LOCUS       NM_030663                770 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sperm mitochondria associated cysteine rich protein
            (SMCP), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_030663
VERSION     NM_030663.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 770)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 770)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 770)
  AUTHORS   Takahashi,A., Hirohashi,Y., Torigoe,T., Tamura,Y., Tsukahara,T.,
            Kanaseki,T., Kochin,V., Saijo,H., Kubo,T., Nakatsugawa,M.,
            Asanuma,H., Hasegawa,T., Kondo,T. and Sato,N.
  TITLE     Ectopically expressed variant form of sperm mitochondria-associated
            cysteine-rich protein augments tumorigenicity of the stem cell
            population of lung adenocarcinoma cells
  JOURNAL   PLoS One 8 (11), e69095 (2013)
   PUBMED   24244262
  REMARK    GeneRIF: the initiation results indicate that an ectopically
            expressed variant form of SMCP has a role in tumor initiation of
            CSCs/CICs and that the variant form of SMCP might be a novel
            CSC/CIC marker
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 770)
  AUTHORS   Yatsenko,A.N., Roy,A., Chen,R., Ma,L., Murthy,L.J., Yan,W.,
            Lamb,D.J. and Matzuk,M.M.
  TITLE     Non-invasive genetic diagnosis of male infertility using
            spermatozoal RNA: KLHL10 mutations in oligozoospermic patients
            impair homodimerization
  JOURNAL   Hum Mol Genet 15 (23), 3411-3419 (2006)
   PUBMED   17047026
REFERENCE   6  (bases 1 to 770)
  AUTHORS   Hawthorne,S.K., Goodarzi,G., Bagarova,J., Gallant,K.E.,
            Busanelli,R.R., Olend,W.J. and Kleene,K.C.
  TITLE     Comparative genomics of the sperm mitochondria-associated
            cysteine-rich protein gene
  JOURNAL   Genomics 87 (3), 382-391 (2006)
   PUBMED   16325371
  REMARK    GeneRIF: The levels of SMCP mRNA in human are much lower than in
            other mammals.
REFERENCE   7  (bases 1 to 770)
  AUTHORS   Behne,D. and Kyriakopoulos,A.
  TITLE     Mammalian selenium-containing proteins
  JOURNAL   Annu Rev Nutr 21, 453-473 (2001)
   PUBMED   11375445
  REMARK    Review article
REFERENCE   8  (bases 1 to 770)
  AUTHORS   Cataldo,L., Baig,K., Oko,R., Mastrangelo,M.A. and Kleene,K.C.
  TITLE     Developmental expression, intracellular localization, and selenium
            content of the cysteine-rich protein associated with the
            mitochondrial capsules of mouse sperm
  JOURNAL   Mol Reprod Dev 45 (3), 320-331 (1996)
   PUBMED   8916043
REFERENCE   9  (bases 1 to 770)
  AUTHORS   Aho,H., Schwemmer,M., Tessman,D., Murphy,D., Mattei,G., Engel,W.
            and Adham,I.M.
  TITLE     Isolation, expression, and chromosomal localization of the human
            mitochondrial capsule selenoprotein gene (MCSP)
  JOURNAL   Genomics 32 (2), 184-190 (1996)
   PUBMED   8833144
REFERENCE   10 (bases 1 to 770)
  AUTHORS   Saaranen,M., Suistomaa,U. and Vanha-Perttula,T.
  TITLE     Semen selenium content and sperm mitochondrial volume in human and
            some animal species
  JOURNAL   Hum Reprod 4 (3), 304-308 (1989)
   PUBMED   2715306
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014593.2.
            
            On Nov 23, 2018 this sequence version replaced NM_030663.2.
            
            Summary: Sperm mitochondria differ in morphology and subcellular
            localization from those of somatic cells. They are elongated,
            flattened, and arranged circumferentially to form a helical coiled
            sheath in the midpiece of the sperm flagellum. The protein encoded
            by this gene localizes to the capsule associated with the
            mitochondrial outer membranes and is thought to function in the
            organization and stabilization of the helical structure of the
            sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014593.2, HM005432.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000368765.4/
                                                  ENSP00000357754.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               BC014593.2         1-770
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..770
                     /gene="SMCP"
                     /gene_synonym="HSMCSGEN1; MCS; MCSP"
                     /note="sperm mitochondria associated cysteine rich
                     protein"
                     /db_xref="GeneID:4184"
                     /db_xref="HGNC:HGNC:6962"
                     /db_xref="MIM:601148"
     exon            1..125
                     /gene="SMCP"
                     /gene_synonym="HSMCSGEN1; MCS; MCSP"
                     /inference="alignment:Splign:2.1.0"
     exon            126..770
                     /gene="SMCP"
                     /gene_synonym="HSMCSGEN1; MCS; MCSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..496
                     /gene="SMCP"
                     /gene_synonym="HSMCSGEN1; MCS; MCSP"
                     /note="testicular tissue protein Li 119; testicular tissue
                     protein Li 161"
                     /codon_start=1
                     /product="sperm mitochondrial-associated cysteine-rich
                     protein"
                     /protein_id="NP_109588.2"
                     /db_xref="CCDS:CCDS1029.1"
                     /db_xref="GeneID:4184"
                     /db_xref="HGNC:HGNC:6962"
                     /db_xref="MIM:601148"
                     /translation="MCDQTKHSKCCPAKGNQCCPPQQNQCCQSKGNQCCPPKQNQCCQ
                     PKGSQCCPPKHNHCCQPKPPCCIQARCCGLETKPEVSPLNMESEPNSPQTQDKGCQTQ
                     QQPHSPQNESRPSK"
     regulatory      750..755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMCP"
                     /gene_synonym="HSMCSGEN1; MCS; MCSP"
                     /note="hexamer: AATAAA"
     polyA_site      770
                     /gene="SMCP"
                     /gene_synonym="HSMCSGEN1; MCS; MCSP"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcttt ggcttctgat agtcatggac tcactaggct gctgaggaag atcaataata
       61 cctactggaa tcagtcatga gaagtcaagc atggaaattg tgaattgtgt gtgtggccag
      121 accagtacct ccaagtgttc agaagatgtg tgaccagaca aaacacagta aatgctgccc
      181 agcaaaaggc aatcaatgct gcccaccaca gcagaaccag tgctgccagt caaaaggcaa
      241 tcaatgctgc ccaccaaaac agaaccagtg ctgccagcca aaaggcagtc aatgctgccc
      301 accaaaacac aatcactgct gccagccaaa acccccatgc tgcattcagg ccaggtgctg
      361 tggtttggag accaagcctg aagtctcacc ccttaacatg gagtctgagc ccaactcacc
      421 gcaaactcag gacaagggct gtcaaaccca gcagcagccc catagcccac aaaatgagtc
      481 caggccaagc aaatgagagc agaagaagtc aaacaaagaa gaagtccctg gggccatgcc
      541 tttcactttg tagggtgggg gattactgag agtcaggcta gacctgtgtt tagagaagca
      601 gttttcacag tgactaccat ttccacccaa tgagaggctc ctatttccca tcatagctcc
      661 ctaccctagg gaggcctcca tctggaaatg ggaggatgaa gaggctagaa tcatctttcc
      721 tagtgatcct gacatttaga cagcacagaa ataaagagca ataaaaagaa
//
