaa
     1261 gtgcattctt ttggtggctc gatgttaccc tcatattttc agcactaatt ttagggatac
     1321 agttgatata ttagttggat ggcatataga tcatactcag aaaccttcgc tcacgcagca
     1381 ggtatctggg tggttgcaga gtttggagcc attttgggta gctgatcttg cattttctac
     1441 tactcttctt ggtcagtttc tggaagacat ggaagcatat gctgaggacc tcagccatgt
     1501 ggcctctggg gaatcagtgg atgaagatgt ccctcctcca tcagtgtcat taccaaagct
     1561 ggctgcactt ctccgggtat ttagtactgt ggtgaggagc attggggaac gcttcagccc
     1621 aattcggggt cctccaatta ctgaggcata tgtaacagat gttctgtaca gagtaatgag
     1681 atgtgtgacg gctgcaaacc aggtgttttt ttctgaggct gtgttgacag ctgctaatga
     1741 gtgtgttggt gttttgctcg gcagcttgga tcctagcatg actatacatt gtgacatggt
     1801 cattacatat ggattagacc aactggagaa ttgccagact tgtggtaccg attatatcat
     1861 ctcagtcttg aatttactca cgctgattgt tgaacagata aatacgaaac tgccatcatc
     1921 atttgtagaa aaactgttta taccatcatc taaactacta ttcttgcgtt atcataaaga
     1981 aaaagaggtt gttgctgtag cccatgctgt ttatcaagca gtgctcagct tgaagaatat
     2041 tcctgttttg gagactgcct ataagttaat attgggagaa atgacttgtg ccctaaacaa
     2101 cctcctacac agtctacaac ttcctgaggc ctgttctgaa ataaaacatg aggcttttaa
     2161 gaatcatgtg ttcaatgtag acaatgcaaa atttgtagtt atatttgacc tcagtgccct
     2221 gactacaatt ggaaatgcca aaaactcact aatagggatg tgggcgctat ctccaactgt
     2281 ctttgcactt ctgagtaaga atctgatgat tgtgcacagt gacctggctg ttcacttccc
     2341 tgccattcag tatgctgtgc tctacacatt gtattctcat tgtaccaggc atgatcactt
     2401 tatctctagt agcctcagtt cttcctctcc ttctttgttt gatggagctg tgattagcac
     2461 tgtaactacg gctacaaaga aacatttctc aattatatta aatcttctgg gaatattact
     2521 taagaaagat aaccttaacc aggacacgag gaaactgtta atgacttggg ctttggaagc
     2581 agctgtttta atgaagaagt ctgaaacata cgcaccttta ttctctcttc cgtctttcca
     2641 taaattttgc aaaggccttt tagccaacac tctcgttgaa gatgtgaata tctgtctgca
     2701 ggcatgcagc agtctacatg ctctgtcctc ttccttgcca gatgatcttt tacagagatg
     2761 tgtcgatgtt tgccgtgttc aactagtgca cagtggaact cgtattcgac aagcatttgg
     2821 aaaactgttg aaatcaattc ctttagatgt tgtcctaagc aataacaatc acacagaaat
     2881 tcaagaaatt tctttagcat taagaagtca catgagtaaa gcaccaagta atacattcca
     2941 cccccaagat ttctctgatg ttattagttt tattttgtat gggaactctc atagaacagg
     3001 gaaggacaat tggttggaaa gactgttcta tagctgccag agactggata agcgtgacca
     3061 gtcaacaatt ccacgcaatc tcctgaagac agatgctgtc ctttggcagt gggccatatg
     3121 ggaagctgca caattcactg ttctttctaa gctgagaacc ccactgggca gagctcaaga
     3181 caccttccag acaattgaag gtatcattcg aagtctcgca gctcacacat taaaccctga
     3241 tcaggatgtt agtcagtgga caactgcaga caatgatgaa ggccatggta acaaccaact
     3301 tagacttgtt cttcttctgc agtatctgga aaatctggag aaattaatgt ataatgcata
