LOCUS       NM_020179                987 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens single-pass membrane protein with coiled-coil domains
            4 (SMCO4), mRNA.
ACCESSION   NM_020179
VERSION     NM_020179.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 987)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   3  (bases 1 to 987)
  AUTHORS   Kehrer-Sawatzki,H., Moschgath,E., Maier,C., Legius,E., Elgar,G. and
            Krone,W.
  TITLE     Characterization of the Fugu rubripes NLK and FN5 genes flanking
            the NF1 (Neurofibromatosis type 1) gene in the 5' direction and
            mapping of the human counterparts
  JOURNAL   Gene 251 (1), 63-71 (2000)
   PUBMED   10863097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003499.2, BC031564.1 and AF197137.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020179.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.264209.1,
                                           SRR1163658.125096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298966.7/ ENSP00000298966.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AP003499.2         6247-6257           c
            12-370              BC031564.1         1-359
            371-489             AF197137.1         332-450
            490-739             BC031564.1         479-728
            740-987             AF197137.1         703-950
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..987
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /note="single-pass membrane protein with coiled-coil
                     domains 4"
                     /db_xref="GeneID:56935"
                     /db_xref="HGNC:HGNC:24810"
                     /db_xref="MIM:609477"
     exon            1..116
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /inference="alignment:Splign:2.1.0"
     exon            117..189
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /inference="alignment:Splign:2.1.0"
     exon            190..987
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..449
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /note="UPF0443 protein C11orf75"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4"
                     /protein_id="NP_064564.1"
                     /db_xref="CCDS:CCDS8292.1"
                     /db_xref="GeneID:56935"
                     /db_xref="HGNC:HGNC:24810"
                     /db_xref="MIM:609477"
                     /translation="MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLL
                     IVVFVYVATRPTITE"
     regulatory      964..969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /note="hexamer: AATAAA"
     polyA_site      987
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgccc gcgcgggcgc cgagaggaga ggcgaggcgg ggagcgcaag cggcggcggc
       61 cactgccacg tattcccggc agtggtggcg gcggcggcgg cggcgcccgc gggcaggaat
      121 aactcaagtc acctgtactg gaaatcagtt tgctgaaatt aatcaacgat tcttgaagtt
      181 gaagaaaagg aggttccagc cttggcaaga ggagtgtggc ccttcctgga atccctctgg
      241 acacaccctc ctagcatcct ctaggaaaga tgcggcagct caaagggaag cccaagaagg
      301 agacctccaa ggacaagaag gagcggaagc aagccatgca ggaggcccgg cagcagatca
      361 ctacagtggt gctgcccacg ctggccgtgg tcgtgctctt gatcgtggtg tttgtgtacg
      421 tggccacgcg ccccaccatc accgagtgag ccccgcagcc ggctgcggac cccatcggca
      481 gggagaggag gcgcgggagg gggacgcaaa caaaaaatgg ctttcatatt cagagatgtt
      541 catgttgctg agctgtaagc aggagcaccc tgtcttctct ggtctttgac ttgattaaag
      601 tatctccgct ttcttgggag ggaatagggg atgttttatc agtgaatgtg ccatacacct
      661 tatggtccac ttcatgtgcc tttcagactt caaagcgcgc gcgcatgtgt gtgtgtgtgt
      721 gtgtgtgtgt gtgtgtgtgt gtgtgcttct ttttctctcc taaaaatcga taagtagctc
      781 cacctgaaga gggatggaac ctctgggtca ggaaacagct ggaatccaca ctcacctcat
      841 tcccattgtt tggatcatgc ttctttccaa cacgtgttca caatctccaa agggactgta
      901 tttcttctct gtgcttaatg tgatttgaaa tatgttgaat caaagtgaaa tatttatttt
      961 ttgaataaag gagataatag ccttaaa
//
