LOCUS       NM_001387218             802 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens single-pass membrane protein with coiled-coil domains
            2 (SMCO2), transcript variant 2, mRNA.
ACCESSION   NM_001387218 XM_017019255
VERSION     NM_001387218.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 802)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068794.25.
            
            On Oct 18, 2021 this sequence version replaced NM_001387218.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279875.6049.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC068794.25        41901-41990
            91-218              AC068794.25        69951-70078
            219-306             AC068794.25        83625-83712
            307-363             AC068794.25        89465-89521
            364-539             AC068794.25        90845-91020
            540-802             AC068794.25        97088-97350
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..802
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="single-pass membrane protein with coiled-coil
                     domains 2"
                     /db_xref="GeneID:341346"
                     /db_xref="HGNC:HGNC:34448"
     exon            1..90
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            91..218
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..738
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="isoform 2 is encoded by transcript variant 2;
                     single-pass membrane and coiled-coil domain-containing
                     protein 2"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 2 isoform 2"
                     /protein_id="NP_001374147.1"
                     /db_xref="CCDS:CCDS91667.1"
                     /db_xref="GeneID:341346"
                     /db_xref="HGNC:HGNC:34448"
                     /translation="MLELEAEHDQDLSKQDKQETDVDEDPQASTSLQFSKKNLLELLL
                     KDMLTLKGQIEKLEDRGLDLDQGTSTEVNTCNEVYELKKKVIERLEDLCKNVELLSAK
                     LRMYQMEAEDTDSHSSEEIDTEEMEALLPQAPASFLVQKSPPRNTAWKRALRIFIMFD
                     VLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNLEVEALLPS"
     exon            219..306
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            307..363
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            364..539
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     exon            540..802
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      778..783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="hexamer: AGTAAA"
     polyA_site      802
                     /gene="SMCO2"
                     /gene_synonym="C12orf70"
                     /note="major polyA site"
ORIGIN      
        1 agtggttctc aaacattagc tgtacctgag gcccttgggg agcttcttaa acctcaggct
       61 gctgggccca ctcccggagt tcctgattca ggtatgttgg agctagaggc tgagcatgac
      121 caggacctga gtaaacagga taagcaagaa acagatgttg atgaggaccc tcaagcgtct
      181 acatctctgc agttttcaaa gaagaacctc cttgaactct tattaaaaga catgctgacc
      241 ctgaagggtc aaattgaaaa gctggaggac cggggccttg accttgatca agggacaagc
      301 actgaggtga atacttgtaa tgaagtttat gaattaaaga agaaagtcat agaaaggctg
      361 gaggaccttt gcaagaatgt ggaactgctg agtgcaaagc taaggatgta tcaaatggag
      421 gcagaggaca ctgactctca cagttctgag gaaatagata cggaagagat ggaggccctg
      481 cttcctcagg ccccagcatc ctttttagtg cagaagtctc ctccccgcaa tacagcatgg
      541 aaacgtgcac tgaggatttt catcatgttt gatgtcctca ccgtcactgg acttttatgt
      601 tacatactat tttttggtgc tacatttctc tttgaaaggg tgcttctgag aatgcttggg
      661 tgccgcacca catgggacct acgggagatg agagagcctt tcttgaattt ggaagtggaa
      721 gccttgttac cctcctaaag atacagaagt tactgtcacc ctactgactt tctcaccagt
      781 aaacattgtg gctgttcctg ta
//