     3361 cgagggatgt gctaatgcat taacttcacc tcccaaggtc attagaactt ttttctatac
     3421 caatcgccaa acttgtcagg actggctaac gcggattcga ctctccatca tgagggtagg
     3481 attgttggca ggccagcctg cagtgacagt gagacatggc tttgacttgc ttacagagat
     3541 gaaaacaacc agcctatctc aggggaatga attggaagta accattatga tggtggtaga
     3601 agcattatgt gaacttcatt gtcctgaagc tatacaggga attgctgtct ggtcatcatc
     3661 tattgttgga aaaaatcttc tgtggattaa ctcagtggct caacaggctg aagggaggtt
     3721 tgaaaaggcc tctgtggagt accaggaaca cctgtgtgcc atgacaggtg ttgattgctg
     3781 catctccagc tttgacaaat cggtgctcac cttagccaat gctgggcgta acagtgccag
     3841 cccgaaacat tctctgaatg gtgaatccag aaaaactgtg ctgtccaaac cgactgactc
     3901 ttcccctgag gttataaatt atttaggaaa taaagcatgt gagtgctaca tctcaattgc
     3961 cgattgggct gctgtgcagg aatggcagaa cgctatccat gacttgaaaa agagtaccag
     4021 tagcacttcc ctcaacctga aagctgactt caactatata aaatcattaa gcagctttga
     4081 gtctggaaaa tttgttgaat gtaccgagca gttagaattg ttaccaggag aaaatatcaa
     4141 tctacttgct ggaggatcaa aagaaaaaat agacatgaaa aaactgcttc ctaacatgtt
     4201 aagtccggat ccgagggaac ttcagaaatc cattgaagtt caattgttaa gaagttctgt
     4261 ttgtttggca actgctttaa acccgataga acaagatcag aagtggcagt ctataactga
     4321 aaatgtggta aagtacttga agcaaacatc ccgcatcgct attggacctc tgagactttc
     4381 tactttaaca gtttcacagt ctttgccagt tctaagtacc ttgcagctgt attgctcatc
     4441 tgctttggag aacacagttt ctaacagact ttcaacagag gactgtctta ttccactctt
     4501 cagtgaagct ttacgttcat gtaaacagca tgacgtgagg ccatggatgc aggcattaag
     4561 gtatactatg taccagaatc agttgttgga gaaaattaaa gaacaaacag tcccaattag
     4621 aagccatctc atggaattag gtctaacagc agcaaaattt gctagaaaac gagggaatgt
     4681 gtcccttgca acaagactgc tggcacagtg cagtgaagtt cagctgggaa agaccaccac
     4741 tgcacaggat ttagtccaac attttaaaaa actatcaacc caaggtcaag tggatgaaaa
     4801 atgggggccc gaacttgata ttgaaaaaac caaattgctt tatacagcag gccagtcaac
     4861 acatgcaatg gaaatgttga gttcttgtgc catatctttc tgcaagtctg tgaaagctga
     4921 atatgcagtt gctaaatcaa ttctgacact ggctaaatgg atccaggcag aatggaaaga
     4981 gatttcagga cagctgaaac aggtttacag agctcagcac caacagaact tcacaggtct
     5041 ttctactttg tctaaaaaca tactcactct aatagaactg ccatctgtta atacgatgga
     5101 agaagagtat cctcggatcg agagtgaatc tacagtgcat attggagttg gagaacctga
     5161 cttcattttg ggacagttgt atcacctgtc ttcagtacag gcacctgaag tagccaaatc
     5221 ttgggcagcg ttggccagct gggcttatag gtggggcaga aaggtggttg acaatgccag
     5281 tcagggagaa ggtgttcgtc tgctgcctag agaaaaatct gaagttcaga atctacttcc
     5341 agacactata actgaggaag agaaagagag aatatatggt attcttggac aggctgtgtg
     5401 tcggccggcg gggattcagg atgaagatat aacacttcag ataactgaga gtgaagacaa
