LOCUS       NM_001395208            1196 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens single-pass membrane protein with coiled-coil domains
            2 (SMCO2), transcript variant 3, mRNA.
ACCESSION   NM_001395208 XM_011520634
VERSION     NM_001395208.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1196)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068794.25.
            
            On Oct 18, 2021 this sequence version replaced NM_001395208.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535986.2/ ENSP00000441688.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC068794.25        41901-41990
            91-234              AC068794.25        65787-65930
            235-334             AC068794.25        67941-68040
            335-462             AC068794.25        69951-70078
            463-612             AC068794.25        70747-70896
            613-700             AC068794.25        83625-83712
            701-757             AC068794.25        89465-89521
            758-933             AC068794.25        90845-91020
            934-1196            AC068794.25        97088-97350
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..1196
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="single-pass membrane protein with coiled-coil
                     domains 2"
                     /db_xref="GeneID:341346"
                     /db_xref="HGNC:HGNC:34448"
     exon            1..90
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            91..234
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1132
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="isoform 1 is encoded by transcript variant 3;
                     single-pass membrane and coiled-coil domain-containing
                     protein 2"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 2 isoform 1"
                     /protein_id="NP_001382137.1"
                     /db_xref="CCDS:CCDS44852.1"
                     /db_xref="GeneID:341346"
                     /db_xref="HGNC:HGNC:34448"
                     /translation="MALTPTNLNNKMSLQMKMDCQEQQLTKKNNGFFQKLNVTEGAMQ
                     DLLKEIIKVDHILDRSDDEDDISSENPQTDFLHKGMLELEAEHDQDLSKQDKQETDVD
                     EDPQASTSLQFSKKNLLELCLKGMFLKLNYWNTKIGLQVKELGADYIDGTEKIDNIIK
                     KINVTENTVKSLLKDMLTLKGQIEKLEDRGLDLDQGTSTEVNTCNEVYELKKKVIERL
                     EDLCKNVELLSAKLRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNT
                     AWKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLN
                     LEVEALLPS"
     exon            235..334
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            335..462
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            463..612
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            613..700
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            701..757
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            758..933
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1196
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="hexamer: AGTAAA"
     polyA_site      1196
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="major polyA site"
ORIGIN      
        1 agtggttctc aaacattagc tgtacctgag gcccttgggg agcttcttaa acctcaggct
       61 gctgggccca ctcccggagt tcctgattca tgccgaagaa atggctctca cgcccacaaa
      121 cctaaataac aaaatgtctc tgcagatgaa gatggactgc caggaacaac agctgactaa
      181 gaaaaacaat ggctttttcc aaaagctcaa tgtgactgaa ggtgcaatgc aggatttgct
      241 aaaggaaatt atcaaagtgg accacatctt agacagatcg gatgatgagg atgacatttc
      301 ctccgaaaac cctcaaactg acttccttca caagggtatg ttggagctag aggctgagca
      361 tgaccaggac ctgagtaaac aggataagca agaaacagat gttgatgagg accctcaagc
      421 gtctacatct ctgcagtttt caaagaagaa cctccttgaa ctgtgtctga agggcatgtt
      481 cctcaagcta aactactgga acacaaagat aggtctccag gtgaaagaac ttggagctga
      541 ttacatagac ggaacggaga aaattgacaa tattattaaa aaaataaatg taacagaaaa
      601 cacagtgaag agcttattaa aagacatgct gaccctgaag ggtcaaattg aaaagctgga
      661 ggaccggggc cttgaccttg atcaagggac aagcactgag gtgaatactt gtaatgaagt
      721 ttatgaatta aagaagaaag tcatagaaag gctggaggac ctttgcaaga atgtggaact
      781 gctgagtgca aagctaagga tgtatcaaat ggaggcagag gacactgact ctcacagttc
      841 tgaggaaata gatacggaag agatggaggc cctgcttcct caggccccag catccttttt
      901 agtgcagaag tctcctcccc gcaatacagc atggaaacgt gcactgagga ttttcatcat
      961 gtttgatgtc ctcaccgtca ctggactttt atgttacata ctattttttg gtgctacatt
     1021 tctctttgaa agggtgcttc tgagaatgct tgggtgccgc accacatggg acctacggga
     1081 gatgagagag cctttcttga atttggaagt ggaagccttg ttaccctcct aaagatacag
     1141 aagttactgt caccctactg actttctcac cagtaaacat tgtggctgtt cctgta
//
