LOCUS       NM_001013698            2104 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens single-pass membrane protein with coiled-coil domains
            3 (SMCO3), mRNA.
ACCESSION   NM_001013698 XM_495913
VERSION     NM_001013698.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2104)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2104)
  AUTHORS   Cousminer,D.L., Berry,D.J., Timpson,N.J., Ang,W., Thiering,E.,
            Byrne,E.M., Taal,H.R., Huikari,V., Bradfield,J.P., Kerkhof,M.,
            Groen-Blokhuis,M.M., Kreiner-Moller,E., Marinelli,M., Holst,C.,
            Leinonen,J.T., Perry,J.R., Surakka,I., Pietilainen,O., Kettunen,J.,
            Anttila,V., Kaakinen,M., Sovio,U., Pouta,A., Das,S., Lagou,V.,
            Power,C., Prokopenko,I., Evans,D.M., Kemp,J.P., St Pourcain,B.,
            Ring,S., Palotie,A., Kajantie,E., Osmond,C., Lehtimaki,T.,
            Viikari,J.S., Kahonen,M., Warrington,N.M., Lye,S.J., Palmer,L.J.,
            Tiesler,C.M., Flexeder,C., Montgomery,G.W., Medland,S.E.,
            Hofman,A., Hakonarson,H., Guxens,M., Bartels,M., Salomaa,V.,
            Murabito,J.M., Kaprio,J., Sorensen,T.I., Ballester,F., Bisgaard,H.,
            Boomsma,D.I., Koppelman,G.H., Grant,S.F., Jaddoe,V.W., Martin,N.G.,
            Heinrich,J., Pennell,C.E., Raitakari,O.T., Eriksson,J.G.,
            Smith,G.D., Hypponen,E., Jarvelin,M.R., McCarthy,M.I., Ripatti,S.
            and Widen,E.
  CONSRTM   ReproGen Consortium; Early Growth Genetics (EGG) Consortium
  TITLE     Genome-wide association and longitudinal analyses reveal genetic
            loci linking pubertal height growth, pubertal timing and childhood
            adiposity
  JOURNAL   Hum Mol Genet 22 (13), 2735-2747 (2013)
   PUBMED   23449627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK092637.1, BM696674.1 and BU735185.1.
            
            On Nov 3, 2006 this sequence version replaced NM_001013698.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK092637.1, BC132752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316048.2/ ENSP00000381895.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-728               AK092637.1         1-728
            729-730             BM696674.1         252-253
            731-1680            AK092637.1         729-1678
            1681-1704           BU735185.1         238-261             c
            1705-2104           AK092637.1         1703-2102
FEATURES             Location/Qualifiers
     source          1..2104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..2104
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /note="single-pass membrane protein with coiled-coil
                     domains 3"
                     /db_xref="GeneID:440087"
                     /db_xref="HGNC:HGNC:34401"
     exon            1..57
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /inference="alignment:Splign:2.1.0"
     exon            58..2104
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..751
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 3"
                     /protein_id="NP_001013720.2"
                     /db_xref="CCDS:CCDS41759.1"
                     /db_xref="GeneID:440087"
                     /db_xref="HGNC:HGNC:34401"
                     /translation="MAQSDFLYPENPKRREEVNRLHQQLLDCLSDSFDVTNKLTEVLN