     5461 cgaagaagat gacatggttg atgttatctg gcgtcagttg atatcaagct gcccatggct
     5521 ttcagaactt gatgaaagtg caactgaagg agttattaaa gtgtggagga aagttgtaga
     5581 tagaatattc agcctgtaca aactctcttg cagtgcatac tttactttcc ttaaactcaa
     5641 cgctggtcaa attcctttag atgaggatga ccctaggctg catttaagtc acagagtgga
     5701 acagagcact gatgacatga ttgtgatggc cacattgcgc ctgctgcggt tgctcgtgaa
     5761 gcatgctggt gagcttcggc agtatctgga gcacggcttg gagacaacac ccactgcacc
     5821 atggagagga attattccgc aacttttctc acgcttaaac caccctgaag tgtatgtgcg
     5881 ccaaagtatt tgtaaccttc tctgccgtgt ggctcaagat tccccacatc tcatattgta
     5941 tcctgcaata gtgggtacca tatcgcttag tagtgaatcc caggcttcag gaaataaatt
     6001 ttccactgca attccaactt tacttggcaa tattcaagga gaagaattgc tggtttctga
     6061 atgtgaggga ggaagtcctc ctgcatctca ggatagcaat aaggatgaac ctaaaagtgg
     6121 attaaatgaa gaccaagcca tgatgcagga ttgttacagc aaaattgtag ataagctgtc
     6181 ctctgcaaac cccaccatgg tattacaggt tcagatgctc gtggctgaac tgcgcagggt
     6241 cactgtgctc tgggatgagc tctggctggg agttttgctg caacaacaca tgtatgtcct
     6301 gagacgaatt cagcagcttg aagatgaggt gaagagagtc cagaacaaca acaccttacg
     6361 caaagaagag aaaattgcaa tcatgaggga gaagcacaca gctttgatga agcccatcgt
     6421 atttgctttg gagcatgtga ggagtatcac agcggctcct gcagaaacac ctcatgaaaa
     6481 atggtttcag gataactatg gtgatgccat tgaaaatgcc ctagaaaaac tgaagactcc
     6541 attgaaccct gcaaagcctg ggagcagctg gattccattt aaagagataa tgctaagttt
     6601 gcaacagaga gcacagaaac gtgcaagtta catcttgcgt cttgaagaaa tcagtccatg
     6661 gttggctgcc atgactaaca ctgaaattgc tcttcctggg gaagtctcag ccagagacac
     6721 tgtcacaatc catagtgtgg gcggaaccat cacaatctta ccgactaaaa ccaagccaaa
     6781 gaaacttctc tttcttggat cagatgggaa gagctatcct tatcttttca aaggactgga
     6841 ggatttacat ctggatgaga gaataatgca gttcctatct attgtgaata ccatgtttgc
     6901 tacaattaat cgccaagaaa caccccggtt ccatgctcga cactattctg taacaccact
     6961 aggaacaaga tcaggactaa tccagtgggt agatggagcc acacccttat ttggtcttta
     7021 caaacgatgg caacaacggg aagctgcctt acaagcacaa aaggcccaag attcctacca
     7081 aactcctcag aatcctggaa ttgtaccccg tcctagtgaa ctttattaca gtaaaattgg
     7141 ccctgctttg aaaacagttg ggcttagcct ggatgtgtcc cgtcgggatt ggcctcttca
     7201 tgtaatgaag gcagtattgg aagagttaat ggaggccaca cccccgaatc tccttgccaa
     7261 agagctctgg tcatcttgca caacacctga tgaatggtgg agagttacgc agtcttatgc
     7321 aagatctact gcagtcatgt ctatggttgg atacataatt ggccttggag acagacatct
     7381 ggataatgtt cttatagata tgacgactgg agaagttgtt cacatagatt acaatgtttg
     7441 ctttgaaaaa ggtaaaagcc ttagagttcc tgagaaagta ccttttcgaa tgacacaaaa
     7501 cattgaaaca gcactgggtg taactggagt agaaggtgta tttaggcttt catgtgagca
     7561 ggttttacac attatgcggc gtggcagaga gaccctgctg acgctgctgg aggcctttgt
