LOCUS       NM_001077657            1790 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens single-pass membrane protein with coiled-coil domains
            1 (SMCO1), transcript variant 1, mRNA.
ACCESSION   NM_001077657 XM_173087 XM_931549 XM_942639 XM_946179
VERSION     NM_001077657.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1790)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1790)
  AUTHORS   Zhang,C., Chang,C., Li,D., Zhang,F. and Xu,C.
  TITLE     The novel protein C3orf43 accelerates hepatocyte proliferation
  JOURNAL   Cell Mol Biol Lett 22, 21 (2017)
   PUBMED   28932249
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK123917.1, BC118636.1 and AL833140.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001077657.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.172946.1, AL833140.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397537.3/ ENSP00000380671.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK123917.1         21-38
            19-1191             BC118636.1         1-1173
            1192-1790           AL833140.1         1193-1791
FEATURES             Location/Qualifiers
     source          1..1790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1790
                     /gene="SMCO1"
                     /gene_synonym="C3orf43"
                     /note="single-pass membrane protein with coiled-coil
                     domains 1"
                     /db_xref="GeneID:255798"
                     /db_xref="HGNC:HGNC:27407"
     exon            1..187
                     /gene="SMCO1"
                     /gene_synonym="C3orf43"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..782
                     /gene="SMCO1"
                     /gene_synonym="C3orf43"
                     /note="isoform 1 is encoded by transcript variant 1;
                     single-pass membrane and coiled-coil domain-containing
                     protein 1"
                     /codon_start=1
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_001071125.1"
                     /db_xref="CCDS:CCDS43192.1"
                     /db_xref="GeneID:255798"
                     /db_xref="HGNC:HGNC:27407"
                     /translation="MNNETTTLISLKEAMKRVDHKLQALETQFKELDFTKDNLMQKFE
                     HHSKALASQAAQDEMWTAVRALQLTSMELNILYSYVIEVLICLHTRVLEKLPDLVRGL
                     PTLASVLRRKVKNKRVRVVWESILEECGLQEGDITALCTFFIARGNKAEHYTAKVRQM
                     YIRDVTFLITNMVKNQALQDSLLRAVQVIEKGKAVRTPEKQKSSLEELIPSVKN"
     exon            188..337
                     /gene="SMCO1"
                     /gene_synonym="C3orf43"
                     /inference="alignment:Splign:2.1.0"
     exon            338..1790
                     /gene="SMCO1"
                     /gene_synonym="C3orf43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMCO1"
                     /gene_synonym="C3orf43"
                     /note="hexamer: AATAAA"
     polyA_site      1790
                     /gene="SMCO1"
                     /gene_synonym="C3orf43"
                     /note="major polyA site"
ORIGIN      
        1 aggcagaatg tagactgagc gctcctgcta ctgctgcctg ttgctgagag gaagaccgca
       61 gaaaattctg gattcaaaca tttattgctt tttttgtttt gctttgtttt tgttttcttt
      121 ccttttgcct tcagaagatg aacaatgaaa ccacaaccct gatatccttg aaggaggcaa
      181 tgaaaagagt agaccacaaa ctccaagcgt tagaaacaca gttcaaagaa ctagacttca
      241 ccaaggataa cctgatgcag aaattcgaac atcatagtaa ggctttggca agccaagcag
      301 cccaagatga gatgtggaca gcagttcggg cactccagct cacttcaatg gaattgaata
      361 ttttatacag ctacgtcatt gaagtactta tctgcttgca tactcgtgtg cttgagaagc
      421 tgccagacct ggtgagaggt cttccaacct tagcctctgt actcagaaga aaagttaaga
      481 acaagcgcgt tagagttgta tgggagtcca tactggagga gtgtgggctg caagaaggag
      541 acatcacagc actttgtacc ttctttattg cacgtggtaa caaggcagaa cactatactg
      601 ctaaagtgag gcagatgtac atcagggatg tcacgttcct aattactaac atggtaaaga
      661 accaggctct gcaggacagt ttgctgaggg ctgtgcaggt aattgagaag gggaaagcag
      721 ttaggacccc tgaaaagcaa aagtcatccc tcgaagagtt gataccatct gtcaaaaact
      781 aacctgttac cctatgaccc agtgattcca cctacagtaa tttatcttgg aaacagcaaa
      841 aagtatgcac aatttattat agtcttattt ttatagcaaa gagtgagagg atgttaaata
      901 aattatgaca aattgataca atagatactt tctttgcagc catataaaag aatgaagaag
      961 ctctttgtgt aatgatatga agtgatcacc aaatgtattg ttgttttcaa atgtttattt
     1021 ccaatataca ttgctaagtg gaaaaaaggt gacaaatata tatatataaa tatatatata
     1081 acacatatta gtttacatat ccataaactt cttctgcaga gatacacaag acagtgataa
     1141 cattagttgt caggaaagaa agctaagagg ctaggggtca aagacaagag gaagtctttt
     1201 cactgttaat ccatttttta cattttcaat tttgaaccat gtgaatgtat tacctattta
     1261 aaaaataaac aaggccggac atggtggctc atgcctataa tccaagcacc ttaggaggcc
     1321 aaggtaggag gatcacttga gctcaggggt ttcagaccag cctgggcaac acagtgatag
     1381 caataggagg caggtaaatt cctaggcaga cagggagggg tccctggtga aactcaacct
     1441 tcaagccaag gacagtctaa agcctgaaaa ccaagctatg agttctggat aaatccatga
     1501 gccagactga gagctcccat tctcgtctgg caccctctct cctgattggt ccttaccctt
     1561 cacctatttt atacatacct acccttccgc gattggtcct ctacactatc gtgcctattt
     1621 ctgaatggtg ctttgtcaag catagccaca gaccaatcag catgcacttg cccatttcta
     1681 gcccacaaaa acccatagac tcaggctcgt ggccagcaac ccaccttcgg gtcccctctc
     1741 actgccaaga gccgttctgt cactcaataa attctacttt gccttactca
//