                     MHLGCRLASIEMKRDGTIKENCDLIIQAIMKIQKELQKVDEALKDKLEPTLYRKLQDI
                     KEKETDKIAIVQKVISVILGEATSAASAVAVKLVGSNVTTGIINKLVTVLAQIGASLL
                     GSIGVAVLGLGIDMIVRAILGAVEKTQLQAAIKSYEKHLVEFKSASEKYNHAITEVIN
                     TVKHQMK"
     regulatory      1077..1082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /note="hexamer: AGTAAA"
     polyA_site      1096
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /note="major polyA site"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /note="hexamer: AATAAA"
     polyA_site      1928
                     /gene="SMCO3"
                     /gene_synonym="C12orf69"
                     /note="major polyA site"
ORIGIN      
        1 actttaacaa tactcctaaa caactgctag gaccacggaa ctcagaaaca cagcaagcga
       61 tcatattgga aatatggccc aaagtgactt cctttaccca gagaacccaa aaaggcggga
      121 agaagtaaat cgtcttcacc agcagcttct tgattgctta tctgacagct tcgatgtcac
      181 caataagctg actgaggttc taaatatgca cttggggtgc aggctggcct ccattgagat
      241 gaaaagagat gggaccatca aagaaaactg tgacctcatc atccaagcca ttatgaaaat
      301 ccaaaaggaa ttgcagaagg ttgatgaagc actaaaagat aagctagagc caaccctcta
      361 tagaaaactt caggatatta aggaaaagga aacagacaaa attgcaatag tgcaaaaggt
      421 tatttcggtc atcctgggag aagctacatc tgcagccagt gcagtcgctg ttaaacttgt
      481 gggctcaaat gtcacaactg gcataattaa caagttggtc actgtgttag ctcaaattgg
      541 tgcttctctc cttggtagta ttggagttgc tgttcttggc cttggcatag atatgattgt
      601 ccgtgccatc ctgggagcag tggaaaaaac acagcttcaa gcagccatca aaagttatga
      661 gaagcatctg gtggagttca aatcagcctc agaaaaatat aatcatgcca ttactgaggt
      721 catcaataca gtgaaacacc aaatgaaatg aacagccgtt ttatttgcca ctgaagtgtt
      781 tttctgcttc cttttcagta acagtgtttg cttctttgat taggttcatt ttctataggc
      841 ttccaatatg gacttaaata agataaacaa tttggagagg gaaactggag atgccaagac
      901 tagatgacta gatgagtttt gagtcaacaa tgcctggatc agctgatgct agaccctgtg
      961 aggtaaaaaa attttctccc tggatgtttt cacaccctgc tctaccagat caacattggg
     1021 gtaaatgcta tcgtagagta gcaagtatag gggttacttt tctcttttct aatttcagta
     1081 aaattcttaa atttcacatt gaatgcagag actttcattt ctaccaccag cttcaaacat
     1141 catttagtta taaggggaca tactcagtaa cttctgccta gacacaaact ctaggccttc
     1201 gaatgagaca gaaatactac catatttttg accatcagag taaatctggt tttctgtaaa
     1261 ctagaagaga ctgaaaaatg gtttgtaaca atgtgcttca attaggacag gaagctgatc
     1321 tgtaaacgtc tactgattac acaatgtaaa ccggatggat ttgaaaatgg taaaaatcaa
     1381 aactaaaaac atcaaggtcc tgtttcagtc actgcaatca accctgacca actgtgataa
     1441 ttaaatatcg ctcaagtgaa tgttcaaaca ctgaaacatt tagaagacaa gaaagcaaaa
     1501 cacagctaca catattgcat ttaggatgca gaatagaagg tcactactca aagcatttgt
     1561 catttaaaag aaagtcataa tttattataa gctttcagaa aaaagaatat aatttcattt
     1621 tcaacactag caaaaaggag gcagctgcct ttgctacatg acgcattagg tgggccattt
     1681 cactaattac ctgattttag aaaacgccaa aggctatgga agcctattaa tggttccgct
     1741 gaatctctgc agatgtgttt gttttctaaa tcctttgcca accaataatt cccatgagga
     1801 ctcttttagt ctatactgac aaaattatta atatgctgtt gatgccagac tgtgtttgtt
     1861 atagttgatt ctcccatcca agtacaagaa atgtattgaa ataaaaactg ctcagcatat
     1921 cttaaaaata gtagctacat ataaaatttt agctacatga aagactttaa tatttccaac
     1981 atacactgtt ttctctttct cttcttgcat tgtttttcaa aacgagttgc aaaactatga
     2041 tcactaatgt gttaggaaag aaaaaaaact agttgcaaaa cattacaact tagctcacct
     2101 tcgc
//