     7621 gtacgaccct ctggtggact ggacagcagg aggcgaggct gggtttgctg gtgctgtcta
     7681 tggtggaggt ggccagcagg ccgagagcaa gcagagcaag agagagatgg agcgagagat
     7741 cacccgcagc ctgttttctt ctagagtagc tgagattaag gtgaactggt ttaagaatag
     7801 agatgagatg ctggttgtgc ttcccaagtt ggacggtagc ttagatgaat acctaagctt
     7861 gcaagagcaa ctgacagatg tggaaaaact gcagggcaaa ctactggagg aaatagagtt
     7921 tctagaagga gctgaagggg tggatcatcc ttctcatact ctgcaacaca ggtattctga
     7981 gcacacccaa ctacagactc agcaaagagc tgttcaggaa gcaatccagg tgaagctgaa
     8041 tgaatttgaa caatggataa cacattatca ggctgcattc aataatttag aagcaacaca
     8101 gcttgcaagc ttgcttcaag agataagcac acaaatggac cttggtcctc caagttacgt
     8161 gccagcaaca gcctttctgc agaatgctgg tcaggcccac ttgattagcc agtgcgagca
     8221 gctggagggg gaggttggtg ctctcctgca gcagaggcgc tccgtgctcc gtggctgtct
     8281 ggagcaactg catcactatg caaccgtggc cctgcagtat ccgaaggcca tatttcagaa
     8341 acatcgaatt gaacagtgga agacctggat ggaagagctc atctgtaaca ccacagtaga
     8401 gcgttgtcaa gagctctata ggaaatatga aatgcaatat gctccccagc cacccccaac
     8461 agtgtgtcag ttcatcactg ccactgaaat gaccctgcag cgatacgcag cagacatcaa
     8521 cagcagactt attagacaag tggaacgctt gaaacaggaa gctgtcactg tgccagtttg
     8581 tgaagatcag ttgaaagaaa ttgaacgttg cattaaagtt ttccttcatg agaatggaga
     8641 agaaggatct ttgagtctag caagtgttat tatttctgcc ctttgtaccc ttacaaggcg
     8701 taacctgatg atggaaggtg cagcgtcaag tgctggagaa cagctggttg atctgacttc
     8761 tcgggatgga gcctggttct tggaggaact ctgcagtatg agcggaaacg tcacctgctt
     8821 ggttcagtta ctgaagcagt gccacctggt gccacaggac ttagatatcc cgaaccccat
     8881 ggaagcgtct gagacagttc acttagccaa tggagtgtat acctcacttc aggaattgaa
     8941 ttcgaatttc cggcaaatca tatttccaga agcacttcga tgtttaatga aaggggaata
     9001 cacgttagaa agtatgctgc atgaactgga cggtcttatt gagcagacca ccgatggcgt
     9061 tcccctgcag actctagtgg aatctcttca ggcctactta agaaacgcag ctatgggact
     9121 ggaagaagaa acacatgctc attacatcga tgttgccaga ctactacatg ctcagtacgg
     9181 tgaattaatc caaccgagaa atggttcagt tgatgaaaca cccaaaatgt cagctggcca
     9241 gatgcttttg gtagcattcg atggcatgtt tgctcaagtt gaaactgctt tcagcttatt
     9301 agttgaaaag ttgaacaaga tggaaattcc catagcttgg cgaaagattg acatcataag
     9361 ggaagccagg agtactcaag ttaatttttt tgatgatgat aatcaccggc aggtgctaga
     9421 agagattttc tttctaaaaa gactacagac tattaaggag ttcttcaggc tctgtggtac
     9481 cttttctaaa acattgtcag gatcaagttc acttgaagat cagaatactg tgaatgggcc
     9541 tgtacagatt gtcaatgtga aaaccctttt tagaaactct tgtttcagtg aagaccaaat
     9601 ggccaaacct atcaaggcat tcacagctga ctttgtgagg cagctcttga tagggctacc
     9661 caaccaagcc ctcggactca cactgtgcag ttttatcagt gctctgggtg tagacatcat
     9721 tgctcaagta gaggcaaagg actttggtgc cgaaagcaaa gtttctgttg atgatctctg
     9781 taagaaagcg gtggaacata acatccagat agggaagttc tctcagctgg ttatgaacag
     9841 ggcaactgtg ttagcaagtt cttacgacac tgcctggaag aagcatgact tggtgcgaag
     9901 gctagaaacc agtatttctt cttgtaagac aagcctgcag cgggttcagc tgcatattgc
     9961 catgtttcag tggcaacatg aagatctact tatcaataga ccacaagcca tgtcagtcac
    10021 acctccccca cggtctgcta tcctaaccag catgaaaaag aagctgcata ccctgagcca
    10081 gattgaaact tctattgcaa cagttcagga gaagctagct gcacttgaat caagtattga
    10141 acagcgactc aagtgggcag gtggtgccaa ccctgcattg gcccctgtac tacaagattt
    10201 tgaagcaacg atagctgaaa gaagaaatct tgtccttaaa gagagccaaa gagcaagtca
    10261 ggtcacattt ctctgcagca atatcattca ttttgaaagt ttacgaacaa gaactgcaga
    10321 agccttaaac ctggatgcgg cgttatttga actaatcaag cgatgtcagc agatgtgttc
    10381 gtttgcatca cagtttaaca gttcagtgtc tgagttagag cttcgtttat tacagagagt
    10441 ggacactggt cttgaacatc ctattggcag ctctgaatgg cttttgtcag cacacaaaca
    10501 gttgacccag gatatgtcta ctcagagggc aattcagaca gagaaagagc agcagataga
    10561 aacggtctgt gaaacaattc agaatctggt tgataatata aagactgtgc tcactggtca
    10621 taaccgacag cttggagatg tcaaacatct cttgaaagct atggctaagg atgaagaagc
    10681 tgctctggca gatggtgaag atgttcccta tgagaacagt gttaggcagt ttttgggtga
    10741 atataaatca tggcaagaca acattcaaac agttctattt acattagtcc aggctatggg
    10801 tcaggttcga agtcaagaac acgttgaaat gctccaggaa atcactccca ccttgaaaga
    10861 actgaaaaca caaagtcaga gtatctataa taatttagtg agttttgcat cacccttagt
    10921 caccgatgca acaaatgaat gttcgagtcc aacgtcatct gctacttatc agccatcctt
    10981 cgctgcagca gtccggagta acactggcca gaagactcag cctgatgtca tgtcacagaa
    11041 tgctagaaag ctgatccaaa aaaatcttgc tacatcagct gatactccac caagcaccgt
    11101 tccaggaact ggcaagagtg ttgcttgtag tcctaaaaag gcagtcagag accctaaaac
    11161 tgggaaagcg gtgcaagaga gaaactccta tgcagtgagt gtgtggaaga gagtgaaagc
    11221 caagttagag ggccgagatg ttgatccgaa taggaggatg tcagttgctg aacaggttga
    11281 ctatgtcatt aaggaagcaa ctaatctaga taacttggct cagctgtatg aaggttggac
    11341 agcctgggtg tgaatggcaa gacagtagat gagtctggtt aagcgaggtc agacatccac
    11401 cagaatcaac tcagcctcag gcatccaaag ccacaccaca gtcggtggtg atgcaactgg
    11461 gggcttactc tgaggaaacc taggaaatct cggtgcacta ggaagtgaat cccgcaggac
    11521 agctgcactc agggatacgc ccaacaccat ggcctgcaac cccagggtca agggtgaagg
    11581 aaagcaagct caccgcctga acacggagat tgtctttctg ccacagaaca gcagcagacg
    11641 tgtcgggagg ttagctgcgg aaagaaatcg ggatgccgcg gagcacagag tgatttggaa
    11701 ctccattcca cctgaccctg tgtgtacaat ccaggaaaaa aacaaacccc actcagaaac
    11761 agagaaaact ggggtcgcga agaaatcaca gccaaggaag atttgatgca ttcagattct
    11821 cgtgtaacac ttgttgcttg gcaacagtac tggttgggtt gaccagtaag tagaaaaagg
    11881 ctaaaggcta tgcgatatga atttcagaaa tggactgaaa atggagagct atgtaacaga
    11941 tacactacag tagaagaact tacttctgaa atgaagggaa aaaaaccacc ccatcgttcc
    12001 ctactcctcc ccaccactta cccgttcccc ctttacctaa tctagtagat tagccatctt
    12061 tcaaattcac ttttatttca gtccttatat ttcatatact tccgtctcga tgctgttaac
    12121 aacttctgat aacatggaaa attcaaggat tgtttaaagg tctgatgatc acacacaaaa
    12181 tgtaattccg gttatttaag tcatttctgt gattctatca tgtacagttt ccagaattgt
    12241 cactgtgcat tcaaaagtaa tgaatctaac agacatttga tttaatgtac actccctttt
    12301 gcttatagtg tgcatttttt ttggaggtca ttcaaatttt ccctcttctg tgatagctgt
    12361 agtttctttc atagaaagta gctaatccag tgtaatcttt taccttttta aaaaccaaga
    12421 tagagtatct attagagttt tacattgttg atgatagatt aacaataaag tgatgttctg
    12481 gtggaggtag actgaaattt ttttaattca tgtttttcat ttgatacttt taatttacac
    12541 ttagtaaatt aaaagttgtt taatttactt ggcattttag gacatgtaca tgaaacagtg
    12601 aaaatgagat ccaccaacat cttttattaa gttcagttat tagtctgtga agtgctttac
    12661 tttttgcaca attttaatag cttgctattc agtaatacat tatagtgaat tcatgatcaa
    12721 ggtttcctta aatttagcat tgcatttcag tactgactgt gtaagctaaa ttgctgatcc
    12781 aaaataaaaa cccagactag aatagggttc ttaaaatcaa gtatcaatac aaaatagaac
    12841 acaattaaaa tcttaattgt tggctgggca cagtggctca cgcctgtaat cccagcactt
    12901 tgggaggccg aggcgggcgg atcatgaggt taggagagcg agaccatcct ggctaacacg
    12961 gtgaaacccc gtctttacta aaaatacaaa aaaaattagc cgggcgtggt ggcgggcgcc
    13021 tgtagtccca gctactcggg aggctgaggc aggagaatgg cgtgaaccca ggaggcggag
    13081 cttgcagtga gccgagattg tgccactgca ctccagcctg ggcaacagag ctagactctg
    13141 tgtcaaaaat aaatgactag ataaaaaaaa aaattgtttg agtacatttt ccctgcattt
    13201 tagagattag gacagtggtc actttctagt tgccgtcttc acagacaaac ttgaaaggta
    13261 ttaaggaaaa aattccacat agctctgggc cttttttgta ttctgattgc cacgttaatc
    13321 tgtaatcgtt aagtacccat gaaagaatgt gtttcagtat cagtgctttt ttggtacttt
    13381 aacaagtatt gtaggcacgg tggatttttt tgaaataccc atgtgtccaa tagcaagtta
    13441 aggaacctag cgcatcaaat tttgttttct tcattcattt ggaaccttat tttcgcaaaa
    13501 aacctagctg gaataataat gccatattgt attttgcaca ctgctttatt ttctagaggc
    13561 tctgggagca aattacattc atcacattac ctctgctctc tcaagattaa agtctttcag
    13621 caacattctt tattgtcatc ataaggaaaa acttttatcg caatgatagt cagttcacat
    13681 tagtttagca ctatagatag tattcagaaa ttgctttctc tttggtaaag aagataaata
    13741 ggtgaatttt attgcctgtg ttttcaggct tcagaggtac ctggcacctt actcaagcaa
    13801 aaacaaaaaa cagctttact tcaaaagcat gtgcctctgg taaattatcc atcacttttg
    13861 ttttaaagtg gtccctccaa gaataatgtg gcatacacag tgggtttggt tgtaaggcag
    13921 atgtaataga tgacttcaaa agcctgctcc ttactgcact ctggacaagg ccctggtctg
    13981 tatagtttgg cttcctctgt taagtcattc tacaaggtga cttgccattt gaactttcgt
    14041 aagagacctc agcagttaga ctgagaaaag ttagagtgct gtagttatga agtcatacat
    14101 ttttgataaa atacctgtgg aaaaccaggg atcctctcct gtttctctct cttgcctccc
    14161 cctttccctc cattcctctg tcgcctcccc ctctcctcca ctttctttaa gaatcagggg
    14221 gtacagaata acctacaaac aacctcttca aagtaccctt ggaaattgaa gttcaatctt
    14281 aagttttttg ctgtctttaa tttactagaa ttgcctaatt tttagttgat ttctctacag
    14341 agcttagctt gtgtagttat ttctctttta ctgttgcttt ggtgtgtctt gaagtttgat
    14401 tgattatttt tggtcattga gttcttagtg tagtttgcta gatgattatt aagattcttt
    14461 tgtgtctgac acttgtggtg agttgctttt gaaatctgtt gagatttcca tgtgagaact
    14521 gataatcagg ctcttgatct gcttccctaa attacttttt tagagcccaa accccaggtt
    14581 tagggtgagg gtttgtaata caaagaaaca cttccatcac ttctgccctt aacccttgcc
    14641 tctattacct aagcttagta agtagttttc ttaatattgt ccaatgtttg gtgttatctg
    14701 cattgttttt tgttttttta attgtggttg ttctgacgtg tgaaatttaa ggaaagagcc
    14761 attttttaaa aatgccgagc agggcaatgc aagtacagcc aaatattaga cttgatgtgc
    14821 aatcttcggt cctttttaat ctggggtatt ataggcagta ctttaaattg caaagtcttc
    14881 cgggcctatt ttcctctaca tttttgtaat taactctggg ggcttacttg ttttggcagt
    14941 actgaaatca aaggagctgg ttcttctttt ctcccaatta ttttcatatg aaagcaccta
    15001 caattagcct gttagtccta ttcagataca tcaaatatca gtgaatgctt tactattcgc
    15061 acatttaagc atctttgttt tacataaaat tagagtatga aaaccagtgt tcaatttttt
    15121 atcttgttga gcttgtaaaa tgccagcaat ttaaaactag gacttttccc cccataagcc
    15181 aaggaggtag aattactaat acaagggtta aagaaggtag attttgtttt caatatttgg
    15241 gtaatattag aaagattctt cccacaggga agaactagca agtgtcccaa ttttttccaa
    15301 acgttgggga ggggaaaatt cactgtatca tgaaacccta agggtttgtt gcacttcctg
    15361 ctttttaggc ctggataaca gtatcaccat ccttatttac agaagggtaa aactgactct
    15421 taatgagaaa agctttataa gttcaagggc tgtaaaatat gaactactta gggtcgtttg
    15481 ccttccatgg gaacttggct agacttagaa aaagctgttt gttgtgctaa tgtaaaagtg
    15541 tcatacaatt tagaagattt ttgaagatgg taaacttaga agaattctat gttctgaaat
    15601 gcacactttt agaatgtttt tctttgaaaa caggctaata gttttttctt tttttgacaa
    15661 agtttcagct cctctttaaa gttattgtgt catttttctg gtttaaattt cccttatatt
    15721 tccacctgta atgtcagtgg caacaacatc atacttcact tacttgttaa tttacttttt
    15781 acccttattc taagagcaag ttgagttgaa ctgaatcttc cttgtcttag taacaatgta
    15841 taaatagtgg cttttctgta caaaaggttg taatgcctcc tgatggatat aattttgtga
    15901 ttgtatttaa aagttgaata aatcacacca gcttcctgaa aatgttcata atgcatcttt
    15961 tggaaaacaa atacatgcct actttgtgca tatttgcatt aacatggcaa agattgtatg
    16021 aaatacctgt ttttcagaaa ataaaggttc agtctcaaaa ga
//
